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Aliases for METTL9 Gene

Aliases for METTL9 Gene

  • Methyltransferase Like 9 2 3 5
  • DORA Reverse Strand Protein 1 2 3
  • DREV1 3 4
  • DREV 3 4
  • Methyltransferase-Like Protein 9 3
  • DORA Reverse Strand Protein 4
  • P53 Activated Protein 1 3
  • CTB-31N19.3 3
  • CGI-81 3
  • PAP1 3

External Ids for METTL9 Gene

Previous GeneCards Identifiers for METTL9 Gene

  • GC16P021519
  • GC16P019992

Summaries for METTL9 Gene

GeneCards Summary for METTL9 Gene

METTL9 (Methyltransferase Like 9) is a Protein Coding gene. Diseases associated with METTL9 include Inflammatory Bowel Disease 1. Gene Ontology (GO) annotations related to this gene include methyltransferase activity.

Additional gene information for METTL9 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL9 Gene

Genomics for METTL9 Gene

GeneHancer (GH) Regulatory Elements for METTL9 Gene

Promoters and enhancers for METTL9 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J021597 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 674.9 +2.3 2349 4.6 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 METTL9 LOC101927814 IGSF6 NPIPB5 REXO5 NPIPB4 NPIPB3 THUMPD1 SMG1P3 MFSD13B
GH16J021624 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 27.8 +30.3 30303 6.3 PKNOX1 FOXA2 ARID4B DMAP1 ZNF48 SLC30A9 ATF7 NFKBIZ NFYC KAT8 ENSG00000261596 METTL9 IGSF6 MOSMO ERI2 ENSG00000260905 ENSG00000260973 CRYM GC16P021642
GH16J021644 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 22.6 +50.6 50592 7.6 HDGF PKNOX1 FOXA2 STAT5A BATF KLF5 IRF4 THRB RARA YY1 METTL9 IGSF6 ENSG00000260905 CRYM GC16P021651 RNU6-196P
GH16J021607 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 18.2 +13.5 13482 5.8 ATF1 ARNT NCOA2 TCF12 ATF7 RUNX3 NCOA1 REST MEF2D ATF4 IGSF6 METTL9 ENSG00000261596 RNU6-196P RNU6-1005P CRYM ERI2 PIR54824
GH16J021517 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 10.1 -77.0 -76989 4.7 HDGF PKNOX1 CLOCK FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 SMG1P3 SLC7A5P2 THUMPD1 RRN3P1 NPIPB4 NPIPB3 NPIPB5 SMG1P1 POLR3E LOC646828
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around METTL9 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the METTL9 gene promoter:
  • HEN1
  • AML1a
  • Egr-2
  • Hlf
  • RP58
  • SRY
  • HOXA9
  • HOXA9B
  • Meis-1a
  • Meis-1

Genomic Locations for METTL9 Gene

Genomic Locations for METTL9 Gene
60,256 bases
Plus strand
60,256 bases
Plus strand

Genomic View for METTL9 Gene

Genes around METTL9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METTL9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METTL9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL9 Gene

Proteins for METTL9 Gene

  • Protein details for METTL9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Methyltransferase-like protein 9
    Protein Accession:
    Secondary Accessions:
    • Q8NBT8
    • Q9BWJ7
    • Q9H1A2
    • Q9Y390

    Protein attributes for METTL9 Gene

    318 amino acids
    Molecular mass:
    36536 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAD34076.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for METTL9 Gene


neXtProt entry for METTL9 Gene

Post-translational modifications for METTL9 Gene

  • Ubiquitination at isoforms=251
  • Glycosylation at isoforms=235
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for METTL9 Gene

Domains & Families for METTL9 Gene

Gene Families for METTL9 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for METTL9 Gene

Suggested Antigen Peptide Sequences for METTL9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the DREV family.
  • Belongs to the DREV family.
genes like me logo Genes that share domains with METTL9: view

Function for METTL9 Gene

Gene Ontology (GO) - Molecular Function for METTL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21784977
genes like me logo Genes that share ontologies with METTL9: view
genes like me logo Genes that share phenotypes with METTL9: view

Animal Model Products

miRNA for METTL9 Gene

miRTarBase miRNAs that target METTL9

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for METTL9 Gene

Localization for METTL9 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for METTL9 gene
Compartment Confidence
cytosol 3
mitochondrion 2
nucleus 2
extracellular 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for METTL9 Gene

Pathways & Interactions for METTL9 Gene

SuperPathways for METTL9 Gene

No Data Available

Interacting Proteins for METTL9 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
Selected Interacting proteins: Q9H1A3-METL9_HUMAN ENSP00000350874 for METTL9 Gene via IID STRING

Gene Ontology (GO) - Biological Process for METTL9 Gene


No data available for Pathways by source and SIGNOR curated interactions for METTL9 Gene

Drugs & Compounds for METTL9 Gene

No Compound Related Data Available

Transcripts for METTL9 Gene

Unigene Clusters for METTL9 Gene

Methyltransferase like 9:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for METTL9 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d
SP1: - - - - -
SP2: - - - - -
SP4: -
SP5: - - -
SP6: -
SP7: - -

Relevant External Links for METTL9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for METTL9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for METTL9 Gene

mRNA differential expression in normal tissues according to GTEx for METTL9 Gene

This gene is overexpressed in Whole Blood (x7.6).

Protein differential expression in normal tissues from HIPED for METTL9 Gene

This gene is overexpressed in Bone (33.0), Monocytes (17.5), and Platelet (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for METTL9 Gene

NURSA nuclear receptor signaling pathways regulating expression of METTL9 Gene:


SOURCE GeneReport for Unigene cluster for METTL9 Gene:


Evidence on tissue expression from TISSUES for METTL9 Gene

  • Nervous system(3.9)
  • Skin(3.6)
  • Lung(2.4)
genes like me logo Genes that share expression patterns with METTL9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for METTL9 Gene

Orthologs for METTL9 Gene

This gene was present in the common ancestor of animals.

Orthologs for METTL9 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia METTL9 34 33
  • 99.68 (n)
(Bos Taurus)
Mammalia METTL9 34 33
  • 96.33 (n)
(Canis familiaris)
Mammalia METTL9 34 33
  • 96.23 (n)
(Mus musculus)
Mammalia Mettl9 16 34 33
  • 92.87 (n)
(Rattus norvegicus)
Mammalia Mettl9 33
  • 92.77 (n)
(Monodelphis domestica)
Mammalia METTL9 34
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia METTL9 34
  • 92 (a)
(Gallus gallus)
Aves METTL9 34 33
  • 83.07 (n)
(Anolis carolinensis)
Reptilia METTL9 34
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mettl9 33
  • 72.76 (n)
Str.3222 33
African clawed frog
(Xenopus laevis)
Amphibia MGC53836 33
(Danio rerio)
Actinopterygii mettl9 34 33
  • 58.2 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003602 33
  • 46.96 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5339 34 33
  • 46.35 (n)
(Caenorhabditis elegans)
Secernentea T03G11.6 34 33
  • 49.43 (n)
Species where no ortholog for METTL9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for METTL9 Gene

Gene Tree for METTL9 (if available)
Gene Tree for METTL9 (if available)
Evolutionary constrained regions (ECRs) for METTL9: view image

Paralogs for METTL9 Gene

(1) SIMAP similar genes for METTL9 Gene using alignment to 7 proteins:

  • H3BM54_HUMAN
  • H3BN86_HUMAN
genes like me logo Genes that share paralogs with METTL9: view

No data available for Paralogs for METTL9 Gene

Variants for METTL9 Gene

Sequence variations from dbSNP and Humsavar for METTL9 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000065174 -- 21,631,613(+) G/A/C/T intron_variant
rs1000074434 -- 21,651,162(+) G/T intron_variant
rs1000197427 -- 21,619,379(+) A/G/T intron_variant
rs1000246842 -- 21,606,118(+) C/T intron_variant
rs1000298197 -- 21,637,866(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for METTL9 Gene

Variant ID Type Subtype PubMed ID
nsv9397 CNV gain+loss 18304495
nsv817726 CNV gain 17921354
nsv7280 OTHER inversion 18451855
nsv571640 CNV loss 21841781
nsv571639 CNV loss 21841781
nsv571635 CNV gain 21841781
nsv571634 CNV gain 21841781
nsv571631 CNV loss 21841781
nsv517713 CNV gain+loss 19592680
nsv499139 OTHER inversion 21111241
nsv471086 CNV loss 18288195
nsv457460 CNV loss 19166990
nsv433438 CNV gain 18776910
nsv428322 CNV gain 18775914
nsv1140248 OTHER inversion 24896259
nsv1131233 CNV deletion 24896259
nsv1077770 OTHER inversion 25765185
esv998989 OTHER inversion 20482838
esv3892812 CNV gain+loss 25118596
esv3638188 CNV loss 21293372
esv3638187 CNV gain 21293372
esv3638186 CNV loss 21293372
esv3582094 CNV loss 25503493
esv3570431 CNV gain 25503493
esv34544 CNV gain 17911159
esv3427100 CNV insertion 20981092
esv34235 CNV gain 17911159
esv3368991 OTHER inversion 20981092
esv2763135 CNV gain 21179565
esv2762010 CNV gain+loss 21179565
esv2758636 CNV gain+loss 17122850
esv2751552 CNV loss 17911159
esv2751551 CNV gain 17911159
esv25717 CNV gain+loss 19812545
dgv806e212 CNV loss 25503493
dgv4947n54 CNV loss 21841781
dgv4946n54 CNV gain+loss 21841781
dgv4944n54 CNV loss 21841781
dgv47n16 OTHER inversion 17901297
dgv3n29 CNV loss 16826518
dgv3n1 OTHER inversion 15895083
dgv348n27 CNV loss 19166990
dgv347n27 CNV gain 19166990
dgv2810n100 CNV loss 25217958
dgv2809n100 CNV loss 25217958
dgv2808n100 CNV gain+loss 25217958
dgv2807n100 CNV loss 25217958
dgv2806n100 CNV gain 25217958
dgv2805n100 CNV gain+loss 25217958
dgv2804n100 CNV gain 25217958
dgv2803n100 CNV loss 25217958
dgv2800n100 CNV gain 25217958
dgv116e55 CNV loss 17911159

Variation tolerance for METTL9 Gene

Residual Variation Intolerance Score: 35.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.08; 1.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for METTL9 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METTL9 Gene

Disorders for METTL9 Gene

MalaCards: The human disease database

(1) MalaCards diseases for METTL9 Gene - From: HGMD and GeneCards

Disorder Aliases PubMed IDs
inflammatory bowel disease 1
  • ibd1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for METTL9

genes like me logo Genes that share disorders with METTL9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for METTL9 Gene

Publications for METTL9 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 2 3 4 58
  2. The mouse and human IGSF6 (DORA) genes map to the inflammatory bowel disease 1 locus and are embedded in an intron of a gene of unknown function. (PMID: 11132146) Bates EE … Lebecque S (Immunogenetics 2000) 2 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 58
  5. Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes. (PMID: 25544563) Davis ZH … Glaunsinger BA (Molecular cell 2015) 3 58

Products for METTL9 Gene

Sources for METTL9 Gene

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