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Aliases for METTL7B Gene

Aliases for METTL7B Gene

  • Methyltransferase Like 7B 2 3 5
  • Methyltransferase-Like Protein 7B 3 4
  • Associated With Lipid Droplets 1 2 3
  • EC 2.1.1.- 4
  • EC 2.1.1 56
  • ALDI 3

External Ids for METTL7B Gene

Previous GeneCards Identifiers for METTL7B Gene

  • GC12P054362
  • GC12P056075
  • GC12P053114

Summaries for METTL7B Gene

GeneCards Summary for METTL7B Gene

METTL7B (Methyltransferase Like 7B) is a Protein Coding gene. Diseases associated with METTL7B include Muscular Dystrophy, Congenital, Due To Integrin Alpha-7 Deficiency. Gene Ontology (GO) annotations related to this gene include methyltransferase activity and S-adenosylmethionine-dependent methyltransferase activity. An important paralog of this gene is METTL7A.

UniProtKB/Swiss-Prot for METTL7B Gene

Additional gene information for METTL7B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL7B Gene

Genomics for METTL7B Gene

GeneHancer (GH) Regulatory Elements for METTL7B Gene

Promoters and enhancers for METTL7B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J055680 Promoter/Enhancer 1.5 Ensembl ENCODE 643.5 +0.9 855 3.2 CTCF ELF3 POLR2A CEBPG ZSCAN21 AHR SP7 SP1 PPARG KLF14 METTL7B ITGA7 OR10P1 ENSG00000257303 BLOC1S1 BLOC1S1-RDH5
GH12J055702 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 11.4 +26.9 26901 11.7 ZNF148 CEBPG RERE NFIB ZSCAN21 ZBTB7A SP7 SP1 SP5 KLF14 ITGA7 BLOC1S1 RN7SL809P RPL41 RBMS2 METTL7B BAZ2A CD63 GDF11 RNU6-343P
GH12J055676 Enhancer 0.5 FANTOM5 43.1 -4.7 -4714 0.2 SP1 CEBPB CEBPG METTL7B MMP19 BLOC1S1 ITGA7 ZC3H10 ENSG00000270458
GH12J055673 Enhancer 0.6 ENCODE 16.2 -7.7 -7681 1.3 ZNF687 SP1 MLLT1 IKZF1 ELF1 NR2F1 NBN IRF4 METTL7B ITGA7 BLOC1S1 RDH5 ENSG00000270458
GH12J056078 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 3.1 +399.7 399749 6.1 HDGF ZNF652 SP1 ELF3 CTCF MNT POLR2A MLLT1 CEBPG RERE ERBB3 SUOX ANKRD52 RAB5B IKZF4 BAZ2A PHC1P1 ENSG00000257740 PAN2 SMARCC2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around METTL7B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the METTL7B gene promoter:
  • Arnt
  • c-Myb
  • C/EBPalpha
  • FAC1
  • GR
  • MZF-1
  • Nkx2-5
  • STAT1
  • STAT1alpha
  • STAT1beta

Genomic Locations for METTL7B Gene

Genomic Locations for METTL7B Gene
chr12:55,681,546-55,684,611
(GRCh38/hg38)
Size:
3,066 bases
Orientation:
Plus strand
chr12:56,075,330-56,078,395
(GRCh37/hg19)
Size:
3,066 bases
Orientation:
Plus strand

Genomic View for METTL7B Gene

Genes around METTL7B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METTL7B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METTL7B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL7B Gene

Proteins for METTL7B Gene

  • Protein details for METTL7B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UX53-MET7B_HUMAN
    Recommended name:
    Methyltransferase-like protein 7B
    Protein Accession:
    Q6UX53
    Secondary Accessions:
    • A8K247
    • Q8WUI1

    Protein attributes for METTL7B Gene

    Size:
    244 amino acids
    Molecular mass:
    27775 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAQ88872.1; Type=Erroneous termination; Positions=245; Note=Translated as stop.; Evidence={ECO:0000305}; Sequence=BAF82801.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for METTL7B Gene

Selected DME Specific Peptides for METTL7B Gene

Q6UX53:
  • RVLRPGG
  • DVVVCTLVLCSV

Post-translational modifications for METTL7B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for METTL7B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for METTL7B

Domains & Families for METTL7B Gene

Gene Families for METTL7B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for METTL7B Gene

Suggested Antigen Peptide Sequences for METTL7B Gene

GenScript: Design optimal peptide antigens:
  • Methyltransferase-like protein 7B (MET7B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6UX53

UniProtKB/Swiss-Prot:

MET7B_HUMAN :
  • Belongs to the methyltransferase superfamily.
Family:
  • Belongs to the methyltransferase superfamily.
genes like me logo Genes that share domains with METTL7B: view

Function for METTL7B Gene

Molecular function for METTL7B Gene

UniProtKB/Swiss-Prot Function:
Probable methyltransferase.

Enzyme Numbers (IUBMB) for METTL7B Gene

Phenotypes From GWAS Catalog for METTL7B Gene

Gene Ontology (GO) - Molecular Function for METTL7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with METTL7B: view
genes like me logo Genes that share phenotypes with METTL7B: view

Animal Models for METTL7B Gene

MGI Knock Outs for METTL7B:

Animal Model Products

  • Taconic Biosciences Mouse Models for METTL7B

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for METTL7B

Clone Products

  • Applied Biological Materials (abm): Clones for METTL7B - Now 50% OFF >
  • * METTL7B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * METTL7B tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for METTL7B Gene

Localization for METTL7B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for METTL7B gene
Compartment Confidence
extracellular 3
plasma membrane 2
cytoskeleton 2
peroxisome 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubules (3)
  • Vesicles (3)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for METTL7B Gene

Pathways & Interactions for METTL7B Gene

PathCards logo

SuperPathways for METTL7B Gene

No Data Available

Gene Ontology (GO) - Biological Process for METTL7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with METTL7B: view

No data available for Pathways by source and SIGNOR curated interactions for METTL7B Gene

Drugs & Compounds for METTL7B Gene

No Compound Related Data Available

Transcripts for METTL7B Gene

mRNA/cDNA for METTL7B Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(85) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for METTL7B Gene

Methyltransferase like 7B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for METTL7B

Clone Products

  • Applied Biological Materials (abm): Clones for METTL7B - Now 50% OFF >
  • * METTL7B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * METTL7B tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for METTL7B Gene

No ASD Table

Relevant External Links for METTL7B Gene

GeneLoc Exon Structure for
METTL7B
ECgene alternative splicing isoforms for
METTL7B

Expression for METTL7B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for METTL7B Gene

mRNA differential expression in normal tissues according to GTEx for METTL7B Gene

This gene is overexpressed in Heart - Atrial Appendage (x18.0) and Liver (x13.5).

Protein differential expression in normal tissues from HIPED for METTL7B Gene

This gene is overexpressed in Liver (27.8), Fetal gut (15.0), and Kidney (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for METTL7B Gene



Protein tissue co-expression partners for METTL7B Gene

NURSA nuclear receptor signaling pathways regulating expression of METTL7B Gene:

METTL7B

SOURCE GeneReport for Unigene cluster for METTL7B Gene:

Hs.51483

Evidence on tissue expression from TISSUES for METTL7B Gene

  • Liver(4.5)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with METTL7B: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for METTL7B Gene

Orthologs for METTL7B Gene

This gene was present in the common ancestor of chordates.

Orthologs for METTL7B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia METTL7B 35 34
  • 100 (n)
OneToOne
dog
(Canis familiaris)
Mammalia METTL7B 35 34
  • 89.09 (n)
OneToOne
cow
(Bos Taurus)
Mammalia METTL7B 35 34
  • 86.07 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Mettl7b 17 35 34
  • 84.3 (n)
rat
(Rattus norvegicus)
Mammalia Mettl7b 34
  • 83.11 (n)
oppossum
(Monodelphis domestica)
Mammalia METTL7B 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 54 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 59 (a)
ManyToMany
-- 35
  • 48 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii si:ch211-173n18.3 35
  • 47 (a)
ManyToMany
si:ch211-173n18.4 35
  • 45 (a)
ManyToMany
mettl7a 35
  • 45 (a)
ManyToMany
Species where no ortholog for METTL7B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for METTL7B Gene

ENSEMBL:
Gene Tree for METTL7B (if available)
TreeFam:
Gene Tree for METTL7B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for METTL7B: view image

Paralogs for METTL7B Gene

Paralogs for METTL7B Gene

(1) SIMAP similar genes for METTL7B Gene using alignment to 1 proteins:

  • MET7B_HUMAN
genes like me logo Genes that share paralogs with METTL7B: view

Variants for METTL7B Gene

Sequence variations from dbSNP and Humsavar for METTL7B Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs139711828 uncertain-significance, Congenital Muscular Dystrophy, ITGA7-related 55,684,669(+) C/G downstream_transcript_variant
rs141486781 likely-benign, not specified, Muscular dystrophy, congenital, due to integrin alpha-7 deficiency 55,685,100(+) G/A downstream_transcript_variant
rs144436282 uncertain-significance, Congenital Muscular Dystrophy, ITGA7-related 55,684,963(+) C/T downstream_transcript_variant
rs146354904 uncertain-significance, Congenital Muscular Dystrophy, ITGA7-related 55,684,640(+) T/C downstream_transcript_variant
rs148170949 benign-likely-benign, uncertain-significance, benign, not specified, Congenital Muscular Dystrophy, ITGA7-related, Muscular dystrophy, congenital, due to integrin alpha-7 deficiency 55,685,088(+) G/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for METTL7B Gene

Variant ID Type Subtype PubMed ID
nsv525231 CNV loss 19592680

Variation tolerance for METTL7B Gene

Residual Variation Intolerance Score: 81.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.63; 56.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for METTL7B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
METTL7B
Human Gene Mutation Database (HGMD)
METTL7B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METTL7B Gene

Disorders for METTL7B Gene

MalaCards: The human disease database

(1) MalaCards diseases for METTL7B Gene - From: HGMD and GeneCards

Disorder Aliases PubMed IDs
muscular dystrophy, congenital, due to integrin alpha-7 deficiency
  • myopathy, congenital, due to integrin alpha-7 deficiency
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for METTL7B

genes like me logo Genes that share disorders with METTL7B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for METTL7B Gene

Publications for METTL7B Gene

  1. Identification and characterization of associated with lipid droplet protein 1: A novel membrane-associated protein that resides on hepatic lipid droplets. (PMID: 17004324) Turró S … Pol A (Traffic (Copenhagen, Denmark) 2006) 2 3 58
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. (PMID: 29180619) Kumar R … Vertegaal ACO (Nature communications 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for METTL7B Gene

Sources for METTL7B Gene

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