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Aliases for METTL7A Gene

Aliases for METTL7A Gene

  • Methyltransferase Like 7A 2 3 5
  • Protein AAM-B 3 4
  • Methyltransferase-Like Protein 7A 3
  • EC 2.1.1.- 4
  • EC 2.1.1 56
  • AAM-B 3

External Ids for METTL7A Gene

Previous GeneCards Identifiers for METTL7A Gene

  • GC12P049604
  • GC12P051318
  • GC12P048351

Summaries for METTL7A Gene

GeneCards Summary for METTL7A Gene

METTL7A (Methyltransferase Like 7A) is a Protein Coding gene. Among its related pathways are Innate Immune System. Gene Ontology (GO) annotations related to this gene include methyltransferase activity and S-adenosylmethionine-dependent methyltransferase activity. An important paralog of this gene is METTL7B.

UniProtKB/Swiss-Prot for METTL7A Gene

  • Probable methyltransferase.

Additional gene information for METTL7A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL7A Gene

Genomics for METTL7A Gene

GeneHancer (GH) Regulatory Elements for METTL7A Gene

Promoters and enhancers for METTL7A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I050921 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 550.8 +2.0 2020 7 SMAD1 MLX ARNT ARID4B FEZF1 DMAP1 ZNF2 YY1 SP3 SP5 METTL7A SMARCD1 SLC11A2 HNRNPA3P10 LIMA1 ATF1 LETMD1 TFCP2 ENSG00000257298 RNU6-1273P
GH12I050930 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 4.8 +10.1 10089 5.1 ATF1 FOXA2 ARID4B DMAP1 ETS1 YY1 TCF12 POLR2B ZNF766 FOS ENSG00000274156 SLC11A2 RNU6-1273P CSRNP2 METTL7A
GH12I051004 Enhancer 0.9 ENCODE dbSUPER 4.9 +82.2 82170 2.7 CTCF ESRRA SIN3A RAD21 ZKSCAN1 CTBP1 GATA3 ZNF444 RCOR1 SMARCE1 SLC11A2 CSRNP2 METTL7A RNU7-39P ENSG00000274797
GH12I051398 Enhancer 1 FANTOM5 Ensembl ENCODE 3.6 +476.8 476790 4.5 MEIS2 HLF CEBPB CBFA2T3 MITF ZNF121 TCF12 GLIS1 PRDM10 ZBTB17 GALNT6 HIGD1C SCN8A SLC4A8 METTL7A ENSG00000271065
GH12I050929 Enhancer 0.3 ENCODE 0.4 +6.9 6926 1 ZBTB33 SLC11A2 RNU6-1273P LETMD1 ENSG00000274156 METTL7A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around METTL7A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the METTL7A gene promoter:

Genomic Locations for METTL7A Gene

Genomic Locations for METTL7A Gene
9,046 bases
Plus strand

Genomic View for METTL7A Gene

Genes around METTL7A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METTL7A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METTL7A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL7A Gene

Proteins for METTL7A Gene

  • Protein details for METTL7A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Methyltransferase-like protein 7A
    Protein Accession:
    Secondary Accessions:
    • Q9H7R3
    • Q9UHZ7
    • Q9Y422

    Protein attributes for METTL7A Gene

    244 amino acids
    Molecular mass:
    28319 Da
    Quaternary structure:
    • Self-associates.
    • Sequence=AAF20268.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for METTL7A Gene

Selected DME Specific Peptides for METTL7A Gene


Post-translational modifications for METTL7A Gene

  • Ubiquitination at isoforms=34
  • Modification sites at PhosphoSitePlus

Other Protein References for METTL7A Gene

Domains & Families for METTL7A Gene

Gene Families for METTL7A Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for METTL7A Gene

Suggested Antigen Peptide Sequences for METTL7A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the methyltransferase superfamily.
  • Belongs to the methyltransferase superfamily.
genes like me logo Genes that share domains with METTL7A: view

Function for METTL7A Gene

Molecular function for METTL7A Gene

UniProtKB/Swiss-Prot Function:
Probable methyltransferase.

Enzyme Numbers (IUBMB) for METTL7A Gene

Gene Ontology (GO) - Molecular Function for METTL7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with METTL7A: view
genes like me logo Genes that share phenotypes with METTL7A: view

Animal Model Products

miRNA for METTL7A Gene

miRTarBase miRNAs that target METTL7A

Inhibitory RNA Products

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for METTL7A Gene

Localization for METTL7A Gene

Subcellular locations from UniProtKB/Swiss-Prot for METTL7A Gene

Lipid droplet. Endoplasmic reticulum. Membrane.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for METTL7A gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
plasma membrane 3
mitochondrion 1
peroxisome 1
cytosol 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Lipid droplets (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for METTL7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005783 endoplasmic reticulum IEA --
GO:0005811 lipid droplet IEA,IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with METTL7A: view

Pathways & Interactions for METTL7A Gene

genes like me logo Genes that share pathways with METTL7A: view

Pathways by source for METTL7A Gene

3 Reactome pathways for METTL7A Gene

Interacting Proteins for METTL7A Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q9H8H3-MET7A_HUMAN ENSP00000331787 for METTL7A Gene via IID STRING

Gene Ontology (GO) - Biological Process for METTL7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
GO:0032259 methylation IEA --
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with METTL7A: view

No data available for SIGNOR curated interactions for METTL7A Gene

Drugs & Compounds for METTL7A Gene

No Compound Related Data Available

Transcripts for METTL7A Gene

Unigene Clusters for METTL7A Gene

Methyltransferase like 7A:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for METTL7A Gene

No ASD Table

Relevant External Links for METTL7A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for METTL7A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for METTL7A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for METTL7A Gene

This gene is overexpressed in Nasal epithelium (12.2) and Liver (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for METTL7A Gene

Protein tissue co-expression partners for METTL7A Gene

NURSA nuclear receptor signaling pathways regulating expression of METTL7A Gene:


SOURCE GeneReport for Unigene cluster for METTL7A Gene:


Evidence on tissue expression from TISSUES for METTL7A Gene

  • Liver(4.6)
  • Thyroid gland(4.4)
  • Pancreas(4.3)
  • Nervous system(3.8)
  • Kidney(2.8)
  • Stomach(2.1)
genes like me logo Genes that share expression patterns with METTL7A: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for METTL7A Gene

Orthologs for METTL7A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for METTL7A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia METTL7A 33 34
  • 99.04 (n)
(Bos Taurus)
Mammalia METTL7A 33 34
  • 87.7 (n)
-- 34
  • 80 (a)
(Canis familiaris)
Mammalia METTL7A 33 34
  • 84.58 (n)
(Mus musculus)
Mammalia Mettl7a1 33 16 34
  • 83.61 (n)
Mettl7a2 34
  • 79 (a)
Mettl7a3 34
  • 78 (a)
AB099516 34
  • 53 (a)
(Rattus norvegicus)
Mammalia Mettl7a 33
  • 83.61 (n)
(Gallus gallus)
Aves METTL7A 33
  • 65.15 (n)
-- 34
  • 60 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 63 (a)
-- 34
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mettl7a 33
  • 63.25 (n)
Str.4191 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.20056 33
(Danio rerio)
Actinopterygii si:ch211-173n18.3 33 34
  • 58.94 (n)
si:ch211-173n18.4 34
  • 52 (a)
mettl7a 34
  • 51 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G69523 33
  • 51.32 (n)
(Oryza sativa)
Liliopsida Os02g0744100 33
  • 49.35 (n)
Species where no ortholog for METTL7A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for METTL7A Gene

Gene Tree for METTL7A (if available)
Gene Tree for METTL7A (if available)

Paralogs for METTL7A Gene

Paralogs for METTL7A Gene

(1) SIMAP similar genes for METTL7A Gene using alignment to 3 proteins: Pseudogenes for METTL7A Gene

genes like me logo Genes that share paralogs with METTL7A: view

Variants for METTL7A Gene

Sequence variations from dbSNP and Humsavar for METTL7A Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1001066648 -- 50,928,516(+) G/A intron_variant
rs1001274023 -- 50,930,434(+) C/G 3_prime_UTR_variant
rs1001405059 -- 50,930,217(+) C/T 3_prime_UTR_variant
rs1001457539 -- 50,929,817(+) T/C intron_variant
rs1001503330 -- 50,923,837(+) A/G 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant

Variation tolerance for METTL7A Gene

Residual Variation Intolerance Score: 34.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.45; 54.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for METTL7A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for METTL7A Gene

Disorders for METTL7A Gene

Additional Disease Information for METTL7A

No disorders were found for METTL7A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for METTL7A Gene

Publications for METTL7A Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. AAM-B Interacts with Nonstructural 4B and Regulates Hepatitis C Virus Propagation. (PMID: 26185986) Park EM … Hwang SB (PloS one 2015) 3 58

Products for METTL7A Gene

Sources for METTL7A Gene

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