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Aliases for METTL6 Gene

Aliases for METTL6 Gene

  • Methyltransferase Like 6 2 3 5
  • EC 2.1.1.41 56
  • EC 2.1.1.- 4
  • EC 2.1.1 56

External Ids for METTL6 Gene

Previous GeneCards Identifiers for METTL6 Gene

  • GC03M015428
  • GC03M015386

Summaries for METTL6 Gene

GeneCards Summary for METTL6 Gene

METTL6 (Methyltransferase Like 6) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include methyltransferase activity. An important paralog of this gene is METTL2B.

UniProtKB/Swiss-Prot for METTL6 Gene

  • Probable methyltransferase.

Additional gene information for METTL6 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL6 Gene

Genomics for METTL6 Gene

GeneHancer (GH) Regulatory Elements for METTL6 Gene

Promoters and enhancers for METTL6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I015426 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 563.4 +12.4 12395 2.8 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 ZNF213 E2F8 METTL6 GC03P015427 EAF1 GC03M015433 RNU6-1024P
GH03I015440 Enhancer 0.7 ENCODE dbSUPER 550.8 -0.6 -612 1.4 JUN MAX ZNF384 MYC PIR42374 METTL6 EAF1-AS1 EAF1
GH03I015438 Enhancer 0.4 ENCODE dbSUPER 550.8 +1.3 1280 1.8 PIR42374 METTL6 RNU6-1024P GC03M015433 EAF1 EAF1-AS1
GH03I015323 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 15.8 +111.8 111810 11.1 HDGF PKNOX1 CLOCK FOXA2 SIN3A FEZF1 ZBTB7B IRF4 YY1 ZNF143 SH3BP5 RBSN SH3BP5-AS1 CCDC174 METTL6 NR2C2 ENSG00000270409 CAPN7 HACL1 RPS3AP53
GH03I015858 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 11.8 -419.3 -419309 3 CLOCK FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZBTB7B YY1 POLR2B ANKRD28 CAPN7 SH3BP5-AS1 NR2C2 METTL6 IMPDH1P8 EAF1-AS1 GC03P015866
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around METTL6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the METTL6 gene promoter:

Genomic Locations for METTL6 Gene

Genomic Locations for METTL6 Gene
chr3:15,381,063-15,440,566
(GRCh38/hg38)
Size:
59,504 bases
Orientation:
Minus strand
chr3:15,422,782-15,482,073
(GRCh37/hg19)

Genomic View for METTL6 Gene

Genes around METTL6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METTL6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METTL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL6 Gene

Proteins for METTL6 Gene

  • Protein details for METTL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TCB7-METL6_HUMAN
    Recommended name:
    Methyltransferase-like protein 6
    Protein Accession:
    Q8TCB7
    Secondary Accessions:
    • Q96LU4

    Protein attributes for METTL6 Gene

    Size:
    284 amino acids
    Molecular mass:
    33251 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH22400.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for METTL6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for METTL6 Gene

Selected DME Specific Peptides for METTL6 Gene

Q8TCB7:
  • SKLGENFYVRQDGTRSYFFTD
  • FFKDRHW
  • CDFSPRA
  • YKVLKPG
  • LIFVLSA

Post-translational modifications for METTL6 Gene

  • Ubiquitination at posLast=120120
  • Modification sites at PhosphoSitePlus

Domains & Families for METTL6 Gene

Gene Families for METTL6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for METTL6 Gene

Suggested Antigen Peptide Sequences for METTL6 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TCB7

UniProtKB/Swiss-Prot:

METL6_HUMAN :
  • Belongs to the methyltransferase superfamily. METL family.
Family:
  • Belongs to the methyltransferase superfamily. METL family.
genes like me logo Genes that share domains with METTL6: view

Function for METTL6 Gene

Molecular function for METTL6 Gene

UniProtKB/Swiss-Prot Function:
Probable methyltransferase.

Enzyme Numbers (IUBMB) for METTL6 Gene

Phenotypes From GWAS Catalog for METTL6 Gene

Gene Ontology (GO) - Molecular Function for METTL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with METTL6: view

Phenotypes for METTL6 Gene

MGI mutant phenotypes for METTL6:
inferred from 1 alleles
GenomeRNAi human phenotypes for METTL6:
genes like me logo Genes that share phenotypes with METTL6: view

Animal Model Products

  • Taconic Biosciences Mouse Models for METTL6

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for METTL6 Gene

Localization for METTL6 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for METTL6 gene
Compartment Confidence
cytosol 3
extracellular 1
mitochondrion 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for METTL6 Gene

Pathways & Interactions for METTL6 Gene

SuperPathways for METTL6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for METTL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with METTL6: view

No data available for Pathways by source and SIGNOR curated interactions for METTL6 Gene

Drugs & Compounds for METTL6 Gene

(6) Drugs for METTL6 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
3-hydroxyanthranilic acid Experimental Pharma 0
s-adenosylhomocysteine Experimental Pharma 0
5-methyltetrahydrofolic acid Investigational Nutra 0
Serotonin Pharma 3755
Xanthurenic acid Pharma 0

(16) Additional Compounds for METTL6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1,6-Dimethoxypyrene
1-Hydroxy-6-methoxypyrene
1-Hydroxyphenanthrene
  • 1-phenanthrenol
  • phenanthren-1-ol
1-Hydroxypyrene
  • 1-Hydroxy pyrene
  • 1-HYDROXYPYRENE
  • 1-Pyrenol
  • Pyren-1-ol
5315-79-7
1-Methoxyphenanthrene
genes like me logo Genes that share compounds with METTL6: view

Transcripts for METTL6 Gene

Unigene Clusters for METTL6 Gene

Methyltransferase like 6:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for METTL6 Gene

No ASD Table

Relevant External Links for METTL6 Gene

GeneLoc Exon Structure for
METTL6
ECgene alternative splicing isoforms for
METTL6

Expression for METTL6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for METTL6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for METTL6 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for METTL6 Gene



Protein tissue co-expression partners for METTL6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of METTL6 Gene:

METTL6

SOURCE GeneReport for Unigene cluster for METTL6 Gene:

Hs.149487

Evidence on tissue expression from TISSUES for METTL6 Gene

  • Nervous system(4.5)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with METTL6: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for METTL6 Gene

Orthologs for METTL6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for METTL6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia METTL6 33 34
  • 99.53 (n)
dog
(Canis familiaris)
Mammalia -- 34
  • 93 (a)
OneToMany
METTL6 33
  • 91 (n)
-- 34
  • 84 (a)
OneToMany
cow
(Bos Taurus)
Mammalia METTL6 33 34
  • 90.14 (n)
mouse
(Mus musculus)
Mammalia Mettl6 33 16 34
  • 86.59 (n)
rat
(Rattus norvegicus)
Mammalia Mettl6 33
  • 85.44 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia METTL6 34
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia METTL6 34
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves METTL6 33 34
  • 80.22 (n)
lizard
(Anolis carolinensis)
Reptilia METTL6 34
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mettl6 33
  • 72.51 (n)
Str.6152 33
zebrafish
(Danio rerio)
Actinopterygii mettl6 33 34
  • 71.07 (n)
zgc56175 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1367 33
fruit fly
(Drosophila melanogaster)
Insecta CG34195 33 34
  • 58.07 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009818 33
  • 56.11 (n)
worm
(Caenorhabditis elegans)
Secernentea ZK1058.5 33 34
  • 53.6 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ABP140 34
  • 15 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G26200 33
  • 53.22 (n)
rice
(Oryza sativa)
Liliopsida Os03g0143000 33
  • 55.49 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 55 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC3H7.11 33
  • 50 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3599 33
Species where no ortholog for METTL6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for METTL6 Gene

ENSEMBL:
Gene Tree for METTL6 (if available)
TreeFam:
Gene Tree for METTL6 (if available)

Paralogs for METTL6 Gene

Paralogs for METTL6 Gene

(2) SIMAP similar genes for METTL6 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with METTL6: view

Variants for METTL6 Gene

Sequence variations from dbSNP and Humsavar for METTL6 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000000393 -- 15,384,792(-) T/G genic_downstream_transcript_variant, intron_variant
rs1000028728 -- 15,426,696(-) T/C intron_variant
rs1000062227 -- 15,427,819(-) C/T upstream_transcript_variant
rs1000121476 -- 15,427,090(-) G/A intron_variant
rs1000143824 -- 15,419,211(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for METTL6 Gene

Variant ID Type Subtype PubMed ID
nsv834621 CNV gain 17160897
nsv834622 CNV gain 17160897

Variation tolerance for METTL6 Gene

Residual Variation Intolerance Score: 29.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.66; 14.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for METTL6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
METTL6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METTL6 Gene

Disorders for METTL6 Gene

Additional Disease Information for METTL6

No disorders were found for METTL6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for METTL6 Gene

Publications for METTL6 Gene

  1. A tRNA methyltransferase paralog is important for ribosome stability and cell division in Trypanosoma brucei. (PMID: 26888608) Fleming IM … Alfonzo JD (Scientific reports 2016) 2 3 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Three distinct 3-methylcytidine (m3C) methyltransferases modify tRNA and mRNA in mice and humans. (PMID: 28655767) Xu L … Fu XY (The Journal of biological chemistry 2017) 3 58

Products for METTL6 Gene

Sources for METTL6 Gene

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