Aliases for METTL6 Gene

Aliases for METTL6 Gene

  • Methyltransferase Like 6 2 3 5
  • TRNA N(3)-Methylcytidine Methyltransferase METTL6 3 4
  • Methyltransferase-Like Protein 6 3 4
  • EC 2.1.1.41 50
  • EC 2.1.1.- 4
  • MGC24132 2
  • EC 2.1.1 50
  • METTL6 5

External Ids for METTL6 Gene

Previous GeneCards Identifiers for METTL6 Gene

  • GC03M015428
  • GC03M015386
  • GC03M015422
  • GC03M015395
  • GC03M015456
  • GC03M015813
  • GC03M016141

Summaries for METTL6 Gene

GeneCards Summary for METTL6 Gene

METTL6 (Methyltransferase Like 6) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include methyltransferase activity. An important paralog of this gene is METTL2B.

UniProtKB/Swiss-Prot Summary for METTL6 Gene

  • S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Ser).

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for METTL6 Gene

Genomics for METTL6 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for METTL6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around METTL6 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for METTL6

Top Transcription factor binding sites by QIAGEN in the METTL6 gene promoter:
  • AREB6
  • C/EBPalpha
  • FOXO4
  • POU2F1
  • POU2F1a
  • RSRFC4
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c
  • TBP

Genomic Locations for METTL6 Gene

Latest Assembly
chr3:15,381,275-15,440,566
(GRCh38/hg38)
Size:
59,292 bases
Orientation:
Minus strand

Previous Assembly
chr3:15,451,267-15,469,051
(GRCh37/hg19 by Entrez Gene)
Size:
17,785 bases
Orientation:
Minus strand

chr3:15,422,782-15,482,073
(GRCh37/hg19 by Ensembl)
Size:
59,292 bases
Orientation:
Minus strand

Genomic View for METTL6 Gene

Genes around METTL6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METTL6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METTL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL6 Gene

Proteins for METTL6 Gene

  • Protein details for METTL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TCB7-METL6_HUMAN
    Recommended name:
    tRNA N(3)-methylcytidine methyltransferase METTL6
    Protein Accession:
    Q8TCB7
    Secondary Accessions:
    • Q96LU4

    Protein attributes for METTL6 Gene

    Size:
    284 amino acids
    Molecular mass:
    33251 Da
    Quaternary structure:
    • Interacts with SARS1.
    SequenceCaution:
    • Sequence=AAH22400.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for METTL6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for METTL6 Gene

Selected DME Specific Peptides for METTL6 Gene

Q8TCB7:
  • SKLGENFYVRQDGTRSYFFTD
  • FFKDRHW
  • CDFSPRA
  • YKVLKPG
  • LIFVLSA

Post-translational modifications for METTL6 Gene

  • Ubiquitination at Lys120
  • Modification sites at PhosphoSitePlus

Antibodies for research

  • Santa Cruz Biotechnology (SCBT) Antibodies for METTL6

Domains & Families for METTL6 Gene

Gene Families for METTL6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for METTL6 Gene

Suggested Antigen Peptide Sequences for METTL6 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ57901, highly similar to Methyltransferase-like protein 6 (EC 2.1.1.-) (B4DDX3_HUMAN)
  • Methyltransferase-like protein 6 (METL6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8TCB7

UniProtKB/Swiss-Prot:

METL6_HUMAN :
  • Belongs to the methyltransferase superfamily. METL family.
Family:
  • Belongs to the methyltransferase superfamily. METL family.
genes like me logo Genes that share domains with METTL6: view

Function for METTL6 Gene

Molecular function for METTL6 Gene

UniProtKB/Swiss-Prot Function:
S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Ser).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=cytidine(32) in tRNA(Ser) + S-adenosyl-L-methionine = H(+) + N(3)-methylcytidine(32) in tRNA(Ser) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:50956, Rhea:RHEA-COMP:12849, Rhea:RHEA-COMP:12851, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74894, ChEBI:CHEBI:82748; Evidence={ECO:0000250|UniProtKB:Q8BVH9};.

Enzyme Numbers (IUBMB) for METTL6 Gene

Phenotypes From GWAS Catalog for METTL6 Gene

Gene Ontology (GO) - Molecular Function for METTL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 32296183
GO:0008168 methyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0019899 enzyme binding IPI 28655767
GO:0052735 tRNA (cytosine-3-)-methyltransferase activity ISS --
genes like me logo Genes that share ontologies with METTL6: view
genes like me logo Genes that share phenotypes with METTL6: view

Animal Models for research

  • Taconic Biosciences Mouse Models for METTL6

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for METTL6

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for METTL6 Gene

Localization for METTL6 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for METTL6 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for METTL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with METTL6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for METTL6 Gene

Pathways & Interactions for METTL6 Gene

PathCards logo

SuperPathways for METTL6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for METTL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008033 tRNA processing IEA --
GO:0030488 tRNA methylation IMP 28655767
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with METTL6: view

No data available for Pathways by source and SIGNOR curated interactions for METTL6 Gene

Drugs & Compounds for METTL6 Gene

(7) Drugs for METTL6 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
3-hydroxyanthranilic acid Experimental Pharma 0
s-adenosylhomocysteine Experimental Pharma 0
5-methyltetrahydrofolic acid Investigational Nutra 0
Histidine Investigational Nutra 67
Serotonin Investigational Nutra 4400

(15) Additional Compounds for METTL6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1,6-Dimethoxypyrene
1-Hydroxy-6-methoxypyrene
  • 6-Methoxy-1-pyrenol
1-Hydroxyphenanthrene
  • 1-Phenanthrenol
  • 1-Hydroxyphenanthrene
1-Hydroxypyrene
  • 1-Pyrenol
  • 1-Hydroxypyrene
  • 3-Hydroxypyrene
  • 3-Pyrenol
5315-79-7
1-Methoxyphenanthrene
  • Methyl 1-phenanthryl ether
genes like me logo Genes that share compounds with METTL6: view

Transcripts for METTL6 Gene

mRNA/cDNA for METTL6 Gene

5 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for METTL6

Alternative Splicing Database (ASD) splice patterns (SP) for METTL6 Gene

No ASD Table

Relevant External Links for METTL6 Gene

GeneLoc Exon Structure for
METTL6

Expression for METTL6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for METTL6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for METTL6 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for METTL6 Gene



Protein tissue co-expression partners for METTL6 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for METTL6

SOURCE GeneReport for Unigene cluster for METTL6 Gene:

Hs.149487

Evidence on tissue expression from TISSUES for METTL6 Gene

  • Nervous system(4.5)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with METTL6: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for METTL6 Gene

Orthologs for METTL6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for METTL6 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia METTL6 29 30
  • 99.53 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 30
  • 93 (a)
OneToMany
METTL6 29
  • 91 (n)
-- 30
  • 84 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia METTL6 29 30
  • 90.14 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Mettl6 29 16 30
  • 86.59 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Mettl6 29
  • 85.44 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia METTL6 30
  • 81 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia METTL6 30
  • 74 (a)
OneToOne
Chicken
(Gallus gallus)
Aves METTL6 29 30
  • 80.22 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia METTL6 30
  • 74 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia mettl6 29
  • 72.51 (n)
Str.6152 29
Zebrafish
(Danio rerio)
Actinopterygii mettl6 29 30
  • 71.07 (n)
OneToOne
zgc56175 29
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1367 29
Fruit Fly
(Drosophila melanogaster)
Insecta CG34195 29 30
  • 58.07 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009818 29
  • 56.11 (n)
Worm
(Caenorhabditis elegans)
Secernentea ZK1058.5 29 30
  • 53.6 (n)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ABP140 30
  • 15 (a)
OneToMany
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT2G26200 29
  • 53.22 (n)
Rice
(Oryza sativa)
Liliopsida Os03g0143000 29
  • 55.49 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 55 (a)
OneToOne
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC3H7.11 29
  • 50 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.3599 29
Species where no ortholog for METTL6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for METTL6 Gene

ENSEMBL:
Gene Tree for METTL6 (if available)
TreeFam:
Gene Tree for METTL6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for METTL6: view image
Alliance of Genome Resources:
Additional Orthologs for METTL6

Paralogs for METTL6 Gene

Paralogs for METTL6 Gene

(2) SIMAP similar genes for METTL6 Gene using alignment to 5 proteins:

  • METL6_HUMAN
  • B4DDX3_HUMAN
  • H7C1L4_HUMAN
  • H7C3H9_HUMAN
  • M0R0W0_HUMAN
genes like me logo Genes that share paralogs with METTL6: view

Variants for METTL6 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for METTL6 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for METTL6 Gene

Variant ID Type Subtype PubMed ID
nsv834621 CNV gain 17160897
nsv834622 CNV gain 17160897

Variation tolerance for METTL6 Gene

Residual Variation Intolerance Score: 29.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.66; 14.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for METTL6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
METTL6
Leiden Open Variation Database (LOVD)
METTL6

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for METTL6 Gene

Disorders for METTL6 Gene

Additional Disease Information for METTL6

No disorders were found for METTL6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for METTL6 Gene

Publications for METTL6 Gene

  1. Three distinct 3-methylcytidine (m3C) methyltransferases modify tRNA and mRNA in mice and humans. (PMID: 28655767) Xu L … Fu XY (The Journal of biological chemistry 2017) 3 4
  2. A tRNA methyltransferase paralog is important for ribosome stability and cell division in Trypanosoma brucei. (PMID: 26888608) Fleming IM … Alfonzo JD (Scientific reports 2016) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for METTL6 Gene

Sources for METTL6 Gene