Free for academic non-profit institutions. Other users need a Commercial license

Aliases for METTL5 Gene

Aliases for METTL5 Gene

  • Methyltransferase Like 5 2 3 5
  • Methyltransferase-Like Protein 5 3
  • EC 2.1.1.- 4
  • HSPC133 3

External Ids for METTL5 Gene

Previous GeneCards Identifiers for METTL5 Gene

  • GC02M170493
  • GC02M170376
  • GC02M170666
  • GC02M162556

Summaries for METTL5 Gene

GeneCards Summary for METTL5 Gene

METTL5 (Methyltransferase Like 5) is a Protein Coding gene. Diseases associated with METTL5 include Epilepsy, Familial Temporal Lobe, 4. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and protein methyltransferase activity.

UniProtKB/Swiss-Prot for METTL5 Gene

  • Probable methyltransferase.

Additional gene information for METTL5 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL5 Gene

Genomics for METTL5 Gene

GeneHancer (GH) Regulatory Elements for METTL5 Gene

Promoters and enhancers for METTL5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I169822 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 558.6 +0.7 652 3.2 HDGF CLOCK SMAD1 ARID4B SIN3A DMAP1 SLC30A9 POLR2B CBX5 ZNF213 METTL5 SSB PHOSPHO2 UBR3 LOC100421689 GC02P169805
GH02I169798 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 12 +25.5 25516 2.8 HDGF SMAD1 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF207 ZNF143 SP3 SSB UBR3 METTL5 PHOSPHO2 GC02P169805
GH02I169826 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 6.8 -3.2 -3191 2.6 HDGF HNRNPUL1 PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 ZNF143 UBR3 METTL5 FASTKD1 MYO3B PPIG PHOSPHO2 CCDC173 GC02P169866
GH02I169925 Enhancer 0.8 ENCODE 16.9 -101.3 -101333 0.7 HDAC1 HDGF PKNOX1 ARNT CHAMP1 TCF12 GATA2 ATF7 ZBTB11 NCOA1 METTL5 UBR3 GC02P169970 GC02P169866
GH02I169528 Enhancer 1 ENCODE dbSUPER 10.5 +296.5 296515 0.2 ARNT ARID4B MZF1 ZNF2 RAD21 CHAMP1 ZNF143 KDM4B CREM THAP11 GC02M169526 GC02M169527 CYB5AP2 SSB METTL5 UBR3 FASTKD1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around METTL5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the METTL5 gene promoter:

Genomic Locations for METTL5 Gene

Genomic Locations for METTL5 Gene
14,851 bases
Minus strand

Genomic View for METTL5 Gene

Genes around METTL5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METTL5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METTL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL5 Gene

Proteins for METTL5 Gene

  • Protein details for METTL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Methyltransferase-like protein 5
    Protein Accession:
    Secondary Accessions:
    • D3DPC9
    • Q9NVX1

    Protein attributes for METTL5 Gene

    209 amino acids
    Molecular mass:
    23719 Da
    Quaternary structure:
    No Data Available

neXtProt entry for METTL5 Gene

Post-translational modifications for METTL5 Gene

No Post-translational modifications

No data available for DME Specific Peptides for METTL5 Gene

Domains & Families for METTL5 Gene

Gene Families for METTL5 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for METTL5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the methyltransferase superfamily. PrmA family.
  • Belongs to the methyltransferase superfamily. PrmA family.
genes like me logo Genes that share domains with METTL5: view

Function for METTL5 Gene

Molecular function for METTL5 Gene

UniProtKB/Swiss-Prot Function:
Probable methyltransferase.

Enzyme Numbers (IUBMB) for METTL5 Gene

Gene Ontology (GO) - Molecular Function for METTL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0008168 methyltransferase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with METTL5: view

Phenotypes for METTL5 Gene

GenomeRNAi human phenotypes for METTL5:
genes like me logo Genes that share phenotypes with METTL5: view

Animal Model Products

miRNA for METTL5 Gene

miRTarBase miRNAs that target METTL5

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for METTL5 Gene

Localization for METTL5 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for METTL5 gene
Compartment Confidence
cytosol 4
nucleus 3
mitochondrion 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for METTL5 Gene

Pathways & Interactions for METTL5 Gene

SuperPathways for METTL5 Gene

No Data Available

Interacting Proteins for METTL5 Gene

Gene Ontology (GO) - Biological Process for METTL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with METTL5: view

No data available for Pathways by source and SIGNOR curated interactions for METTL5 Gene

Drugs & Compounds for METTL5 Gene

No Compound Related Data Available

Transcripts for METTL5 Gene

Unigene Clusters for METTL5 Gene

Methyltransferase like 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for METTL5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c
SP1: - - - -
SP2: - - -
SP3: - -
SP4: -
SP5: - -
SP6: - - - - - -
SP7: - - -
SP8: -

Relevant External Links for METTL5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for METTL5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for METTL5 Gene

Protein differential expression in normal tissues from HIPED for METTL5 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (25.3), Skin (13.1), Blymphocyte (6.3), and Lymph node (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for METTL5 Gene

NURSA nuclear receptor signaling pathways regulating expression of METTL5 Gene:


SOURCE GeneReport for Unigene cluster for METTL5 Gene:


Evidence on tissue expression from TISSUES for METTL5 Gene

  • Nervous system(4.5)
  • Lymph node(4.3)
  • Blood(4.2)
  • Spleen(4.2)
genes like me logo Genes that share expression patterns with METTL5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for METTL5 Gene

Orthologs for METTL5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for METTL5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia METTL5 33 34
  • 99.84 (n)
(Canis familiaris)
Mammalia METTL5 33 34
  • 93.78 (n)
(Bos Taurus)
Mammalia METTL5 33 34
  • 93.46 (n)
(Mus musculus)
Mammalia Mettl5 33 16 34
  • 91.55 (n)
(Rattus norvegicus)
Mammalia Mettl5 33
  • 89.79 (n)
(Ornithorhynchus anatinus)
Mammalia METTL5 34
  • 89 (a)
(Monodelphis domestica)
Mammalia METTL5 34
  • 86 (a)
(Gallus gallus)
Aves METTL5 33 34
  • 78.53 (n)
(Anolis carolinensis)
Reptilia METTL5 34
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mettl5 33
  • 74.43 (n)
(Danio rerio)
Actinopterygii mettl5 33 34
  • 71.71 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9666 33 34
  • 57.97 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000172 33
  • 54.75 (n)
(Caenorhabditis elegans)
Secernentea CELE_C38D4.9 33
  • 56.19 (n)
C38D4.9 34
  • 43 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G28830 33
  • 57.38 (n)
(Glycine max)
eudicotyledons Gma.6728 33
(Oryza sativa)
Liliopsida Os06g0162600 33
  • 56.55 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1427 34
  • 57 (a)
Species where no ortholog for METTL5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for METTL5 Gene

Gene Tree for METTL5 (if available)
Gene Tree for METTL5 (if available)

Paralogs for METTL5 Gene Pseudogenes for METTL5 Gene

genes like me logo Genes that share paralogs with METTL5: view

No data available for Paralogs for METTL5 Gene

Variants for METTL5 Gene

Sequence variations from dbSNP and Humsavar for METTL5 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000062870 -- 169,812,221(-) T/C intron_variant
rs1000117530 -- 169,818,871(-) C/T intron_variant
rs1000226919 -- 169,819,308(-) TTTT/TT intron_variant
rs1000350487 -- 169,824,868(-) C/T 5_prime_UTR_variant
rs1000399055 -- 169,812,515(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for METTL5 Gene

Variant ID Type Subtype PubMed ID
esv3584166 CNV loss 25503493
nsv1011368 CNV loss 25217958
nsv10201 CNV loss 18304495
nsv3026 CNV deletion 18451855
nsv583606 CNV loss 21841781
nsv583607 CNV gain 21841781
nsv583608 CNV gain 21841781

Variation tolerance for METTL5 Gene

Residual Variation Intolerance Score: 51.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.26; 40.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for METTL5 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METTL5 Gene

Disorders for METTL5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for METTL5 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
epilepsy, familial temporal lobe, 4
  • etl4
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for METTL5

genes like me logo Genes that share disorders with METTL5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for METTL5 Gene

Publications for METTL5 Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 58
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 58

Products for METTL5 Gene

Sources for METTL5 Gene

Loading form....