Aliases for METTL4 Gene
External Ids for METTL4 Gene
Previous GeneCards Identifiers for METTL4 Gene
GeneCards Summary for METTL4 Gene
METTL4 (Methyltransferase Like 4) is a Protein Coding gene. Diseases associated with METTL4 include Chromosome 18P Deletion Syndrome. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and methyltransferase activity.
UniProtKB/Swiss-Prot Summary for METTL4 Gene
N(6)-adenine-specific DNA methyltransferase that mediates methylation of DNA on the 6th position of adenine (N(6)-methyladenosine) and is required to regulate Polycomb silencing. N(6)-methyladenosine deposition by METTL4 triggers ubiquitination and degradation of sensor proteins ASXL1 and MPND, leading to inactivation of the PR-DUB complex and subsequent preservation of Polycomb silencing.