Aliases for METTL4 Gene
External Ids for METTL4 Gene
Previous GeneCards Identifiers for METTL4 Gene
GeneCards Summary for METTL4 Gene
METTL4 (Methyltransferase Like 4) is a Protein Coding gene. Diseases associated with METTL4 include Chromosome 18P Deletion Syndrome and Facioscapulohumeral Muscular Dystrophy 2. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and methyltransferase activity.
UniProtKB/Swiss-Prot Summary for METTL4 Gene
N(6)-adenine-specific methyltransferase that can methylate both RNAs and DNA (PubMed:31913360). Acts as a N(6)-adenine-specific RNA methyltransferase by catalyzing formation of N6,2'-O-dimethyladenosine (m6A(m)) on internal positions of U2 small nuclear RNA (snRNA): methylates the 6th position of adenine residues with a pre-deposited 2'-O-methylation (PubMed:31913360). Internal m6A(m) methylation of snRNAs regulates RNA splicing (PubMed:31913360). Also acts as a N(6)-adenine-specific DNA methyltransferase by mediating methylation of DNA on the 6th position of adenine (N(6)-methyladenosine), a modification that regulates Polycomb silencing (By similarity). N(6)-methyladenosine deposition by METTL4 triggers ubiquitination and degradation of sensor proteins ASXL1 and MPND, leading to inactivation of the PR-DUB complex and subsequent preservation of Polycomb silencing (By similarity).