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Aliases for METTL4 Gene

Aliases for METTL4 Gene

  • Methyltransferase Like 4 2 3 5
  • Methyltransferase-Like Protein 4 3
  • EC 2.1.1.- 4
  • HsT661 3

External Ids for METTL4 Gene

Previous GeneCards Identifiers for METTL4 Gene

  • GC18M002528

Summaries for METTL4 Gene

GeneCards Summary for METTL4 Gene

METTL4 (Methyltransferase Like 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and methyltransferase activity.

UniProtKB/Swiss-Prot for METTL4 Gene

  • Probable methyltransferase.

Additional gene information for METTL4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL4 Gene

Genomics for METTL4 Gene

GeneHancer (GH) Regulatory Elements for METTL4 Gene

Promoters and enhancers for METTL4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18J002569 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 674.1 -0.4 -425 4.1 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 METTL4 NDC80 SMCHD1 CBX3P2 KATNBL1P3 GC18M002508
GH18J002653 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE dbSUPER 52 -85.3 -85260 6.5 HDGF PKNOX1 CLOCK FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 SMCHD1 CBX3P2 METTL4 EMILIN2 NDC80 ENSG00000266783 LPIN2 GC18M002508
GH18J003445 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 34.1 -881.5 -881493 14.4 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 TGIF1 METTL4 CBX3P2 DLGAP1-AS1 RPL21P127 MYL12B GAPLINC BOD1P1 GC18P003299
GH18J003245 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 24.2 -684.6 -684572 22.1 CLOCK ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 E2F8 MYOM1 MYL12B MYL12A METTL4 CBX3P2 LOC104968399 LOC101927044 LPIN2 EMILIN2 SMCHD1
GH18J003296 Enhancer 1.3 Ensembl ENCODE 34 -725.8 -725768 1.8 MLX FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 MEF2D CBX3P2 METTL4 SMCHD1 ENSG00000266783 GC18P003299 ENSG00000266578
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around METTL4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the METTL4 gene promoter:
  • deltaCREB
  • CREB
  • IRF-1
  • GR-alpha
  • GR
  • STAT5B
  • Pax-5
  • Bach1
  • ISGF-3
  • AML1a

Genomic Locations for METTL4 Gene

Genomic Locations for METTL4 Gene
33,985 bases
Minus strand
33,985 bases
Minus strand

Genomic View for METTL4 Gene

Genes around METTL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METTL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METTL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL4 Gene

Proteins for METTL4 Gene

  • Protein details for METTL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Methyltransferase-like protein 4
    Protein Accession:
    Secondary Accessions:
    • B2RNA1
    • Q2TAA7
    • Q9H5U9

    Protein attributes for METTL4 Gene

    472 amino acids
    Molecular mass:
    54041 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB15520.1; Type=Frameshift; Positions=343; Evidence={ECO:0000305};

neXtProt entry for METTL4 Gene

Post-translational modifications for METTL4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for METTL4 Gene

Domains & Families for METTL4 Gene

Gene Families for METTL4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for METTL4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MT-A70-like family.
  • Belongs to the MT-A70-like family.
genes like me logo Genes that share domains with METTL4: view

Function for METTL4 Gene

Molecular function for METTL4 Gene

UniProtKB/Swiss-Prot Function:
Probable methyltransferase.

Enzyme Numbers (IUBMB) for METTL4 Gene

Phenotypes From GWAS Catalog for METTL4 Gene

Gene Ontology (GO) - Molecular Function for METTL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0008168 methyltransferase activity IBA,IEA --
GO:0009007 site-specific DNA-methyltransferase (adenine-specific) activity IBA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with METTL4: view
genes like me logo Genes that share phenotypes with METTL4: view

Animal Model Products

CRISPR Products

miRNA for METTL4 Gene

miRTarBase miRNAs that target METTL4

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for METTL4

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for METTL4 Gene

Localization for METTL4 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for METTL4 gene
Compartment Confidence
nucleus 4
mitochondrion 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for METTL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with METTL4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for METTL4 Gene

Pathways & Interactions for METTL4 Gene

SuperPathways for METTL4 Gene

No Data Available

Interacting Proteins for METTL4 Gene

Selected Interacting proteins: Q8N3J2-METL4_HUMAN for METTL4 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for METTL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032259 methylation IEA --
GO:0032775 DNA methylation on adenine IEA --
genes like me logo Genes that share ontologies with METTL4: view

No data available for Pathways by source and SIGNOR curated interactions for METTL4 Gene

Drugs & Compounds for METTL4 Gene

No Compound Related Data Available

Transcripts for METTL4 Gene

Unigene Clusters for METTL4 Gene

Methyltransferase like 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for METTL4

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for METTL4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP2: - - -
SP3: - -
SP4: -

Relevant External Links for METTL4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for METTL4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for METTL4 Gene

Protein differential expression in normal tissues from HIPED for METTL4 Gene

This gene is overexpressed in Adipocyte (66.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for METTL4 Gene

Protein tissue co-expression partners for METTL4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of METTL4 Gene:


SOURCE GeneReport for Unigene cluster for METTL4 Gene:


Evidence on tissue expression from TISSUES for METTL4 Gene

  • Lung(4.1)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with METTL4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for METTL4 Gene

Orthologs for METTL4 Gene

This gene was present in the common ancestor of animals.

Orthologs for METTL4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia METTL4 34 33
  • 99.29 (n)
(Canis familiaris)
Mammalia METTL4 34 33
  • 88.96 (n)
(Bos Taurus)
Mammalia METTL4 34 33
  • 86.99 (n)
(Mus musculus)
Mammalia Mettl4 16 34 33
  • 80.78 (n)
(Rattus norvegicus)
Mammalia Mettl4 33
  • 80.64 (n)
(Monodelphis domestica)
Mammalia METTL4 34
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia METTL4 34
  • 62 (a)
(Gallus gallus)
Aves METTL4 34 33
  • 67.62 (n)
(Anolis carolinensis)
Reptilia METTL4 34
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mettl4 33
  • 61.3 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19454 33
(Danio rerio)
Actinopterygii LOC560686 33
  • 55.62 (n)
  • 42 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14906 34 33
  • 47.81 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008665 33
  • 47.33 (n)
(Caenorhabditis elegans)
Secernentea C18A3.1 34
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 46 (a)
Species where no ortholog for METTL4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for METTL4 Gene

Gene Tree for METTL4 (if available)
Gene Tree for METTL4 (if available)
Evolutionary constrained regions (ECRs) for METTL4: view image

Paralogs for METTL4 Gene

No data available for Paralogs for METTL4 Gene

Variants for METTL4 Gene

Sequence variations from dbSNP and Humsavar for METTL4 Gene

SNP ID Clin Chr 18 pos Variation AA Info Type
rs1000138505 -- 2,572,914(-) A/G upstream_transcript_variant
rs1000155953 -- 2,553,962(-) A/C intron_variant
rs1000182831 -- 2,545,341(-) T/A intron_variant
rs1000351302 -- 2,548,755(-) C/T intron_variant
rs1000363345 -- 2,542,327(-) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for METTL4 Gene

Variant ID Type Subtype PubMed ID
esv2761986 CNV gain 21179565
esv3446409 CNV duplication 20981092
esv3641561 CNV loss 21293372
esv3641562 CNV gain 21293372
esv3893063 CNV loss 25118596
nsv1061548 CNV gain 25217958
nsv1065830 CNV gain 25217958
nsv1066735 CNV gain 25217958
nsv132209 CNV deletion 16902084
nsv482935 CNV loss 15286789
nsv576251 CNV gain 21841781
nsv576310 CNV gain 21841781
nsv576311 CNV gain 21841781

Variation tolerance for METTL4 Gene

Residual Variation Intolerance Score: 52.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.01; 80.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for METTL4 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METTL4 Gene

Disorders for METTL4 Gene

Additional Disease Information for METTL4

No disorders were found for METTL4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for METTL4 Gene

Publications for METTL4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases. (PMID: 27373337) Wang P … Nam Y (Molecular cell 2016) 3 58
  5. A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus. (PMID: 25130324) Cai DC … Hagoort P (Genes, brain, and behavior 2014) 3 58

Products for METTL4 Gene

Sources for METTL4 Gene

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