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Aliases for METTL3 Gene

Aliases for METTL3 Gene

  • Methyltransferase Like 3 2 3 5
  • N6-Adenosine-Methyltransferase 70 KDa Subunit 2 3 4
  • MRNA (2-O-Methyladenosine-N(6)-)-Methyltransferase 2 3
  • Methyltransferase-Like Protein 3 3 4
  • HMETTL3 3 4
  • MT-A70 3 4
  • AdoMet-Binding Subunit Of The Human MRNA (N6-Adenosine)-Methyltransferase 3
  • N6-Adenosine-Methyltransferase Catalytic Subunit 3
  • MRNA M(6)A Methyltransferase 3
  • EC 2.1.1.62 4
  • MTA70 4
  • IME4 3
  • Spo8 3
  • M6A 3

External Ids for METTL3 Gene

Previous GeneCards Identifiers for METTL3 Gene

  • GC14M015753
  • GC14M019956
  • GC14M021036
  • GC14U900552
  • GC14M021966
  • GC14M002084

Summaries for METTL3 Gene

Entrez Gene Summary for METTL3 Gene

  • This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine. [provided by RefSeq, Jul 2008]

GeneCards Summary for METTL3 Gene

METTL3 (Methyltransferase Like 3) is a Protein Coding gene. Among its related pathways are Circadian rythm related genes and mRNA Splicing - Major Pathway. Gene Ontology (GO) annotations related to this gene include RNA binding and mRNA (2-O-methyladenosine-N6-)-methyltransferase activity.

UniProtKB/Swiss-Prot for METTL3 Gene

  • The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some RNAs and regulates various processes such as the circadian clock, differentiation of embryonic and haematopoietic stem cells, cortical neurogenesis, response to DNA damage, differentiation of T-cells and primary miRNA processing (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:27627798, PubMed:27373337, PubMed:27281194, PubMed:28297716, PubMed:9409616). In the heterodimer formed with METTL14, METTL3 constitutes the catalytic core (PubMed:27627798, PubMed:27373337, PubMed:27281194). N6-methyladenosine (m6A), which takes place at the 5-[AG]GAC-3 consensus sites of some mRNAs, plays a role in mRNA stability, processing, translation efficiency and editing (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:28297716, PubMed:9409616). M6A acts as a key regulator of mRNA stability: methylation is completed upon the release of mRNA into the nucleoplasm and promotes mRNA destabilization and degradation (PubMed:28637692). In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization, promoting differentiation of ESCs (By similarity). M6A regulates the length of the circadian clock: acts as an early pace-setter in the circadian loop by putting mRNA production on a fast-track for facilitating nuclear processing, thereby providing an early point of control in setting the dynamics of the feedback loop (By similarity). M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (By similarity). Involved in the response to DNA damage: in response to ultraviolet irradiation, METTL3 rapidly catalyzes the formation of m6A on poly(A) transcripts at DNA damage sites, leading to the recruitment of POLK to DNA damage sites (PubMed:28297716). M6A is also required for T-cell homeostasis and differentiation: m6A methylation of transcripts of SOCS family members (SOCS1, SOCS3 and CISH) in naive T-cells promotes mRNA destabilization and degradation, promoting T-cell differentiation (By similarity). M6A also takes place in other RNA molecules, such as primary miRNA (pri-miRNAs) (PubMed:25799998). M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (By similarity). METTL3 mediates methylation of pri-miRNAs, marking them for recognition and processing by DGCR8 (PubMed:25799998). Acts as a positive regulator of mRNA translation independently of the methyltransferase activity: promotes translation by interacting with the translation initiation machinery in the cytoplasm (PubMed:27117702). Its overexpression in a number of cancer cells suggests that it may participate to cancer cell proliferation by promoting mRNA translation (PubMed:27117702).

Gene Wiki entry for METTL3 Gene

Additional gene information for METTL3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL3 Gene

Genomics for METTL3 Gene

GeneHancer (GH) Regulatory Elements for METTL3 Gene

Promoters and enhancers for METTL3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J021509 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 680.1 +0.3 280 2.4 PKNOX1 CLOCK FOXA2 SMAD1 ARNT MLX ZFP64 ARID4B SIN3A DMAP1 METTL3 METTL17 CHD8 SUPT16H HNRNPC TOX4 PIR42881
GH14J020679 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 75.5 +826.8 826842 9.8 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 RNASE4 ANG TRP-TGG3-2 PIR55020 ENSG00000259171 TRY-GTA5-5 METTL3 SUPT16H CHD8 METTL17
GH14J021092 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 66.6 +409.9 409949 18.3 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF219 METTL3 METTL17 SUPT16H CHD8 TEP1 APEX1 SNORA79B PNP ARHGEF40
GH14J020622 Enhancer 1.2 Ensembl ENCODE 104.2 +886.6 886626 3.9 HNRNPUL1 SIN3A FEZF1 ZNF2 ZNF213 ZNF143 FOS KLF13 ZC3H11A REST TRL-TAG2-1 PIR59363 GC14P020627 METTL3 SUPT16H METTL17 CHD8 ENSG00000258515 TEP1 PARP2
GH14J020657 Enhancer 1.2 Ensembl ENCODE 93.4 +853.6 853648 1.1 HDGF PKNOX1 SIN3A ZNF2 ZNF213 ZNF143 ZNF548 FOS KLF13 SP3 TRY-GTA4-1 METTL3 SUPT16H METTL17 ENSG00000258515 CHD8 TEP1 ENSG00000258768 TTC5 PARP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around METTL3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the METTL3 gene promoter:
  • SREBP-1c
  • SREBP-1b
  • SREBP-1a
  • GR-alpha
  • GR
  • c-Ets-1
  • CREB
  • deltaCREB
  • RP58
  • MyoD

Genomic Locations for METTL3 Gene

Genomic Locations for METTL3 Gene
chr14:21,498,131-21,511,375
(GRCh38/hg38)
Size:
13,245 bases
Orientation:
Minus strand
chr14:21,966,277-21,979,517
(GRCh37/hg19)
Size:
13,241 bases
Orientation:
Minus strand

Genomic View for METTL3 Gene

Genes around METTL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METTL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METTL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL3 Gene

Proteins for METTL3 Gene

  • Protein details for METTL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86U44-MTA70_HUMAN
    Recommended name:
    N6-adenosine-methyltransferase catalytic subunit
    Protein Accession:
    Q86U44
    Secondary Accessions:
    • O14736
    • Q86V05
    • Q9HB32

    Protein attributes for METTL3 Gene

    Size:
    580 amino acids
    Molecular mass:
    64474 Da
    Quaternary structure:
    • Heterodimer; heterodimerizes with METTL14 to form an antiparallel heterodimer that constitutes an active methyltransferase (PubMed:27627798, PubMed:27373337, PubMed:27281194). Component of the WMM complex, a N6-methyltransferase complex composed of WTAP, METTL3 and METTL14 (PubMed:24407421, PubMed:24981863). Interacts with NCBP1/CBP80 (PubMed:27117702). Interacts with EIF4E (PubMed:27117702). Interacts with EIF3B (PubMed:27117702).

    Three dimensional structures from OCA and Proteopedia for METTL3 Gene

    Alternative splice isoforms for METTL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for METTL3 Gene

Post-translational modifications for METTL3 Gene

  • Ubiquitination at posLast=488488 and isoforms=2459
  • Modification sites at PhosphoSitePlus

Other Protein References for METTL3 Gene

No data available for DME Specific Peptides for METTL3 Gene

Domains & Families for METTL3 Gene

Gene Families for METTL3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for METTL3 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q86U44

UniProtKB/Swiss-Prot:

MTA70_HUMAN :
  • Gate loop 1 and gate loop 2 regions are adjacent to the S-adenosyl-L-homocysteine-binding site and display large conformational changes upon ligand-binding. They may play an important role in adenosine recognition. The interface loop contributes to the heterodimer interaction.
  • Belongs to the MT-A70-like family.
Domain:
  • Gate loop 1 and gate loop 2 regions are adjacent to the S-adenosyl-L-homocysteine-binding site and display large conformational changes upon ligand-binding. They may play an important role in adenosine recognition. The interface loop contributes to the heterodimer interaction.
Family:
  • Belongs to the MT-A70-like family.
genes like me logo Genes that share domains with METTL3: view

Function for METTL3 Gene

Molecular function for METTL3 Gene

UniProtKB/Swiss-Prot Function:
The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some RNAs and regulates various processes such as the circadian clock, differentiation of embryonic and haematopoietic stem cells, cortical neurogenesis, response to DNA damage, differentiation of T-cells and primary miRNA processing (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:27627798, PubMed:27373337, PubMed:27281194, PubMed:28297716, PubMed:9409616). In the heterodimer formed with METTL14, METTL3 constitutes the catalytic core (PubMed:27627798, PubMed:27373337, PubMed:27281194). N6-methyladenosine (m6A), which takes place at the 5-[AG]GAC-3 consensus sites of some mRNAs, plays a role in mRNA stability, processing, translation efficiency and editing (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:28297716, PubMed:9409616). M6A acts as a key regulator of mRNA stability: methylation is completed upon the release of mRNA into the nucleoplasm and promotes mRNA destabilization and degradation (PubMed:28637692). In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization, promoting differentiation of ESCs (By similarity). M6A regulates the length of the circadian clock: acts as an early pace-setter in the circadian loop by putting mRNA production on a fast-track for facilitating nuclear processing, thereby providing an early point of control in setting the dynamics of the feedback loop (By similarity). M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (By similarity). Involved in the response to DNA damage: in response to ultraviolet irradiation, METTL3 rapidly catalyzes the formation of m6A on poly(A) transcripts at DNA damage sites, leading to the recruitment of POLK to DNA damage sites (PubMed:28297716). M6A is also required for T-cell homeostasis and differentiation: m6A methylation of transcripts of SOCS family members (SOCS1, SOCS3 and CISH) in naive T-cells promotes mRNA destabilization and degradation, promoting T-cell differentiation (By similarity). M6A also takes place in other RNA molecules, such as primary miRNA (pri-miRNAs) (PubMed:25799998). M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (By similarity). METTL3 mediates methylation of pri-miRNAs, marking them for recognition and processing by DGCR8 (PubMed:25799998). Acts as a positive regulator of mRNA translation independently of the methyltransferase activity: promotes translation by interacting with the translation initiation machinery in the cytoplasm (PubMed:27117702). Its overexpression in a number of cancer cells suggests that it may participate to cancer cell proliferation by promoting mRNA translation (PubMed:27117702).
UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + a 5-(N(7)-methyl 5-triphosphoguanosine)-2-O-methyladenosine-[mRNA] = S-adenosyl-L-homocysteine + a 5-(N(7)-methyl 5-triphosphoguanosine)-N(6),2-O-dimethyladenosine-[mRNA].
UniProtKB/Swiss-Prot EnzymeRegulation:
Methyltransferase activity is regulated by miRNAs via a sequence pairing mechanism.
UniProtKB/Swiss-Prot Induction:
Overexpressed in a number of cancer tissues, such as lung adenocarcinoma and colon adenocarcinoma (PubMed:27117702).

Enzyme Numbers (IUBMB) for METTL3 Gene

Phenotypes From GWAS Catalog for METTL3 Gene

Gene Ontology (GO) - Molecular Function for METTL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0003729 mRNA binding IDA 27281194
GO:0005515 protein binding IPI 24316715
GO:0008168 methyltransferase activity IEA,IBA --
GO:0008173 RNA methyltransferase activity IDA 25799998
genes like me logo Genes that share ontologies with METTL3: view
genes like me logo Genes that share phenotypes with METTL3: view

Animal Models for METTL3 Gene

MGI Knock Outs for METTL3:

Animal Model Products

miRNA for METTL3 Gene

miRTarBase miRNAs that target METTL3

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for METTL3 Gene

Localization for METTL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for METTL3 Gene

Nucleus. Nucleus speckle. Cytoplasm. Note=Colocalizes with speckles in interphase nuclei, suggesting that it may be associated with nuclear pre-mRNA splicing components (PubMed:9409616). In response to ultraviolet irradiation, colocalizes to DNA damage sites however, it probably does not bind DNA but localizes in the vicinity of DNA damage sites (PubMed:28297716). {ECO:0000269 PubMed:28297716, ECO:0000269 PubMed:9409616}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for METTL3 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for METTL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 9409616
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0016607 nuclear speck IDA,IEA 24407421
GO:0036396 RNA N6-methyladenosine methyltransferase complex IDA 24316715
genes like me logo Genes that share ontologies with METTL3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for METTL3 Gene

Pathways & Interactions for METTL3 Gene

genes like me logo Genes that share pathways with METTL3: view

Pathways by source for METTL3 Gene

2 BioSystems pathways for METTL3 Gene
1 Cell Signaling Technology pathway for METTL3 Gene

Gene Ontology (GO) - Biological Process for METTL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 NOT mRNA splicing, via spliceosome ISS --
GO:0001510 RNA methylation IMP,IEA 9409616
GO:0006382 adenosine to inosine editing ISS --
GO:0006397 mRNA processing ISS --
GO:0006402 mRNA catabolic process ISS --
genes like me logo Genes that share ontologies with METTL3: view

No data available for SIGNOR curated interactions for METTL3 Gene

Drugs & Compounds for METTL3 Gene

(1) Drugs for METTL3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
s-adenosylhomocysteine Experimental Pharma 0

(2) Additional Compounds for METTL3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
N6-Methyladenosine
  • (2R,3S,4R,5R)-2-Hydroxymethyl-5-(6-methylamino-purin-9-yl)-tetrahydro-furan-3,4-diol
  • 6-Methyladenosine
  • 6-Methylaminopurine D-riboside
  • 6-Methylaminopurine ribonucleoside
  • 6-Methylaminopurine riboside
1867-73-8
s-adenosylmethionine
  • (3S)-5'-[(3-amino-3-Carboxypropyl)methylsulfonio]-5'-deoxyadenosine, inner salt
  • [1-(Adenin-9-yl)-1,5-dideoxy-beta-D-ribofuranos-5-yl][(3S)-3-amino-3-carboxypropyl](methyl)sulfonium
  • Acylcarnitine
  • AdoMet
  • S-(5'-Deoxyadenosin-5'-yl)-L-methionine
485-80-3
genes like me logo Genes that share compounds with METTL3: view

Transcripts for METTL3 Gene

mRNA/cDNA for METTL3 Gene

(3) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(14) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for METTL3 Gene

Methyltransferase like 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for METTL3 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a ·
SP1:
SP2: - - - -
SP3: -
SP4: - - - - - - - - - - -
SP5: - - - - - - - - - -
SP6:
SP7: - - - - - - -
SP8: - - - - - - -
SP9: -
SP10: - - - - - -
SP11: - - - - - -
SP12: - - - - - -
SP13:
SP14: - - - - - -
SP15: -
SP16: - - - -

ExUns: 11b · 11c · 11d ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for METTL3 Gene

GeneLoc Exon Structure for
METTL3
ECgene alternative splicing isoforms for
METTL3

Expression for METTL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for METTL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for METTL3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.6) and CD8 Tcells (11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for METTL3 Gene



Protein tissue co-expression partners for METTL3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of METTL3 Gene:

METTL3

SOURCE GeneReport for Unigene cluster for METTL3 Gene:

Hs.168799

mRNA Expression by UniProt/SwissProt for METTL3 Gene:

Q86U44-MTA70_HUMAN
Tissue specificity: Widely expressed at low level. Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for METTL3 Gene

  • Nervous system(4.7)
  • Lung(4.5)
  • Liver(4.2)
  • Pancreas(4.2)
genes like me logo Genes that share expression patterns with METTL3: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for METTL3 Gene

Orthologs for METTL3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for METTL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia METTL3 34 33
  • 99.66 (n)
OneToOne
cow
(Bos Taurus)
Mammalia METTL3 34 33
  • 94.25 (n)
OneToOne
dog
(Canis familiaris)
Mammalia METTL3 34 33
  • 94.2 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mettl3 33
  • 90.4 (n)
mouse
(Mus musculus)
Mammalia Mettl3 16 34 33
  • 90.06 (n)
oppossum
(Monodelphis domestica)
Mammalia METTL3 34
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia METTL3 34
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mettl3 33
  • 71.96 (n)
zebrafish
(Danio rerio)
Actinopterygii mettl3 34 33
  • 65.96 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Ime4 34 33
  • 56.1 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002895 33
  • 54.53 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IME4 36 34
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1577 34
  • 50 (a)
OneToOne
Species where no ortholog for METTL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for METTL3 Gene

ENSEMBL:
Gene Tree for METTL3 (if available)
TreeFam:
Gene Tree for METTL3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for METTL3: view image

Paralogs for METTL3 Gene

No data available for Paralogs for METTL3 Gene

Variants for METTL3 Gene

Sequence variations from dbSNP and Humsavar for METTL3 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000165463 -- 21,505,465(-) A/G intron_variant
rs1000174585 -- 21,510,483(-) A/T intron_variant
rs1000219668 -- 21,505,790(-) C/T intron_variant
rs1000373945 -- 21,498,838(-) C/T intron_variant
rs1000723956 -- 21,498,492(-) G/A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for METTL3 Gene

Variant ID Type Subtype PubMed ID
esv2422459 CNV duplication 17116639
esv3633716 CNV gain 21293372
esv3633718 CNV gain 21293372
nsv85879 CNV deletion 16902084

Variation tolerance for METTL3 Gene

Residual Variation Intolerance Score: 47.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.84; 34.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for METTL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
METTL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METTL3 Gene

Disorders for METTL3 Gene

Additional Disease Information for METTL3

No disorders were found for METTL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for METTL3 Gene

Publications for METTL3 Gene

  1. RNA m6A methylation regulates the ultraviolet-induced DNA damage response. (PMID: 28297716) Xiang Y … Shi Y (Nature 2017) 3 4 58
  2. Structural basis of N(6)-adenosine methylation by the METTL3-METTL14 complex. (PMID: 27281194) Wang X … Yin P (Nature 2016) 3 4 58
  3. Structural insights into the molecular mechanism of the m(6)A writer complex. (PMID: 27627798) Śledź P … Jinek M (eLife 2016) 3 4 58
  4. The m(6)A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells. (PMID: 27117702) Lin S … Gregory RI (Molecular cell 2016) 3 4 58
  5. Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases. (PMID: 27373337) Wang P … Nam Y (Molecular cell 2016) 3 4 58

Products for METTL3 Gene

Sources for METTL3 Gene

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