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Aliases for METTL2B Gene

Aliases for METTL2B Gene

  • Methyltransferase Like 2B 2 3 5
  • Methyltransferase-Like Protein 2B 3
  • Methyltransferase Like 2 2
  • EC 2.1.1.- 4
  • METTL2A 3
  • PSENIP1 3
  • METTL2 3
  • METL 3

External Ids for METTL2B Gene

Previous HGNC Symbols for METTL2B Gene

  • METTL2

Previous GeneCards Identifiers for METTL2B Gene

  • GC07P127904
  • GC07P128098
  • GC07P128103
  • GC07P122477
  • GC07P128105
  • GC07P128108
  • GC07P128120
  • GC07P128510
  • GC07P128530
  • GC07P128549
  • GC07P128565
  • GC07P128584
  • GC07P128599
  • GC07P128619
  • GC07P128640

Summaries for METTL2B Gene

Entrez Gene Summary for METTL2B Gene

  • This gene is a member of a family of methyltransferases that share homology with, but are distinct from, the UbiE family of methyltransferases. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for METTL2B Gene

METTL2B (Methyltransferase Like 2B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include methyltransferase activity and tRNA (cytosine) methyltransferase activity. An important paralog of this gene is METTL2A.

UniProtKB/Swiss-Prot for METTL2B Gene

  • Probable S-adenosyl-L-methionine-dependent methyltransferase that mediates 3-methylcytidine modification of some tRNAs.

Gene Wiki entry for METTL2B Gene

Additional gene information for METTL2B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL2B Gene

Genomics for METTL2B Gene

GeneHancer (GH) Regulatory Elements for METTL2B Gene

Promoters and enhancers for METTL2B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J128476 Promoter/Enhancer 1.6 EPDnew ENCODE 674.3 +0.3 254 1.7 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B E2F8 METTL2B ENSG00000243302 GCC1 ENSG00000230715 ENSG00000242588 ENSG00000243679 CDC26P1 TNPO3 ENSG00000229413 RN7SL81P
GH07J128441 Enhancer 1.1 Ensembl ENCODE dbSUPER 24.1 -33.0 -33031 3.7 EBF1 ZNF507 E2F1 CTBP1 GATA3 SCRT2 ZNF143 ATF7 FOSL2 ZNF444 RNU7-54P METTL2B IMPDH1 ENSG00000242588 OPN1SW LOC102724660 GC07P129012
GH07J128429 Enhancer 0.9 ENCODE 28.1 -43.6 -43634 6.9 ELF3 FOXA2 SIN3A RAD21 ZNF48 RARA ZSCAN5C SCRT2 FOS RCOR1 RPL37P16 IMPDH1 METTL2B ENSG00000242588 PRRT4 ENSG00000240758 HILPDA OPN1SW ENSG00000230715 ENSG00000272601
GH07J128403 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 10.8 -69.5 -69532 7.3 HDGF ARNT ZFP64 SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 E2F8 IMPDH1 PIR61424 ENSG00000273270 ENSG00000271553 ENSG00000242588 PRRT4 ENSG00000230715 LRRC4 RBM28 ENSG00000240758
GH07J128214 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 14.8 -259.2 -259233 5.4 CTCF ATF1 ZMYM3 CEBPG MCM2 CTBP1 POLR2A ZNF366 ATF7 CREM ENSG00000230715 ENSG00000243302 ENSG00000229413 ENSG00000243679 ZNF800 LEP METTL2B ENSG00000224138 GCC1 ENSG00000242588
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around METTL2B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the METTL2B gene promoter:
  • FOXO4
  • AML1a
  • C/EBPalpha
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • NF-AT4
  • LyF-1

Genomic Locations for METTL2B Gene

Genomic Locations for METTL2B Gene
chr7:128,476,729-128,506,602
(GRCh38/hg38)
Size:
29,874 bases
Orientation:
Plus strand
chr7:128,116,783-128,146,656
(GRCh37/hg19)
Size:
29,874 bases
Orientation:
Plus strand

Genomic View for METTL2B Gene

Genes around METTL2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METTL2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METTL2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL2B Gene

Proteins for METTL2B Gene

  • Protein details for METTL2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P1Q9-MET2B_HUMAN
    Recommended name:
    Methyltransferase-like protein 2B
    Protein Accession:
    Q6P1Q9
    Secondary Accessions:
    • B4DZ68
    • Q0IJ54
    • Q3B7J1

    Protein attributes for METTL2B Gene

    Size:
    378 amino acids
    Molecular mass:
    43426 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for METTL2B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for METTL2B Gene

Post-translational modifications for METTL2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for METTL2B Gene

No data available for DME Specific Peptides for METTL2B Gene

Domains & Families for METTL2B Gene

Gene Families for METTL2B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for METTL2B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for METTL2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P1Q9

UniProtKB/Swiss-Prot:

MET2B_HUMAN :
  • Belongs to the methyltransferase superfamily. METL family.
Family:
  • Belongs to the methyltransferase superfamily. METL family.
genes like me logo Genes that share domains with METTL2B: view

Function for METTL2B Gene

Molecular function for METTL2B Gene

UniProtKB/Swiss-Prot Function:
Probable S-adenosyl-L-methionine-dependent methyltransferase that mediates 3-methylcytidine modification of some tRNAs.

Enzyme Numbers (IUBMB) for METTL2B Gene

Phenotypes From GWAS Catalog for METTL2B Gene

Gene Ontology (GO) - Molecular Function for METTL2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity IBA --
GO:0016427 tRNA (cytosine) methyltransferase activity IMP 21518805
GO:0016740 transferase activity IEA --
GO:0052735 tRNA (cytosine-3-)-methyltransferase activity IBA --
genes like me logo Genes that share ontologies with METTL2B: view
genes like me logo Genes that share phenotypes with METTL2B: view

Animal Model Products

CRISPR Products

miRNA for METTL2B Gene

miRTarBase miRNAs that target METTL2B

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for METTL2B

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for METTL2B Gene

Localization for METTL2B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for METTL2B gene
Compartment Confidence
cytosol 3
plasma membrane 1
mitochondrion 1
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for METTL2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with METTL2B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for METTL2B Gene

Pathways & Interactions for METTL2B Gene

SuperPathways for METTL2B Gene

No Data Available

Gene Ontology (GO) - Biological Process for METTL2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030488 tRNA methylation IMP 21518805
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with METTL2B: view

No data available for Pathways by source and SIGNOR curated interactions for METTL2B Gene

Drugs & Compounds for METTL2B Gene

(7) Drugs for METTL2B Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Histidine Approved Nutra 50
3-hydroxyanthranilic acid Experimental Pharma 0
s-adenosylhomocysteine Experimental Pharma 0
5-methyltetrahydrofolic acid Investigational Nutra 0
Serotonin Investigational Nutra 3755

(15) Additional Compounds for METTL2B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1,6-Dimethoxypyrene
1-Hydroxy-6-methoxypyrene
  • 6-Methoxy-1-pyrenol
1-Hydroxyphenanthrene
  • 1-Hydroxyphenanthrene
  • 1-Phenanthrenol
1-Hydroxypyrene
  • 1-Hydroxy pyrene
  • 1-Pyrenol
  • Pyren-1-ol
5315-79-7
1-Methoxyphenanthrene
  • Methyl 1-phenanthryl ether
genes like me logo Genes that share compounds with METTL2B: view

Transcripts for METTL2B Gene

mRNA/cDNA for METTL2B Gene

Unigene Clusters for METTL2B Gene

Methyltransferase like 2B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for METTL2B

Alternative Splicing Database (ASD) splice patterns (SP) for METTL2B Gene

No ASD Table

Relevant External Links for METTL2B Gene

GeneLoc Exon Structure for
METTL2B
ECgene alternative splicing isoforms for
METTL2B

Expression for METTL2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for METTL2B Gene

Protein differential expression in normal tissues from HIPED for METTL2B Gene

This gene is overexpressed in Adrenal (55.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for METTL2B Gene



NURSA nuclear receptor signaling pathways regulating expression of METTL2B Gene:

METTL2B

SOURCE GeneReport for Unigene cluster for METTL2B Gene:

Hs.433213

Evidence on tissue expression from TISSUES for METTL2B Gene

  • Eye(4.1)
genes like me logo Genes that share expression patterns with METTL2B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for METTL2B Gene

Orthologs for METTL2B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for METTL2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia METTL2B 34 33
  • 99.21 (n)
OneToOne
cow
(Bos Taurus)
Mammalia METTL2 34
  • 84 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Mettl2 34
  • 76 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 73 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 66 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 64 (a)
OneToMany
chicken
(Gallus gallus)
Aves METTL2 34
  • 65 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 60 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii mettl2a 34
  • 66 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta metl 34
  • 48 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y53F4B.42 34
  • 48 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ABP140 34
  • 21 (a)
OneToMany
Species where no ortholog for METTL2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for METTL2B Gene

ENSEMBL:
Gene Tree for METTL2B (if available)
TreeFam:
Gene Tree for METTL2B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for METTL2B: view image

Paralogs for METTL2B Gene

Paralogs for METTL2B Gene

(8) SIMAP similar genes for METTL2B Gene using alignment to 4 proteins:

  • MET2B_HUMAN
  • F8WAS9_HUMAN
  • H7C2C8_HUMAN
  • H7C552_HUMAN
genes like me logo Genes that share paralogs with METTL2B: view

Variants for METTL2B Gene

Sequence variations from dbSNP and Humsavar for METTL2B Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000170248 -- 128,482,568(+) C/A intron_variant
rs1000179787 -- 128,500,410(+) C/G intron_variant
rs1000220334 -- 128,489,613(+) G/A/C intron_variant
rs1000235961 -- 128,496,495(+) G/C intron_variant
rs1000266264 -- 128,476,591(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for METTL2B Gene

Variant ID Type Subtype PubMed ID
esv2670312 CNV deletion 23128226
esv2735137 CNV deletion 23290073
esv3614971 CNV loss 21293372
nsv1117759 CNV deletion 24896259
nsv1140843 CNV deletion 24896259
nsv1142501 CNV tandem duplication 24896259
nsv476160 CNV novel sequence insertion 20440878
nsv831124 CNV gain+loss 17160897
nsv966883 CNV duplication 23825009

Variation tolerance for METTL2B Gene

Residual Variation Intolerance Score: 88.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.19; 80.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for METTL2B Gene

Human Gene Mutation Database (HGMD)
METTL2B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
METTL2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METTL2B Gene

Disorders for METTL2B Gene

Additional Disease Information for METTL2B

No disorders were found for METTL2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for METTL2B Gene

Publications for METTL2B Gene

  1. Identification of a novel family of putative methyltransferases that interact with human and Drosophila presenilins. (PMID: 11738826) Zhang SX … Boulianne GL (Gene 2001) 2 3 22 58
  2. Actin-binding protein ABP140 is a methyltransferase for 3-methylcytidine at position 32 of tRNAs in Saccharomyces cerevisiae. (PMID: 21518805) Noma A … Suzuki T (RNA (New York, N.Y.) 2011) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for METTL2B Gene

Sources for METTL2B Gene

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