Aliases for METTL2A Gene

Aliases for METTL2A Gene

  • Methyltransferase Like 2A 2 3 5
  • METTL2 2 3 4
  • TRNA N(3)-Methylcytidine Methyltransferase METTL2A 3 4
  • Methyltransferase-Like Protein 2A 3 4
  • EC 2.1.1.- 4
  • FLJ12760 2
  • METTL2A 5

External Ids for METTL2A Gene

Previous GeneCards Identifiers for METTL2A Gene

  • GC17P057855
  • GC17P060501
  • GC17P055867

Summaries for METTL2A Gene

GeneCards Summary for METTL2A Gene

METTL2A (Methyltransferase Like 2A) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include methyltransferase activity and tRNA (cytosine) methyltransferase activity. An important paralog of this gene is METTL2B.

UniProtKB/Swiss-Prot Summary for METTL2A Gene

  • S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU).

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for METTL2A Gene

Genomics for METTL2A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for METTL2A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around METTL2A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for METTL2A

Top Transcription factor binding sites by QIAGEN in the METTL2A gene promoter:
  • AML1a
  • E47
  • FOXO4
  • HSF1 (long)
  • HSF1short
  • RP58
  • RSRFC4
  • TBP
  • TFIID

Genomic Locations for METTL2A Gene

Latest Assembly
chr17:62,423,875-62,453,385
(GRCh38/hg38)
Size:
29,511 bases
Orientation:
Plus strand

Previous Assembly
chr17:60,501,258-60,530,746
(GRCh37/hg19 by Entrez Gene)
Size:
29,489 bases
Orientation:
Plus strand

chr17:60,501,228-60,527,454
(GRCh37/hg19 by Ensembl)
Size:
26,227 bases
Orientation:
Plus strand

Genomic View for METTL2A Gene

Genes around METTL2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METTL2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METTL2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL2A Gene

Proteins for METTL2A Gene

  • Protein details for METTL2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96IZ6-MET2A_HUMAN
    Recommended name:
    tRNA N(3)-methylcytidine methyltransferase METTL2A
    Protein Accession:
    Q96IZ6
    Secondary Accessions:
    • A6NNC4
    • Q9H9G9
    • Q9NUI8
    • Q9P0B5

    Protein attributes for METTL2A Gene

    Size:
    378 amino acids
    Molecular mass:
    43537 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14260.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for METTL2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for METTL2A Gene

Post-translational modifications for METTL2A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for METTL2A Gene

No data available for DME Specific Peptides for METTL2A Gene

Domains & Families for METTL2A Gene

Gene Families for METTL2A Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for METTL2A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for METTL2A Gene

GenScript: Design optimal peptide antigens:
  • Methyltransferase-like protein 2A (MTL2A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96IZ6

UniProtKB/Swiss-Prot:

MET2A_HUMAN :
  • Belongs to the methyltransferase superfamily. METL family.
Family:
  • Belongs to the methyltransferase superfamily. METL family.
genes like me logo Genes that share domains with METTL2A: view

Function for METTL2A Gene

Molecular function for METTL2A Gene

UniProtKB/Swiss-Prot Function:
S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=cytidine(32) in tRNA(Thr) + S-adenosyl-L-methionine = H(+) + N(3)-methylcytidine(32) in tRNA(Thr) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:50960, Rhea:RHEA-COMP:12850, Rhea:RHEA-COMP:12852, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74894, ChEBI:CHEBI:82748; Evidence={ECO:0000305|PubMed:28655767};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=cytidine(32) in tRNA(Arg)(CCU) + S-adenosyl-L-methionine = H(+) + N(3)-methylcytidine(32) in tRNA(Arg)(CCU) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:60912, Rhea:RHEA-COMP:15710, Rhea:RHEA-COMP:15712, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74894, ChEBI:CHEBI:82748; Evidence={ECO:0000305|PubMed:28655767};.

Enzyme Numbers (IUBMB) for METTL2A Gene

Phenotypes From GWAS Catalog for METTL2A Gene

Gene Ontology (GO) - Molecular Function for METTL2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity IEA --
GO:0016427 tRNA (cytosine) methyltransferase activity ISS --
GO:0016740 transferase activity IEA --
GO:0052735 tRNA (cytosine-3-)-methyltransferase activity IMP 28655767
genes like me logo Genes that share ontologies with METTL2A: view
genes like me logo Genes that share phenotypes with METTL2A: view

miRNA for METTL2A Gene

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for METTL2A

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for METTL2A Gene

Localization for METTL2A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for METTL2A gene
Compartment Confidence
cytosol 3
mitochondrion 1
nucleus 1
peroxisome 0

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for METTL2A Gene

Pathways & Interactions for METTL2A Gene

PathCards logo

SuperPathways for METTL2A Gene

No Data Available

Gene Ontology (GO) - Biological Process for METTL2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008033 tRNA processing IEA --
GO:0030488 tRNA methylation ISS --
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with METTL2A: view

No data available for Pathways by source and SIGNOR curated interactions for METTL2A Gene

Drugs & Compounds for METTL2A Gene

No Compound Related Data Available

Transcripts for METTL2A Gene

mRNA/cDNA for METTL2A Gene

2 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for METTL2A

Alternative Splicing Database (ASD) splice patterns (SP) for METTL2A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP1:
SP2:

Relevant External Links for METTL2A Gene

GeneLoc Exon Structure for
METTL2A

Expression for METTL2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for METTL2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for METTL2A Gene

This gene is overexpressed in Fetal Liver (28.3), Fetal ovary (24.4), and Fetal heart (15.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for METTL2A Gene



Protein tissue co-expression partners for METTL2A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for METTL2A

SOURCE GeneReport for Unigene cluster for METTL2A Gene:

Hs.381204

Evidence on tissue expression from TISSUES for METTL2A Gene

  • Nervous system(4.5)
  • Blood(4.1)
genes like me logo Genes that share expression patterns with METTL2A: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for METTL2A Gene

Orthologs for METTL2A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for METTL2A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia METTL2A 30 31
  • 98.94 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia METTL2A 30
  • 88.89 (n)
-- 31
  • 63 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia METTL2B 30
  • 87.02 (n)
METTL2 31
  • 84 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Mettl2b 30
  • 83.11 (n)
Mouse
(Mus musculus)
Mammalia Mettl2 30 17 31
  • 83.06 (n)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 74 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 66 (a)
OneToMany
Chicken
(Gallus gallus)
Aves METTL2A 30
  • 70.31 (n)
METTL2 31
  • 65 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 60 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia mettl2b 30
  • 68.11 (n)
Str.3463 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.5270 30
Zebrafish
(Danio rerio)
Actinopterygii mettl2a 30 31
  • 70.72 (n)
OneToMany
Dr.25461 30
Fruit Fly
(Drosophila melanogaster)
Insecta metl 30 31
  • 57.45 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005973 30
  • 56.37 (n)
Worm
(Caenorhabditis elegans)
Secernentea CELE_Y53F4B.42 30
  • 54.9 (n)
Y53F4B.42 31
  • 48 (a)
OneToMany
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F11385g 30
  • 50.96 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ABP140 31
  • 21 (a)
OneToMany
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC21C3.07c 30
  • 52.89 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU04647 30
  • 51.27 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.4466 30
Species where no ortholog for METTL2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for METTL2A Gene

ENSEMBL:
Gene Tree for METTL2A (if available)
TreeFam:
Gene Tree for METTL2A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for METTL2A: view image

Paralogs for METTL2A Gene

Paralogs for METTL2A Gene

(3) SIMAP similar genes for METTL2A Gene using alignment to 1 proteins:

  • MET2A_HUMAN
genes like me logo Genes that share paralogs with METTL2A: view

Variants for METTL2A Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for METTL2A Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for METTL2A Gene

Variant ID Type Subtype PubMed ID
esv3640974 CNV gain 21293372
esv3640975 CNV loss 21293372
nsv962358 CNV duplication 23825009

Variation tolerance for METTL2A Gene

Residual Variation Intolerance Score: 71.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.14; 38.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for METTL2A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
METTL2A

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for METTL2A Gene

Disorders for METTL2A Gene

Additional Disease Information for METTL2A

No disorders were found for METTL2A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for METTL2A Gene

Publications for METTL2A Gene

  1. Three distinct 3-methylcytidine (m3C) methyltransferases modify tRNA and mRNA in mice and humans. (PMID: 28655767) Xu L … Fu XY (The Journal of biological chemistry 2017) 3 4
  2. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3

Products for METTL2A Gene

Sources for METTL2A Gene