Aliases for METTL26 Gene

Aliases for METTL26 Gene

  • Methyltransferase Like 26 2 3 5
  • Methyltransferase-Like 26 3 4
  • JFP2 3 4
  • Chromosome 16 Open Reading Frame 13 2
  • UPF0585 Protein C16orf13 3
  • C16orf13 3

External Ids for METTL26 Gene

Previous HGNC Symbols for METTL26 Gene

  • C16orf13

Summaries for METTL26 Gene

GeneCards Summary for METTL26 Gene

METTL26 (Methyltransferase Like 26) is a Protein Coding gene. Diseases associated with METTL26 include Left Ventricular Noncompaction.

Additional gene information for METTL26 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for METTL26 Gene

Genomics for METTL26 Gene

GeneHancer (GH) Regulatory Elements for METTL26 Gene

Promoters and enhancers for METTL26 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around METTL26 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for METTL26

Genomic Locations for METTL26 Gene

Genomic Locations for METTL26 Gene
1,940 bases
Minus strand
1,930 bases
Minus strand

Genomic View for METTL26 Gene

Genes around METTL26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METTL26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METTL26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL26 Gene

Proteins for METTL26 Gene

  • Protein details for METTL26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Methyltransferase-like 26
    Protein Accession:
    Secondary Accessions:
    • A8MTR1
    • A8MWJ8
    • A8MZA1
    • B4DG95
    • B4DIJ3
    • D6REA6
    • F6TF62
    • F6VM53
    • Q96IW1
    • Q96MD6

    Protein attributes for METTL26 Gene

    204 amino acids
    Molecular mass:
    22578 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAK61238.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW85785.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for METTL26 Gene

neXtProt entry for METTL26 Gene

Post-translational modifications for METTL26 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for METTL26 Gene

Domains & Families for METTL26 Gene

Gene Families for METTL26 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for METTL26 Gene


Suggested Antigen Peptide Sequences for METTL26 Gene

GenScript: Design optimal peptide antigens:
  • UPF0585 protein C16orf13 (CP013_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UPF0585 family.
  • Belongs to the UPF0585 family.
genes like me logo Genes that share domains with METTL26: view

Function for METTL26 Gene

Phenotypes From GWAS Catalog for METTL26 Gene

genes like me logo Genes that share phenotypes with METTL26: view

Animal Models for METTL26 Gene

MGI Knock Outs for METTL26:

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for METTL26 Gene

Localization for METTL26 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for METTL26 gene
Compartment Confidence
extracellular 2
nucleus 2
plasma membrane 1
cytosol 1
mitochondrion 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for METTL26 Gene

Pathways & Interactions for METTL26 Gene

PathCards logo

SuperPathways for METTL26 Gene

No Data Available

Interacting Proteins for METTL26 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000440765 Q96S19-MTL26_HUMAN for METTL26 Gene via STRING IID


Gene Ontology (GO) - Biological Process for METTL26 Gene


No data available for Pathways by source and SIGNOR curated interactions for METTL26 Gene

Drugs & Compounds for METTL26 Gene

No Compound Related Data Available

Transcripts for METTL26 Gene

mRNA/cDNA for METTL26 Gene

19 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for METTL26 Gene

No ASD Table

Relevant External Links for METTL26 Gene

GeneLoc Exon Structure for

Expression for METTL26 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for METTL26

Evidence on tissue expression from TISSUES for METTL26 Gene

  • Lung(3.3)
  • Nervous system(2.5)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for METTL26 Gene

Orthologs for METTL26 Gene

This gene was present in the common ancestor of animals.

Orthologs for METTL26 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C16orf13 31
  • 98 (a)
C16H16orf13 30
  • 97.88 (n)
(Canis familiaris)
Mammalia C6H16orf13 30
  • 88.56 (n)
C16orf13 31
  • 50 (a)
(Bos Taurus)
Mammalia C25H16orf13 30
  • 87.42 (n)
C25H16ORF13 31
  • 61 (a)
(Mus musculus)
Mammalia 0610011F06Rik 31 30
  • 85.71 (n)
Mettl26 17
(Rattus norvegicus)
Mammalia RGD1307155 30
  • 84.92 (n)
(Monodelphis domestica)
Mammalia C16orf13 31
  • 44 (a)
(Anolis carolinensis)
Reptilia C16orf13 31
  • 44 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c16orf13 30
  • 61.88 (n)
(Danio rerio)
Actinopterygii zgc:56719 30
  • 58.78 (n)
C3H16orf13 31
  • 34 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG18661 31 30
  • 51.68 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009967 30
  • 50.58 (n)
(Caenorhabditis elegans)
Secernentea Y26E6A.3 31 30
  • 48 (n)
Species where no ortholog for METTL26 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for METTL26 Gene

Gene Tree for METTL26 (if available)
Gene Tree for METTL26 (if available)

Paralogs for METTL26 Gene

No data available for Paralogs for METTL26 Gene

Variants for METTL26 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for METTL26 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
rs865791888 - p.Leu136Pro

Additional dbSNP identifiers (rs#s) for METTL26 Gene

Structural Variations from Database of Genomic Variants (DGV) for METTL26 Gene

Variant ID Type Subtype PubMed ID
dgv334n27 CNV loss 19166990
dgv4823n54 CNV loss 21841781
dgv4824n54 CNV loss 21841781
esv2422427 CNV duplication 17116639
esv2750219 CNV deletion 23290073
nsv1160325 CNV duplication 26073780
nsv1160326 CNV duplication 26073780
nsv471063 CNV loss 18288195
nsv471065 CNV gain 18288195
nsv516590 CNV loss 19592680
nsv526903 CNV loss 19592680
nsv571012 CNV loss 21841781
nsv571015 CNV loss 21841781
nsv833114 CNV gain+loss 17160897
nsv952898 CNV deletion 24416366

Variation tolerance for METTL26 Gene

Gene Damage Index Score: 0.88; 18.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for METTL26 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METTL26 Gene

Disorders for METTL26 Gene

MalaCards: The human disease database

(1) MalaCards diseases for METTL26 Gene - From: DISEASES

Disorder Aliases PubMed IDs
left ventricular noncompaction
  • left ventricular hypertrabeculation
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for METTL26

genes like me logo Genes that share disorders with METTL26: view

No data available for UniProtKB/Swiss-Prot and Genatlas for METTL26 Gene

Publications for METTL26 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  2. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels RJ … Higgs DR (Human molecular genetics 2001) 3 4 54
  3. Endogenous Cell Type-Specific Disrupted in Schizophrenia 1 Interactomes Reveal Protein Networks Associated With Neurodevelopmental Disorders. (PMID: 29961565) Wilkinson B … Coba MP (Biological psychiatry 2019) 3 54
  4. Reversible oxidation of phosphatase and tensin homolog (PTEN) alters its interactions with signaling and regulatory proteins. (PMID: 26561776) Verrastro I … Pitt AR (Free radical biology & medicine 2016) 3 54
  5. A census of human soluble protein complexes. (PMID: 22939629) Havugimana PC … Emili A (Cell 2012) 3 54

Products for METTL26 Gene

Sources for METTL26 Gene