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Aliases for METTL26 Gene

Aliases for METTL26 Gene

  • Methyltransferase Like 26 2 3 5
  • JFP2 3 4
  • Chromosome 16 Open Reading Frame 13 2
  • Methyltransferase-Like 26 3
  • UPF0585 Protein C16orf13 3
  • C16orf13 3

External Ids for METTL26 Gene

Previous HGNC Symbols for METTL26 Gene

  • C16orf13

Summaries for METTL26 Gene

GeneCards Summary for METTL26 Gene

METTL26 (Methyltransferase Like 26) is a Protein Coding gene.

Additional gene information for METTL26 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL26 Gene

Genomics for METTL26 Gene

GeneHancer (GH) Regulatory Elements for METTL26 Gene

Promoters and enhancers for METTL26 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J000635 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 696.7 -0.7 -706 4.1 CLOCK DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 SSRP1 ZNF610 METTL26 LOC100287175 TRG-CCC2-2 MCRIP2 GC16P001015 WFIKKN1 WDR90 CRAMP1 JMJD8 TELO2
GH16J000666 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 43.1 -31.9 -31911 3 HDGF PKNOX1 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 YY1 POLR2B RHOT2 METTL26 WDR90 WFIKKN1 RHBDL1 CRAMP1 UNKL UBE2I ENSG00000262528 CHTF18
GH16J001308 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 18.8 -674.4 -674388 5.2 CLOCK FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 UBE2I LOC102723815 WDR90 CRAMP1 ENSG00000261505 TELO2 ENSG00000260051 E4F1 TSC2 IFT140
GH16J000659 Enhancer 1.3 Ensembl ENCODE dbSUPER 25.2 -24.6 -24590 2.7 HDGF SIN3A ZNF2 GLIS2 ZNF143 SP3 REST SMARCB1 ZNF592 GMEB1 METTL26 WFIKKN1 RHBDL1 ENSG00000262528 RHOT2 WDR90
GH16J000739 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.4 -104.4 -104365 1.9 PKNOX1 CLOCK MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 CIAO3 UBE2I WDR90 ENSG00000261505 TELO2 UNKL CRAMP1 WASH4P ENSG00000268836 ENSG00000260051
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around METTL26 on UCSC Golden Path with GeneCards custom track

Genomic Locations for METTL26 Gene

Genomic Locations for METTL26 Gene
1,940 bases
Minus strand
1,930 bases
Minus strand

Genomic View for METTL26 Gene

Genes around METTL26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METTL26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METTL26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL26 Gene

Proteins for METTL26 Gene

  • Protein details for METTL26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Methyltransferase-like 26
    Protein Accession:
    Secondary Accessions:
    • A8MTR1
    • A8MWJ8
    • A8MZA1
    • B4DG95
    • B4DIJ3
    • D6REA6
    • F6TF62
    • F6VM53
    • Q96IW1
    • Q96MD6

    Protein attributes for METTL26 Gene

    204 amino acids
    Molecular mass:
    22578 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAK61238.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW85785.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for METTL26 Gene

neXtProt entry for METTL26 Gene

Post-translational modifications for METTL26 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for METTL26 Gene

Domains & Families for METTL26 Gene

Gene Families for METTL26 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for METTL26 Gene


Suggested Antigen Peptide Sequences for METTL26 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UPF0585 family.
  • Belongs to the UPF0585 family.
genes like me logo Genes that share domains with METTL26: view

Function for METTL26 Gene

Phenotypes From GWAS Catalog for METTL26 Gene

genes like me logo Genes that share phenotypes with METTL26: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for METTL26 Gene

Localization for METTL26 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for METTL26 gene
Compartment Confidence
nucleus 3
extracellular 2
plasma membrane 1
mitochondrion 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for METTL26 Gene

Pathways & Interactions for METTL26 Gene

SuperPathways for METTL26 Gene

No Data Available

Interacting Proteins for METTL26 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q96S19-MTL26_HUMAN ENSP00000440765 for METTL26 Gene via IID STRING

Gene Ontology (GO) - Biological Process for METTL26 Gene


No data available for Pathways by source and SIGNOR curated interactions for METTL26 Gene

Drugs & Compounds for METTL26 Gene

No Compound Related Data Available

Transcripts for METTL26 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for METTL26 Gene

No ASD Table

Relevant External Links for METTL26 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for METTL26 Gene

NURSA nuclear receptor signaling pathways regulating expression of METTL26 Gene:


Evidence on tissue expression from TISSUES for METTL26 Gene

  • Lung(3.3)
  • Nervous system(2.5)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for METTL26 Gene

Orthologs for METTL26 Gene

This gene was present in the common ancestor of animals.

Orthologs for METTL26 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C16orf13 34
  • 98 (a)
C16H16orf13 33
  • 97.88 (n)
(Canis familiaris)
Mammalia C6H16orf13 33
  • 88.56 (n)
C16orf13 34
  • 50 (a)
(Bos Taurus)
Mammalia C25H16orf13 33
  • 87.42 (n)
C25H16ORF13 34
  • 61 (a)
(Mus musculus)
Mammalia 0610011F06Rik 34 33
  • 85.71 (n)
Mettl26 16
(Rattus norvegicus)
Mammalia RGD1307155 33
  • 84.92 (n)
(Monodelphis domestica)
Mammalia C16orf13 34
  • 44 (a)
(Anolis carolinensis)
Reptilia C16orf13 34
  • 44 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c16orf13 33
  • 61.88 (n)
(Danio rerio)
Actinopterygii zgc:56719 33
  • 58.78 (n)
C3H16orf13 34
  • 34 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG18661 34 33
  • 51.68 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009967 33
  • 50.58 (n)
(Caenorhabditis elegans)
Secernentea Y26E6A.3 34 33
  • 48 (n)
Species where no ortholog for METTL26 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for METTL26 Gene

Gene Tree for METTL26 (if available)
Gene Tree for METTL26 (if available)

Paralogs for METTL26 Gene

No data available for Paralogs for METTL26 Gene

Variants for METTL26 Gene

Sequence variations from dbSNP and Humsavar for METTL26 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000286847 -- 635,667(-) A/C coding_sequence_variant, intron_variant, missense_variant, non_coding_transcript_variant
rs1000384641 -- 636,112(-) T/C coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000651143 -- 636,841(-) A/G upstream_transcript_variant
rs1000725409 -- 635,136(-) G/C intron_variant
rs1001470645 -- 636,730(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for METTL26 Gene

Variant ID Type Subtype PubMed ID
dgv334n27 CNV loss 19166990
dgv4823n54 CNV loss 21841781
dgv4824n54 CNV loss 21841781
esv2422427 CNV duplication 17116639
esv2750219 CNV deletion 23290073
nsv1160325 CNV duplication 26073780
nsv1160326 CNV duplication 26073780
nsv471063 CNV loss 18288195
nsv471065 CNV gain 18288195
nsv516590 CNV loss 19592680
nsv526903 CNV loss 19592680
nsv571012 CNV loss 21841781
nsv571015 CNV loss 21841781
nsv833114 CNV gain+loss 17160897
nsv952898 CNV deletion 24416366

Variation tolerance for METTL26 Gene

Gene Damage Index Score: 0.88; 18.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for METTL26 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METTL26 Gene

Disorders for METTL26 Gene

No disorders were found for METTL26 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for METTL26 Gene

Publications for METTL26 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels RJ … Higgs DR (Human molecular genetics 2001) 3 4 58
  3. Reversible oxidation of phosphatase and tensin homolog (PTEN) alters its interactions with signaling and regulatory proteins. (PMID: 26561776) Verrastro I … Pitt AR (Free radical biology & medicine 2016) 3 58
  4. A census of human soluble protein complexes. (PMID: 22939629) Havugimana PC … Emili A (Cell 2012) 3 58
  5. N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P … Aldabe R (Proceedings of the National Academy of Sciences of the United States of America 2012) 4 58

Products for METTL26 Gene

Sources for METTL26 Gene

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