Aliases for METTL25 Gene

Aliases for METTL25 Gene

  • Methyltransferase Like 25 2 3 5
  • Methyltransferase-Like Protein 25 3 4
  • C12orf26 3 4
  • Chromosome 12 Open Reading Frame 26 2
  • EC 2.1.1.- 4
  • FLJ22789 2
  • METTL25 5

External Ids for METTL25 Gene

Previous HGNC Symbols for METTL25 Gene

  • C12orf26

Previous GeneCards Identifiers for METTL25 Gene

  • GC12P082754

Summaries for METTL25 Gene

GeneCards Summary for METTL25 Gene

METTL25 (Methyltransferase Like 25) is a Protein Coding gene. Diseases associated with METTL25 include Optic Atrophy 7 With Or Without Auditory Neuropathy. Gene Ontology (GO) annotations related to this gene include methyltransferase activity. An important paralog of this gene is METTL25B.

UniProtKB/Swiss-Prot Summary for METTL25 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for METTL25 Gene

Genomics for METTL25 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for METTL25 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J082357 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas 331.8 0.0 -16 3.6 BCLAF1 SP1 ZNF207 NCOR1 MYC IKZF1 ZNF600 SIX5 SSRP1 ZNF580 METTL25 CCDC59 lnc-PPFIA2-5 piR-58846 ENSG00000257875 ENSG00000257431 HSALNG0092739 PPFIA2
GH12J082861 Enhancer 1 Ensembl dbSUPER 13.8 +504.4 504383 1.2 ZNF580 ATF2 ZNF10 ZSCAN16 ZIC2 FEZF1 KLF7 ZNF513 ZNF610 ZNF843 METTL25 CCDC59 RF00017-1087 piR-30876-029 TMTC2
GH12J082407 Enhancer 0.4 Ensembl ENCODE 4.3 +49.1 49084 1.8 CEBPB ENSG00000257431 METTL25 HSALNG0092743 CCDC59 piR-39930 TMTC2
GH12J082329 Enhancer 0.6 Ensembl ENCODE 0.3 -28.9 -28916 1.4 FEZF1 PRDM6 ZNF384 HSALNG0092738 ENSG00000257431 HSALNG0092739 CCDC59 METTL25 PPFIA2
GH12J082364 Enhancer 0.3 Ensembl 0.4 +5.9 5884 0.2 MNT ZNF335 piR-39930 CCDC59 METTL25 HSALNG0092743 TMTC2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around METTL25 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for METTL25

Genomic Locations for METTL25 Gene

Latest Assembly
120,823 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
120,711 bases
Plus strand

(GRCh37/hg19 by Ensembl)
120,740 bases
Plus strand

Genomic View for METTL25 Gene

Genes around METTL25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METTL25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METTL25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL25 Gene

Proteins for METTL25 Gene

  • Protein details for METTL25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Methyltransferase-like protein 25
    Protein Accession:
    Secondary Accessions:
    • Q9H5Y3

    Protein attributes for METTL25 Gene

    603 amino acids
    Molecular mass:
    68213 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB15484.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for METTL25 Gene

Post-translational modifications for METTL25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for METTL25 Gene

Domains & Families for METTL25 Gene

Gene Families for METTL25 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for METTL25 Gene

genes like me logo Genes that share domains with METTL25: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for METTL25 Gene

Function for METTL25 Gene

Molecular function for METTL25 Gene

UniProtKB/Swiss-Prot Function:
Putative methyltransferase.

Enzyme Numbers (IUBMB) for METTL25 Gene

Phenotypes From GWAS Catalog for METTL25 Gene

Gene Ontology (GO) - Molecular Function for METTL25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with METTL25: view
genes like me logo Genes that share phenotypes with METTL25: view

miRNA for METTL25 Gene

miRTarBase miRNAs that target METTL25

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for METTL25

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for METTL25 Gene

Localization for METTL25 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for METTL25 gene
Compartment Confidence
nucleus 1
endoplasmic reticulum 1
cytosol 1
golgi apparatus 1
mitochondrion 0
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Mitochondria (1)
  • Plasma membrane (1)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for METTL25 Gene

Pathways & Interactions for METTL25 Gene

PathCards logo

SuperPathways for METTL25 Gene

No Data Available

Gene Ontology (GO) - Biological Process for METTL25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with METTL25: view

No data available for Pathways by source and SIGNOR curated interactions for METTL25 Gene

Drugs & Compounds for METTL25 Gene

No Compound Related Data Available

Transcripts for METTL25 Gene

mRNA/cDNA for METTL25 Gene

5 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for METTL25

Alternative Splicing Database (ASD) splice patterns (SP) for METTL25 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP2: - - - -
SP3: -
SP4: - - -
SP6: - -

Relevant External Links for METTL25 Gene

GeneLoc Exon Structure for

Expression for METTL25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for METTL25 Gene

Protein differential expression in normal tissues from HIPED for METTL25 Gene

This gene is overexpressed in Bone marrow stromal cell (33.4) and Peripheral blood mononuclear cells (26.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for METTL25 Gene

Protein tissue co-expression partners for METTL25 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for METTL25

SOURCE GeneReport for Unigene cluster for METTL25 Gene:


Evidence on tissue expression from TISSUES for METTL25 Gene

  • Intestine(4.1)
genes like me logo Genes that share expression patterns with METTL25: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for METTL25 Gene

Orthologs for METTL25 Gene

This gene was present in the common ancestor of animals.

Orthologs for METTL25 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia METTL25 29 30
  • 99.23 (n)
(Canis familiaris)
Mammalia METTL25 29
  • 88.1 (n)
C12ORF26 30
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 83 (a)
-- 30
  • 49 (a)
(Mus musculus)
Mammalia Mettl25 29 16 30
  • 80.8 (n)
(Rattus norvegicus)
Mammalia Mettl25 29
  • 79.53 (n)
(Bos Taurus)
Mammalia METTL25 29 30
  • 77.31 (n)
(Monodelphis domestica)
Mammalia METTL25 30
  • 63 (a)
(Gallus gallus)
Aves C1H12ORF26 29
  • 68.95 (n)
METTL25 30
  • 58 (a)
(Anolis carolinensis)
Reptilia METTL25 30
  • 57 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia mettl25 29
  • 60.83 (n)
Str.14343 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.13226 29
(Danio rerio)
Actinopterygii mettl25 29 30
  • 56.03 (n)
Dr.17382 29
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010960 29
  • 44.7 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG33964 29 30
  • 27.32 (n)
Species where no ortholog for METTL25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for METTL25 Gene

Gene Tree for METTL25 (if available)
Gene Tree for METTL25 (if available)
Evolutionary constrained regions (ECRs) for METTL25: view image
Alliance of Genome Resources:
Additional Orthologs for METTL25

Paralogs for METTL25 Gene

Paralogs for METTL25 Gene

genes like me logo Genes that share paralogs with METTL25: view

Variants for METTL25 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for METTL25 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs386352284 Uncertain Significance: not provided 82,358,773(+) G/A
NM_032230.3(METTL25):c.208G>A (p.Glu70Lys)
rs4296098 -- p.Gln249Lys

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for METTL25 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for METTL25 Gene

Variant ID Type Subtype PubMed ID
esv2666887 CNV deletion 23128226
esv3303417 CNV mobile element insertion 20981092
esv3442704 CNV insertion 20981092
esv3549486 CNV deletion 23714750
esv3630157 CNV loss 21293372
esv3630158 CNV loss 21293372
nsv478456 CNV novel sequence insertion 20440878
nsv519197 CNV gain 19592680
nsv559539 CNV gain 21841781
nsv559541 CNV gain 21841781
nsv832471 CNV loss 17160897

Variation tolerance for METTL25 Gene

Residual Variation Intolerance Score: 36.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.61; 65.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for METTL25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METTL25 Gene

Disorders for METTL25 Gene

MalaCards: The human disease database

(1) MalaCards diseases for METTL25 Gene - From: COP

Disorder Aliases PubMed IDs
optic atrophy 7 with or without auditory neuropathy
  • opa7
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for METTL25

genes like me logo Genes that share disorders with METTL25: view

No data available for UniProtKB/Swiss-Prot and Genatlas for METTL25 Gene

Publications for METTL25 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis. (PMID: 31586073) Capalbo L … D'Avino PP (Nature communications 2019) 3
  4. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. (PMID: 30021884) Fasci D … Heck AJR (Molecular & cellular proteomics : MCP 2018) 3
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

Products for METTL25 Gene

Sources for METTL25 Gene