Aliases for METTL21A Gene

Aliases for METTL21A Gene

  • Methyltransferase Like 21A 2 3 5
  • Hepatocellular Carcinoma-Associated Antigen 557b 2 3 4
  • Heat Shock Protein 70kDa Lysine (K) Methyltransferase 2 3
  • Family With Sequence Similarity 119, Member A 2 3
  • Protein N-Lysine Methyltransferase METTL21A 3 4
  • Methyltransferase-Like Protein 21A 3 4
  • HSPA Lysine Methyltransferase 3 4
  • HSPA-KMT 3 4
  • FAM119A 3 4
  • EC 2.1.1.- 4
  • HCA557b 3
  • HCA557B 4

External Ids for METTL21A Gene

Previous HGNC Symbols for METTL21A Gene

  • FAM119A

Previous GeneCards Identifiers for METTL21A Gene

  • GC02M208446

Summaries for METTL21A Gene

GeneCards Summary for METTL21A Gene

METTL21A (Methyltransferase Like 21A) is a Protein Coding gene. Diseases associated with METTL21A include Bardet-Biedl Syndrome 5 and Pontocerebellar Hypoplasia, Type 2A. Among its related pathways are Metabolism of proteins and Protein methylation. Gene Ontology (GO) annotations related to this gene include methyltransferase activity and Hsp70 protein binding. An important paralog of this gene is EEF1AKMT3.

UniProtKB/Swiss-Prot Summary for METTL21A Gene

  • Protein-lysine methyltransferase that selectively trimethylates residues in heat shock protein 70 (HSP70) family members. Contributes to the in vivo trimethylation of Lys residues in HSPA1 and HSPA8. In vitro methylates 'Lys-561' in HSPA1, 'Lys-564' in HSPA2, 'Lys-585' in HSPA5, 'Lys-563' in HSPA6 and 'Lys-561' in HSPA8.

Additional gene information for METTL21A Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for METTL21A Gene

Genomics for METTL21A Gene

GeneHancer (GH) Regulatory Elements for METTL21A Gene

Promoters and enhancers for METTL21A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around METTL21A on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for METTL21A

Genomic Locations for METTL21A Gene

Genomic Locations for METTL21A Gene
chr2:207,580,631-207,625,928
(GRCh38/hg38)
Size:
45,298 bases
Orientation:
Minus strand
chr2:208,445,355-208,490,652
(GRCh37/hg19)
Size:
45,298 bases
Orientation:
Minus strand

Genomic View for METTL21A Gene

Genes around METTL21A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METTL21A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METTL21A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL21A Gene

Proteins for METTL21A Gene

  • Protein details for METTL21A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WXB1-MT21A_HUMAN
    Recommended name:
    Protein N-lysine methyltransferase METTL21A
    Protein Accession:
    Q8WXB1
    Secondary Accessions:
    • Q53RV0
    • Q8N1Z9
    • Q96GH6

    Protein attributes for METTL21A Gene

    Size:
    218 amino acids
    Molecular mass:
    24600 Da
    Quaternary structure:
    • Interacts with heat shock protein 70 family members; at least some of these proteins are methylation substrates (PubMed:23349634 and PubMed:23921388).

    Three dimensional structures from OCA and Proteopedia for METTL21A Gene

    Alternative splice isoforms for METTL21A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for METTL21A Gene

Post-translational modifications for METTL21A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for METTL21A Gene

Domains & Families for METTL21A Gene

Gene Families for METTL21A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for METTL21A Gene

Suggested Antigen Peptide Sequences for METTL21A Gene

GenScript: Design optimal peptide antigens:
  • Hepatocellular carcinoma-associated antigen 557b (MT21A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8WXB1

UniProtKB/Swiss-Prot:

MT21A_HUMAN :
  • Belongs to the methyltransferase superfamily. METTL21 family.
Family:
  • Belongs to the methyltransferase superfamily. METTL21 family.
genes like me logo Genes that share domains with METTL21A: view

Function for METTL21A Gene

Molecular function for METTL21A Gene

UniProtKB/Swiss-Prot Function:
Protein-lysine methyltransferase that selectively trimethylates residues in heat shock protein 70 (HSP70) family members. Contributes to the in vivo trimethylation of Lys residues in HSPA1 and HSPA8. In vitro methylates 'Lys-561' in HSPA1, 'Lys-564' in HSPA2, 'Lys-585' in HSPA5, 'Lys-563' in HSPA6 and 'Lys-561' in HSPA8.

Enzyme Numbers (IUBMB) for METTL21A Gene

Phenotypes From GWAS Catalog for METTL21A Gene

Gene Ontology (GO) - Molecular Function for METTL21A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
GO:0008168 methyltransferase activity IEA --
GO:0008276 protein methyltransferase activity IDA 23349634
GO:0016279 protein-lysine N-methyltransferase activity TAS --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with METTL21A: view

Phenotypes for METTL21A Gene

genes like me logo Genes that share phenotypes with METTL21A: view

Animal Model Products

CRISPR Products

miRNA for METTL21A Gene

miRTarBase miRNAs that target METTL21A

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for METTL21A

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for METTL21A Gene

Localization for METTL21A Gene

Subcellular locations from UniProtKB/Swiss-Prot for METTL21A Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for METTL21A gene
Compartment Confidence
nucleus 4
cytosol 3
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
extracellular 0
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for METTL21A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0032991 protein-containing complex IDA 23349634
genes like me logo Genes that share ontologies with METTL21A: view

Pathways & Interactions for METTL21A Gene

PathCards logo

SuperPathways for METTL21A Gene

genes like me logo Genes that share pathways with METTL21A: view

Pathways by source for METTL21A Gene

Gene Ontology (GO) - Biological Process for METTL21A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006479 protein methylation TAS --
GO:0018022 peptidyl-lysine methylation IDA 23921388
GO:0032259 methylation IEA --
GO:0043462 NOT regulation of ATPase activity IDA 23921388
genes like me logo Genes that share ontologies with METTL21A: view

No data available for SIGNOR curated interactions for METTL21A Gene

Drugs & Compounds for METTL21A Gene

(2) Drugs for METTL21A Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Citalopram Approved Pharma 582
antidepressants Pharma 0
genes like me logo Genes that share compounds with METTL21A: view

Transcripts for METTL21A Gene

mRNA/cDNA for METTL21A Gene

11 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for METTL21A

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for METTL21A Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d
SP1: - - - - - -
SP2: - - - -
SP3: - - -
SP4: - -
SP5: - -
SP6: -

Relevant External Links for METTL21A Gene

GeneLoc Exon Structure for
METTL21A

Expression for METTL21A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for METTL21A Gene

Protein differential expression in normal tissues from HIPED for METTL21A Gene

This gene is overexpressed in Spleen (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for METTL21A Gene



Protein tissue co-expression partners for METTL21A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for METTL21A

SOURCE GeneReport for Unigene cluster for METTL21A Gene:

Hs.664764

Evidence on tissue expression from TISSUES for METTL21A Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with METTL21A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for METTL21A Gene

Orthologs for METTL21A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for METTL21A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia METTL21A 31 30
  • 99.08 (n)
OneToOne
dog
(Canis familiaris)
Mammalia METTL21A 31 30
  • 92.66 (n)
OneToOne
cow
(Bos Taurus)
Mammalia METTL21A 31 30
  • 91.13 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Mettl21a 17 31 30
  • 88.84 (n)
rat
(Rattus norvegicus)
Mammalia LOC102553119 30
  • 88.23 (n)
oppossum
(Monodelphis domestica)
Mammalia METTL21A 31
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 29 (a)
ManyToMany
chicken
(Gallus gallus)
Aves METTL21A 31 30
  • 67.75 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia METTL21A 31
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mettl21a 30
  • 62.31 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12020 30
zebrafish
(Danio rerio)
Actinopterygii mettl21a 31 30
  • 59.02 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1640 30
worm
(Caenorhabditis elegans)
Secernentea C42C1.13 31
  • 23 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 31
  • 26 (a)
OneToMany
EFM6 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 33 (a)
OneToMany
Species where no ortholog for METTL21A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for METTL21A Gene

ENSEMBL:
Gene Tree for METTL21A (if available)
TreeFam:
Gene Tree for METTL21A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for METTL21A: view image

Paralogs for METTL21A Gene

Paralogs for METTL21A Gene

(3) SIMAP similar genes for METTL21A Gene using alignment to 4 proteins:

  • MT21A_HUMAN
  • C9JES0_HUMAN
  • C9JSX1_HUMAN
  • H7BXH9_HUMAN

Pseudogenes.org Pseudogenes for METTL21A Gene

genes like me logo Genes that share paralogs with METTL21A: view

Variants for METTL21A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for METTL21A Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
729121 Benign: not provided 207,597,017(-) C/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,INTRON_VARIANT
rs2551949 - p.Thr192Ile

Additional dbSNP identifiers (rs#s) for METTL21A Gene

Structural Variations from Database of Genomic Variants (DGV) for METTL21A Gene

Variant ID Type Subtype PubMed ID
dgv77n6 CNV deletion 16902084
esv2173449 CNV deletion 18987734
esv2523513 CNV deletion 19546169
esv2669520 CNV deletion 23128226
esv2671467 CNV deletion 23128226
esv2839347 CNV deletion 24192839
esv3560884 CNV deletion 23714750
esv3594090 CNV gain 21293372
esv3594091 CNV loss 21293372
esv996264 CNV deletion 20482838
nsv1013908 CNV loss 25217958
nsv1072486 CNV deletion 25765185
nsv1117323 CNV deletion 24896259
nsv1118891 CNV deletion 24896259
nsv3131 CNV deletion 18451855
nsv498953 CNV loss 21111241
nsv511834 CNV loss 21212237
nsv955000 CNV deletion 24416366

Variation tolerance for METTL21A Gene

Residual Variation Intolerance Score: 81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.29; 53.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for METTL21A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
METTL21A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METTL21A Gene

Disorders for METTL21A Gene

MalaCards: The human disease database

(2) MalaCards diseases for METTL21A Gene - From: DISEASES

Disorder Aliases PubMed IDs
bardet-biedl syndrome 5
  • bbs5
pontocerebellar hypoplasia, type 2a
  • pch2a
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for METTL21A

genes like me logo Genes that share disorders with METTL21A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for METTL21A Gene

Publications for METTL21A Gene

  1. Identification and characterization of a novel human methyltransferase modulating Hsp70 protein function through lysine methylation. (PMID: 23921388) Jakobsson ME … Falnes PØ (The Journal of biological chemistry 2013) 2 3 4 54
  2. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PMID: 23349634) Cloutier P … Coulombe B (PLoS genetics 2013) 3 4 54
  3. Lysine methylation of VCP by a member of a novel human protein methyltransferase family. (PMID: 22948820) Kernstock S … Falnes PØ (Nature communications 2012) 3 4 54
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54

Products for METTL21A Gene

Sources for METTL21A Gene