Aliases for METTL18 Gene

Aliases for METTL18 Gene

  • Methyltransferase Like 18 2 3 5
  • AsTP2 2 3 4
  • Histidine Protein Methyltransferase 1 Homolog 3 4
  • Methyltransferase-Like Protein 18 3 4
  • Arsenic-Transactivated Protein 2 3 4
  • C1orf156 3 4
  • HPM1 2 3
  • Histidine Protein Methyltransferase 1 2
  • Chromosome 1 Open Reading Frame 156 2
  • EC 2.1.1.- 4
  • METTL18 5
  • MGC9084 2
  • ASTP2 4

External Ids for METTL18 Gene

Previous HGNC Symbols for METTL18 Gene

  • C1orf156

Previous GeneCards Identifiers for METTL18 Gene

  • GC01M169762

Summaries for METTL18 Gene

GeneCards Summary for METTL18 Gene

METTL18 (Methyltransferase Like 18) is a Protein Coding gene. Diseases associated with METTL18 include Combined Oxidative Phosphorylation Deficiency 3 and Transient Global Amnesia. Gene Ontology (GO) annotations related to this gene include methyltransferase activity and protein methyltransferase activity.

UniProtKB/Swiss-Prot Summary for METTL18 Gene

Additional gene information for METTL18 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for METTL18 Gene

Genomics for METTL18 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for METTL18 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J169793 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 664.6 -0.3 -338 3 GATAD2A ZNF629 PRDM10 REST TFE3 SIX5 IKZF1 ZNF692 POLR2A TARDBP METTL18 C1orf112 SCYL3 RN7SL333P F5 KIFAP3 RF00017-389
GH01J169889 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 61.1 -97.4 -97370 5.7 CREB1 GATAD2A HNRNPL ATF7 PRDM10 ZNF629 REST ZNF512 SIX5 IKZF1 SCYL3 METTL18 C1orf112 KIFAP3 RN7SL333P piR-36573-005
GH01J169707 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 51.5 +85.3 85268 6.2 RNF2 CTCF PRDM10 ZNF512 NFKBIZ TARDBP FOXA1 PRDM1 RELA REST MN308830 SELL lnc-SELE-1 METTL18 C1orf112 GORAB RN7SL333P F5 SELP SCYL3
GH01J170072 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 37.4 -279.3 -279310 2.7 CREB1 GATAD2A CTCF PRDM10 ZNF629 RFX1 IKZF1 POLR2A BACH1 FOXA1 KIFAP3 METTL18 C1orf112 LOC105371608 SCYL3
GH01J169482 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 28.6 +309.8 309763 6.4 SP1 HNRNPL CREB1 GATAD2A ATF7 PRDM10 REST ZNF629 TFE3 SOX13 ENSG00000213062 SLC19A2 SCYL3 RN7SL333P C1orf112 METTL18 NME7 CCDC181 piR-38611
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around METTL18 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for METTL18

Genomic Locations for METTL18 Gene

Genomic Locations for METTL18 Gene
2,440 bases
Minus strand
2,438 bases
Minus strand

Genomic View for METTL18 Gene

Genes around METTL18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METTL18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METTL18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL18 Gene

Proteins for METTL18 Gene

  • Protein details for METTL18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Histidine protein methyltransferase 1 homolog
    Protein Accession:
    Secondary Accessions:
    • B2R9T5

    Protein attributes for METTL18 Gene

    372 amino acids
    Molecular mass:
    42148 Da
    Quaternary structure:
    • Interacts with GRWD1, RPL3 and members of the heat shock protein 90 and 70 families; these proteins may possibly be methylation substrates for the enzyme.

    Three dimensional structures from OCA and Proteopedia for METTL18 Gene

neXtProt entry for METTL18 Gene

Post-translational modifications for METTL18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for METTL18 Gene

No data available for DME Specific Peptides for METTL18 Gene

Domains & Families for METTL18 Gene

Gene Families for METTL18 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for METTL18 Gene


Suggested Antigen Peptide Sequences for METTL18 Gene

GenScript: Design optimal peptide antigens:
  • Methyltransferase-like protein 18 (MET18_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the methyltransferase superfamily. METTL18 family.
  • Belongs to the methyltransferase superfamily. METTL18 family.
genes like me logo Genes that share domains with METTL18: view

Function for METTL18 Gene

Molecular function for METTL18 Gene

UniProtKB/Swiss-Prot Function:
Probable histidine methyltransferase.

Enzyme Numbers (IUBMB) for METTL18 Gene

Phenotypes From GWAS Catalog for METTL18 Gene

Gene Ontology (GO) - Molecular Function for METTL18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23349634
GO:0008168 methyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0018064 protein-histidine N-methyltransferase activity IBA 21873635
GO:0031072 heat shock protein binding IPI 23349634
genes like me logo Genes that share ontologies with METTL18: view
genes like me logo Genes that share phenotypes with METTL18: view

Animal Model Products

CRISPR Products

miRNA for METTL18 Gene

miRTarBase miRNAs that target METTL18

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for METTL18

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for METTL18 Gene

Localization for METTL18 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for METTL18 gene
Compartment Confidence
cytosol 3
nucleus 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for METTL18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032991 protein-containing complex IDA 23349634
genes like me logo Genes that share ontologies with METTL18: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for METTL18 Gene

Pathways & Interactions for METTL18 Gene

PathCards logo

SuperPathways for METTL18 Gene

No Data Available

Gene Ontology (GO) - Biological Process for METTL18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0032259 methylation IEA --
GO:0042038 peptidyl-histidine methylation, to form tele-methylhistidine IBA 21873635
genes like me logo Genes that share ontologies with METTL18: view

No data available for Pathways by source and SIGNOR curated interactions for METTL18 Gene

Drugs & Compounds for METTL18 Gene

No Compound Related Data Available

Transcripts for METTL18 Gene

mRNA/cDNA for METTL18 Gene

8 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for METTL18

Alternative Splicing Database (ASD) splice patterns (SP) for METTL18 Gene

No ASD Table

Relevant External Links for METTL18 Gene

GeneLoc Exon Structure for

Expression for METTL18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for METTL18 Gene

Protein differential expression in normal tissues from HIPED for METTL18 Gene

This gene is overexpressed in Lung (20.9), Spleen (13.0), Heart (12.1), and CD4 Tcells (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for METTL18 Gene

Protein tissue co-expression partners for METTL18 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for METTL18

SOURCE GeneReport for Unigene cluster for METTL18 Gene:


Evidence on tissue expression from TISSUES for METTL18 Gene

  • Nervous system(4.2)
  • Intestine(4.1)
  • Heart(2.7)
  • Lung(2.5)
  • Pancreas(2.5)
genes like me logo Genes that share expression patterns with METTL18: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for METTL18 Gene

Orthologs for METTL18 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for METTL18 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia METTL18 30 31
  • 99.73 (n)
(Canis familiaris)
Mammalia METTL18 30 31
  • 88.28 (n)
(Bos Taurus)
Mammalia METTL18 30 31
  • 87.15 (n)
(Rattus norvegicus)
Mammalia Mettl18 30
  • 79.44 (n)
(Mus musculus)
Mammalia Mettl18 30 17 31
  • 77.69 (n)
(Monodelphis domestica)
Mammalia METTL18 31
  • 62 (a)
(Gallus gallus)
Aves METTL18 30
  • 65.69 (n)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia mettl18 30
  • 56.67 (n)
Str.10924 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.15802 30
(Danio rerio)
Actinopterygii LOC796750 30
  • 56.01 (n)
METTL18 31
  • 44 (a)
Fruit Fly
(Drosophila melanogaster)
Insecta CG17219 30 31
  • 51.69 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009532 30
  • 50.92 (n)
(Caenorhabditis elegans)
Secernentea K01A11.2 30 31
  • 52.49 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HPM1 31 33 33
  • 24 (a)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT4G14000 30
  • 47.25 (n)
(Oryza sativa)
Liliopsida Os09g0359900 30
  • 49.34 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 32 (a)
Species where no ortholog for METTL18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for METTL18 Gene

Gene Tree for METTL18 (if available)
Gene Tree for METTL18 (if available)
Evolutionary constrained regions (ECRs) for METTL18: view image

Paralogs for METTL18 Gene

No data available for Paralogs for METTL18 Gene

Variants for METTL18 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for METTL18 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
789951 Benign: not provided 169,793,039(-) G/A SYNONYMOUS_VARIANT
rs10489177 - p.Glu10Asp
rs13375701 - p.Lys360Met
rs16862686 - p.Ala325Val
rs34396097 - p.Phe309Leu

Additional dbSNP identifiers (rs#s) for METTL18 Gene

Structural Variations from Database of Genomic Variants (DGV) for METTL18 Gene

Variant ID Type Subtype PubMed ID
nsv1078878 OTHER inversion 25765185

Variation tolerance for METTL18 Gene

Residual Variation Intolerance Score: 65% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.11; 84.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for METTL18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METTL18 Gene

Disorders for METTL18 Gene

MalaCards: The human disease database

(3) MalaCards diseases for METTL18 Gene - From: DISEASES

Disorder Aliases PubMed IDs
combined oxidative phosphorylation deficiency 3
  • coxpd3
transient global amnesia
  • amnesia, transient global
col4a1-related familial vascular leukoencephalopathy
  • brain small vessel disease with hemorrhage
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with METTL18: view

No data available for UniProtKB/Swiss-Prot and Genatlas for METTL18 Gene

Publications for METTL18 Gene

  1. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PMID: 23349634) Cloutier P … Coulombe B (PLoS genetics 2013) 3 4
  2. A novel 3-methylhistidine modification of yeast ribosomal protein Rpl3 is dependent upon the YIL110W methyltransferase. (PMID: 20864530) Webb KJ … Clarke SG (The Journal of biological chemistry 2010) 2 3
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

Products for METTL18 Gene

Sources for METTL18 Gene