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Aliases for METTL18 Gene

Aliases for METTL18 Gene

  • Methyltransferase Like 18 2 3 5
  • Methyltransferase-Like Protein 18 3 4
  • Arsenic-Transactivated Protein 2 3 4
  • C1orf156 3 4
  • AsTP2 3 4
  • Histidine Protein Methyltransferase 1 Homolog 3
  • Histidine Protein Methyltransferase 1 2
  • Chromosome 1 Open Reading Frame 156 2
  • EC 2.1.1.- 4
  • HPM1 3

External Ids for METTL18 Gene

Previous HGNC Symbols for METTL18 Gene

  • C1orf156

Summaries for METTL18 Gene

GeneCards Summary for METTL18 Gene

METTL18 (Methyltransferase Like 18) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include methyltransferase activity and protein methyltransferase activity.

UniProtKB/Swiss-Prot for METTL18 Gene

  • Probable histidine methyltransferase.

Additional gene information for METTL18 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL18 Gene

Genomics for METTL18 Gene

GeneHancer (GH) Regulatory Elements for METTL18 Gene

Promoters and enhancers for METTL18 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I169793 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 614.7 -0.1 -97 2.3 SMAD1 ARNT ARID4B NEUROD1 SIN3A DMAP1 ZNF2 ZBTB7B IRF4 YY1 METTL18 C1orf112 SCYL3 RN7SL333P KIFAP3
GH01I169889 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 51.7 -97.3 -97270 5.5 ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC SCYL3 METTL18 C1orf112 KIFAP3 BLZF1 RN7SL333P GC01M169872
GH01I169707 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 40.9 +84.6 84628 4.9 HDGF PKNOX1 YBX1 GLI4 ZNF2 ZBTB7B IRF4 ZNF280A ZNF207 ZNF143 SELL METTL18 RN7SL333P GORAB SCYL3 C1orf112 GC01M169692
GH01I170072 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE 37.4 -279.3 -279266 2.6 HDGF FOXA2 PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 KIFAP3 METTL18 C1orf112 GC01M170068 LOC105371608
GH01I169688 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 42 +98.0 97970 17.4 CTCF PKNOX1 EBF1 BATF RAD21 GATA3 ZNF316 ATF7 ETV6 IKZF2 METTL18 C1orf112 SELP F5 SELL SCYL3 KIFAP3 ENSG00000230704 METTL11B GC01M169692
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around METTL18 on UCSC Golden Path with GeneCards custom track

Genomic Locations for METTL18 Gene

Genomic Locations for METTL18 Gene
2,438 bases
Minus strand

Genomic View for METTL18 Gene

Genes around METTL18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METTL18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METTL18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL18 Gene

Proteins for METTL18 Gene

  • Protein details for METTL18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Histidine protein methyltransferase 1 homolog
    Protein Accession:
    Secondary Accessions:
    • B2R9T5

    Protein attributes for METTL18 Gene

    372 amino acids
    Molecular mass:
    42148 Da
    Quaternary structure:
    • Interacts with GRWD1, RPL3 and members of the heat shock protein 90 and 70 families; these proteins may possibly be methylation substrates for the enzyme.

    Three dimensional structures from OCA and Proteopedia for METTL18 Gene

neXtProt entry for METTL18 Gene

Post-translational modifications for METTL18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for METTL18 Gene

No data available for DME Specific Peptides for METTL18 Gene

Domains & Families for METTL18 Gene

Gene Families for METTL18 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for METTL18 Gene


Suggested Antigen Peptide Sequences for METTL18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the methyltransferase superfamily. METTL18 family.
  • Belongs to the methyltransferase superfamily. METTL18 family.
genes like me logo Genes that share domains with METTL18: view

Function for METTL18 Gene

Molecular function for METTL18 Gene

UniProtKB/Swiss-Prot Function:
Probable histidine methyltransferase.

Enzyme Numbers (IUBMB) for METTL18 Gene

Phenotypes From GWAS Catalog for METTL18 Gene

Gene Ontology (GO) - Molecular Function for METTL18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23349634
GO:0008168 methyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0031072 heat shock protein binding IPI 23349634
genes like me logo Genes that share ontologies with METTL18: view
genes like me logo Genes that share phenotypes with METTL18: view

miRNA for METTL18 Gene

miRTarBase miRNAs that target METTL18

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for METTL18 Gene

Localization for METTL18 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for METTL18 gene
Compartment Confidence
cytosol 3
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for METTL18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043234 protein complex IDA 23349634
genes like me logo Genes that share ontologies with METTL18: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for METTL18 Gene

Pathways & Interactions for METTL18 Gene

SuperPathways for METTL18 Gene

No Data Available

Gene Ontology (GO) - Biological Process for METTL18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with METTL18: view

No data available for Pathways by source and SIGNOR curated interactions for METTL18 Gene

Drugs & Compounds for METTL18 Gene

No Compound Related Data Available

Transcripts for METTL18 Gene

Unigene Clusters for METTL18 Gene

Methyltransferase like 18:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for METTL18 Gene

No ASD Table

Relevant External Links for METTL18 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for METTL18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for METTL18 Gene

Protein differential expression in normal tissues from HIPED for METTL18 Gene

This gene is overexpressed in Lung (20.9), Spleen (13.0), Heart (12.1), and CD4 Tcells (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for METTL18 Gene

Protein tissue co-expression partners for METTL18 Gene

NURSA nuclear receptor signaling pathways regulating expression of METTL18 Gene:


SOURCE GeneReport for Unigene cluster for METTL18 Gene:


Evidence on tissue expression from TISSUES for METTL18 Gene

  • Nervous system(4.2)
  • Intestine(4.1)
  • Heart(2.7)
  • Lung(2.5)
  • Pancreas(2.5)
genes like me logo Genes that share expression patterns with METTL18: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for METTL18 Gene

Orthologs for METTL18 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for METTL18 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia METTL18 33 34
  • 99.73 (n)
(Canis familiaris)
Mammalia METTL18 33 34
  • 88.28 (n)
(Bos Taurus)
Mammalia METTL18 33 34
  • 87.15 (n)
(Rattus norvegicus)
Mammalia Mettl18 33
  • 79.44 (n)
(Mus musculus)
Mammalia Mettl18 33 16 34
  • 77.69 (n)
(Monodelphis domestica)
Mammalia METTL18 34
  • 62 (a)
(Gallus gallus)
Aves METTL18 33
  • 65.69 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia mettl18 33
  • 56.67 (n)
Str.10924 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.15802 33
(Danio rerio)
Actinopterygii LOC796750 33
  • 56.01 (n)
METTL18 34
  • 44 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17219 33 34
  • 51.69 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009532 33
  • 50.92 (n)
(Caenorhabditis elegans)
Secernentea K01A11.2 33 34
  • 52.49 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HPM1 34 36
  • 24 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G14000 33
  • 47.25 (n)
(Oryza sativa)
Liliopsida Os09g0359900 33
  • 49.34 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 32 (a)
Species where no ortholog for METTL18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for METTL18 Gene

Gene Tree for METTL18 (if available)
Gene Tree for METTL18 (if available)

Paralogs for METTL18 Gene

No data available for Paralogs for METTL18 Gene

Variants for METTL18 Gene

Sequence variations from dbSNP and Humsavar for METTL18 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000357893 -- 169,795,914(-) G/A upstream_transcript_variant
rs1001074639 -- 169,792,627(-) C/G coding_sequence_variant, missense_variant
rs1001750158 -- 169,795,552(-) G/T upstream_transcript_variant
rs1003874865 -- 169,793,846(-) A/G 5_prime_UTR_variant
rs1005117596 -- 169,796,580(-) C/G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for METTL18 Gene

Variant ID Type Subtype PubMed ID
nsv1078878 OTHER inversion 25765185

Variation tolerance for METTL18 Gene

Residual Variation Intolerance Score: 65% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.11; 84.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for METTL18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METTL18 Gene

Disorders for METTL18 Gene

Additional Disease Information for METTL18

No disorders were found for METTL18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for METTL18 Gene

Publications for METTL18 Gene

  1. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PMID: 23349634) Cloutier P … Coulombe B (PLoS genetics 2013) 3 4 58
  2. A novel 3-methylhistidine modification of yeast ribosomal protein Rpl3 is dependent upon the YIL110W methyltransferase. (PMID: 20864530) Webb KJ … Clarke SG (The Journal of biological chemistry 2010) 2 3 58
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for METTL18 Gene

Sources for METTL18 Gene

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