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Aliases for METTL17 Gene

Aliases for METTL17 Gene

  • Methyltransferase Like 17 2 3 5
  • Methyltransferase 11 Domain-Containing Protein 1 3 4
  • Methyltransferase 11 Domain Containing 1 2 3
  • Protein RSM22 Homolog, Mitochondrial 3 4
  • False P73 Target Gene Protein 3 4
  • METT11D1 3 4
  • Methyltransferase-Like Protein 17, Mitochondrial 3
  • EC 2.1.1.- 4

External Ids for METTL17 Gene

Previous HGNC Symbols for METTL17 Gene

  • METT11D1

Previous GeneCards Identifiers for METTL17 Gene

  • GC14P021458
  • GC14P021028
  • GC14P021040
  • GC14P021047
  • GC14P021053
  • GC14P021065
  • GC14P021073
  • GC14P021082

Summaries for METTL17 Gene

GeneCards Summary for METTL17 Gene

METTL17 (Methyltransferase Like 17) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include methyltransferase activity and copper ion binding.

UniProtKB/Swiss-Prot for METTL17 Gene

  • May be a component of the mitochondrial small ribosomal subunit.

Additional gene information for METTL17 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL17 Gene

Genomics for METTL17 Gene

GeneHancer (GH) Regulatory Elements for METTL17 Gene

Promoters and enhancers for METTL17 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I020988 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 565.1 +0.0 11 2.5 PKNOX1 CLOCK ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B E2F8 ZNF207 METTL17 SUPT16H METTL3 TTC5 SLC39A2 LOC101929718
GH14I020453 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 100.5 -534.2 -534227 3.9 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 SP3 NFYC OSGEP APEX1 SUPT16H METTL17 ENSG00000258515 TEP1 TTC5 PIP4P1 ZNF219 PNP
GH14I021092 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 54.9 +111.7 111656 18.3 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF219 TMEM253 METTL3 METTL17 SUPT16H CHD8 TEP1 APEX1 PNP ARHGEF40
GH14I020468 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 37.1 -518.0 -518041 5.9 HDGF FOXA2 SMAD1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 PNP SUPT16H METTL17 TEP1 CHD8 APEX1 HNRNPC ENSG00000260830 TTC5 RNASE10
GH14I020622 Enhancer 1.2 Ensembl ENCODE 61.1 -365.0 -365021 3.9 HNRNPUL1 SIN3A FEZF1 ZNF2 ZNF213 ZNF143 FOS KLF13 ZC3H11A REST GC14P020627 PIR59363 TRL-TAG2-1 METTL3 SUPT16H METTL17 ENSG00000258515 CHD8 PARP2 TEP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around METTL17 on UCSC Golden Path with GeneCards custom track

Genomic Locations for METTL17 Gene

Genomic Locations for METTL17 Gene
chr14:20,989,770-20,997,035
(GRCh38/hg38)
Size:
7,266 bases
Orientation:
Plus strand
chr14:21,457,929-21,465,194
(GRCh37/hg19)

Genomic View for METTL17 Gene

Genes around METTL17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METTL17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METTL17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL17 Gene

Proteins for METTL17 Gene

  • Protein details for METTL17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H7H0-MET17_HUMAN
    Recommended name:
    Methyltransferase-like protein 17, mitochondrial
    Protein Accession:
    Q9H7H0
    Secondary Accessions:
    • Q9BSH1
    • Q9BZH2
    • Q9BZH3

    Protein attributes for METTL17 Gene

    Size:
    456 amino acids
    Molecular mass:
    50734 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for METTL17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for METTL17 Gene

Post-translational modifications for METTL17 Gene

No Post-translational modifications

No data available for DME Specific Peptides for METTL17 Gene

Domains & Families for METTL17 Gene

Gene Families for METTL17 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for METTL17 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H7H0

UniProtKB/Swiss-Prot:

MET17_HUMAN :
  • Belongs to the methyltransferase superfamily. Rsm22 family.
Family:
  • Belongs to the methyltransferase superfamily. Rsm22 family.
genes like me logo Genes that share domains with METTL17: view

Function for METTL17 Gene

Molecular function for METTL17 Gene

UniProtKB/Swiss-Prot Function:
May be a component of the mitochondrial small ribosomal subunit.

Enzyme Numbers (IUBMB) for METTL17 Gene

Phenotypes From GWAS Catalog for METTL17 Gene

Gene Ontology (GO) - Molecular Function for METTL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0008168 methyltransferase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with METTL17: view

Phenotypes for METTL17 Gene

genes like me logo Genes that share phenotypes with METTL17: view

miRNA for METTL17 Gene

miRTarBase miRNAs that target METTL17

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for METTL17 Gene

Localization for METTL17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for METTL17 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for METTL17 gene
Compartment Confidence
mitochondrion 3
nucleus 3
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for METTL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IEA --
GO:0005840 ribosome IEA --
GO:0030529 intracellular ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with METTL17: view

Pathways & Interactions for METTL17 Gene

SuperPathways for METTL17 Gene

No Data Available

Gene Ontology (GO) - Biological Process for METTL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with METTL17: view

No data available for Pathways by source and SIGNOR curated interactions for METTL17 Gene

Drugs & Compounds for METTL17 Gene

No Compound Related Data Available

Transcripts for METTL17 Gene

Unigene Clusters for METTL17 Gene

Methyltransferase like 17:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for METTL17 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9 ^
SP1: - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - -
SP6: - - - - - -
SP7: - - -
SP8: - - - -
SP9: - - - - - - - - - - - - - - - - -
SP10: - - -
SP11: - - - - - -
SP12: - - - - -
SP13:
SP14: - - - - - - - - - - - - - -
SP15: - -
SP16: - - -
SP17: - - -
SP18:
SP19:
SP20:
SP21:

ExUns: 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b · 14c · 14d ^ 15a · 15b · 15c · 15d · 15e
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: - -
SP5:
SP6:
SP7:
SP8:
SP9: - - - - - - - -
SP10:
SP11:
SP12:
SP13: -
SP14: - - - - - - -
SP15:
SP16:
SP17:
SP18:
SP19:
SP20: -
SP21:

Relevant External Links for METTL17 Gene

GeneLoc Exon Structure for
METTL17
ECgene alternative splicing isoforms for
METTL17

Expression for METTL17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for METTL17 Gene

Protein differential expression in normal tissues from HIPED for METTL17 Gene

This gene is overexpressed in Adipocyte (28.5) and Lung (24.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for METTL17 Gene



NURSA nuclear receptor signaling pathways regulating expression of METTL17 Gene:

METTL17

SOURCE GeneReport for Unigene cluster for METTL17 Gene:

Hs.512693

Evidence on tissue expression from TISSUES for METTL17 Gene

  • Lung(4.4)
  • Nervous system(3.8)
genes like me logo Genes that share expression patterns with METTL17: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for METTL17 Gene

Orthologs for METTL17 Gene

This gene was present in the common ancestor of animals.

Orthologs for METTL17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia METTL17 33 34
  • 99.42 (n)
cow
(Bos Taurus)
Mammalia METTL17 33 34
  • 85.7 (n)
dog
(Canis familiaris)
Mammalia METTL17 33 34
  • 84.74 (n)
mouse
(Mus musculus)
Mammalia Mettl17 33 16 34
  • 82.89 (n)
rat
(Rattus norvegicus)
Mammalia Mettl17 33
  • 82.53 (n)
oppossum
(Monodelphis domestica)
Mammalia METTL17 34
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 64 (a)
OneToMany
-- 34
  • 52 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia METTL17 34
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mettl17 33
  • 61.15 (n)
zebrafish
(Danio rerio)
Actinopterygii mettl17 33 34
  • 56.28 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6407 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002734 33
  • 44.68 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG13126 33 34
  • 44.11 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_F32A7.4 33
  • 44.23 (n)
F32A7.4 34
  • 22 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 30 (a)
OneToOne
Species where no ortholog for METTL17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for METTL17 Gene

ENSEMBL:
Gene Tree for METTL17 (if available)
TreeFam:
Gene Tree for METTL17 (if available)

Paralogs for METTL17 Gene

No data available for Paralogs for METTL17 Gene

Variants for METTL17 Gene

Sequence variations from dbSNP and Humsavar for METTL17 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000185701 -- 20,992,853(+) C/A intron_variant
rs1000317830 -- 20,993,782(+) TTTTTTTTTTT/TTTTTTTTTT intron_variant
rs1000544424 -- 20,988,754(+) C/T upstream_transcript_variant
rs1000662131 -- 20,992,437(+) G/A intron_variant
rs1001307849 -- 20,988,179(+) A/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for METTL17 Gene

Variant ID Type Subtype PubMed ID
nsv832740 CNV gain 17160897
nsv563847 CNV loss 21841781
nsv470622 CNV loss 18288195
nsv428293 CNV gain+loss 18775914
esv2759972 CNV gain+loss 17122850

Variation tolerance for METTL17 Gene

Residual Variation Intolerance Score: 63.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.47; 64.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for METTL17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
METTL17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METTL17 Gene

Disorders for METTL17 Gene

Additional Disease Information for METTL17

No disorders were found for METTL17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for METTL17 Gene

Publications for METTL17 Gene

  1. Identification of 12 new yeast mitochondrial ribosomal proteins including 6 that have no prokaryotic homologues. (PMID: 11278769) Saveanu C … Jacquier A (The Journal of biological chemistry 2001) 2 3 4 58
  2. Methyltransferase-like 17 physically and functionally interacts with estrogen receptors. (PMID: 26488768) Du P … Ye Q (IUBMB life 2015) 2 3 58
  3. Sequence variants in four candidate genes (NIPSNAP1, GBAS, CHCHD1 and METT11D1) in patients with combined oxidative phosphorylation system deficiencies. (PMID: 24137763) Smits P … van den Heuvel LP (Journal of inherited metabolic disease 2010) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X … Vidal M (Cell 2016) 3 58

Products for METTL17 Gene

Sources for METTL17 Gene

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