Aliases for METTL16 Gene
- Methyltransferase Like 16 2 3 5
- U6 Small Nuclear RNA (Adenine-(43)-N(6))-Methyltransferase 3 4
- Methyltransferase 10 Domain-Containing Protein 3 4
- RNA N6-Adenosine-Methyltransferase METTL16 3 4
- Methyltransferase 10 Domain Containing 2 3
- N6-Adenosine-Methyltransferase METTL16 3 4
- Methyltransferase-Like Protein 16 3 4
External Ids for METTL16 Gene
Previous HGNC Symbols for METTL16 Gene
Previous GeneCards Identifiers for METTL16 Gene
GeneCards Summary for METTL16 Gene
METTL16 (Methyltransferase Like 16) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include 23S rRNA (adenine(1618)-N(6))-methyltransferase activity.
UniProtKB/Swiss-Prot Summary for METTL16 Gene
RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts (PubMed:28525753, PubMed:30197299, PubMed:30197297). Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs) (PubMed:28525753). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure (PubMed:28525753, PubMed:30197299, PubMed:30197297). Plays a key role in S-adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2A mRNAs, altering splicing and/or stability of MAT2A transcripts: in presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifically N6-methylates the first hairpin of MAT2A mRNA, impairing MAT2A expression (PubMed:28525753). In S-adenosyl-L-methionine-limiting conditions, binds the 3'-UTR region of MAT2A mRNA but stalls due to the lack of a methyl donor, preventing N6-methylation and promoting expression of MAT2A (PubMed:28525753). In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA): specifically N6-methylates adenine in position 43 of U6 snRNAs (PubMed:28525753, PubMed:29051200). Also able to bind various lncRNAs, such as 7SK snRNA (7SK RNA) or 7SL RNA (PubMed:29051200). Specifically binds the 3'-end of the MALAT1 long non-coding RNA (PubMed:27872311).