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Aliases for METTL15 Gene

Aliases for METTL15 Gene

  • Methyltransferase Like 15 2 3 5
  • Methyltransferase 5 Domain-Containing Protein 1 3 4
  • Methyltransferase 5 Domain Containing 1 2 3
  • METT5D1 3 4
  • Probable S-Adenosyl-L-Methionine-Dependent Methyltransferase METT5D1 3
  • Putative S-Adenosyl-L-Methionine-Dependent Methyltransferase METT5D1 3
  • Probable Methyltransferase-Like Protein 15 3
  • EC 2.1.1.- 4

External Ids for METTL15 Gene

Previous HGNC Symbols for METTL15 Gene

  • METT5D1

Summaries for METTL15 Gene

GeneCards Summary for METTL15 Gene

METTL15 (Methyltransferase Like 15) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include methyltransferase activity and rRNA (cytosine-N4-)-methyltransferase activity.

UniProtKB/Swiss-Prot for METTL15 Gene

  • Probable S-adenosyl-L-methionine-dependent methyltransferase.

Additional gene information for METTL15 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL15 Gene

Genomics for METTL15 Gene

GeneHancer (GH) Regulatory Elements for METTL15 Gene

Promoters and enhancers for METTL15 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I028105 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 569.6 +0.4 361 6.2 ZFP64 DMAP1 IRF4 YY1 E2F8 ZNF143 SP3 NFYC ZC3H11A SSRP1 METTL15 KIF18A BDNF GC11M028129
GH11I027158 Enhancer 0.7 ENCODE 11.7 -949.3 -949289 0.2 CTCF JUN BATF RAD21 RFX5 GTF3C2 FOSL1 POLR3A ZNF143 SMC3 METTL15 BBOX1 GC11P027127 LOC105376600 BBOX1-AS1
GH11I028122 Enhancer 0.8 Ensembl ENCODE dbSUPER 5.5 +15.2 15241 1.1 JUND FOS MIR610 BDNF METTL15 GC11M028129 KIF18A
GH11I028102 Enhancer 0.2 dbSUPER 4.4 -5.3 -5285 1 BDNF METTL15 KIF18A GC11M028056
GH11I028088 Enhancer 0.6 dbSUPER 0.4 -18.2 -18245 2.7 JUN CEBPB MAFG ATF2 MAFF JUND ZNF316 CREB1 FOS FOSL2 MIR610 KIF18A METTL15 GC11M028056
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around METTL15 on UCSC Golden Path with GeneCards custom track

Genomic Locations for METTL15 Gene

Genomic Locations for METTL15 Gene
418,794 bases
Plus strand

Genomic View for METTL15 Gene

Genes around METTL15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METTL15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METTL15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL15 Gene

Proteins for METTL15 Gene

  • Protein details for METTL15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable methyltransferase-like protein 15
    Protein Accession:
    Secondary Accessions:
    • A8MRS5
    • B7WNU2
    • Q3MHD3
    • Q8N601
    • Q8NBA7

    Protein attributes for METTL15 Gene

    407 amino acids
    Molecular mass:
    46121 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH30997.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for METTL15 Gene


neXtProt entry for METTL15 Gene

Post-translational modifications for METTL15 Gene

  • Ubiquitination at posLast=352352 and isoforms=381

No data available for DME Specific Peptides for METTL15 Gene

Domains & Families for METTL15 Gene

Gene Families for METTL15 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for METTL15 Gene

Suggested Antigen Peptide Sequences for METTL15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the methyltransferase superfamily. RsmH family.
  • Belongs to the methyltransferase superfamily. RsmH family.
genes like me logo Genes that share domains with METTL15: view

Function for METTL15 Gene

Molecular function for METTL15 Gene

UniProtKB/Swiss-Prot Function:
Probable S-adenosyl-L-methionine-dependent methyltransferase.

Enzyme Numbers (IUBMB) for METTL15 Gene

Phenotypes From GWAS Catalog for METTL15 Gene

Gene Ontology (GO) - Molecular Function for METTL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016740 transferase activity IEA --
GO:0071424 rRNA (cytosine-N4-)-methyltransferase activity IBA --
genes like me logo Genes that share ontologies with METTL15: view

Phenotypes for METTL15 Gene

GenomeRNAi human phenotypes for METTL15:
genes like me logo Genes that share phenotypes with METTL15: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for METTL15 Gene

Localization for METTL15 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for METTL15 gene
Compartment Confidence
nucleus 4
cytosol 3
plasma membrane 2
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
  • Golgi apparatus (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for METTL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with METTL15: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for METTL15 Gene

Pathways & Interactions for METTL15 Gene

SuperPathways for METTL15 Gene

No Data Available

Gene Ontology (GO) - Biological Process for METTL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032259 methylation IEA --
GO:0070475 rRNA base methylation IBA --
genes like me logo Genes that share ontologies with METTL15: view

No data available for Pathways by source and SIGNOR curated interactions for METTL15 Gene

Drugs & Compounds for METTL15 Gene

(1) Additional Compounds for METTL15 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine
  • 2-S-Adenosyl-L-methionine
  • 5'-Deoxyadenosine-5'-L-methionine disulfate ditosylate
  • 5'-Deoxyadenosine-5'-L-methionine disulphate ditosylate
  • Active methionine
genes like me logo Genes that share compounds with METTL15: view

Transcripts for METTL15 Gene

Unigene Clusters for METTL15 Gene

Methyltransferase like 15:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for METTL15 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b
SP1: - - - - -
SP2: - - -
SP3: - - - -

Relevant External Links for METTL15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for METTL15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for METTL15 Gene

Protein differential expression in normal tissues from HIPED for METTL15 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (39.7), Cervix (14.2), and Plasma (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for METTL15 Gene

NURSA nuclear receptor signaling pathways regulating expression of METTL15 Gene:


SOURCE GeneReport for Unigene cluster for METTL15 Gene:


Evidence on tissue expression from TISSUES for METTL15 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with METTL15: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for METTL15 Gene

Orthologs for METTL15 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for METTL15 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia METTL15 33 34
  • 99.59 (n)
(Canis familiaris)
Mammalia METTL15 33 34
  • 88.7 (n)
(Bos Taurus)
Mammalia METTL15 33 34
  • 88.62 (n)
(Mus musculus)
Mammalia Mettl15 33 16 34
  • 80.79 (n)
(Monodelphis domestica)
Mammalia METTL15 34
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia METTL15 34
  • 70 (a)
(Gallus gallus)
Aves METTL15 33 34
  • 70.77 (n)
(Anolis carolinensis)
Reptilia METTL15 34
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mettl15 33
  • 68.18 (n)
Str.17107 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.3963 33
(Danio rerio)
Actinopterygii LOC560573 33
  • 60.5 (n)
METTL15 34
  • 50 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8699 33
fruit fly
(Drosophila melanogaster)
Insecta CG14683 33 34
  • 51.38 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002831 33
  • 50.95 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G10910 33
  • 47.04 (n)
(Oryza sativa)
Liliopsida Os02g0137600 33
  • 45.99 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 41 (a)
Species where no ortholog for METTL15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for METTL15 Gene

Gene Tree for METTL15 (if available)
Gene Tree for METTL15 (if available)

Paralogs for METTL15 Gene

(1) SIMAP similar genes for METTL15 Gene using alignment to 3 proteins: Pseudogenes for METTL15 Gene

genes like me logo Genes that share paralogs with METTL15: view

No data available for Paralogs for METTL15 Gene

Variants for METTL15 Gene

Sequence variations from dbSNP and Humsavar for METTL15 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000004230 -- 28,327,806(+) C/A genic_downstream_transcript_variant, intron_variant
rs1000006181 -- 28,285,582(+) A/G intron_variant
rs1000013594 -- 28,219,960(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000014506 -- 28,171,437(+) G/A/T genic_upstream_transcript_variant, intron_variant
rs1000020002 -- 28,418,713(+) C/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for METTL15 Gene

Variant ID Type Subtype PubMed ID
nsv975896 CNV duplication 23825009
nsv951594 CNV deletion 24416366
nsv832096 CNV loss 17160897
nsv553915 CNV loss 21841781
nsv38603 CNV deletion 16902084
nsv1040043 CNV loss 25217958
esv3891961 CNV loss 25118596
esv3891960 CNV loss 25118596
esv3891958 CNV gain 25118596
esv3625781 CNV loss 21293372
esv3625780 CNV loss 21293372
esv3625779 CNV loss 21293372
esv3579455 CNV loss 25503493
esv2670715 CNV deletion 23128226

Variation tolerance for METTL15 Gene

Residual Variation Intolerance Score: 63.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.44; 54.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for METTL15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METTL15 Gene

Disorders for METTL15 Gene

Additional Disease Information for METTL15

No disorders were found for METTL15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for METTL15 Gene

Publications for METTL15 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. KCMF1 (potassium channel modulatory factor 1) Links RAD6 to UBR4 (ubiquitin N-recognin domain-containing E3 ligase 4) and lysosome-mediated degradation. (PMID: 25582440) Hong JH … Raught B (Molecular & cellular proteomics : MCP 2015) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for METTL15 Gene

Sources for METTL15 Gene

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