Aliases for METTL11B Gene

Aliases for METTL11B Gene

  • Methyltransferase Like 11B 2 3 5
  • X-Pro-Lys N-Terminal Protein Methyltransferase 1B 3 4
  • Alpha N-Terminal Protein Methyltransferase 1B 3 4
  • Methyltransferase-Like Protein 11B 3 4
  • C1orf184 3 4
  • HOMT1B 2 3
  • NTM1B 3 4
  • Chromosome 1 Open Reading Frame 184 2
  • EC 2.1.1.299 4
  • METTL11B 5
  • NRMT2 4

External Ids for METTL11B Gene

Previous HGNC Symbols for METTL11B Gene

  • C1orf184

Previous GeneCards Identifiers for METTL11B Gene

  • GC01P168382
  • GC01P170115
  • GC01P141338

Summaries for METTL11B Gene

GeneCards Summary for METTL11B Gene

METTL11B (Methyltransferase Like 11B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include methyltransferase activity and N-terminal protein N-methyltransferase activity. An important paralog of this gene is NTMT1.

UniProtKB/Swiss-Prot Summary for METTL11B Gene

  • Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes monomethylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and Pro in the Pro-Pro-Lys motif. May activate NTMT1 by priming its substrates for trimethylation.

Additional gene information for METTL11B Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for METTL11B Gene

Genomics for METTL11B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for METTL11B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J170145 Promoter/Enhancer 1 Ensembl ENCODE 600.7 +0.5 481 1.1 TEAD4 PRDM10 ZNF629 ZIC2 POLR2A ZNF600 ZNF341 RAD21 ZNF10 ZNF184 METTL11B KIFAP3 METTL18 MIR3119-2 GORAB
GH01J170094 Promoter 0.6 EPDnew 600.2 -51.2 -51165 0.1 IKZF1 MGA EGR1 L3MBTL2 METTL11B METTL18 KIFAP3 piR-57195-022
GH01J169688 Promoter/Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 2.5 -449.0 -448963 17.4 BRCA1 CTCF STAT3 RAD21 IKZF2 PKNOX1 EED RELB RUNX3 ZNF316 METTL18 C1orf112 SELP F5 SELL SCYL3 KIFAP3 ENSG00000230704 METTL11B piR-56133-012
GH01J170126 Enhancer 0.8 Ensembl ENCODE 0.4 -19.0 -18993 1 TEAD4 RELA TCF12 IKZF2 EED DPF2 CEBPB RUNX3 BCLAF1 BCL11A piR-34822-020 METTL18 KIFAP3 SIGLEC30P METTL11B
GH01J170095 Enhancer 0.8 Ensembl CraniofacialAtlas 0.3 -48.9 -48929 2.1 ZNF512 FOXA1 ZNF561 SCRT2 EZH2 OSR2 ZBTB17 SCRT1 OVOL3 GATA3 METTL18 KIFAP3 piR-57195-022 METTL11B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around METTL11B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for METTL11B

Top Transcription factor binding sites by QIAGEN in the METTL11B gene promoter:
  • aMEF-2
  • GCNF
  • GCNF-1
  • Gfi-1
  • HNF-1
  • HNF-1A
  • MEF-2A
  • Pax-2
  • Pax-2a
  • Pax-4a

Genomic Locations for METTL11B Gene

Genomic Locations for METTL11B Gene
chr1:170,145,959-170,168,866
(GRCh38/hg38)
Size:
22,908 bases
Orientation:
Plus strand
chr1:170,115,142-170,136,931
(GRCh37/hg19)
Size:
21,790 bases
Orientation:
Plus strand

Genomic View for METTL11B Gene

Genes around METTL11B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METTL11B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METTL11B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL11B Gene

Proteins for METTL11B Gene

  • Protein details for METTL11B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VVY1-NTM1B_HUMAN
    Recommended name:
    Alpha N-terminal protein methyltransferase 1B
    Protein Accession:
    Q5VVY1
    Secondary Accessions:
    • B2RXI0

    Protein attributes for METTL11B Gene

    Size:
    283 amino acids
    Molecular mass:
    32400 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for METTL11B Gene

neXtProt entry for METTL11B Gene

Post-translational modifications for METTL11B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for METTL11B Gene

No data available for DME Specific Peptides for METTL11B Gene

Domains & Families for METTL11B Gene

Gene Families for METTL11B Gene

Protein Domains for METTL11B Gene

Suggested Antigen Peptide Sequences for METTL11B Gene

GenScript: Design optimal peptide antigens:
  • X-Pro-Lys N-terminal protein methyltransferase 1B (NTM1B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5VVY1

UniProtKB/Swiss-Prot:

NTM1B_HUMAN :
  • Belongs to the methyltransferase superfamily. NTM1 family.
Family:
  • Belongs to the methyltransferase superfamily. NTM1 family.
genes like me logo Genes that share domains with METTL11B: view

Function for METTL11B Gene

Molecular function for METTL11B Gene

UniProtKB/Swiss-Prot Function:
Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes monomethylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and Pro in the Pro-Pro-Lys motif. May activate NTMT1 by priming its substrates for trimethylation.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:54096, Rhea:RHEA-COMP:13785, Rhea:RHEA-COMP:13786, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:138057, ChEBI:CHEBI:138058; EC=2.1.1.299; Evidence={ECO:0000269|PubMed:24090352};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:54100, Rhea:RHEA-COMP:13787, Rhea:RHEA-COMP:13788, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:138059, ChEBI:CHEBI:138060; EC=2.1.1.299; Evidence={ECO:0000269|PubMed:24090352};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:54104, Rhea:RHEA-COMP:13789, Rhea:RHEA-COMP:13790, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:138061, ChEBI:CHEBI:138062; EC=2.1.1.299; Evidence={ECO:0000269|PubMed:24090352};.

Enzyme Numbers (IUBMB) for METTL11B Gene

Phenotypes From GWAS Catalog for METTL11B Gene

Gene Ontology (GO) - Molecular Function for METTL11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity IBA 21873635
GO:0016740 transferase activity IEA --
GO:0071885 N-terminal protein N-methyltransferase activity IBA 21873635
genes like me logo Genes that share ontologies with METTL11B: view

Phenotypes for METTL11B Gene

genes like me logo Genes that share phenotypes with METTL11B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for METTL11B

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for METTL11B Gene

Localization for METTL11B Gene

Subcellular locations from UniProtKB/Swiss-Prot for METTL11B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for METTL11B gene
Compartment Confidence
nucleus 4
cytosol 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for METTL11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IBA 21873635
genes like me logo Genes that share ontologies with METTL11B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for METTL11B Gene

Pathways & Interactions for METTL11B Gene

PathCards logo

SuperPathways for METTL11B Gene

No Data Available

Interacting Proteins for METTL11B Gene

Gene Ontology (GO) - Biological Process for METTL11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006480 N-terminal protein amino acid methylation IBA 21873635
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with METTL11B: view

No data available for Pathways by source and SIGNOR curated interactions for METTL11B Gene

Drugs & Compounds for METTL11B Gene

(1) Drugs for METTL11B Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
s-adenosylhomocysteine Experimental Pharma 0

(1) Additional Compounds for METTL11B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
s-adenosylmethionine
  • (3S)-5'-[(3-amino-3-Carboxypropyl)methylsulfonio]-5'-deoxyadenosine, inner salt
  • [1-(Adenin-9-yl)-1,5-dideoxy-beta-D-ribofuranos-5-yl][(3S)-3-amino-3-carboxypropyl](methyl)sulfonium
  • Acylcarnitine
  • AdoMet
  • S-(5'-Deoxyadenosin-5'-yl)-L-methionine
485-80-3
genes like me logo Genes that share compounds with METTL11B: view

Transcripts for METTL11B Gene

mRNA/cDNA for METTL11B Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for METTL11B

Alternative Splicing Database (ASD) splice patterns (SP) for METTL11B Gene

No ASD Table

Relevant External Links for METTL11B Gene

GeneLoc Exon Structure for
METTL11B

Expression for METTL11B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for METTL11B Gene

mRNA differential expression in normal tissues according to GTEx for METTL11B Gene

This gene is overexpressed in Heart - Left Ventricle (x22.0) and Heart - Atrial Appendage (x19.0).

Protein differential expression in normal tissues from HIPED for METTL11B Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for METTL11B Gene



Protein tissue co-expression partners for METTL11B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for METTL11B

SOURCE GeneReport for Unigene cluster for METTL11B Gene:

Hs.553612
genes like me logo Genes that share expression patterns with METTL11B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for METTL11B Gene

Orthologs for METTL11B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for METTL11B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia METTL11B 30 31
  • 99.65 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia METTL11B 30 31
  • 92.93 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia METTL11B 30 31
  • 90.69 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Mettl11b 30 17 31
  • 90.46 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Mettl11b 30
  • 90.46 (n)
Oppossum
(Monodelphis domestica)
Mammalia METTL11B 31
  • 85 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia METTL11B 31
  • 62 (a)
OneToOne
Chicken
(Gallus gallus)
Aves METTL11B 30 31
  • 76.02 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia METTL11B 31
  • 72 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia mettl11b 30
  • 70.5 (n)
Zebrafish
(Danio rerio)
Actinopterygii mettl11b 30 31
  • 63.77 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Ntmt 31
  • 28 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea homt-1 31
  • 38 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAE1 31
  • 33 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 39 (a)
OneToMany
Species where no ortholog for METTL11B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for METTL11B Gene

ENSEMBL:
Gene Tree for METTL11B (if available)
TreeFam:
Gene Tree for METTL11B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for METTL11B: view image

Paralogs for METTL11B Gene

Paralogs for METTL11B Gene

(1) SIMAP similar genes for METTL11B Gene using alignment to 1 proteins:

  • NTM1B_HUMAN
genes like me logo Genes that share paralogs with METTL11B: view

Variants for METTL11B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for METTL11B Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
689666 Uncertain Significance: Marfanoid habitus and intellectual disability 170,146,120(+) G/C MISSENSE_VARIANT
rs12073565 - p.Ala72Gly
rs12735494 - p.Ser247Arg
rs6427235 - p.Ser150Pro

Additional dbSNP identifiers (rs#s) for METTL11B Gene

Structural Variations from Database of Genomic Variants (DGV) for METTL11B Gene

Variant ID Type Subtype PubMed ID
esv3542456 CNV deletion 23714750
esv3587888 CNV loss 21293372
nsv1078878 OTHER inversion 25765185
nsv3454 CNV deletion 18451855
nsv999310 CNV loss 25217958

Variation tolerance for METTL11B Gene

Gene Damage Index Score: 9.01; 87.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for METTL11B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
METTL11B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METTL11B Gene

Disorders for METTL11B Gene

No disorders were found for METTL11B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for METTL11B Gene

Publications for METTL11B Gene

  1. NRMT2 is an N-terminal monomethylase that primes for its homologue NRMT1. (PMID: 24090352) Petkowski JJ … Schaner Tooley CE (The Biochemical journal 2013) 2 3 4
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects. (PMID: 19901119) Treviño LR … Relling MV (Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4

Products for METTL11B Gene

Sources for METTL11B Gene