Aliases for METTL1 Gene
External Ids for METTL1 Gene
Previous HGNC Symbols for METTL1 Gene
Previous GeneCards Identifiers for METTL1 Gene
This gene is similar in sequence to the S. cerevisiae YDL201w gene. The gene product contains a conserved S-adenosylmethionine-binding motif and is inactivated by phosphorylation. Alternative splice variants encoding different protein isoforms have been described for this gene. A pseudogene has been identified on chromosome X. [provided by RefSeq, Jul 2008]
GeneCards Summary for METTL1 Gene
METTL1 (Methyltransferase Like 1) is a Protein Coding gene. Diseases associated with METTL1 include Thiamine-Responsive Megaloblastic Anemia Syndrome and Isolated Growth Hormone Deficiency, Type Ia. Among its related pathways are Gene Expression and MAPK Erk Pathway. Gene Ontology (GO) annotations related to this gene include tRNA binding and tRNA (guanine-N7-)-methyltransferase activity.
UniProtKB/Swiss-Prot Summary for METTL1 Gene
Methyltransferase that mediates the formation of N(7)-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs) (PubMed:12403464, PubMed:31031084, PubMed:31031083). Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (PubMed:12403464, PubMed:31031084). Also acts as a methyltransferase for a subset of internal N(7)-methylguanine in mRNAs (PubMed:31031084). Internal N(7)-methylguanine methylation of mRNAs regulates translation (PubMed:31031084). Also methylates a specific subset of miRNAs, such as let-7 (PubMed:31031083). N(7)-methylguanine methylation of let-7 miRNA promotes let-7 miRNA processing by disrupting an inhibitory secondary structure within the primary miRNA transcript (pri-miRNA) (PubMed:31031083). Acts as a regulator of embryonic stem cell self-renewal and differentiation (By similarity).