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Aliases for METRN Gene

Aliases for METRN Gene

  • Meteorin, Glial Cell Differentiation Regulator 2 3 5
  • C16orf23 3 4
  • Chromosome 16 Open Reading Frame 23 2
  • C380A1.2 3
  • Meteorin 3

External Ids for METRN Gene

Previous HGNC Symbols for METRN Gene

  • C16orf23

Previous GeneCards Identifiers for METRN Gene

  • GC16P000709
  • GC16P000765
  • GC16P000768
  • GC16P000853
  • GC16P000875
  • GC16P000894
  • GC16P000911
  • GC16P000931
  • GC16P000950
  • GC16P000979

Summaries for METRN Gene

Entrez Gene Summary for METRN Gene

  • Meteorin regulates glial cell differentiation and promotes the formation of axonal networks during neurogenesis (Nishino et al., 2004 [PubMed 15085178]).[supplied by OMIM, Mar 2008]

GeneCards Summary for METRN Gene

METRN (Meteorin, Glial Cell Differentiation Regulator) is a Protein Coding gene. An important paralog of this gene is METRNL.

UniProtKB/Swiss-Prot for METRN Gene

  • Involved in both glial cell differentiation and axonal network formation during neurogenesis. Promotes astrocyte differentiation and transforms cerebellar astrocytes into radial glia. Also induces axonal extension in small and intermediate neurons of sensory ganglia by activating nearby satellite glia (By similarity).

Additional gene information for METRN Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METRN Gene

Genomics for METRN Gene

GeneHancer (GH) Regulatory Elements for METRN Gene

Promoters and enhancers for METRN Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J000713 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.5 499 3.8 ARNT ARID4B SIN3A GLIS2 FOS SP3 RXRA SP5 NFYC MXD4 METRN CIAO3 ENSG00000262528 FBXL16 RPUSD1 GC16P001020
GH16J001609 Promoter/Enhancer 1.6 Ensembl ENCODE 5.5 +897.4 897399 6.4 HDGF PKNOX1 SMAD1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 CRAMP1 IFT140 PIR54168 GC16P001615 WDR90 TELO2 TSC2 NUBP2 WDR24 ENSG00000261207
GH16J000718 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 0.4 +5.6 5648 3.6 HDGF PKNOX1 SIN3A ZNF2 ZBTB7B POLR2B ZNF207 ZNF143 DEK SP3 FAM173A PIR42074 UBE2I CRAMP1 UNKL LUC7L ENSG00000268836 WDR24 CIAO3 WDR90
GH16J000712 Enhancer 1.2 Ensembl ENCODE 0.7 -2.2 -2175 1.2 FOXA2 MLX ARNT ARID4B SIN3A ZNF2 ZNF213 ARID2 KLF7 FOS ENSG00000259840 WFIKKN1 HAGHL METRN
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around METRN on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the METRN gene promoter:
  • NF-1
  • Zic3
  • AP-1
  • E47
  • AML1a
  • c-Myb
  • ZID
  • c-Myc
  • Max1

Genomic Locations for METRN Gene

Genomic Locations for METRN Gene
chr16:715,115-719,655
(GRCh38/hg38)
Size:
4,541 bases
Orientation:
Plus strand
chr16:765,115-769,655
(GRCh37/hg19)
Size:
4,541 bases
Orientation:
Plus strand

Genomic View for METRN Gene

Genes around METRN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METRN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METRN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METRN Gene

Proteins for METRN Gene

  • Protein details for METRN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJH8-METRN_HUMAN
    Recommended name:
    Meteorin
    Protein Accession:
    Q9UJH8
    Secondary Accessions:
    • Q9UJH9

    Protein attributes for METRN Gene

    Size:
    293 amino acids
    Molecular mass:
    31207 Da
    Quaternary structure:
    • Monomer.

neXtProt entry for METRN Gene

Post-translational modifications for METRN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for METRN Gene

No data available for DME Specific Peptides for METRN Gene

Domains & Families for METRN Gene

Gene Families for METRN Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for METRN Gene

ProtoNet:

Suggested Antigen Peptide Sequences for METRN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UJH8

UniProtKB/Swiss-Prot:

METRN_HUMAN :
  • Belongs to the meteorin family.
Family:
  • Belongs to the meteorin family.
genes like me logo Genes that share domains with METRN: view

Function for METRN Gene

Molecular function for METRN Gene

UniProtKB/Swiss-Prot Function:
Involved in both glial cell differentiation and axonal network formation during neurogenesis. Promotes astrocyte differentiation and transforms cerebellar astrocytes into radial glia. Also induces axonal extension in small and intermediate neurons of sensory ganglia by activating nearby satellite glia (By similarity).
genes like me logo Genes that share phenotypes with METRN: view

Animal Model Products

  • Taconic Biosciences Mouse Models for METRN

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for METRN Gene

Localization for METRN Gene

Subcellular locations from UniProtKB/Swiss-Prot for METRN Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for METRN gene
Compartment Confidence
extracellular 3
nucleus 2
cytosol 2
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear membrane (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for METRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with METRN: view

Pathways & Interactions for METRN Gene

SuperPathways for METRN Gene

No Data Available

Interacting Proteins for METRN Gene

Gene Ontology (GO) - Biological Process for METRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007399 nervous system development IEA --
GO:0010001 glial cell differentiation IEA --
GO:0030154 cell differentiation IEA --
GO:0050772 positive regulation of axonogenesis IEA --
genes like me logo Genes that share ontologies with METRN: view

No data available for Pathways by source and SIGNOR curated interactions for METRN Gene

Drugs & Compounds for METRN Gene

No Compound Related Data Available

Transcripts for METRN Gene

mRNA/cDNA for METRN Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(202) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for METRN Gene

Meteorin, glial cell differentiation regulator:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for METRN Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: - -
SP2: -
SP3:

Relevant External Links for METRN Gene

GeneLoc Exon Structure for
METRN
ECgene alternative splicing isoforms for
METRN

Expression for METRN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for METRN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for METRN Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x4.6).

Protein differential expression in normal tissues from HIPED for METRN Gene

This gene is overexpressed in Vitreous humor (41.6) and Retina (27.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for METRN Gene



Protein tissue co-expression partners for METRN Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of METRN Gene:

METRN

SOURCE GeneReport for Unigene cluster for METRN Gene:

Hs.533772

Evidence on tissue expression from TISSUES for METRN Gene

  • Nervous system(4.3)
  • Kidney(4.2)
genes like me logo Genes that share expression patterns with METRN: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for METRN Gene

Orthologs for METRN Gene

This gene was present in the common ancestor of chordates.

Orthologs for METRN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia METRN 34 33
  • 98.63 (n)
OneToOne
cow
(Bos Taurus)
Mammalia METRN 34 33
  • 84.73 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Metrn 16 34 33
  • 81.32 (n)
rat
(Rattus norvegicus)
Mammalia Metrn 33
  • 80.71 (n)
dog
(Canis familiaris)
Mammalia METRN 34
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia METRN 34
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia METRN 34
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves METRN 34 33
  • 70.4 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia METRN 34
  • 57 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii metrn 34 33
  • 59.33 (n)
OneToOne
Species where no ortholog for METRN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for METRN Gene

ENSEMBL:
Gene Tree for METRN (if available)
TreeFam:
Gene Tree for METRN (if available)
Aminode:
Evolutionary constrained regions (ECRs) for METRN: view image

Paralogs for METRN Gene

Paralogs for METRN Gene

(1) SIMAP similar genes for METRN Gene using alignment to 5 proteins:

  • METRN_HUMAN
  • H3BSC8_HUMAN
  • H3BUM1_HUMAN
  • I3L2T3_HUMAN
  • J3KMW6_HUMAN
genes like me logo Genes that share paralogs with METRN: view

Variants for METRN Gene

Sequence variations from dbSNP and Humsavar for METRN Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000567164 -- 713,622(+) C/G upstream_transcript_variant
rs1000578260 -- 713,888(+) T/C upstream_transcript_variant
rs1001158385 -- 717,240(+) C/G coding_sequence_variant, missense_variant
rs1001191934 -- 719,335(+) C/G 3_prime_UTR_variant
rs1001250614 -- 715,406(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for METRN Gene

Variant ID Type Subtype PubMed ID
dgv4825n54 CNV loss 21841781
esv2422427 CNV duplication 17116639
nsv1160325 CNV duplication 26073780
nsv1160326 CNV duplication 26073780
nsv457311 CNV loss 19166990
nsv471063 CNV loss 18288195
nsv471065 CNV gain 18288195
nsv516590 CNV loss 19592680
nsv526903 CNV loss 19592680
nsv571012 CNV loss 21841781
nsv571021 CNV loss 21841781
nsv9321 CNV gain+loss 18304495
nsv952898 CNV deletion 24416366

Variation tolerance for METRN Gene

Gene Damage Index Score: 2.24; 40.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for METRN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
METRN

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METRN Gene

Disorders for METRN Gene

Additional Disease Information for METRN

No disorders were found for METRN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for METRN Gene

Publications for METRN Gene

  1. Meteorin: a secreted protein that regulates glial cell differentiation and promotes axonal extension. (PMID: 15085178) Nishino J … Hamada H (The EMBO journal 2004) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 3 4 58
  4. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels RJ … Higgs DR (Human molecular genetics 2001) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for METRN Gene

Sources for METRN Gene

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