The protein encoded by this gene is a member of the methionyl aminopeptidase family. The encoded protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent proteins. Increased expression of this gene is associated with various forms of cancer, and the... See more...

Aliases for METAP2 Gene

Aliases for METAP2 Gene

  • Methionyl Aminopeptidase 2 2 3 5
  • Initiation Factor 2-Associated 67 KDa Glycoprotein 3 4
  • Methionine Aminopeptidase 2 3 4
  • Peptidase M 2 4
  • P67eIF2 3 4
  • MNPEP 3 4
  • Testicular Tissue Protein Li 17 3
  • EIF-2-Associated P67 Homolog 3
  • Peptidase M 2 3
  • EC 3.4.11.18 4
  • MetAP 2 4
  • P67EIF2 4
  • MAP 2 4
  • MAP2 3
  • P67 4

External Ids for METAP2 Gene

Previous GeneCards Identifiers for METAP2 Gene

  • GC12M095311
  • GC12P096231
  • GC12P095800
  • GC12P094370
  • GC12P092936

Summaries for METAP2 Gene

Entrez Gene Summary for METAP2 Gene

  • The protein encoded by this gene is a member of the methionyl aminopeptidase family. The encoded protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent proteins. Increased expression of this gene is associated with various forms of cancer, and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. Inhibitors of this gene have also been shown to be effective for the treatment of obesity. A pseudogene of this gene is located on chromosome 2. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

GeneCards Summary for METAP2 Gene

METAP2 (Methionyl Aminopeptidase 2) is a Protein Coding gene. Diseases associated with METAP2 include Microsporidiosis and Amebiasis. Among its related pathways are Signaling by GPCR and Metabolism of fat-soluble vitamins. Gene Ontology (GO) annotations related to this gene include aminopeptidase activity. An important paralog of this gene is PA2G4.

UniProtKB/Swiss-Prot Summary for METAP2 Gene

  • Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo.
  • Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.

Tocris Summary for METAP2 Gene

Gene Wiki entry for METAP2 Gene

Additional gene information for METAP2 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for METAP2 Gene

Genomics for METAP2 Gene

GeneHancer (GH) Regulatory Elements for METAP2 Gene

Promoters and enhancers for METAP2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J095472 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 506 +0.9 881 3.6 ZBTB40 EP300 TCF12 SIN3A NRF1 POLR2G SP1 GTF2E2 PHF8 ZFX METAP2 lnc-USP44-3 ELK3 USP44 FJ601684-082
GH12J096419 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 38.6 +952.4 952359 12.6 TCF12 RBAK JUND FOS ZNF639 ZNF354C REST POLR2A ZNF623 ZNF510 CDK17 RN7SKP11 RF00100-031 RF00017-1216 lnc-CDK17-6 METAP2 ELK3 USP44 CFAP54 LTA4H
GH12J095941 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 29.2 +469.6 469552 2.5 ZBTB40 TCF12 POLR2G USF1 RBAK PHF8 ZNF639 CTCF ZNF354C ZIC2 AMDHD1 CCDC38 RF00017-1212 lnc-HAL-2 ELK3 METAP2 NR2C1 USP44 VEZT LTA4H
GH12J095652 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 31.3 +180.2 180212 2.4 ZNF217 TCF12 FOS ZBTB10 CLOCK RFX1 CUX1 TSC22D4 EP300 SKI NR2C1 ELK3 METAP2 SNRPF NTN4 USP44 VEZT LTA4H piR-34822-070 lnc-USP44-2
GH12J095211 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 13.3 -257.3 -257323 8.7 ZNF217 EP300 CTCF ZSCAN5C TCF12 NRF1 USF1 POLR2G SP1 GTF2E2 FGD6 VEZT METAP2 lnc-NR2C1-5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around METAP2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for METAP2

Top Transcription factor binding sites by QIAGEN in the METAP2 gene promoter:
  • AML1a
  • AP-1
  • ATF-2
  • c-Jun
  • c-Myc
  • HSF1 (long)
  • HSF1short
  • Max
  • NRF-2

Genomic Locations for METAP2 Gene

Genomic Locations for METAP2 Gene
chr12:95,473,520-95,515,839
(GRCh38/hg38)
Size:
42,320 bases
Orientation:
Plus strand
chr12:95,867,296-95,909,615
(GRCh37/hg19)
Size:
42,320 bases
Orientation:
Plus strand

Genomic View for METAP2 Gene

Genes around METAP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METAP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METAP2 Gene

Proteins for METAP2 Gene

  • Protein details for METAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50579-MAP2_HUMAN
    Recommended name:
    Methionine aminopeptidase 2
    Protein Accession:
    P50579
    Secondary Accessions:
    • B2RDI8
    • B4DUX5
    • G3XA91
    • Q8NB11

    Protein attributes for METAP2 Gene

    Size:
    478 amino acids
    Molecular mass:
    52892 Da
    Cofactor:
    Name=Co(2+); Xref=ChEBI:CHEBI:48828; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
    Quaternary structure:
    • Interacts strongly with the eIF-2 gamma-subunit EIF2S3 (By similarity). Binds EIF2S1 at low magnesium concentrations.

    Three dimensional structures from OCA and Proteopedia for METAP2 Gene

    Alternative splice isoforms for METAP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for METAP2 Gene

Post-translational modifications for METAP2 Gene

  • Contains approximately 12 O-linked N-acetylglucosamine (GlcNAc) residues. O-glycosylation is required for EIF2S1 binding.
  • Glycosylation at Ser60 and Ser63
  • Ubiquitination at Lys289 and Lys427
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for METAP2 Gene

Domains & Families for METAP2 Gene

Gene Families for METAP2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for METAP2 Gene

Suggested Antigen Peptide Sequences for METAP2 Gene

GenScript: Design optimal peptide antigens:
  • p67eIF2 (AMPM2_HUMAN)
  • Methionine aminopeptidase (B4DUX5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P50579

UniProtKB/Swiss-Prot:

MAP2_HUMAN :
  • Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
Family:
  • Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
genes like me logo Genes that share domains with METAP2: view

Function for METAP2 Gene

Molecular function for METAP2 Gene

UniProtKB/Swiss-Prot Function:
Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo.
UniProtKB/Swiss-Prot Function:
Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.; EC=3.4.11.18; Evidence={ECO:0000255 HAMAP-Rule:MF_03175, ECO:0000269 PubMed:20521764};.

Enzyme Numbers (IUBMB) for METAP2 Gene

Phenotypes From GWAS Catalog for METAP2 Gene

Gene Ontology (GO) - Molecular Function for METAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0004177 aminopeptidase activity IDA,IEA 8858118
GO:0008233 peptidase activity IEA --
GO:0008235 metalloexopeptidase activity IEA,IDA 8858118
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with METAP2: view
genes like me logo Genes that share phenotypes with METAP2: view

Animal Models for METAP2 Gene

MGI Knock Outs for METAP2:

Animal Model Products

  • Taconic Biosciences Mouse Models for METAP2

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for METAP2

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for METAP2 Gene

Localization for METAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for METAP2 Gene

Cytoplasm. Note=About 30% of expressed METAP2 associates with polysomes.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for METAP2 gene
Compartment Confidence
plasma membrane 5
cytosol 5
mitochondrion 2
nucleus 2
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for METAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 15102683
GO:0005829 cytosol IDA,TAS --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with METAP2: view

Pathways & Interactions for METAP2 Gene

genes like me logo Genes that share pathways with METAP2: view

Pathways by source for METAP2 Gene

Gene Ontology (GO) - Biological Process for METAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0016485 protein processing IDA 8858118
GO:0018206 peptidyl-methionine modification IDA 8858118
GO:0022400 regulation of rhodopsin mediated signaling pathway TAS --
GO:0031365 N-terminal protein amino acid modification IDA 8858118
genes like me logo Genes that share ontologies with METAP2: view

No data available for SIGNOR curated interactions for METAP2 Gene

Drugs & Compounds for METAP2 Gene

(27) Drugs for METAP2 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Methionine Approved Nutra Target, product of 114
Cobalt Approved, Experimental Pharma 198
D-Methionine Approved, Experimental, Investigational Pharma Target 0
Fumagillin Experimental Pharma Target, ligand Antibiotic and antiangiogenic agent, Methionine aminopeptidase-2 inhibitor; antiangiogenic 0
Ovalicin Experimental Pharma Target 0

(6) Additional Compounds for METAP2 Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-Methylpropan-2-ol
  • (CH3)3C-OH
  • 1,1-Dimethylethanol
  • t-Butanol
  • t-Butyl alchohol
  • t-Butylalkohol
75-65-0
CHR 2797
238750-77-1
HFI 142
332164-34-8

(4) Tocris Compounds for METAP2 Gene

Compound Action Cas Number
Bestatin Aminopeptidase inhibitor 58970-76-6
CHR 2797 Aminopeptidase inhibitor 238750-77-1
Fumagillin Methionine aminopeptidase-2 inhibitor; antiangiogenic 23110-15-8
HFI 142 Insulin-regulated aminopeptidase (IRAP) inhibitor 332164-34-8

(1) ApexBio Compounds for METAP2 Gene

Compound Action Cas Number
Fumagillin Antibiotic and antiangiogenic agent 23110-15-8
genes like me logo Genes that share compounds with METAP2: view

Transcripts for METAP2 Gene

mRNA/cDNA for METAP2 Gene

4 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for METAP2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for METAP2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - - -
SP2: - -
SP3: -
SP4:
SP5: - - -
SP6:

Relevant External Links for METAP2 Gene

GeneLoc Exon Structure for
METAP2

Expression for METAP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for METAP2 Gene

Protein differential expression in normal tissues from HIPED for METAP2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (16.8) and Lavage (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for METAP2 Gene



Protein tissue co-expression partners for METAP2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for METAP2

SOURCE GeneReport for Unigene cluster for METAP2 Gene:

Hs.444986

Evidence on tissue expression from TISSUES for METAP2 Gene

  • Nervous system(4.8)
  • Liver(4.5)
  • Heart(4.3)
  • Intestine(4.3)
genes like me logo Genes that share expression patterns with METAP2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for METAP2 Gene

Orthologs for METAP2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for METAP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia METAP2 31 30
  • 99.72 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia METAP2 31
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia METAP2 31 30
  • 95.32 (n)
OneToOne
dog
(Canis familiaris)
Mammalia METAP2 31 30
  • 94.97 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Metap2 30
  • 89.2 (n)
mouse
(Mus musculus)
Mammalia Metap2 17 31 30
  • 89.19 (n)
oppossum
(Monodelphis domestica)
Mammalia METAP2 31
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves METAP2 31 30
  • 80.56 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia METAP2 31
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia metap2 30
  • 77.97 (n)
Str.8946 30
African clawed frog
(Xenopus laevis)
Amphibia metap2-prov 30
zebrafish
(Danio rerio)
Actinopterygii metap2a 31 30
  • 75.45 (n)
OneToOne
wufb98h06 30
fruit fly
(Drosophila melanogaster)
Insecta und 31 32 30
  • 63.94 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008345 30
  • 61.67 (n)
worm
(Caenorhabditis elegans)
Secernentea Y116A8A.9 32
  • 73 (a)
map-2 31
  • 55 (a)
OneToMany
F53B6.5 31 32
  • 50 (a)
OneToMany
T27A8.3 31 32
  • 49 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MAP2 33 31 30
  • 61.08 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E06887g 30
  • 59.51 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL283W 30
  • 54.61 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons MAP2B 30
  • 65.01 (n)
soybean
(Glycine max)
eudicotyledons Gma.4154 30
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.9148 30
rice
(Oryza sativa)
Liliopsida Os12g0628500 30
  • 65.76 (n)
Os.12322 30
barley
(Hordeum vulgare)
Liliopsida Hv.1251 30
corn
(Zea mays)
Liliopsida Zm.4989 30
wheat
(Triticum aestivum)
Liliopsida Ta.2490 30
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11326 31
  • 70 (a)
OneToOne
Cin.4546 30
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes fma2 30
  • 62.22 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU04306 30
  • 56.07 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4546 30
Species where no ortholog for METAP2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for METAP2 Gene

ENSEMBL:
Gene Tree for METAP2 (if available)
TreeFam:
Gene Tree for METAP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for METAP2: view image

Paralogs for METAP2 Gene

(1) SIMAP similar genes for METAP2 Gene using alignment to 11 proteins:

  • MAP2_HUMAN
  • B4DUX5_HUMAN
  • F8VQZ7_HUMAN
  • F8VRR3_HUMAN
  • F8VSC4_HUMAN
  • F8VY03_HUMAN
  • F8VZX9_HUMAN
  • G3V1U3_HUMAN
  • G3XA91_HUMAN
  • L0R5B9_HUMAN
  • Q8NB11_HUMAN

Pseudogenes.org Pseudogenes for METAP2 Gene

genes like me logo Genes that share paralogs with METAP2: view

Variants for METAP2 Gene

Additional dbSNP identifiers (rs#s) for METAP2 Gene

Structural Variations from Database of Genomic Variants (DGV) for METAP2 Gene

Variant ID Type Subtype PubMed ID
nsv1119977 CNV deletion 24896259
nsv7234 OTHER inversion 18451855
nsv976647 CNV duplication 23825009

Variation tolerance for METAP2 Gene

Residual Variation Intolerance Score: 57.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.04; 37.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for METAP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
METAP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for METAP2 Gene

Disorders for METAP2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for METAP2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
microsporidiosis
  • infection by microspora
amebiasis
  • amoebiasis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for METAP2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with METAP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for METAP2 Gene

Publications for METAP2 Gene

  1. Eukaryotic methionyl aminopeptidases: two classes of cobalt-dependent enzymes. (PMID: 7644482) Arfin SM … Bradshaw RA (Proceedings of the National Academy of Sciences of the United States of America 1995) 2 3 4 23 54
  2. Physiologically relevant metal cofactor for methionine aminopeptidase-2 is manganese. (PMID: 12718546) Wang J … Henkin J (Biochemistry 2003) 3 4 23 54
  3. Structure of human methionine aminopeptidase-2 complexed with fumagillin. (PMID: 9812898) Liu S … Clardy J (Science (New York, N.Y.) 1998) 3 4 23 54
  4. Evidence that the human homologue of a rat initiation factor-2 associated protein (p67) is a methionine aminopeptidase. (PMID: 8858118) Li X … Chang YH (Biochemical and biophysical research communications 1996) 2 3 23 54
  5. Molecular cloning of a human complementary DNA encoding an initiation factor 2-associated protein (p67). (PMID: 7873610) Li X … Chang YH (Biochimica et biophysica acta 1995) 3 4 23 54

Products for METAP2 Gene

Sources for METAP2 Gene