Aliases for METAP1 Gene

Aliases for METAP1 Gene

  • Methionyl Aminopeptidase 1 2 3 5
  • Methionine Aminopeptidase 1 3 4
  • Peptidase M 1 3 4
  • KIAA0094 2 4
  • MetAP1A 2 3
  • MetAP 1 3 4
  • MAP1A 2 3
  • MAP 1 3 4
  • EC 3.4.11.18 4
  • Peptidase M 2
  • METAP1 5

External Ids for METAP1 Gene

Previous GeneCards Identifiers for METAP1 Gene

  • GC04P100162
  • GC04P100309
  • GC04P100375
  • GC04P100274
  • GC04P099916
  • GC04P095655

Summaries for METAP1 Gene

GeneCards Summary for METAP1 Gene

METAP1 (Methionyl Aminopeptidase 1) is a Protein Coding gene. Diseases associated with METAP1 include Microsporidiosis. Among its related pathways are Signaling by GPCR and Metabolism of fat-soluble vitamins. Gene Ontology (GO) annotations related to this gene include hydrolase activity and metalloexopeptidase activity. An important paralog of this gene is METAP1D.

UniProtKB/Swiss-Prot Summary for METAP1 Gene

  • Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle.

Gene Wiki entry for METAP1 Gene

Additional gene information for METAP1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for METAP1 Gene

Genomics for METAP1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for METAP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J098994 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +1.2 1166 5.3 GATAD2A CTCF ZBTB33 PRDM10 IKZF1 NFKBIZ POLR2A BACH1 ETV6 JUND MIR3684 METAP1 ENSG00000272777 ENSG00000246090 EIF4E ADH5 RNU7-149P ADH1A ADH4 ENSG00000263923
GH04J099763 Enhancer 0.8 Ensembl ENCODE 4.7 +768.3 768342 1.2 CEBPB JUND FOS JUN EP300 FOSL2 RFX5 STAT3 MAFK HNF4A piR-61532-224 C4orf54 METAP1 DAPP1 ENSG00000248676 piR-32291-007
GH04J099022 Promoter/Enhancer 1.1 Ensembl ENCODE 0.3 +28.8 28797 3.3 IKZF1 MTA2 MTA1 NR2C1 DPF2 HDAC1 SOX6 GATAD2B TCF12 EP300 ABT1P1 lnc-ADH5-2 ENSG00000272777 ENSG00000246090 EIF4E ADH5 METAP1
GH04J099013 Enhancer 0.8 Ensembl ENCODE 0.4 +18.0 18042 1.8 IKZF1 POLR2A CEBPA SOX13 ZNF766 NR2F2 TBP NR2F1 SPI1 KLF6 ENSG00000272777 EIF4E lnc-ADH5-2 METAP1 MIR3684 ADH5
GH04J098962 Enhancer 0.8 Ensembl ENCODE 0.3 -31.8 -31823 1.8 PRDM10 PRDM1 REST HMBOX1 EGR1 NFE2 ZNF316 ZSCAN5C MAFG ZFHX2 ENSG00000287512 RF00066-142 RNU7-149P FAM177A1P1 ENSG00000263923 METAP1 EIF4E
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around METAP1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for METAP1

Top Transcription factor binding sites by QIAGEN in the METAP1 gene promoter:
  • AREB6
  • CREB
  • CUTL1
  • deltaCREB
  • Evi-1
  • FOXD3
  • Nkx6-1
  • TBP
  • TFIID
  • ZID

Genomic Locations for METAP1 Gene

Genomic Locations for METAP1 Gene
chr4:98,995,659-99,063,109
(GRCh38/hg38)
Size:
67,451 bases
Orientation:
Plus strand
chr4:99,916,771-99,983,964
(GRCh37/hg19)
Size:
67,194 bases
Orientation:
Plus strand

Genomic View for METAP1 Gene

Genes around METAP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METAP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METAP1 Gene

Proteins for METAP1 Gene

  • Protein details for METAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P53582-MAP11_HUMAN
    Recommended name:
    Methionine aminopeptidase 1
    Protein Accession:
    P53582
    Secondary Accessions:
    • B4E2E6

    Protein attributes for METAP1 Gene

    Size:
    386 amino acids
    Molecular mass:
    43215 Da
    Cofactor:
    Name=Co(2+); Xref=ChEBI:CHEBI:48828;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Cofactor:
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
    Quaternary structure:
    • Associates with the 60S ribosomal subunit of the 80S translational complex.
    SequenceCaution:
    • Sequence=AAH30054.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA07679.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for METAP1 Gene

neXtProt entry for METAP1 Gene

Post-translational modifications for METAP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for METAP1 Gene

Domains & Families for METAP1 Gene

Gene Families for METAP1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for METAP1 Gene

InterPro:
Blocks:
  • Methionine aminopeptidase-1 signature
  • Pancreatic trypsin inhibitor (Kunitz)
  • Methionine aminopeptidase, subfamily 1
ProtoNet:

Suggested Antigen Peptide Sequences for METAP1 Gene

GenScript: Design optimal peptide antigens:
  • Peptidase M 1 (AMPM1_HUMAN)
  • Methionine aminopeptidase (F5GXS7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P53582

UniProtKB/Swiss-Prot:

MAP11_HUMAN :
  • Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
Family:
  • Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
genes like me logo Genes that share domains with METAP1: view

Function for METAP1 Gene

Molecular function for METAP1 Gene

UniProtKB/Swiss-Prot Function:
Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.; EC=3.4.11.18; Evidence={ECO:0000255|HAMAP-Rule:MF_03174, ECO:0000269|PubMed:17114291};.

Enzyme Numbers (IUBMB) for METAP1 Gene

Phenotypes From GWAS Catalog for METAP1 Gene

Gene Ontology (GO) - Molecular Function for METAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004177 aminopeptidase activity IEA,TAS 16386852
GO:0008233 peptidase activity IEA --
GO:0008235 metalloexopeptidase activity IEA,TAS 16386852
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with METAP1: view
genes like me logo Genes that share phenotypes with METAP1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for METAP1

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for METAP1 Gene

Localization for METAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for METAP1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for METAP1 gene
Compartment Confidence
cytosol 5
plasma membrane 3
mitochondrion 2
nucleus 2
extracellular 1
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for METAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 14532271
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with METAP1: view

Pathways & Interactions for METAP1 Gene

genes like me logo Genes that share pathways with METAP1: view

Gene Ontology (GO) - Biological Process for METAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation TAS 16386852
GO:0006508 proteolysis IEA --
GO:0018206 peptidyl-methionine modification TAS 16386852
GO:0022400 regulation of rhodopsin mediated signaling pathway TAS --
GO:0031365 N-terminal protein amino acid modification TAS 16386852
genes like me logo Genes that share ontologies with METAP1: view

No data available for SIGNOR curated interactions for METAP1 Gene

Drugs & Compounds for METAP1 Gene

(7) Drugs for METAP1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cobalt Approved, Experimental Pharma 200
Ovalicin Experimental Pharma Target 0
3-[(2,2-DIMETHYLPROPANOYL)AMINO]-N-1,3-THIAZOL-2-YLPYRIDINE-2-CARBOXAMIDE Experimental Pharma Target 0
5-CHLORO-6-METHYL-N-(2-PHENYLETHYL)-2-PYRIDIN-2-YLPYRIMIDIN-4-AMINE Experimental Pharma Target 0
TERT-BUTYL {2-[(1,3-THIAZOL-2-YLAMINO)CARBONYL]PYRIDIN-3-YL}CARBAMATE Experimental Pharma Target 0

(1) Additional Compounds for METAP1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Na(+)
  • Na+
  • SODIUM ion
7440-23-5
genes like me logo Genes that share compounds with METAP1: view

Transcripts for METAP1 Gene

mRNA/cDNA for METAP1 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for METAP1

Alternative Splicing Database (ASD) splice patterns (SP) for METAP1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c
SP1: - - -
SP2: - -
SP3:
SP4:
SP5: - -
SP6: -
SP7: -

Relevant External Links for METAP1 Gene

GeneLoc Exon Structure for
METAP1

Expression for METAP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for METAP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

Protein differential expression in normal tissues from HIPED for METAP1 Gene

This gene is overexpressed in Bone (11.8), Peripheral blood mononuclear cells (11.2), and Heart (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for METAP1 Gene



Protein tissue co-expression partners for METAP1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for METAP1

SOURCE GeneReport for Unigene cluster for METAP1 Gene:

Hs.480364

Evidence on tissue expression from TISSUES for METAP1 Gene

  • Liver(4.3)
  • Bone marrow(4.2)
  • Nervous system(3.1)
  • Heart(2.3)
  • Skin(2.2)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with METAP1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for METAP1 Gene

Orthologs for METAP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for METAP1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia METAP1 30 31
  • 99.65 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia METAP1 30 31
  • 94.35 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia METAP1 31
  • 94 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia METAP1 30 31
  • 92.92 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Metap1 30 17 31
  • 90.93 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Metap1 30
  • 89.46 (n)
Chicken
(Gallus gallus)
Aves METAP1 30 31
  • 84.5 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia METAP1 31
  • 92 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia metap1 30
  • 80.21 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.29016 30
Zebrafish
(Danio rerio)
Actinopterygii metap1 30 31
  • 75.58 (n)
OneToOne
wufc84e12 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6937 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003700 30
  • 62.02 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG13630 30 31
  • 61.65 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea map-1 30 31
  • 59.64 (n)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MAP1 30 31 33
  • 59.15 (n)
OneToMany
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D18436g 30
  • 56.71 (n)
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AGL122W 30
  • 55.56 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons MAP1A 30
  • 60.87 (n)
Soybean
(Glycine max)
eudicotyledons Gma.10853 30
Rice
(Oryza sativa)
Liliopsida Os10g0508400 30
  • 59.02 (n)
Os.6154 30
Barley
(Hordeum vulgare)
Liliopsida Hv.11208 30
Wheat
(Triticum aestivum)
Liliopsida Ta.7894 30
Corn
(Zea mays)
Liliopsida Zm.16004 30
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes fma1 30
  • 57.46 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU06923 30
  • 56.46 (n)
Species where no ortholog for METAP1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for METAP1 Gene

ENSEMBL:
Gene Tree for METAP1 (if available)
TreeFam:
Gene Tree for METAP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for METAP1: view image

Paralogs for METAP1 Gene

(2) SIMAP similar genes for METAP1 Gene using alignment to 7 proteins:

  • MAP11_HUMAN
  • D6RF24_HUMAN
  • F5GXS7_HUMAN
  • H0Y903_HUMAN
  • H0Y955_HUMAN
  • H0Y9L0_HUMAN
  • H0YAI3_HUMAN

Pseudogenes.org Pseudogenes for METAP1 Gene

genes like me logo Genes that share paralogs with METAP1: view

Variants for METAP1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for METAP1 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
783426 Benign: not provided 99,061,290(+) A/G SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for METAP1 Gene

Structural Variations from Database of Genomic Variants (DGV) for METAP1 Gene

Variant ID Type Subtype PubMed ID
esv2728030 CNV deletion 23290073
esv2728031 CNV deletion 23290073
esv2728032 CNV deletion 23290073
esv3601551 CNV gain 21293372
nsv1002927 CNV gain 25217958
nsv4438 CNV insertion 18451855

Variation tolerance for METAP1 Gene

Residual Variation Intolerance Score: 33.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.87; 18.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for METAP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
METAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METAP1 Gene

Disorders for METAP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for METAP1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
microsporidiosis
  • infection by microspora
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for METAP1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with METAP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for METAP1 Gene

Publications for METAP1 Gene

  1. Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7788527) Nagase T … Kotani H (DNA research : an international journal for rapid publication of reports on genes and genomes 1995) 2 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  3. Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. (PMID: 19898482) Ross CJ … CPNDS Consortium (Nature genetics 2009) 3 41
  4. Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression. (PMID: 17114291) Hu X … Liu JO (Proceedings of the National Academy of Sciences of the United States of America 2006) 3 4
  5. Structural basis for the functional differences between type I and type II human methionine aminopeptidases. (PMID: 16274222) Addlagatta A … Matthews BW (Biochemistry 2005) 3 4

Products for METAP1 Gene

Sources for METAP1 Gene