MET Gene (Protein Coding)

MET Proto-Oncogene, Receptor Tyrosine Kinase

GC07P116672
GIFtS:
54
This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been show... See more...

Aliases for MET Gene

Aliases for MET Gene

  • MET Proto-Oncogene, Receptor Tyrosine Kinase 2 3 5
  • Hepatocyte Growth Factor Receptor 2 3 4
  • Tyrosine-Protein Kinase Met 3 4
  • Scatter Factor Receptor 3 4
  • Proto-Oncogene C-Met 3 4
  • HGF/SF Receptor 3 4
  • HGF Receptor 3 4
  • SF Receptor 3 4
  • EC 2.7.10.1 4 50
  • DFNB97 2 3
  • RCCP2 2 3
  • HGFR 2 3
  • Met Proto-Oncogene 2
  • EC 2.7.10 50
  • AUTS9 3
  • C-Met 3
  • MET 5

External Ids for MET Gene

Previous GeneCards Identifiers for MET Gene

  • GC07P114790
  • GC07P115853
  • GC07P115866
  • GC07P115906
  • GC07P116099
  • GC07P116312
  • GC07P110678

Summaries for MET Gene

Entrez Gene Summary for MET Gene

  • This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016]

CIViC Summary for MET Gene

  • Mesenchymal Epithelial Transition MET is a prototypical receptor tyrosine kinase. Its ligand is Hepatocyte Growth Factor (HGF). MET alterations are drivers of human cancer. Amplification and resulting overexpression has been reported in several cancers, and make the receptor's activity independent of HGF. Gene fusions also decouple kinase activity from the cell membrane and render it constitutively active. Finally, exclusion of the juxtamembrane (JM) domain of the kinase by "skipping" of exon 14 activates the kinase.

GeneCards Summary for MET Gene

MET (MET Proto-Oncogene, Receptor Tyrosine Kinase) is a Protein Coding gene. Diseases associated with MET include Renal Cell Carcinoma, Papillary, 1 and Deafness, Autosomal Recessive 97. Among its related pathways are RET signaling and Insulin receptor recycling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MST1R.

UniProtKB/Swiss-Prot Summary for MET Gene

  • Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells. May regulate cortical bone osteogenesis (By similarity).
  • (Microbial infection) Acts as a receptor for Listeria monocytogenes internalin InlB, mediating entry of the pathogen into cells.

Tocris Summary for MET Gene

  • The MET receptor, also known as hepatocyte growth factor receptor (HGFR), is a proto-oncogenic receptor tyrosine kinase. The endogenous ligand for MET is hepatocyte growth factor/scatter factor (HGF), a disulfide-linked heterodimeric molecule.

Gene Wiki entry for MET Gene

Additional gene information for MET Gene

No data available for PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MET Gene

Genomics for MET Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for MET Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH07J116670 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 258.3 +1.0 976 5.9 ZNF654 ZNF600 JUND CEBPA ZNF10 POLR2A ZIC2 ZBTB10 YY1 MXD4 MET TES CAV2 ST7 COMETT MN298114-237 CAPZA2
GH07J116775 Enhancer 1.2 Ensembl ENCODE dbSUPER 34.3 +108.0 107988 8.8 JUND ZIC2 YY1 ZNF217 CEBPB FEZF1 CTBP1 RXRA ZBTB33 PRDM6 MET CAPZA2 ENSG00000235427 CFTR HSALNG0060764 HSALNG0060766 MN298114-237
GH07J116715 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 26 +44.2 44172 2.6 ZNF600 ATF2 ZNF10 BRCA1 ZBTB10 CEBPB DEK ZNF639 ZEB1 CTCF MET piR-61532-304 COMETT CAPZA2 MN298114-237
GH07J116732 Enhancer 1.1 Ensembl ENCODE dbSUPER 30 +63.7 63741 6.5 CEBPA YY1 MXD4 HOMEZ FOXA2 RXRA SAP130 MIER3 RARA ZBTB33 lnc-CAPZA2-3 MET CAPZA2 RF00066-175 MN298114-237
GH07J116800 Enhancer 1.3 ENCODE CraniofacialAtlas dbSUPER 19.3 +131.4 131373 6.9 MYC JUND ZNF580 ATF2 CEBPA ZNF10 BRCA1 CEBPB REST DEK HSALNG0060766 MET CAPZA2 HSALNG0060764 MN298114-237
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MET on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MET

Top Transcription factor binding sites by QIAGEN in the MET gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • FOXD3
  • N-Myc
  • NF-1
  • p300
  • p53
  • S8
  • Sp1

Genomic Locations for MET Gene

Latest Assembly
chr7:116,672,196-116,798,386
(GRCh38/hg38)
Size:
126,191 bases
Orientation:
Plus strand

Previous Assembly
chr7:116,312,250-116,438,431
(GRCh37/hg19 by Entrez Gene)
Size:
126,182 bases
Orientation:
Plus strand

chr7:116,312,444-116,438,440
(GRCh37/hg19 by Ensembl)
Size:
125,997 bases
Orientation:
Plus strand

Genomic View for MET Gene

Genes around MET on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MET Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MET Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MET Gene

Proteins for MET Gene

Products:

  1. Antibodies for research
  2. Protein products for research
  3. Assay products for research

  • Protein details for MET Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08581-MET_HUMAN
    Recommended name:
    Hepatocyte growth factor receptor
    Protein Accession:
    P08581
    Secondary Accessions:
    • A1L467
    • B5A932
    • E7EQ94
    • O60366
    • Q12875
    • Q9UDX7
    • Q9UPL8

    Protein attributes for MET Gene

    Size:
    1390 amino acids
    Molecular mass:
    155541 Da
    Quaternary structure:
    • Heterodimer made of an alpha chain (50 kDa) and a beta chain (145 kDa) which are disulfide linked. Binds PLXNB1. Interacts when phosphorylated with downstream effectors including STAT3, PIK3R1, SRC, PCLG1, GRB2 and GAB1. Interacts with SPSB1, SPSB2 and SPSB4 (By similarity). Interacts with INPP5D/SHIP1. When phosphorylated at Tyr-1356, interacts with INPPL1/SHIP2. Interacts with RANBP9 and RANBP10, as well as SPSB1, SPSB2, SPSB3 and SPSB4. SPSB1 binding occurs in the presence and in the absence of HGF, however HGF treatment has a positive effect on this interaction. Interacts with MUC20; prevents interaction with GRB2 and suppresses hepatocyte growth factor-induced cell proliferation. Interacts with GRB10. Interacts with PTPN1 and PTPN2. Interacts with LECT2; this interaction may have an antagonistic effect on receptor activation (PubMed:27334921). Interacts with HSP90AA1 and HSP90AB1; the interaction suppresses MET kinase activity (PubMed:26517842).
    • (Microbial infection) Interacts via extracytoplasmic residues 25-656 with L.monocytogenes InlB; MET can bind HGF, its endogenous ligand, and InlB simultaneously (PubMed:11081636, PubMed:17662939). InlB probably dimerizes upon binding to MET, which encourages subsequent dimerization of MET (Probable).

    Three dimensional structures from OCA and Proteopedia for MET Gene

    Alternative splice isoforms for MET Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MET Gene

Protein Expression for MET Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for MET Gene

P08581:
  • IGRGHFGCVYHGTLLDND
  • KANLSGG
  • KSEMNVNM
  • SPILTSGDSD
  • VDTYYDDQLISCGSV
  • FLWLKKRKQ
  • DNINMAL
  • SVRRLKET
  • LHEHHIFLGATNYIYVLNEEDLQKVAE
  • SGGVWKDN
  • RDLAARN
  • SCTLTLSEST
  • APLEGGT
  • GNENVLEIKGNDIDPEAVKGEVLKVGNKSCE
  • LVQAVQHVVIGP
  • EYKTGPV
  • IDPEAVKGEVLKVGNKSCENIH
  • LDSHPVS
  • MNVNMKYQLPNFTA
  • VLLGNESC
  • KGDLTIANLGTSEGRF
  • STVLGKVIVQPDQN
  • AVLCTVP
  • KPGAQLA
  • LIGFGLQVA
  • LPVKWMA
  • GFMFLTDQSY
  • SILECYTP
  • NSSYFPDH
  • KDRFINFFVGNTI
  • GVFAQSKPDSAEPM
  • ELVSRISAIFS
  • CPDCVVSALG
  • FVQCGWC
  • HVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLD
  • LGKVIVQPDQNFTGLI
  • GECKEAL
  • DEYRTEFTTA
  • TVACQHRS
  • PDQNFTGLIAGV
  • EGSPLVVLPYMKHGDLRNFIRNE
  • RGTCQRH
  • HFQSCSQCL
  • ELNIEWKQA
  • CVAPYPSLLSS
  • FIYFLTVQ
  • DLLKLNS
  • PVITSISP
  • YREDPIV
  • RPSFSELVS
  • YQLPNFTAET
  • IPLNGLGC
  • FHTRIIRFCS
  • CAFPIKY
  • GGTLLTL
  • SKYFDLIYVH
  • QPEYCPD
  • LKCTVGPA
  • DDILFGVFAQSKPDSAEP
  • FTVKVADFGLAR
  • HGTTQYSTFSYVDP
  • KQIKDLGSELVRYD
  • SGTWTQQICLPAIYKVFP
  • KLKIDLA
  • NTLKCTVG
  • KSDVWSFG
  • HTPHLDRLVSARS
  • EVMLKCWHP
  • CGWDFGF
  • FSYREDP
  • DCSSKAN
  • FLTDQSYIDVLP
  • MKDFSHPNV
  • KCVRSEEC
  • NNKFDLKKT
  • YVHNPVF
  • CRQVQYPLTD
  • FFNKIVNKNNV
  • EMPLECILTEKR
  • LECYTPAQ
  • FRDSYPIKY
  • EDPIVYEIHPTKSFISGGSTITG
  • TGPVLEHP
  • DLFMGQF
  • DKEYYSV
  • WMALESL
  • GKNLNSVS
  • EVFNILQAAYV
  • FVHRDLA
  • TCTLKSVS
  • LHSISVRR
  • VLLTSISTF
  • FEKPVMIS

Post-translational modifications for MET Gene

  • Autophosphorylated in response to ligand binding on Tyr-1234 and Tyr-1235 in the kinase domain leading to further phosphorylation of Tyr-1349 and Tyr-1356 in the C-terminal multifunctional docking site. Dephosphorylated by PTPRJ at Tyr-1349 and Tyr-1365. Dephosphorylated by PTPN1 and PTPN2.
  • Ubiquitinated. Ubiquitination by CBL regulates MET endocytosis, resulting in decreasing plasma membrane receptor abundance, and in endosomal degradation and/or recycling of internalized receptors.
  • (Microbial infection) Tyrosine phosphorylation is stimulated by L.monocytogenes InlB. Tyrosine phosphorylation is maximal 10-20 minutes after treatment with InlB and disappears by 60 minutes. The phosphorylated residues were not identified.
  • Glycosylation at Asn45, Asn106, Asn149, Asn202, Asn399, Asn405, Asn607, Asn635, Asn785, Asn879, Asn930, Asn998, and Asn1171
  • Ubiquitination at Lys962
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • MET_HUMAN (680)

Other Protein References for MET Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

Domains & Families for MET Gene

Gene Families for MET Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for MET Gene

InterPro:
Blocks:
  • Tyrosine protein kinase, active site
  • Cell surface receptor IPT/TIG

Suggested Antigen Peptide Sequences for MET Gene

GenScript: Design optimal peptide antigens:
  • MET protein (A0PJF7_HUMAN)
  • Met proto-oncogene (Hepatocyte growth factor receptor), isoform CRA_c (A1L467_HUMAN)
  • cDNA FLJ51931, highly similar to Hepatocyte growth factor receptor (EC 2.7.10.1) (B4DPY6_HUMAN)
  • Soluble MET variant 1 (B5A929_HUMAN)
  • Soluble MET variant 2 (B5A930_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P08581

UniProtKB/Swiss-Prot:

MET_HUMAN :
  • The kinase domain is involved in SPSB1 binding.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family.
Domain:
  • The kinase domain is involved in SPSB1 binding.
  • The beta-propeller Sema domain mediates binding to HGF.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family.
genes like me logo Genes that share domains with MET: view

Function for MET Gene

Products:

  1. Animal Models for research
  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Molecular function for MET Gene

UniProtKB/Swiss-Prot Function:
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells. May regulate cortical bone osteogenesis (By similarity).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for Listeria monocytogenes internalin InlB, mediating entry of the pathogen into cells.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence={ECO:0000255|PROSITE-ProRule:PRU10028};.
UniProtKB/Swiss-Prot EnzymeRegulation:
In its inactive state, the C-terminal tail interacts with the catalytic domain and inhibits the kinase activity. Upon ligand binding, the C-terminal tail is displaced and becomes phosphorylated, thus increasing the kinase activity.
GENATLAS Biochemistry:
met proto-oncogene,transmembrane receptor (tyrosine kinase) for hepatocyte growth factor,with two alternatively spliced isoforms,important regulator of cell proliferation and differentiation,organ regeneration,embryogenesis and tumorogenesis,amplified in the glioblastomas,mutated in childhood hepatocellular carcinomas and hereditary papillary renal carcinomas (role in the acceleration of carcinogenesis),paralog to MST1R

Enzyme Numbers (IUBMB) for MET Gene

Phenotypes From GWAS Catalog for MET Gene

Gene Ontology (GO) - Molecular Function for MET Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity TAS --
GO:0004714 transmembrane receptor protein tyrosine kinase activity IBA 21873635
GO:0005008 hepatocyte growth factor-activated receptor activity IBA 21873635
genes like me logo Genes that share ontologies with MET: view
genes like me logo Genes that share phenotypes with MET: view

Human Phenotype Ontology for MET Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MET Gene

MGI Knock Outs for MET:
  • Met Met<tm1Cbm>
  • Met Met<tm1.1Sst>
  • Met Met<tm2.1Cbm>
  • Met Met<tm1.1Ics>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MET

No data available for Transcription Factor Targets and HOMER Transcription for MET Gene

Localization for MET Gene

Subcellular locations from UniProtKB/Swiss-Prot for MET Gene

Membrane. Single-pass type I membrane protein.
[Isoform 3]: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MET gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 3
nucleus 3
cytosol 3
mitochondrion 2
endoplasmic reticulum 2
endosome 2
lysosome 2
golgi apparatus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MET Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS,IBA 21873635
GO:0009925 basal plasma membrane IDA 15314156
GO:0009986 cell surface HDA 19581412
genes like me logo Genes that share ontologies with MET: view

Pathways & Interactions for MET Gene

PathCards logo

SuperPathways for MET Gene

SuperPathway Contained pathways
1 RET signaling
Frs2-mediated activation
.95
GRB2 events in EGFR signaling
.95
MAPK1/MAPK3 signaling
.95
Prolonged ERK activation events
.95
RAF/MAP kinase cascade
.95
SHC1 events in EGFR signaling
.95
Signaling by Leptin
.95
SOS-mediated signalling
.95
VEGFR2 mediated cell proliferation
.95
ARMS-mediated activation
.95
Signalling to ERKs
.95
Signalling to p38 via RIT and RIN
.95
Signalling to RAS
.95
Interleukin receptor SHC signaling
.95
Interleukin-3, 5 and GM-CSF signaling
.94
Interleukin-2 signaling
.94
Downstream signal transduction
.94
Signaling by PDGF
.94
DAP12 signaling
.92
RET signaling
.92
Insulin receptor signalling cascade
.92
Signaling by Insulin receptor
.92
IRS-mediated signalling
.91
Signaling by EGFR
.90
FCERI mediated MAPK activation
.90
IGF1R signaling cascade
.90
IRS-related events triggered by IGF1R
.90
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
.90
DAP12 interactions
.89
NCAM signaling for neurite out-growth
.89
NGF signalling via TRKA from the plasma membrane
.87
MAPK family signaling cascades
.87
Signaling by SCF-KIT
.85
Signalling by NGF
.81
Fc epsilon receptor (FCERI) signaling
.79
VEGFA-VEGFR2 Pathway
.78
Signaling by VEGF
.76
Gastrin-CREB signalling pathway via PKC and MAPK
.55
2 Apoptotic Pathways in Synovial Fibroblasts
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
Apoptotic Pathways in Synovial Fibroblasts
.84
p53 Mediated Apoptosis
.84
DHA Signaling
.74
Telomerase Components in Cell Signaling
.72
PPAR Pathway
.66
Rac1 Pathway
.65
Actin-Based Motility by Rho Family GTPases
.62
ERK5 Signaling
.61
eIF2 Pathway
.60
Nuclear Receptor Activation by Vitamin-A
.57
3 GPCR Pathway
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
Pancreatic Adenocarcinoma
.59
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
P2Y Receptor Signaling
.38
4 PI3K/AKT activation
Negative regulation of the PI3K/AKT network
.93
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
.93
PIP3 activates AKT signaling
.91
Role of LAT2/NTAL/LAB on calcium mobilization
.91
GAB1 signalosome
.89
PI3K/AKT activation
.89
Constitutive Signaling by Aberrant PI3K in Cancer
.75
PI3K/AKT Signaling in Cancer
.72
5 MET promotes cell motility
MET promotes cell motility
.45
Signaling by MET
.45
MET activates PTK2 signaling
.01
MET activates RAP1 and RAC1
.01
MET activates RAS signaling
.01
MET interacts with TNS proteins
.01
MET Receptor Activation
.01
MET receptor recycling
.01
genes like me logo Genes that share pathways with MET: view

Pathways by source for MET Gene

5 GeneGo (Thomson Reuters) pathways for MET Gene
  • Cell adhesion PLAU signaling
  • Cell adhesion_Cadherin-mediated cell adhesion
  • Development HGF signaling pathway
  • Signal transduction AKT signaling
  • Signal transduction IP3 signaling
1 Tocris pathway for MET Gene
62 Qiagen pathways for MET Gene
  • 14-3-3 Induced Intracellular Signaling
  • Actin Nucleation and Branching
  • Actin Nucleation by ARP-WASP Complex
  • Actin-Based Motility by Rho Family GTPases
  • Activation of cAMP-Dependent PKA
1 Cell Signaling Technology pathway for MET Gene

SIGNOR curated interactions for MET Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for MET Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0001886 endothelial cell morphogenesis IDA 14500721
GO:0001889 liver development IBA 21873635
GO:0006468 protein phosphorylation IEA --
GO:0006909 phagocytosis IBA 21873635
genes like me logo Genes that share ontologies with MET: view

Drugs & Compounds for MET Gene

Products:

  1. Drug products for research

(141) Drugs for MET Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Crizotinib Approved Pharma Target, inhibitor, Inhibition, Biomarker C-MET/ALK inhibitor,potent and ATP-competitve, Potent c-MET/ALK inhibitor, cMET Inhibitors, Kinase Inhibitors, Anaplastic lymphoma kinase (ALK) inhibitor 146
cabozantinib Approved, Investigational Pharma Target, antagonist, inhibitor Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 0
capmatinib Approved, Investigational Pharma Target, inhibitor 0
Levoleucovorin Approved, Investigational Pharma 3859,989
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Potent pro-apoptotic anticancer agent; activates caspase-3, Platinum 3624

(34) Additional Compounds for MET Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
 58-64-0
Norleual
334994-34-2
PF 04217903 mesylate
956906-93-7
SGX 523
1022150-57-7

(5) Tocris Compounds for MET Gene

Compound Action Cas Number
Norleual Highly potent HGF/c-MET inhibitor; also AT4 antagonist 334994-34-2
PF 04217903 mesylate Highly selective MET inhibitor 956906-93-7
PHA 665752 Potent and selective MET inhibitor 477575-56-7
SGX 523 Selective and potent c-MET kinase inhibitor 1022150-57-7
SU 11274 Selective inhibitor of MET kinase activity 658084-23-2

(28) ApexBio Compounds for MET Gene

Compound Action Cas Number
(R)-Crizotinib C-MET/ALK inhibitor,potent and ATP-competitve 877399-52-5
Altiratinib c-MET/TIE-2/VEGFR inhibitor 1345847-93-9
AMG-208 C-Met inhibitor,potent and highly selective 1002304-34-8
AMG-458 Potent c-Met inhibitor 913376-83-7
BMS-777607 C-Met inhibitor, potent and selective 1025720-94-8
BMS-794833 Met/VEGFR-2 inhibitor,potent and ATP-competitive 1174046-72-0
Cabozantinib (XL184, BMS-907351) VEGFR2/Met/Ret/Kit/FLT//AXL inhibitor 849217-68-1
Cabozantinib malate (XL184) MET andVEGF receptor2 inhibitor 1140909-48-3
EMD-1214063 C-Met inhibitor,potent and selective 1100598-32-0
Foretinib (GSK1363089) VEGF and HGF receptor inhibitor 849217-64-7
Golvatinib (E7050) C-Met/VEGFR-2 inhibitor 928037-13-2
INCB28060 C-Met inhibitor,ATP-competitive and novel 1029712-80-8
JNJ-38877605 C-Met inhibitor,ATP-competitive 943540-75-8
LY2801653 MET inhibitor 1206799-15-6
MGCD-265 Met/Flt/Flk/Ron/Tie-2 inhibitor 875337-44-3
MK-2461 C-Met (WT/mutants) inhibitor 917879-39-1
MK-8033 C-MET inhibitor 1001917-37-8
NPS-1034 MET inhibitor 1221713-92-3
NVP-BVU972 C-Met inhibitor,potent and selective 1185763-69-2
PF-04217903 C-Met inhibitor,selective and ATP-competitive 956905-27-4
PF-04217903 methanesulfonate C-Met inhibitor,selective and ATP-competitive 956906-93-7
PHA-665752 C-Met inhibitor,potent and ATP-competitive 477575-56-7
SGX-523 MET inibitor, highly selective, ATP-competitive 1022150-57-7
SU11274 C-Met inhibitor,potent and selective 658084-23-2
SU5416 VEGF receptor inhibitor and AHR agonist 204005-46-9
TAE226 (NVP-TAE226) FAK inhibitor,potent and ATP-competitive 761437-28-9
Tivantinib (ARQ 197) C-Met inhibitor,non-ATP-competitive 905854-02-6
ZM 323881 HCl 193000-39-4
genes like me logo Genes that share compounds with MET: view

Transcripts for MET Gene

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mRNA/cDNA for MET Gene

4 REFSEQ mRNAs :
39 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MET

Alternative Splicing Database (ASD) splice patterns (SP) for MET Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b
SP1: -
SP2: - -
SP3:

Relevant External Links for MET Gene

GeneLoc Exon Structure for
MET

Expression for MET Gene

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  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MET Gene

mRNA expression in normal human tissues for MET Gene
mRNA expression by GTEx for MET GenemRNA expression by BioGPS for MET Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MET Gene

This gene is overexpressed in Serum (29.7), Amniocyte (16.0), Breast (8.5), and Pancreas (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MET Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MET

SOURCE GeneReport for Unigene cluster for MET Gene:

Hs.132966

mRNA Expression by UniProt/SwissProt for MET Gene:

P08581-MET_HUMAN
Tissue specificity: Expressed in normal hepatocytes as well as in epithelial cells lining the stomach, the small and the large intestine. Found also in basal keratinocytes of esophagus and skin. High levels are found in liver, gastrointestinal tract, thyroid and kidney. Also present in the brain. Expressed in metaphyseal bone (at protein level) (PubMed:26637977).

Evidence on tissue expression from TISSUES for MET Gene

  • Liver(4.7)
  • Nervous system(4.7)
  • Intestine(3.4)
  • Lung(3.3)
  • Kidney(3.1)
  • Skin(2.9)
  • Blood(2.8)
  • Heart(2.7)
  • Stomach(2.7)
  • Muscle(2.7)
  • Thyroid gland(2.6)
  • Lymph node(2.6)
  • Pancreas(2.5)
  • Bone marrow(2.4)
  • Spleen(2.4)
  • Gall bladder(2.3)
  • Eye(2.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for MET Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • nervous
  • reproductive
  • skeletal muscle
  • skeleton
  • urinary
Regions:
Head and neck:
  • brain
  • cerebellum
  • cranial nerve
  • ear
  • eye
  • head
  • inner ear
  • middle ear
  • mouth
  • outer ear
  • salivary gland
  • skull
Thorax:
  • breast
  • esophagus
Abdomen:
  • kidney
  • liver
  • spleen
Pelvis:
  • testicle
Limb:
  • digit
  • finger
  • foot
  • hand
  • lower limb
  • nail
  • toe
  • upper limb
General:
  • blood vessel
  • coagulation system
  • peripheral nerve
  • peripheral nervous system
  • skin
genes like me logo Genes that share expression patterns with MET: view

Primer products for research

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for MET Gene

Orthologs for MET Gene

This gene was present in the common ancestor of animals.

Orthologs for MET Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia MET 29 30
  • 99.52 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia MET 29 30
  • 90.92 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia MET 29 30
  • 90.46 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Met 29 16 30
  • 86.44 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Met 29
  • 85.17 (n)
Oppossum
(Monodelphis domestica)
 Mammalia MET 30
  • 85 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia MET 30
  • 81 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves C-MET 30
  • 74 (a)
 OneToOne
MET 29
  • 72.08 (n)
Lizard
(Anolis carolinensis)
 Reptilia MET 30
  • 70 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia met 29
  • 66.01 (n)
African clawed frog
(Xenopus laevis)
 Amphibia met-A 29
Zebrafish
(Danio rerio)
 Actinopterygii met 29 30
  • 56.06 (n)
 OneToOne
Dr.18290 29
Worm
(Caenorhabditis elegans)
 Secernentea F11E6.8 31
  • 46 (a)
T14E8.1a 31
  • 39 (a)
T14E8.1b 31
  • 39 (a)
kin-16 31
  • 36 (a)
kin-23 31
  • 33 (a)
R09D1.12 31
  • 33 (a)
F09A5.2 31
  • 31 (a)
F09G2.1 31
  • 31 (a)
R09D1.13 31
  • 31 (a)
svh-2 30
  • 19 (a)
 OneToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 30
  • 46 (a)
 OneToMany
Sea Vase
(Ciona intestinalis)
 Ascidiacea Cin.8531 29
Species where no ortholog for MET was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for MET Gene

ENSEMBL:
Gene Tree for MET (if available)
TreeFam:
Gene Tree for MET (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MET: view image
Alliance of Genome Resources:
Additional Orthologs for MET

Paralogs for MET Gene

Paralogs for MET Gene

(80) SIMAP similar genes for MET Gene using alignment to 22 proteins:

  • MET_HUMAN
  • A0PJF7_HUMAN
  • B4DPY6_HUMAN
  • B5A929_HUMAN
  • B5A930_HUMAN
  • B5A931_HUMAN
  • B5A933_HUMAN
  • B5A934_HUMAN
  • B5A935_HUMAN
  • B5A936_HUMAN
  • B5A937_HUMAN
  • B5A938_HUMAN
  • B5A939_HUMAN
  • B5A940_HUMAN
  • B5A941_HUMAN
  • B5A942_HUMAN
  • B5A943_HUMAN
  • C9JKM5_HUMAN
  • H7C130_HUMAN
  • H7C174_HUMAN
  • Q14825_HUMAN
  • Q9UEJ3_HUMAN
genes like me logo Genes that share paralogs with MET: view

Variants for MET Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MET Gene