This gene encodes a member of the alpha/beta hydrolase superfamily. It is imprinted, exhibiting preferential expression from the paternal allele in fetal tissues, and isoform-specific imprinting in lymphocytes. The loss of imprinting of this gene has been linked to certain types of cancer and may be due to promotor switching. The encoded protein may play a role in development. ... See more...

Aliases for MEST Gene

Aliases for MEST Gene

  • Mesoderm Specific Transcript 2 3 5
  • PEG1 2 3 4
  • Mesoderm-Specific Transcript Homolog Protein 3 4
  • Paternally-Expressed Gene 1 Protein 3 4
  • Mesoderm Specific Transcript (Mouse) Homolog 2
  • Mesoderm Specific Transcript Homolog (Mouse) 2
  • Paternally-Expressed Gene 1 2
  • EC 3.-.-.- 4
  • MEST 5

External Ids for MEST Gene

Previous GeneCards Identifiers for MEST Gene

  • GC07P128602
  • GC07P129665
  • GC07P129679
  • GC07P129719
  • GC07P129913
  • GC07P130126
  • GC07P124488

Summaries for MEST Gene

Entrez Gene Summary for MEST Gene

  • This gene encodes a member of the alpha/beta hydrolase superfamily. It is imprinted, exhibiting preferential expression from the paternal allele in fetal tissues, and isoform-specific imprinting in lymphocytes. The loss of imprinting of this gene has been linked to certain types of cancer and may be due to promotor switching. The encoded protein may play a role in development. Alternatively spliced transcript variants encoding multiple isoforms have been identified for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3 and 4, and the long arm of chromosomes 6 and 15. [provided by RefSeq, Dec 2011]

GeneCards Summary for MEST Gene

MEST (Mesoderm Specific Transcript) is a Protein Coding gene. Diseases associated with MEST include Uniparental Disomy Of Chromosome 7 and Kidney Cortex Disease. Gene Ontology (GO) annotations related to this gene include hydrolase activity. An important paralog of this gene is ABHD5.

Gene Wiki entry for MEST Gene

Additional gene information for MEST Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MEST Gene

Genomics for MEST Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MEST Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J130485 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +0.4 434 2 CEBPG GATAD2A CTCF TFE3 NFKBIZ TARDBP ZHX2 LARP7 ZNF143 RBFOX2 ENSG00000277269 ENSG00000278055 MEST COPG2 MESTIT1
GH07J130488 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 600.4 +5.7 5717 7.8 CTCF TEAD4 PRDM10 LEF1 IKZF1 JUND POLR2A MTA1 REST NR2C1 MESTIT1 MEST COPG2 CPA5 ENSG00000278055 ENSG00000274500 MIR335 ENSG00000270823
GH07J130487 Enhancer 0.2 ENCODE 600.7 +1.5 1503 0 ENSG00000277269 ENSG00000278055 MEST COPG2 MESTIT1
GH07J130362 Promoter/Enhancer 2.1 VISTA FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 31.6 -117.1 -117091 12.7 SP1 HNRNPL GATAD2A PRDM10 ZNF629 REST TFE3 ZNF692 RCOR2 POLR2A LOC105375504 lnc-CEP41-2 CPA5 CPA1 CPA2 MKLN1 MEST ENSG00000238072 KLHDC10 NRF1
GH07J130354 Enhancer 1.4 Ensembl ENCODE CraniofacialAtlas dbSUPER 29.7 -128.6 -128611 5.7 CREB1 TEAD4 PRDM10 ZNF629 REST ZNF692 ZNF174 JUND PRDM1 ZIC2 CPA5 MEST NRF1 CPA1 KLHDC10 CPA4 CPA2 COPG2 LOC105375503 piR-57134-102
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MEST on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MEST

Top Transcription factor binding sites by QIAGEN in the MEST gene promoter:
  • LyF-1
  • NF-AT
  • NF-AT1
  • NF-AT4

Genomic Locations for MEST Gene

Genomic Locations for MEST Gene
chr7:130,486,171-130,506,465
(GRCh38/hg38)
Size:
20,295 bases
Orientation:
Plus strand
chr7:130,126,012-130,146,133
(GRCh37/hg19)
Size:
20,122 bases
Orientation:
Plus strand

Genomic View for MEST Gene

Genes around MEST on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MEST Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MEST Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEST Gene

Proteins for MEST Gene

  • Protein details for MEST Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5EB52-MEST_HUMAN
    Recommended name:
    Mesoderm-specific transcript homolog protein
    Protein Accession:
    Q5EB52
    Secondary Accessions:
    • B2R6S1
    • O14973
    • O15007
    • Q6AI49
    • Q92571

    Protein attributes for MEST Gene

    Size:
    335 amino acids
    Molecular mass:
    38830 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MEST Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MEST Gene

Post-translational modifications for MEST Gene

  • Glycosylation at Asn163
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MEST Gene

Domains & Families for MEST Gene

Gene Families for MEST Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MEST Gene

Suggested Antigen Peptide Sequences for MEST Gene

GenScript: Design optimal peptide antigens:
  • Paternally-expressed gene 1 protein (MEST_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5EB52

UniProtKB/Swiss-Prot:

MEST_HUMAN :
  • Belongs to the AB hydrolase superfamily.
Family:
  • Belongs to the AB hydrolase superfamily.
genes like me logo Genes that share domains with MEST: view

Function for MEST Gene

Molecular function for MEST Gene

GENATLAS Biochemistry:
mesoderm-specific transcript,expressed in fetal tissues from the paternal chromosome and in hydatidiform mole of androgenic origin,identical to the murine imprinted gene Peg1,unlikely to be a contributor to Silver-Russell syndrome with aberrant imprinting in invasive breast carcinomas

Enzyme Numbers (IUBMB) for MEST Gene

Phenotypes From GWAS Catalog for MEST Gene

Gene Ontology (GO) - Molecular Function for MEST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with MEST: view
genes like me logo Genes that share phenotypes with MEST: view

Animal Models for MEST Gene

MGI Knock Outs for MEST:
  • Mest Mest<tm1Masu>

Animal Model Products

CRISPR Products

miRNA for MEST Gene

miRTarBase miRNAs that target MEST

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MEST

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MEST Gene

Localization for MEST Gene

Subcellular locations from UniProtKB/Swiss-Prot for MEST Gene

Endoplasmic reticulum membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MEST gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
golgi apparatus 4
cytosol 3
plasma membrane 2
cytoskeleton 2
mitochondrion 2
nucleus 2
peroxisome 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MEST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum ISS --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome HDA 19199708
genes like me logo Genes that share ontologies with MEST: view

Pathways & Interactions for MEST Gene

PathCards logo

SuperPathways for MEST Gene

No Data Available

SIGNOR curated interactions for MEST Gene

Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for MEST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007498 mesoderm development TAS 9158153
GO:0010883 regulation of lipid storage IBA 21873635
genes like me logo Genes that share ontologies with MEST: view

No data available for Pathways by source for MEST Gene

Drugs & Compounds for MEST Gene

No Compound Related Data Available

Transcripts for MEST Gene

mRNA/cDNA for MEST Gene

6 REFSEQ mRNAs :
22 NCBI additional mRNA sequence :
17 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MEST

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MEST Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a ·
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - - - - - -
SP5: - - - - - - - - - - - - -
SP6: - -
SP7: - - - - - - - -
SP8: - - - -
SP9: - - - - - - - - - - - -
SP10: - -
SP11: - - - - - - -
SP12: -
SP13: -
SP14:
SP15: - - - - - - -
SP16: - -

ExUns: 14b ^ 15a · 15b · 15c ^ 16a · 16b ^ 17 ^ 18a · 18b · 18c · 18d
SP1: - -
SP2: - -
SP3: - -
SP4: - - - -
SP5:
SP6: - - - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for MEST Gene

GeneLoc Exon Structure for
MEST

Expression for MEST Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MEST Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MEST Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x8.9), Adipose - Subcutaneous (x6.0), and Adrenal Gland (x4.0).

Protein differential expression in normal tissues from HIPED for MEST Gene

This gene is overexpressed in Placenta (28.3) and Adipocyte (19.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MEST Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MEST

SOURCE GeneReport for Unigene cluster for MEST Gene:

Hs.270978

mRNA Expression by UniProt/SwissProt for MEST Gene:

Q5EB52-MEST_HUMAN
Tissue specificity: Highly expressed in hydatidiform moles, but barely expressed in dermoid cysts. Biallelic expression is detected in blood lymphocytes. Seems to imprinted in an isoform-specific manner rather than in a tissue-specific manner in lymphocytes. Isoform 1 is expressed only from the paternal allele. Isoform 2 is expressed from both the paternal allele and the maternal allele.

Evidence on tissue expression from TISSUES for MEST Gene

  • Muscle(4.6)
  • Intestine(4.5)
  • Nervous system(4.3)
  • Heart(3.7)
  • Lung(3.1)
  • Kidney(2.9)
  • Liver(2.6)
  • Spleen(2.6)
  • Adrenal gland(2.3)
  • Skin(2.2)
  • Blood(2.2)
  • Pancreas(2.2)
genes like me logo Genes that share expression patterns with MEST: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MEST Gene

Orthologs for MEST Gene

This gene was present in the common ancestor of chordates.

Orthologs for MEST Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MEST 30 31
  • 99.9 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MEST 30 31
  • 93.03 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MEST 30 31
  • 91.94 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Mest 30
  • 91.74 (n)
Mouse
(Mus musculus)
Mammalia Mest 30 17 31
  • 90.85 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia MEST 31
  • 85 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia MEST 31
  • 78 (a)
OneToOne
Chicken
(Gallus gallus)
Aves MEST 30 31
  • 72.53 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia MEST 31
  • 75 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia mest 30
  • 69.34 (n)
Zebrafish
(Danio rerio)
Actinopterygii mest 30 31
  • 68.31 (n)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11262 30
Species where no ortholog for MEST was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MEST Gene

ENSEMBL:
Gene Tree for MEST (if available)
TreeFam:
Gene Tree for MEST (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MEST: view image

Paralogs for MEST Gene

Pseudogenes.org Pseudogenes for MEST Gene

genes like me logo Genes that share paralogs with MEST: view

Variants for MEST Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MEST Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
rs863223353 Likely Pathogenic: Childhood-Onset Schizophrenia 130,499,898(+) C/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for MEST Gene

Structural Variations from Database of Genomic Variants (DGV) for MEST Gene

Variant ID Type Subtype PubMed ID
esv3572140 CNV loss 25503493
nsv472521 CNV novel sequence insertion 20440878
nsv472979 CNV novel sequence insertion 20440878
nsv474824 CNV novel sequence insertion 20440878
nsv475312 CNV novel sequence insertion 20440878
nsv476708 CNV novel sequence insertion 20440878
nsv477727 CNV novel sequence insertion 20440878
nsv478321 CNV novel sequence insertion 20440878
nsv479379 CNV novel sequence insertion 20440878
nsv481112 CNV novel sequence insertion 20440878
nsv481143 CNV novel sequence insertion 20440878
nsv481360 CNV novel sequence insertion 20440878
nsv481618 CNV novel sequence insertion 20440878
nsv831130 CNV loss 17160897
nsv831131 CNV loss 17160897
nsv966888 CNV duplication 23825009

Variation tolerance for MEST Gene

Residual Variation Intolerance Score: 41.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.98; 20.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MEST Gene

Human Gene Mutation Database (HGMD)
MEST
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MEST

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEST Gene

Disorders for MEST Gene

MalaCards: The human disease database

(20) MalaCards diseases for MEST Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
uniparental disomy of chromosome 7
  • upd(7)
kidney cortex disease
adult cystic nephroma
  • multilocular cystic nephroma, mixed epithelial stromal tumour and renal epithelial stromal tumour
mixed epithelial stromal tumour
nephroma
  • benign nephroma
- elite association - COSMIC cancer census association via MalaCards
Search MEST in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MEST

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with MEST: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MEST Gene

Publications for MEST Gene

  1. Genomic imprinting and chromosomal localization of the human MEST gene. (PMID: 8884280) Nishita Y … Takagi N (Genomics 1996) 2 3 4 23
  2. Defective neuronal migration and inhibition of bipolar to multipolar transition of migrating neural cells by Mesoderm-Specific Transcript, Mest, in the developing mouse neocortex. (PMID: 28501506) Ji L … Huh SO (Neuroscience 2017) 2 3
  3. Mesoderm-specific transcript (MEST) is a negative regulator of human adipocyte differentiation. (PMID: 26119994) Karbiener M … Scheideler M (International journal of obesity (2005) 2015) 2 3
  4. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey LT … EPICURO/Spanish Bladder Cancer Study investigators (European urology 2010) 3 41
  5. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PMID: 20628624) Johnatty SE … Australian Cancer Study (Ovarian Cancer) (PLoS genetics 2010) 3 41

Products for MEST Gene

Sources for MEST Gene