Aliases for MESP1 Gene

Aliases for MESP1 Gene

  • Mesoderm Posterior BHLH Transcription Factor 1 2 3 5
  • BHLHc5 2 3 4
  • Mesoderm Posterior Basic Helix-Loop-Helix Transcription Factor 1 2 3
  • Class C Basic Helix-Loop-Helix Protein 5 3 4
  • Mesoderm Posterior Protein 1 3 4
  • Mesoderm Posterior 1 Homolog (Mouse) 2
  • Mesoderm Posterior 1 Homolog 3
  • MGC10676 2
  • BHLHC5 4
  • MESP1 5

External Ids for MESP1 Gene

Previous GeneCards Identifiers for MESP1 Gene

  • GC15M087880
  • GC15M088022
  • GC15M088095
  • GC15M090291
  • GC15M066406

Summaries for MESP1 Gene

GeneCards Summary for MESP1 Gene

MESP1 (Mesoderm Posterior BHLH Transcription Factor 1) is a Protein Coding gene. Diseases associated with MESP1 include Myasthenic Syndrome, Congenital, 20, Presynaptic and Double Outlet Right Ventricle. Among its related pathways are Cardiac Progenitor Differentiation. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein dimerization activity. An important paralog of this gene is MESP2.

UniProtKB/Swiss-Prot Summary for MESP1 Gene

  • Transcription factor. Plays a role in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm. Defines the rostrocaudal patterning of the somites by participating in distinct Notch pathways (By similarity).

Additional gene information for MESP1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MESP1 Gene

Genomics for MESP1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MESP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MESP1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MESP1

Top Transcription factor binding sites by QIAGEN in the MESP1 gene promoter:
  • AhR
  • HOXA9
  • HOXA9B
  • HTF
  • Lmo2
  • Meis-1
  • Meis-1a
  • Nkx2-5

Genomic Locations for MESP1 Gene

Genomic Locations for MESP1 Gene
chr15:89,734,772-89,751,310
(GRCh38/hg38)
Size:
16,539 bases
Orientation:
Minus strand
chr15:90,291,892-90,294,541
(GRCh37/hg19)
Size:
2,650 bases
Orientation:
Minus strand

Genomic View for MESP1 Gene

Genes around MESP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MESP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MESP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MESP1 Gene

Proteins for MESP1 Gene

  • Protein details for MESP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRJ9-MESP1_HUMAN
    Recommended name:
    Mesoderm posterior protein 1
    Protein Accession:
    Q9BRJ9
    Secondary Accessions:
    • Q9NSF1
    • Q9NSF2

    Protein attributes for MESP1 Gene

    Size:
    268 amino acids
    Molecular mass:
    28501 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The N- and C-terminal domains are separated by a 2-repeat G-Q region.

neXtProt entry for MESP1 Gene

Post-translational modifications for MESP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MESP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MESP1 Gene

Domains & Families for MESP1 Gene

Gene Families for MESP1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for MESP1 Gene

InterPro:
Blocks:
  • Basic helix-loop-helix dimerization domain bHLH
ProtoNet:

Suggested Antigen Peptide Sequences for MESP1 Gene

GenScript: Design optimal peptide antigens:
  • Class C basic helix-loop-helix protein 5 (MESP1_HUMAN)
genes like me logo Genes that share domains with MESP1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MESP1 Gene

Function for MESP1 Gene

Molecular function for MESP1 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor. Plays a role in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm. Defines the rostrocaudal patterning of the somites by participating in distinct Notch pathways (By similarity).

Phenotypes From GWAS Catalog for MESP1 Gene

Gene Ontology (GO) - Molecular Function for MESP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IDA 18297060
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA,IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IEA,IBA 21873635
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with MESP1: view
genes like me logo Genes that share phenotypes with MESP1: view

Animal Models for MESP1 Gene

MGI Knock Outs for MESP1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MESP1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for MESP1 Gene

Localization for MESP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MESP1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MESP1 gene
Compartment Confidence
nucleus 4
extracellular 2
cytoskeleton 2
plasma membrane 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MESP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IBA,IC 18297060
genes like me logo Genes that share ontologies with MESP1: view

Pathways & Interactions for MESP1 Gene

PathCards logo

SuperPathways for MESP1 Gene

genes like me logo Genes that share pathways with MESP1: view

Pathways by source for MESP1 Gene

1 BioSystems pathway for MESP1 Gene

Gene Ontology (GO) - Biological Process for MESP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001707 mesoderm formation IBA 21873635
GO:0001756 somitogenesis IBA --
GO:0001947 heart looping IEA,ISS --
GO:0003007 heart morphogenesis IEA,IBA 21873635
GO:0003139 secondary heart field specification IEA,ISS --
genes like me logo Genes that share ontologies with MESP1: view

No data available for SIGNOR curated interactions for MESP1 Gene

Drugs & Compounds for MESP1 Gene

No Compound Related Data Available

Transcripts for MESP1 Gene

mRNA/cDNA for MESP1 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MESP1

Alternative Splicing Database (ASD) splice patterns (SP) for MESP1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b
SP1:
SP2: -

Relevant External Links for MESP1 Gene

GeneLoc Exon Structure for
MESP1

Expression for MESP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MESP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MESP1 Gene

This gene is overexpressed in Prostate (x4.7).

Protein differential expression in normal tissues from HIPED for MESP1 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MESP1 Gene



Protein tissue co-expression partners for MESP1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MESP1

SOURCE GeneReport for Unigene cluster for MESP1 Gene:

Hs.447531

Evidence on tissue expression from TISSUES for MESP1 Gene

  • Lung(4.1)
  • Muscle(2.7)
  • Heart(2.7)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with MESP1: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MESP1 Gene

Orthologs for MESP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MESP1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MESP1 30 31
  • 99.13 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MESP1 30 31
  • 82.42 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Mesp1 30 17 31
  • 74.55 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Mesp1 30
  • 71.87 (n)
Oppossum
(Monodelphis domestica)
Mammalia MESP1 31
  • 47 (a)
OneToOne
Chicken
(Gallus gallus)
Aves MESP2 31
  • 28 (a)
OneToMany
-- 31
  • 26 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia MESP1 31
  • 47 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii mespbb 31
  • 30 (a)
ManyToMany
mespba 31
  • 28 (a)
ManyToMany
BX572619.4 31
  • 26 (a)
ManyToMany
mespaa 31
  • 26 (a)
ManyToMany
mespab 31
  • 25 (a)
ManyToMany
Species where no ortholog for MESP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MESP1 Gene

ENSEMBL:
Gene Tree for MESP1 (if available)
TreeFam:
Gene Tree for MESP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MESP1: view image

Paralogs for MESP1 Gene

Paralogs for MESP1 Gene

(1) SIMAP similar genes for MESP1 Gene using alignment to 1 proteins:

  • MESP1_HUMAN
genes like me logo Genes that share paralogs with MESP1: view

Variants for MESP1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MESP1 Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
rs6496598 - p.Ala53Pro

Additional dbSNP identifiers (rs#s) for MESP1 Gene

Structural Variations from Database of Genomic Variants (DGV) for MESP1 Gene

Variant ID Type Subtype PubMed ID
nsv1046117 CNV gain 25217958
nsv570388 CNV loss 21841781
nsv952025 CNV deletion 24416366

Variation tolerance for MESP1 Gene

Gene Damage Index Score: 9.38; 88.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MESP1 Gene

Human Gene Mutation Database (HGMD)
MESP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MESP1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MESP1 Gene

Disorders for MESP1 Gene

MalaCards: The human disease database

(9) MalaCards diseases for MESP1 Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search MESP1 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with MESP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MESP1 Gene

Publications for MESP1 Gene

  1. Transcriptional regulation of Mesp1 and Mesp2 genes: differential usage of enhancers during development. (PMID: 11578861) Haraguchi S … Saga Y (Mechanisms of development 2001) 2 3 23
  2. MesP1: a novel basic helix-loop-helix protein expressed in the nascent mesodermal cells during mouse gastrulation. (PMID: 8787751) Saga Y … Taketo MM (Development (Cambridge, England) 1996) 2 3
  3. Aberrant expression of embryonic mesendoderm factor MESP1 promotes tumorigenesis. (PMID: 31761621) Tandon N … Liu Y (EBioMedicine 2019) 3
  4. MESP1 knock-down in human iPSC attenuates early vascular progenitor cell differentiation after completed primitive streak specification. (PMID: 30389344) Eskildsen TV … Sheikh SP (Developmental biology 2019) 3
  5. MESP1 loss‑of‑function mutation contributes to double outlet right ventricle. (PMID: 28677747) Zhang M … Yang YQ (Molecular medicine reports 2017) 3

Products for MESP1 Gene

  • Signalway ELISA kits for MESP1

Sources for MESP1 Gene