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Aliases for MEPCE Gene

Aliases for MEPCE Gene

  • Methylphosphate Capping Enzyme 2 3 5
  • Bicoid-Interacting Protein 3 Homolog 3 4
  • Bin3 Homolog 3 4
  • BCDIN3 3 4
  • Bin3, Bicoid-Interacting 3, Homolog (Drosophila) 2
  • 7SK SnRNA Methylphosphate Capping Enzyme 3
  • Bin3, Bicoid-Interacting 3, Homolog 3
  • EC 2.1.1.- 4
  • MePCE 4

External Ids for MEPCE Gene

Previous HGNC Symbols for MEPCE Gene

  • BCDIN3

Previous GeneCards Identifiers for MEPCE Gene

  • GC07P099866
  • GC07P100026
  • GC07P094659

Summaries for MEPCE Gene

GeneCards Summary for MEPCE Gene

MEPCE (Methylphosphate Capping Enzyme) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include S-adenosylmethionine-dependent methyltransferase activity.

UniProtKB/Swiss-Prot for MEPCE Gene

  • S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5-end of 7SK snRNA, leading to stabilize it.

Additional gene information for MEPCE Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEPCE Gene

Genomics for MEPCE Gene

GeneHancer (GH) Regulatory Elements for MEPCE Gene

Promoters and enhancers for MEPCE Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J100427 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 696.6 +4.5 4501 10.8 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 PPP1R35 MEPCE ZCWPW1 PIR54054 ZSCAN25 SRRT TRIM4 GIGYF1 ZNF3 PILRA
GH07J099471 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 70.1 -956.1 -956094 3 CLOCK DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC ZNF610 GLIS1 ZNF789 ZSCAN25 PPP1R35 PTCD1 TRRAP MEPCE TRIM4 STAG3L5P ZNF655 AP4M1
GH07J100475 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 52.8 +49.1 49057 4.4 HDGF PKNOX1 FOXA2 SMAD1 ARNT ZFP64 ARID4B SIN3A FEZF1 ZNF2 TSC22D4 ZSCAN25 SRRT TRIM4 GIGYF1 ZNF655 ZNF3 ENSG00000242798 STAG3L5P PPP1R35
GH07J100076 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 55.7 -348.6 -348595 6.7 CLOCK MLX DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 ZNF3 ZSCAN25 AP4M1 SRRT PPP1R35 MEPCE TRIM4 GIGYF1 ZNF655 ENSG00000242798
GH07J099616 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 50 -810.4 -810429 4.5 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC MEF2D SSRP1 ZNF585B ZSCAN25 TRRAP ZNF3 AP4M1 TRIM4 ZNF655 PTCD1 PPP1R35 ENSG00000242798 MEPCE
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MEPCE on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MEPCE gene promoter:
  • Nkx2-5
  • HOXA5
  • Egr-2
  • CREB
  • Zic3
  • C/EBPalpha
  • deltaCREB
  • Roaz
  • FOXO1
  • FOXO1a

Genomic Locations for MEPCE Gene

Genomic Locations for MEPCE Gene
chr7:100,428,698-100,434,126
(GRCh38/hg38)
Size:
5,429 bases
Orientation:
Plus strand
chr7:100,026,413-100,031,749
(GRCh37/hg19)
Size:
5,337 bases
Orientation:
Plus strand

Genomic View for MEPCE Gene

Genes around MEPCE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MEPCE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MEPCE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEPCE Gene

Proteins for MEPCE Gene

  • Protein details for MEPCE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L2J0-MEPCE_HUMAN
    Recommended name:
    7SK snRNA methylphosphate capping enzyme
    Protein Accession:
    Q7L2J0
    Secondary Accessions:
    • B3KP86
    • D6W5V7
    • Q9NPD4

    Protein attributes for MEPCE Gene

    Size:
    689 amino acids
    Molecular mass:
    74355 Da
    Quaternary structure:
    • Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, MEPCE/BCDIN3, SART3 proteins and 7SK and U6 snRNAs (PubMed:17643375, Ref.23). Interacts with METTL16 (PubMed:29051200).
    SequenceCaution:
    • Sequence=AAF74767.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH16396.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91040.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MEPCE Gene

    Alternative splice isoforms for MEPCE Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MEPCE Gene

Post-translational modifications for MEPCE Gene

  • Ubiquitination at isoforms=2635
  • Modification sites at PhosphoSitePlus

Other Protein References for MEPCE Gene

No data available for DME Specific Peptides for MEPCE Gene

Domains & Families for MEPCE Gene

Gene Families for MEPCE Gene

Protein Domains for MEPCE Gene

Suggested Antigen Peptide Sequences for MEPCE Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7L2J0

UniProtKB/Swiss-Prot:

MEPCE_HUMAN :
  • Belongs to the methyltransferase superfamily.
Family:
  • Belongs to the methyltransferase superfamily.
genes like me logo Genes that share domains with MEPCE: view

Function for MEPCE Gene

Molecular function for MEPCE Gene

UniProtKB/Swiss-Prot Function:
S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5-end of 7SK snRNA, leading to stabilize it.

Enzyme Numbers (IUBMB) for MEPCE Gene

Phenotypes From GWAS Catalog for MEPCE Gene

Gene Ontology (GO) - Molecular Function for MEPCE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0008168 methyltransferase activity IEA --
GO:0008171 O-methyltransferase activity IBA --
GO:0008173 RNA methyltransferase activity IDA 17643375
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity IDA 17643375
genes like me logo Genes that share ontologies with MEPCE: view
genes like me logo Genes that share phenotypes with MEPCE: view

Animal Models for MEPCE Gene

MGI Knock Outs for MEPCE:
  • Mepce Mepce<tm1.1(KOMP)Vlcg>

Animal Model Products

Clone Products

  • Addgene plasmids for MEPCE

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MEPCE Gene

Localization for MEPCE Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MEPCE gene
Compartment Confidence
nucleus 4
cytosol 3
plasma membrane 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MEPCE Gene

Pathways & Interactions for MEPCE Gene

SuperPathways for MEPCE Gene

No Data Available

Gene Ontology (GO) - Biological Process for MEPCE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0001510 RNA methylation IDA 17643375
GO:0016073 snRNA metabolic process IDA 17643375
GO:0032259 methylation IEA --
GO:0035562 negative regulation of chromatin binding IEA --
genes like me logo Genes that share ontologies with MEPCE: view

No data available for Pathways by source and SIGNOR curated interactions for MEPCE Gene

Drugs & Compounds for MEPCE Gene

(1) Additional Compounds for MEPCE Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
s-adenosylmethionine
  • (3S)-5'-[(3-amino-3-Carboxypropyl)methylsulfonio]-5'-deoxyadenosine, inner salt
  • [1-(Adenin-9-yl)-1,5-dideoxy-beta-D-ribofuranos-5-yl][(3S)-3-amino-3-carboxypropyl](methyl)sulfonium
  • Acylcarnitine
  • AdoMet
  • S-(5'-Deoxyadenosin-5'-yl)-L-methionine
485-80-3
genes like me logo Genes that share compounds with MEPCE: view

Transcripts for MEPCE Gene

Unigene Clusters for MEPCE Gene

Methylphosphate capping enzyme:
Representative Sequences:

Clone Products

  • Addgene plasmids for MEPCE

Alternative Splicing Database (ASD) splice patterns (SP) for MEPCE Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9
SP1:
SP2: - - - - -
SP3: - - - -
SP4: - -
SP5: - - -
SP6:
SP7: - -

Relevant External Links for MEPCE Gene

GeneLoc Exon Structure for
MEPCE
ECgene alternative splicing isoforms for
MEPCE

Expression for MEPCE Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MEPCE Gene

Protein differential expression in normal tissues from HIPED for MEPCE Gene

This gene is overexpressed in Lung (22.8), Peripheral blood mononuclear cells (14.9), and Heart (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MEPCE Gene



Protein tissue co-expression partners for MEPCE Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MEPCE Gene:

MEPCE

SOURCE GeneReport for Unigene cluster for MEPCE Gene:

Hs.178011

mRNA Expression by UniProt/SwissProt for MEPCE Gene:

Q7L2J0-MEPCE_HUMAN
Tissue specificity: Expressed in chronic myeloid leukemia cells, adrenal gland, brain, cerebellum, kidney, lung, mammary gland and testis. Weakly or not expressed in other tissues.

Evidence on tissue expression from TISSUES for MEPCE Gene

  • Nervous system(4.7)
  • Intestine(4.4)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with MEPCE: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MEPCE Gene

Orthologs for MEPCE Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MEPCE Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MEPCE 34 33
  • 99.13 (n)
OneToOne
cow
(Bos Taurus)
Mammalia BCDIN3 34
  • 92 (a)
OneToOne
MEPCE 33
  • 89.89 (n)
dog
(Canis familiaris)
Mammalia MEPCE 34 33
  • 91.41 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Mepce 16 34 33
  • 86.99 (n)
oppossum
(Monodelphis domestica)
Mammalia MEPCE 34
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MEPCE 34
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.110 33
zebrafish
(Danio rerio)
Actinopterygii MEPCE (1 of 2) 34
  • 46 (a)
OneToMany
mepce 34
  • 43 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG1239 34
  • 39 (a)
OneToMany
bin3 34
  • 15 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y17G7B.18 34
  • 38 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G51130 33
  • 47.88 (n)
rice
(Oryza sativa)
Liliopsida Os08g0540500 33
  • 46.83 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11343 34
  • 48 (a)
OneToOne
Species where no ortholog for MEPCE was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MEPCE Gene

ENSEMBL:
Gene Tree for MEPCE (if available)
TreeFam:
Gene Tree for MEPCE (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MEPCE: view image

Paralogs for MEPCE Gene

No data available for Paralogs for MEPCE Gene

Variants for MEPCE Gene

Sequence variations from dbSNP and Humsavar for MEPCE Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000000630 -- 100,432,796(+) G/A intron_variant
rs1000333534 -- 100,428,392(+) C/T upstream_transcript_variant
rs1000499934 -- 100,432,794(+) C/T intron_variant
rs1000645204 -- 100,427,491(+) G/C upstream_transcript_variant
rs1000676116 -- 100,427,923(+) C/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MEPCE Gene

Variant ID Type Subtype PubMed ID
nsv831071 CNV loss 17160897
nsv527107 CNV loss 19592680
esv2734888 CNV deletion 23290073
dgv1226e199 CNV deletion 23128226

Variation tolerance for MEPCE Gene

Residual Variation Intolerance Score: 9.65% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.94; 35.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MEPCE Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MEPCE

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEPCE Gene

Disorders for MEPCE Gene

Additional Disease Information for MEPCE

No disorders were found for MEPCE Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MEPCE Gene

Publications for MEPCE Gene

  1. Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. (PMID: 17643375) Jeronimo C … Coulombe B (Molecular cell 2007) 2 3 4 58
  2. Identification and characterization of a novel gene encoding a SEREX antigen in chronic myeloid leukaemia. (PMID: 12358911) Rogers SA … Lim SH (British journal of haematology 2002) 2 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for MEPCE Gene

  • Addgene plasmids for MEPCE

Sources for MEPCE Gene

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