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Aliases for MEP1A Gene

Aliases for MEP1A Gene

  • Meprin A Subunit Alpha 2 3 5
  • PABA Peptide Hydrolase 2 3 4
  • N-Benzoyl-L-Tyrosyl-P-Amino-Benzoic Acid Hydrolase Subunit Alpha 3 4
  • Meprin A, Alpha (PABA Peptide Hydrolase) 2 3
  • Endopeptidase-2 3 4
  • EC 4 56
  • PPH Alpha 3 4
  • BA268F1.1 (Meprin A Alpha (PABA Peptide Hydrolase)) 3
  • EC 3.4.24 56
  • PPHA 3

External Ids for MEP1A Gene

Previous GeneCards Identifiers for MEP1A Gene

  • GC06U990080
  • GC06P046757
  • GC06P046807
  • GC06P046869
  • GC06P046484

Summaries for MEP1A Gene

GeneCards Summary for MEP1A Gene

MEP1A (Meprin A Subunit Alpha) is a Protein Coding gene. Among its related pathways are Collagen chain trimerization. Gene Ontology (GO) annotations related to this gene include metalloendopeptidase activity and metallopeptidase activity. An important paralog of this gene is MEP1B.

Gene Wiki entry for MEP1A Gene

Additional gene information for MEP1A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEP1A Gene

Genomics for MEP1A Gene

GeneHancer (GH) Regulatory Elements for MEP1A Gene

Promoters and enhancers for MEP1A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I046793 Promoter/Enhancer 1.1 EPDnew ENCODE 550.8 -0.1 -55 0.2 SOX13 GATAD2A FOXA2 FOXA3 RARA RERE TCF7 BCL6 HNF4A NR2F6 GC06P046792 MEP1A
GH06I046770 Enhancer 1.3 FANTOM5 Ensembl ENCODE 11.2 -20.8 -20755 4 CTCF MEIS2 TFAP4 PKNOX1 FOXA2 TEAD4 MAX ZNF384 CEBPG TEAD3 PLA2G7 MEP1A TDRD6 ENSG00000236164 GC06P046792
GH06I046946 Enhancer 1.1 FANTOM5 Ensembl ENCODE dbSUPER 9.7 +155.1 155068 4 POLR2A JUN ZSCAN4 MAX NR2F2 MEP1A PLA2G7 ADGRF5 LOC105375080
GH06I046746 Promoter 0.5 EPDnew 10.4 -46.4 -46443 0.1 ANKRD66 MEP1A PLA2G7 GC06P046731
GH06I046900 Enhancer 0.5 dbSUPER 9.7 +109.3 109307 3.6 STAT1 GATA3 SCRT2 MIER2 REST ELF1 NR2F2 LOC101926962 ADGRF5 MEP1A SLC25A27 GC06P046865
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MEP1A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MEP1A gene promoter:

Genomic Locations for MEP1A Gene

Genomic Locations for MEP1A Gene
52,631 bases
Plus strand

Genomic View for MEP1A Gene

Genes around MEP1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MEP1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MEP1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEP1A Gene

Proteins for MEP1A Gene

  • Protein details for MEP1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Meprin A subunit alpha
    Protein Accession:
    Secondary Accessions:
    • A2RRM4
    • B0AZP9
    • B2RCS2
    • Q8TDC9
    • Q9H1R1

    Protein attributes for MEP1A Gene

    746 amino acids
    Molecular mass:
    84419 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Homotetramer consisting of disulfide-linked alpha subunits, homooligomer consisting of disulfide-linked alpha subunit homodimers, or heterotetramer of two alpha and two beta subunits formed by non-covalent association of two disulfide-linked heterodimers (By similarity). Interacts with MBL2 through its carbohydrate moiety. This interaction may inhibit its catalytic activity (By similarity).

neXtProt entry for MEP1A Gene

Selected DME Specific Peptides for MEP1A Gene


Post-translational modifications for MEP1A Gene

  • N-glycosylated; contains GlcNAc, galactose, mannose and a small amount of fucose.
  • Glycosylation at posLast=140140, isoforms=222, posLast=258258, isoforms=414, posLast=440440, posLast=447447, and isoforms=539

Other Protein References for MEP1A Gene

Domains & Families for MEP1A Gene

Gene Families for MEP1A Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for MEP1A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase M12A family.
  • Belongs to the peptidase M12A family.
genes like me logo Genes that share domains with MEP1A: view

Function for MEP1A Gene

Molecular function for MEP1A Gene

GENATLAS Biochemistry:
zinc metalloendopeptidase 1,meprin,alpha subunit,astacin family of metalloendopeptidases
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=110 uM for GRP {ECO:0000269 PubMed:17976009}; KM=18.0 uM for PTH 12-34 {ECO:0000269 PubMed:17976009}; KM=33.9 uM for secretin {ECO:0000269 PubMed:17976009}; KM=41.3 uM for substance P {ECO:0000269 PubMed:17976009}; KM=56.5 uM for LHRH {ECO:0000269 PubMed:17976009}; KM=73.2 uM for orcokinin {ECO:0000269 PubMed:17976009}; KM=292 uM for alpha-MSH {ECO:0000269 PubMed:17976009}; KM=125 uM for bradykinin {ECO:0000269 PubMed:17976009}; KM=200 uM for gastrin {ECO:0000269 PubMed:17976009};
UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic residues.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by several hydroxamate compounds, the most potent inhibitor is actinonin.

Enzyme Numbers (IUBMB) for MEP1A Gene

Gene Ontology (GO) - Molecular Function for MEP1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0005515 protein binding IPI 23123160
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with MEP1A: view
genes like me logo Genes that share phenotypes with MEP1A: view

Animal Models for MEP1A Gene

MGI Knock Outs for MEP1A:

Animal Model Products

CRISPR Products

miRNA for MEP1A Gene

miRTarBase miRNAs that target MEP1A

Inhibitory RNA Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MEP1A Gene

Localization for MEP1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for MEP1A Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MEP1A gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for MEP1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space TAS 8262185
GO:0005887 integral component of plasma membrane TAS 8262185
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0017090 meprin A complex IEA --
genes like me logo Genes that share ontologies with MEP1A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MEP1A Gene

Pathways & Interactions for MEP1A Gene

SuperPathways for MEP1A Gene

SuperPathway Contained pathways
1 Collagen chain trimerization
genes like me logo Genes that share pathways with MEP1A: view

Pathways by source for MEP1A Gene

1 KEGG pathway for MEP1A Gene

Gene Ontology (GO) - Biological Process for MEP1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007586 digestion TAS 9288916
genes like me logo Genes that share ontologies with MEP1A: view

No data available for SIGNOR curated interactions for MEP1A Gene

Drugs & Compounds for MEP1A Gene

No Compound Related Data Available

Transcripts for MEP1A Gene

mRNA/cDNA for MEP1A Gene

Unigene Clusters for MEP1A Gene

Meprin A, alpha (PABA peptide hydrolase):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MEP1A Gene

No ASD Table

Relevant External Links for MEP1A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MEP1A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MEP1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MEP1A Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x34.9) and Colon - Transverse (x16.7).

Protein differential expression in normal tissues from HIPED for MEP1A Gene

This gene is overexpressed in Pancreatic juice (56.5) and Fetal gut (11.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MEP1A Gene

Protein tissue co-expression partners for MEP1A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MEP1A Gene:


SOURCE GeneReport for Unigene cluster for MEP1A Gene:


Evidence on tissue expression from TISSUES for MEP1A Gene

  • Intestine(4.8)
genes like me logo Genes that share expression patterns with MEP1A: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MEP1A Gene

Orthologs for MEP1A Gene

This gene was present in the common ancestor of animals.

Orthologs for MEP1A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MEP1A 33 34
  • 99.46 (n)
(Canis familiaris)
Mammalia MEP1A 33 34
  • 86.76 (n)
(Bos Taurus)
Mammalia MEP1A 33 34
  • 85.39 (n)
(Mus musculus)
Mammalia Mep1a 33 16 34
  • 79.88 (n)
(Rattus norvegicus)
Mammalia Mep1a 33
  • 79.84 (n)
(Monodelphis domestica)
Mammalia MEP1A 34
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia MEP1A 34
  • 69 (a)
(Gallus gallus)
Aves MEP1A 33 34
  • 67.57 (n)
(Anolis carolinensis)
Reptilia MEP1A 34
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mep1a 33
  • 64.5 (n)
(Danio rerio)
Actinopterygii mep1a.2 33
  • 61.47 (n)
mep1a.1 34
  • 57 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2334 33
fruit fly
(Drosophila melanogaster)
Insecta CG6696 35
  • 37 (a)
BG:BACR44L22.1 35
  • 33 (a)
BG:BACR44L22.6 35
  • 33 (a)
CG15253 34
  • 33 (a)
(Caenorhabditis elegans)
Secernentea 4R79.1 35
  • 38 (a)
T04G9.2 35
  • 38 (a)
C05D11.6 35
  • 36 (a)
C07D10.4 35
  • 36 (a)
K04E7.3 35
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 37 (a)
Species where no ortholog for MEP1A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MEP1A Gene

Gene Tree for MEP1A (if available)
Gene Tree for MEP1A (if available)

Paralogs for MEP1A Gene

Paralogs for MEP1A Gene

(1) SIMAP similar genes for MEP1A Gene using alignment to 2 proteins: Pseudogenes for MEP1A Gene

genes like me logo Genes that share paralogs with MEP1A: view

Variants for MEP1A Gene

Sequence variations from dbSNP and Humsavar for MEP1A Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000014173 -- 46,841,175(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000023118 -- 46,799,033(+) G/A intron_variant
rs1000074943 -- 46,811,385(+) T/C intron_variant
rs1000092142 -- 46,792,494(+) T/G upstream_transcript_variant
rs1000135648 -- 46,816,743(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MEP1A Gene

Variant ID Type Subtype PubMed ID
nsv965722 CNV duplication 23825009
nsv830654 CNV gain 17160897
nsv823684 CNV gain 20364138
nsv823683 CNV gain 20364138
nsv7895 CNV gain 18304495
nsv476495 CNV novel sequence insertion 20440878
nsv428147 CNV gain 18775914
esv3567753 CNV deletion 23714750
esv2759425 CNV gain+loss 17122850
esv2535765 CNV deletion 19546169
esv24845 CNV gain 19812545
esv1387664 CNV deletion 17803354

Variation tolerance for MEP1A Gene

Residual Variation Intolerance Score: 34.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.54; 91.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MEP1A Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEP1A Gene

Disorders for MEP1A Gene

Additional Disease Information for MEP1A

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MEP1A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MEP1A Gene

Publications for MEP1A Gene

  1. MEP1A allele for meprin A metalloprotease is a susceptibility gene for inflammatory bowel disease. (PMID: 19262505) Banerjee S … Bond JS (Mucosal immunology 2009) 3 22 44 58
  2. The structural genes, MEP1A and MEP1B, for the alpha and beta subunits of the metalloendopeptidase meprin map to human chromosomes 6p and 18q, respectively. (PMID: 7774936) Bond JS … Jiang W (Genomics 1995) 2 3 22 58
  3. Cloning of the PABA peptide hydrolase alpha subunit (PPH alpha) from human small intestine and its expression in COS-1 cells. (PMID: 8262185) Dumermuth E … Sterchi EE (FEBS letters 1993) 3 4 22 58
  4. Exclusion of the juvenile myoclonic epilepsy gene EFHC1 as the cause of migraine on chromosome 6, but association to two rare polymorphisms in MEP1A and RHAG. (PMID: 16378686) Norberg A … Holmberg M (Neuroscience letters 2006) 3 44 58
  5. Structure and expression of the human MEP1A gene encoding the alpha subunit of metalloendopeptidase meprin A. (PMID: 10898933) Jiang W … Le B (Archives of biochemistry and biophysics 2000) 3 22 58

Products for MEP1A Gene

Sources for MEP1A Gene

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