MEOX2 Gene (Protein Coding)

Mesenchyme Homeobox 2

GC07M015617
GIFtS:
39
This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the regulation of vertebrate limb myogenesis. Mutations in the related mouse protein may be associated with craniofacial and/or skeletal abnormalities, in addition to neurovascular dysfunction observed in Alzheimer's disease. ... See more...

Aliases for MEOX2 Gene

Aliases for MEOX2 Gene

  • Mesenchyme Homeobox 2 2 3 4 5
  • Growth Arrest-Specific Homeobox 2 3 4
  • Homeobox Protein MOX-2 3 4
  • MOX2 3 4
  • GAX 3 4
  • Mesenchyme Homeo Box 2 (Growth Arrest-Specific Homeo Box) 2
  • Mesenchyme Homeobox 2 (Growth Arrest-Specific Homeo Box) 2

External Ids for MEOX2 Gene

Previous HGNC Symbols for MEOX2 Gene

  • GAX

Previous GeneCards Identifiers for MEOX2 Gene

  • GC07M015295
  • GC07M015395
  • GC07M015424

Summaries for MEOX2 Gene

Entrez Gene Summary for MEOX2 Gene

  • This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the regulation of vertebrate limb myogenesis. Mutations in the related mouse protein may be associated with craniofacial and/or skeletal abnormalities, in addition to neurovascular dysfunction observed in Alzheimer's disease. [provided by RefSeq, Jul 2008]

GeneCards Summary for MEOX2 Gene

MEOX2 (Mesenchyme Homeobox 2) is a Protein Coding gene. Diseases associated with MEOX2 include Female Stress Incontinence and Hard Palate Cancer. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is MEOX1.

UniProtKB/Swiss-Prot Summary for MEOX2 Gene

  • Mesodermal transcription factor that plays a key role in somitogenesis and is required for sclerotome development (By similarity). Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner (PubMed:22206000). May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle.

Gene Wiki entry for MEOX2 Gene

Additional gene information for MEOX2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MEOX2 Gene

Genomics for MEOX2 Gene

GeneHancer (GH) Regulatory Elements for MEOX2 Gene

Promoters and enhancers for MEOX2 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH07J015680 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 +2.4 2383 11.4 NR2F2 TCF7L2 CEBPG EZH2 CTCF SIN3A RXRA MAX RAD21 SMARCA4 MEOX2 LINC02587 ENSG00000225974 ENSG00000237070 LOC105375166
GH07J015720 Enhancer 0.5 Ensembl 11.7 -34.4 -34418 1.8 CTCF RAD21 TRIM22 SMC3 ZNF654 PKNOX1 FOXA1 ZNF143 LINC02587 ENSG00000225974 MEOX2 ENSG00000237070 LOC101927558 hsa-miR-5095-451
GH07J016071 Enhancer 0.6 Ensembl 10.5 -384.6 -384618 1 CTCF REST RAD21 SMC3 FOXA2 ZNF654 RXRA ZNF143 FOXA1 FOXK2 ENSG00000225974 LINC02587 MEOX2 RPL36AP29 hsa-miR-5096-089 piR-31534-609 CRPPA
GH07J015710 Enhancer 0.4 Ensembl 12 -22.5 -22518 3.6 FOS GATA2 JUN POLR2A LINC02587 MEOX2 ENSG00000237070 LOC101927558 hsa-miR-5095-451
GH07J015737 Enhancer 0.3 Ensembl 16 -51.5 -51518 3.6 JUN LINC02587 MEOX2 ENSG00000225974 ENSG00000237070 hsa-miR-5095-451 LOC101927558 ENSG00000286376 LOC105375167
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MEOX2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MEOX2

Top Transcription factor binding sites by QIAGEN in the MEOX2 gene promoter:
  • GATA-2
  • GATA-3
  • IRF-1
  • NF-kappaB
  • NF-kappaB1
  • TBP

Genomic Locations for MEOX2 Gene

Genomic Locations for MEOX2 Gene
chr7:15,611,212-15,686,683
(GRCh38/hg38)
Size:
75,472 bases
Orientation:
Minus strand
chr7:15,650,837-15,726,437
(GRCh37/hg19)
Size:
75,601 bases
Orientation:
Minus strand

Genomic View for MEOX2 Gene

Genes around MEOX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MEOX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MEOX2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MEOX2 Gene

Proteins for MEOX2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for MEOX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50222-MEOX2_HUMAN
    Recommended name:
    Homeobox protein MOX-2
    Protein Accession:
    P50222
    Secondary Accessions:
    • A4D127
    • B2R8I7
    • O75263
    • Q9UPL6

    Protein attributes for MEOX2 Gene

    Size:
    304 amino acids
    Molecular mass:
    33594 Da
    Quaternary structure:
    • Interacts with RNF10.

neXtProt entry for MEOX2 Gene

Protein Expression for MEOX2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for MEOX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MEOX2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for MEOX2

No data available for DME Specific Peptides for MEOX2 Gene

Domains & Families for MEOX2 Gene

Gene Families for MEOX2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for MEOX2 Gene

Blocks:
  • Lambda and other repressor helix-turn-helix signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MEOX2 Gene

GenScript: Design optimal peptide antigens:
  • Mesenchyme homeo box 2 (Growth arrest-specific homeo box) (A4D127_HUMAN)
  • Mesenchyme homeobox 2 (MEOX2_HUMAN)
  • MEOX2 protein (Q6FHY5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P50222

UniProtKB/Swiss-Prot:

MEOX2_HUMAN :
  • The polyhistidine repeat may act as a targeting signal to nuclear speckles.
Domain:
  • The polyhistidine repeat may act as a targeting signal to nuclear speckles.
genes like me logo Genes that share domains with MEOX2: view

Function for MEOX2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for MEOX2 Gene

UniProtKB/Swiss-Prot Function:
Mesodermal transcription factor that plays a key role in somitogenesis and is required for sclerotome development (By similarity). Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner (PubMed:22206000). May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle.
GENATLAS Biochemistry:
mesenchyme homeo box, murine Mox2,homolog

Phenotypes From GWAS Catalog for MEOX2 Gene

Gene Ontology (GO) - Molecular Function for MEOX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 17074759
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA 17074759
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IMP 17074759
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with MEOX2: view
genes like me logo Genes that share phenotypes with MEOX2: view

Animal Models for MEOX2 Gene

MGI Knock Outs for MEOX2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MEOX2

Clone Products

  • Addgene plasmids for MEOX2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MEOX2 Gene

Localization for MEOX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MEOX2 Gene

Nucleus. Nucleus speckle.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MEOX2 gene
Compartment Confidence
nucleus 5
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MEOX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IBA,IDA 22206000
GO:0005737 cytoplasm IDA 16335786
GO:0016607 nuclear speck IEA --
genes like me logo Genes that share ontologies with MEOX2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MEOX2 Gene

Pathways & Interactions for MEOX2 Gene

PathCards logo

SuperPathways for MEOX2 Gene

No Data Available

SIGNOR curated interactions for MEOX2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for MEOX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001757 somite specification IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organism development TAS 7713505
GO:0007519 skeletal muscle tissue development IEA --
genes like me logo Genes that share ontologies with MEOX2: view

No data available for Pathways by source for MEOX2 Gene

Drugs & Compounds for MEOX2 Gene

Products:

  1. Drug

(3) Drugs for MEOX2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for MEOX2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MEOX2: view

Transcripts for MEOX2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MEOX2 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MEOX2

Clone Products

  • Addgene plasmids for MEOX2

Alternative Splicing Database (ASD) splice patterns (SP) for MEOX2 Gene

No ASD Table

Relevant External Links for MEOX2 Gene

GeneLoc Exon Structure for
MEOX2

Expression for MEOX2 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MEOX2 Gene

mRNA expression in normal human tissues for MEOX2 Gene
mRNA expression by GTEx for MEOX2 GenemRNA expression by BioGPS for MEOX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MEOX2 Gene

This gene is overexpressed in Nerve - Tibial (x8.9), Adipose - Subcutaneous (x5.9), Artery - Tibial (x5.2), and Adipose - Visceral (Omentum) (x4.2).

Protein differential expression in normal tissues from HIPED for MEOX2 Gene

This gene is overexpressed in Fetal heart (61.6) and Placenta (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MEOX2 Gene



Protein tissue co-expression partners for MEOX2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MEOX2

SOURCE GeneReport for Unigene cluster for MEOX2 Gene:

Hs.170355

mRNA Expression by UniProt/SwissProt for MEOX2 Gene:

P50222-MEOX2_HUMAN
Tissue specificity: Embryo and placenta.

Evidence on tissue expression from TISSUES for MEOX2 Gene

  • Heart(4.4)
  • Skin(4.2)
  • Muscle(2.4)
genes like me logo Genes that share expression patterns with MEOX2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MEOX2 Gene

Orthologs for MEOX2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MEOX2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia MEOX2 31 30
  • 99.23 (n)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia MEOX2 31
  • 95 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia MEOX2 31 30
  • 93.95 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia MEOX2 31 30
  • 93.29 (n)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Meox2 30
  • 89.55 (n)
mouse
(Mus musculus)
 Mammalia Meox2 17 31 30
  • 89.44 (n)
oppossum
(Monodelphis domestica)
 Mammalia MEOX2 31
  • 87 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves MEOX2 31 30
  • 84.11 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia MEOX2 31
  • 87 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia meox2 30
  • 76.22 (n)
Str.10254 30
African clawed frog
(Xenopus laevis)
 Amphibia meox2-prov 30
zebrafish
(Danio rerio)
 Actinopterygii MEOX2 (1 of 2) 31
  • 69 (a)
 OneToMany
meox2b 31
  • 67 (a)
 OneToMany
LOC556898 30
  • 66.21 (n)
fruit fly
(Drosophila melanogaster)
 Insecta btn 31
  • 41 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 33 (a)
 OneToMany
Species where no ortholog for MEOX2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MEOX2 Gene

ENSEMBL:
Gene Tree for MEOX2 (if available)
TreeFam:
Gene Tree for MEOX2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MEOX2: view image

Paralogs for MEOX2 Gene

Paralogs for MEOX2 Gene

(7) SIMAP similar genes for MEOX2 Gene using alignment to 3 proteins:

  • MEOX2_HUMAN
  • A4D127_HUMAN
  • Q6FHY5_HUMAN
genes like me logo Genes that share paralogs with MEOX2: view

Variants for MEOX2 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Polymorphic Variants from UniProtKB/Swiss-Prot for MEOX2 Gene

MEOX2_HUMAN-P50222
The poly-His region of MEOX2 is polymorphic and the number of His varies in the population.

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MEOX2 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
rs2237493 - p.Ile287Leu

Additional dbSNP identifiers (rs#s) for MEOX2 Gene

Structural Variations from Database of Genomic Variants (DGV) for MEOX2 Gene

Variant ID Type Subtype PubMed ID
esv27709 CNV loss 19812545
esv3309437 CNV mobile element insertion 20981092
nsv1018250 CNV loss 25217958
nsv1161502 CNV duplication 26073780
nsv464392 CNV loss 19166990
nsv523199 CNV gain 19592680
nsv606283 CNV gain 21841781
nsv606310 CNV loss 21841781
nsv824016 CNV loss 20364138
nsv830911 CNV gain 17160897

Variation tolerance for MEOX2 Gene

Residual Variation Intolerance Score: 70.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.44; 71.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MEOX2 Gene

Human Gene Mutation Database (HGMD)
MEOX2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MEOX2

SNP Genotyping and Copy Number Assay Products

Disorders for MEOX2 Gene

MalaCards: The human disease database

(8) MalaCards diseases for MEOX2 Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search MEOX2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MEOX2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MEOX2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MEOX2 Gene

Publications for MEOX2 Gene

  1. Characterization of Mesenchyme Homeobox 2 (MEOX2) transcription factor binding to RING finger protein 10. (PMID: 16335786) Lin J … Wigle JT (Molecular and cellular biochemistry 2005) 3 4 23 54
  2. Isolation of the human MOX2 homeobox gene and localization to chromosome 7p22.1-p21.3. (PMID: 7607679) Grigoriou M … Karagogeos D (Genomics 1995) 3 4 23 54
  3. Molecular cloning and localization of the human GAX gene to 7p21. (PMID: 7713505) LePage DF … Walsh K (Genomics 1994) 2 3 4 54
  4. Mechanisms of MEOX1 and MEOX2 regulation of the cyclin dependent kinase inhibitors p21 and p16 in vascular endothelial cells. (PMID: 22206000) Douville JM … Wigle JT (PloS one 2011) 3 4 54
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54

ExternalLinks

View latest publications for MEOX2 gene in Mastermind

Products for MEOX2 Gene

  • Addgene plasmids for MEOX2

Sources for MEOX2 Gene