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This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the regulation of vertebrate limb myogenesis. Mutations in the related mouse protein may be associated with craniofacial and/or skeletal abnormalities, in addition to neurovascular dysfunction observed in Alzheimer's disease. [provided by RefSeq, Jul 2008]
MEOX2 (Mesenchyme Homeobox 2) is a Protein Coding gene. Diseases associated with MEOX2 include Female Stress Incontinence and Cleft Palate With Or Without Ankyloglossia, X-Linked. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is MEOX1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 17074759 |
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IMP | 17074759 |
GO:0003677 | DNA binding | IEA | -- |
GO:0003700 | DNA-binding transcription factor activity | IDA | 22206000 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000790 | nuclear chromatin | ISA | -- |
GO:0005634 | nucleus | IBA,IDA | 22206000 |
GO:0005737 | cytoplasm | IDA | 16335786 |
GO:0016607 | nuclear speck | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001525 | angiogenesis | IEA | -- |
GO:0001757 | somite specification | IEA | -- |
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
GO:0007275 | multicellular organism development | TAS | 7713505 |
GO:0007519 | skeletal muscle tissue development | IEA | -- |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | MEOX2 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | MEOX2 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | MEOX2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | MEOX2 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Meox2 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Meox2 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | MEOX2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | MEOX2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | MEOX2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | meox2 30 |
|
||
Str.10254 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | meox2-prov 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | MEOX2 (1 of 2) 31 |
|
OneToMany | |
meox2b 31 |
|
OneToMany | |||
LOC556898 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | btn 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 07 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs2237493 | - | p.Ile287Leu |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv27709 | CNV | loss | 19812545 |
esv3309437 | CNV | mobile element insertion | 20981092 |
nsv1018250 | CNV | loss | 25217958 |
nsv1161502 | CNV | duplication | 26073780 |
nsv464392 | CNV | loss | 19166990 |
nsv523199 | CNV | gain | 19592680 |
nsv606283 | CNV | gain | 21841781 |
nsv606310 | CNV | loss | 21841781 |
nsv824016 | CNV | loss | 20364138 |
nsv830911 | CNV | gain | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
female stress incontinence |
|
|
cleft palate with or without ankyloglossia, x-linked |
|
|
alzheimer disease |
|
|
cleft palate, isolated |
|
|
low compliance bladder |
|
|