This gene encodes menin, a tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. Menin is a scaffold protein that functions in histone modification and epigenetic gene regulation. It is thought to regulate several pathways and processes by altering chromatin structure through the modification of histones. [provided by RefSeq, May 2019]
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Aliases for MEN1 Gene
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Menin 1
2
3
5
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Menin
2
3
4
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SCG2
3
4
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Multiple Endocrine Neoplasia I
2
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MEAI
3
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MEN1
5
External Ids for MEN1 Gene
Previous GeneCards Identifiers for MEN1 Gene
- GC11P067708
- GC11M066252
- GC11M064821
- GC11M064346
- GC11M064327
- GC11M064570
- GC11M060898
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This gene encodes menin, a tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. Menin is a scaffold protein that functions in histone modification and epigenetic gene regulation. It is thought to regulate several pathways and processes by altering chromatin structure through the modification of histones. [provided by RefSeq, May 2019]
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Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression (By similarity). May be involved in DNA repair.
No data available for
Tocris Summary ,
PharmGKB "VIP" Summary ,
Rfam classification and
piRNA Summary
for MEN1 Gene