Aliases for MEMO1 Gene
External Ids for MEMO1 Gene
Previous HGNC Symbols for MEMO1 Gene
Previous GeneCards Identifiers for MEMO1 Gene
GeneCards Summary for MEMO1 Gene
MEMO1 (Mediator Of Cell Motility 1) is a Protein Coding gene. Diseases associated with MEMO1 include Cleft Palate With Or Without Ankyloglossia, X-Linked and Cleft Palate, Isolated. Among its related pathways are Signaling by GPCR and Signaling by ERBB2.
UniProtKB/Swiss-Prot Summary for MEMO1 Gene
May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell migration.