Aliases for MEMO1 Gene

Aliases for MEMO1 Gene

  • Mediator Of Cell Motility 1 2 3 4 5
  • MEMO 2 3 4
  • Hepatitis C Virus NS5A-Transactivated Protein 7 3 4
  • Mediator Of ErbB2-Driven Cell Motility 1 3 4
  • HCV NS5A-Transactivated Protein 7 3 4
  • C21orf19-Like Protein 3 4
  • Protein MEMO1 3 4
  • NS5ATP7 3 4
  • C2orf4 3 4
  • CGI-27 2 3
  • Chromosome 2 Open Reading Frame 4 2
  • Memo-1 4
  • MEMO1 5

External Ids for MEMO1 Gene

Previous HGNC Symbols for MEMO1 Gene

  • C2orf4

Previous GeneCards Identifiers for MEMO1 Gene

  • GC01U990194
  • GC02M031946
  • GC02M032092

Summaries for MEMO1 Gene

GeneCards Summary for MEMO1 Gene

MEMO1 (Mediator Of Cell Motility 1) is a Protein Coding gene. Diseases associated with MEMO1 include Cleft Palate With Or Without Ankyloglossia, X-Linked and Cleft Palate, Isolated. Among its related pathways are Signaling by GPCR and Signaling by ERBB2.

UniProtKB/Swiss-Prot Summary for MEMO1 Gene

  • May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell migration.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MEMO1 Gene

Genomics for MEMO1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MEMO1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J032008 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 250.7 +1.1 1138 4.6 BCLAF1 SP1 ZNF207 ZNF600 NCOR1 MYC SSRP1 ZNF580 ZNF592 ZMYM3 MEMO1 piR-44603-001 BIRC6 SLC30A6 DDX50P1 TTC27 ENSG00000273165 DPY30 lnc-MEMO1-2 lnc-MEMO1-1
GH02J031891 Promoter/Enhancer 0.8 EPDnew Ensembl 261.6 +118.4 118429 4.8 FEZF1 PRDM6 SPI1 ZNF18 CEBPB EZH2 CEBPG MEMO1 DPY30 SLC30A6 ENSG00000273165 HE856187 lnc-MEMO1-1 SRD5A2
GH02J031868 Promoter 0.3 EPDnew 250.1 +142.9 142945 0.1 ENSG00000273165 MEMO1 HE856187 lnc-MEMO1-1 DPY30 SRD5A2
GH02J031987 Enhancer 1.1 Ensembl ENCODE dbSUPER 11.9 +23.5 23529 1.8 JUND ATF2 CEBPA CHD4 CEBPB HOMEZ EP300 THAP11 SMAD4 FOXP1 SLC30A6 MEMO1 DPY30 piR-61945-272 piR-44603-001 lnc-MEMO1-1 SRD5A2
GH02J031956 Promoter/Enhancer 1 Ensembl ENCODE dbSUPER 11.2 +53.4 53412 2.7 BHLHE40 IKZF1 RAD51 RUNX3 ARNT MEMO1 DPY30 SLC30A6 HSALNG0014051 HE856187 lnc-MEMO1-1 SRD5A2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MEMO1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MEMO1

Top Transcription factor binding sites by QIAGEN in the MEMO1 gene promoter:
  • AP-2gamma
  • Arnt
  • C/EBPalpha
  • E2F
  • E2F-1
  • GR
  • GR-alpha
  • HSF1short
  • NF-kappaB
  • NF-kappaB1

Genomic Locations for MEMO1 Gene

Latest Assembly
chr2:31,865,060-32,011,230
(GRCh38/hg38)
Size:
146,171 bases
Orientation:
Minus strand

Previous Assembly
chr2:32,092,892-32,236,077
(GRCh37/hg19 by Entrez Gene)
Size:
143,186 bases
Orientation:
Minus strand

chr2:32,090,129-32,236,299
(GRCh37/hg19 by Ensembl)
Size:
146,171 bases
Orientation:
Minus strand

Genomic View for MEMO1 Gene

Genes around MEMO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MEMO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MEMO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEMO1 Gene

Proteins for MEMO1 Gene

  • Protein details for MEMO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y316-MEMO1_HUMAN
    Recommended name:
    Protein MEMO1
    Protein Accession:
    Q9Y316
    Secondary Accessions:
    • B4DLS0
    • D6W575
    • Q5R2V8
    • Q5R2V9
    • Q6NSL5

    Protein attributes for MEMO1 Gene

    Size:
    297 amino acids
    Molecular mass:
    33733 Da
    Quaternary structure:
    • Interacts with ERBB2 phosphorylated on 'Tyr-1248'.

    Three dimensional structures from OCA and Proteopedia for MEMO1 Gene

    Alternative splice isoforms for MEMO1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MEMO1 Gene

Post-translational modifications for MEMO1 Gene

  • Ubiquitination at Lys115
  • Modification sites at PhosphoSitePlus

Antibodies for research

  • Abcam antibodies for MEMO1
  • Boster Bio Antibodies for MEMO1
  • Santa Cruz Biotechnology (SCBT) Antibodies for MEMO1

No data available for DME Specific Peptides for MEMO1 Gene

Domains & Families for MEMO1 Gene

Gene Families for MEMO1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for MEMO1 Gene

InterPro:
Blocks:
  • Protein of unknown function DUF52

Suggested Antigen Peptide Sequences for MEMO1 Gene

GenScript: Design optimal peptide antigens:
  • Mediator of ErbB2-driven cell motility 1 (MEMO1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y316

UniProtKB/Swiss-Prot:

MEMO1_HUMAN :
  • Belongs to the MEMO1 family.
Family:
  • Belongs to the MEMO1 family.
genes like me logo Genes that share domains with MEMO1: view

Function for MEMO1 Gene

Molecular function for MEMO1 Gene

UniProtKB/Swiss-Prot Function:
May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell migration.
GENATLAS Biochemistry:
modifier of methylation for class I HLA genes,often deleted in neuroblastoma

Phenotypes From GWAS Catalog for MEMO1 Gene

Gene Ontology (GO) - Molecular Function for MEMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with MEMO1: view
genes like me logo Genes that share phenotypes with MEMO1: view

Animal Models for MEMO1 Gene

MGI Knock Outs for MEMO1:
  • Memo1 Memo1<tm1b(EUCOMM)Wtsi>
  • Memo1 Memo1<tm1a(EUCOMM)Wtsi>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MEMO1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MEMO1 Gene

Localization for MEMO1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MEMO1 gene
Compartment Confidence
nucleus 4
cytosol 4
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MEMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA 16780588
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MEMO1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MEMO1 Gene

Pathways & Interactions for MEMO1 Gene

PathCards logo

SuperPathways for MEMO1 Gene

genes like me logo Genes that share pathways with MEMO1: view

Pathways by source for MEMO1 Gene

Gene Ontology (GO) - Biological Process for MEMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032886 regulation of microtubule-based process IMP 20937854
GO:2000145 regulation of cell motility TAS --
genes like me logo Genes that share ontologies with MEMO1: view

No data available for SIGNOR curated interactions for MEMO1 Gene

Drugs & Compounds for MEMO1 Gene

No Compound Related Data Available

Transcripts for MEMO1 Gene

mRNA/cDNA for MEMO1 Gene

13 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MEMO1

Alternative Splicing Database (ASD) splice patterns (SP) for MEMO1 Gene

No ASD Table

Relevant External Links for MEMO1 Gene

GeneLoc Exon Structure for
MEMO1

Expression for MEMO1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MEMO1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MEMO1 Gene

This gene is overexpressed in Lymph node (7.2) and Peripheral blood mononuclear cells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MEMO1 Gene



Protein tissue co-expression partners for MEMO1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MEMO1

SOURCE GeneReport for Unigene cluster for MEMO1 Gene:

Hs.444969

Evidence on tissue expression from TISSUES for MEMO1 Gene

  • Nervous system(4.2)
  • Heart(4.2)
  • Muscle(4)
genes like me logo Genes that share expression patterns with MEMO1: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MEMO1 Gene

Orthologs for MEMO1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MEMO1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MEMO1 29
  • 99.89 (n)
Dog
(Canis familiaris)
Mammalia MEMO1 29 30
  • 98.19 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MEMO1 29 30
  • 97.2 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Memo1 29 16 30
  • 96.07 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Memo1 29
  • 96.07 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia MEMO1 30
  • 94 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia MEMO1 30
  • 93 (a)
OneToOne
Chicken
(Gallus gallus)
Aves MEMO1 29 30
  • 90.12 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia MEMO1 30
  • 97 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia memo1 29
  • 81.82 (n)
Str.10150 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.24007 29
Zebrafish
(Danio rerio)
Actinopterygii memo1 29 30
  • 76.54 (n)
OneToOne
wufi04d12 29
Fruit Fly
(Drosophila melanogaster)
Insecta CG8031 29 30
  • 61.46 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010011 29
  • 58.07 (n)
Worm
(Caenorhabditis elegans)
Secernentea tag-253 29 30
  • 54.17 (n)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MHO1 29 32
  • 48.83 (n)
-- 30
  • 35 (a)
OneToOne
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A11836g 29
  • 47.55 (n)
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AGR321W 29
  • 45.15 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT2G25280 29
  • 55.52 (n)
Rice
(Oryza sativa)
Liliopsida Os08g0299000 29
  • 55.99 (n)
Os.8918 29
Barley
(Hordeum vulgare)
Liliopsida Hv.792 29
Wheat
(Triticum aestivum)
Liliopsida Ta.8110 29
Corn
(Zea mays)
Liliopsida Zm.10697 29
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC4H3.04c 29
  • 49.05 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU11386 29
  • 48.12 (n)
Species where no ortholog for MEMO1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for MEMO1 Gene

ENSEMBL:
Gene Tree for MEMO1 (if available)
TreeFam:
Gene Tree for MEMO1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MEMO1: view image
Alliance of Genome Resources:
Additional Orthologs for MEMO1

Paralogs for MEMO1 Gene

genes like me logo Genes that share paralogs with MEMO1: view

No data available for Paralogs for MEMO1 Gene

Variants for MEMO1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MEMO1 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
916455 Uncertain Significance: not provided 31,892,013(-) A/G
NM_001301852.3(MEMO1):c.293-8551T>C
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MEMO1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MEMO1 Gene

Variant ID Type Subtype PubMed ID
esv2659847 CNV deletion 23128226
esv2719875 CNV deletion 23290073
esv3351835 CNV insertion 20981092
esv3590232 CNV loss 21293372
esv3590233 CNV loss 21293372
esv3590235 CNV loss 21293372
nsv1123308 CNV deletion 24896259
nsv1134847 CNV deletion 24896259
nsv508718 CNV deletion 20534489
nsv963219 CNV duplication 23825009

Variation tolerance for MEMO1 Gene

Residual Variation Intolerance Score: 36.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.95; 19.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MEMO1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MEMO1
Leiden Open Variation Database (LOVD)
MEMO1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEMO1 Gene

Disorders for MEMO1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MEMO1 Gene - From: COP

- elite association - COSMIC cancer census association via MalaCards
Search MEMO1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MEMO1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with MEMO1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MEMO1 Gene

Publications for MEMO1 Gene

  1. Memo mediates ErbB2-driven cell motility. (PMID: 15156151) Marone R … Badache A (Nature cell biology 2004) 2 3 4
  2. ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells. (PMID: 20937854) Zaoui K … Badache A (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40
  4. Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts. (PMID: 20468071) Dick DM … Bierut L (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 40
  5. Memo is homologous to nonheme iron dioxygenases and binds an ErbB2-derived phosphopeptide in its vestigial active site. (PMID: 18045866) Qiu C … Leahy DJ (The Journal of biological chemistry 2008) 3 4

Products for MEMO1 Gene

Sources for MEMO1 Gene