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Aliases for MELTF Gene

Aliases for MELTF Gene

  • Melanotransferrin 2 2 3 3 5
  • Antigen P97 (Melanoma Associated) Identified By Monoclonal Antibodies 133.2 And 96.5 2 3
  • Membrane-Bound Transferrin-Like Protein 2 3
  • Melanoma-Associated Antigen P97 3 4
  • MAP97 3 4
  • MFI2 3 4
  • CD228 Antigen 4
  • CD228 3
  • MTF1 3
  • MTf 3

External Ids for MELTF Gene

Previous HGNC Symbols for MELTF Gene

  • MFI2

Summaries for MELTF Gene

Entrez Gene Summary for MELTF Gene

  • The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. The importance of the iron binding function has not yet been identified. This gene resides in the same region of chromosome 3 as members of the transferrin superfamily. Alternative splicing results in two transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for MELTF Gene

MELTF (Melanotransferrin) is a Protein Coding gene. Diseases associated with MELTF include Osteogenic Sarcoma and Melanotic Neuroectodermal Tumor. Among its related pathways are Metabolism of proteins and Post-translational modification- synthesis of GPI-anchored proteins. An important paralog of this gene is LTF.

UniProtKB/Swiss-Prot for MELTF Gene

  • Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc.

Gene Wiki entry for MELTF Gene

Additional gene information for MELTF Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MELTF Gene

Genomics for MELTF Gene

GeneHancer (GH) Regulatory Elements for MELTF Gene

Promoters and enhancers for MELTF Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J197028 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 655.3 -0.6 -560 4 HDGF FOXA2 PKNOX1 SMAD1 ARNT SIN3A YY1 ZNF766 ZNF143 FOS MELTF ENSG00000234742 ENSG00000230732 MELTF-AS1 LOC220729 UBXN7 RNF168 DLG1 SENP5 NRROS
GH03J197029 Enhancer 0.4 ENCODE 650.7 +1.6 1591 0.2 NFIB ZIC2 MELTF MELTF-AS1 NCBP2 NCBP2-AS1 GC03P197002
GH03J197295 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 6.6 -268.3 -268315 5.2 HDGF PKNOX1 ZFP64 ARID4B SIN3A ZBTB7B YY1 POLR2B ZNF766 ZNF143 DLG1 GC03P197299 DLG1-AS1 UBXN7 LRCH3 SENP5 LOC220729 UBXN7-AS1 MELTF CEP19
GH03J197001 Promoter/Enhancer 1.6 Ensembl ENCODE dbSUPER 6.5 +25.9 25910 4 HDGF PKNOX1 SIN3A ELK1 ZNF207 ZNF143 ATF7 REST ZNF592 NBN GC03P197002 GC03M197001 UBXN7 LRCH3 SENP5 PIGZ LOC220729 ENSG00000234742 UBXN7-AS1 MELTF
GH03J197305 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 6.8 -278.2 -278152 5.1 FOS ATF7 RUNX3 JUNB ZNF518A NFIL3 MAFF ATF4 SMARCA4 NBN DLG1 MELTF GC03M197310 GC03P197299
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MELTF on UCSC Golden Path with GeneCards custom track

Genomic Locations for MELTF Gene

Genomic Locations for MELTF Gene
42,258 bases
Minus strand
41,196 bases
Minus strand

Genomic View for MELTF Gene

Genes around MELTF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MELTF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MELTF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MELTF Gene

Proteins for MELTF Gene

  • Protein details for MELTF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q9BQE2

    Protein attributes for MELTF Gene

    738 amino acids
    Molecular mass:
    80215 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MELTF Gene


neXtProt entry for MELTF Gene

Post-translational modifications for MELTF Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MELTF Gene

No data available for DME Specific Peptides for MELTF Gene

Domains & Families for MELTF Gene

Gene Families for MELTF Gene

Human Protein Atlas (HPA):
  • CD markers
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for MELTF Gene

Suggested Antigen Peptide Sequences for MELTF Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the transferrin family.
  • Belongs to the transferrin family.
genes like me logo Genes that share domains with MELTF: view

Function for MELTF Gene

Molecular function for MELTF Gene

UniProtKB/Swiss-Prot Function:
Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc.

Gene Ontology (GO) - Molecular Function for MELTF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005047 signal recognition particle binding IBA --
GO:0005506 iron ion binding IMP 7556058
GO:0005515 protein binding IPI 19815549
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MELTF: view
genes like me logo Genes that share phenotypes with MELTF: view

Animal Models for MELTF Gene

MGI Knock Outs for MELTF:

Animal Model Products

  • Taconic Biosciences Mouse Models for MELTF

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MELTF

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MELTF Gene

Localization for MELTF Gene

Subcellular locations from UniProtKB/Swiss-Prot for MELTF Gene

Isoform 1: Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MELTF gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 4
peroxisome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MELTF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IEA --
GO:0005785 signal recognition particle receptor complex IBA --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with MELTF: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MELTF Gene

Pathways & Interactions for MELTF Gene

genes like me logo Genes that share pathways with MELTF: view

Gene Ontology (GO) - Biological Process for MELTF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 NOT regulation of cell growth IMP 7556058
GO:0006501 C-terminal protein lipidation TAS --
GO:0006811 ion transport IEA --
GO:0010756 positive regulation of plasminogen activation IDA 16713448
GO:0042127 NOT regulation of cell proliferation IMP 7556058
genes like me logo Genes that share ontologies with MELTF: view

No data available for SIGNOR curated interactions for MELTF Gene

Drugs & Compounds for MELTF Gene

(4) Drugs for MELTF Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for MELTF Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • FE (II) ion
  • Fe(II)
  • Fe(2+)
  • Ferrous ion
  • Iron ion(2+)
genes like me logo Genes that share compounds with MELTF: view

Transcripts for MELTF Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MELTF

Alternative Splicing Database (ASD) splice patterns (SP) for MELTF Gene

No ASD Table

Relevant External Links for MELTF Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MELTF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of MELTF Gene:


mRNA Expression by UniProt/SwissProt for MELTF Gene:

Tissue specificity: Found predominantly in human melanomas and in certain fetal tissues; also found in liver, epithelium, umbilical chord, placenta and sweat gland ducts.

Evidence on tissue expression from TISSUES for MELTF Gene

  • Skin(4.6)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with MELTF: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MELTF Gene

Orthologs for MELTF Gene

This gene was present in the common ancestor of animals.

Orthologs for MELTF Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MFI2 34 33
  • 99.02 (n)
(Bos Taurus)
Mammalia MFI2 34 33
  • 89.31 (n)
(Canis familiaris)
Mammalia MFI2 34 33
  • 87.31 (n)
(Mus musculus)
Mammalia Mfi2 34 33
  • 83.22 (n)
Meltf 16
(Rattus norvegicus)
Mammalia Mfi2 33
  • 83.12 (n)
(Ornithorhynchus anatinus)
Mammalia MFI2 34
  • 73 (a)
(Monodelphis domestica)
Mammalia MFI2 34
  • 59 (a)
(Gallus gallus)
Aves MFI2 34 33
  • 65.21 (n)
(Anolis carolinensis)
Reptilia MFI2 34
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mfi2 33
  • 59.11 (n)
(Danio rerio)
Actinopterygii mfi2 34 33
  • 56.32 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005003 33
  • 50.41 (n)
fruit fly
(Drosophila melanogaster)
Insecta Tsf2 34 33
  • 49.57 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 40 (a)
Species where no ortholog for MELTF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MELTF Gene

Gene Tree for MELTF (if available)
Gene Tree for MELTF (if available)
Evolutionary constrained regions (ECRs) for MELTF: view image

Paralogs for MELTF Gene

Paralogs for MELTF Gene

genes like me logo Genes that share paralogs with MELTF: view

Variants for MELTF Gene

Sequence variations from dbSNP and Humsavar for MELTF Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000022723 -- 197,006,800(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000036512 -- 197,013,201(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000054898 -- 197,014,950(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000108195 -- 197,013,479(-) G/A/T genic_downstream_transcript_variant, intron_variant
rs1000190221 -- 197,031,566(-) C/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MELTF Gene

Variant ID Type Subtype PubMed ID
dgv8855n54 CNV gain 21841781
dgv8856n54 CNV gain+loss 21841781
dgv8857n54 CNV loss 21841781
esv2763775 CNV gain+loss 21179565
esv29143 CNV loss 19812545
esv3599293 CNV gain 21293372
nsv1003135 CNV gain 25217958
nsv1073277 CNV deletion 25765185
nsv1144060 CNV deletion 24896259
nsv475582 CNV novel sequence insertion 20440878
nsv517987 CNV loss 19592680
nsv593106 CNV loss 21841781
nsv822421 CNV loss 20364138
nsv822422 CNV loss 20364138

Variation tolerance for MELTF Gene

Residual Variation Intolerance Score: 96.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.25; 76.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MELTF Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MELTF Gene

Disorders for MELTF Gene

MalaCards: The human disease database

(3) MalaCards diseases for MELTF Gene - From: HGMD, LncRNADisease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
osteogenic sarcoma
  • osteosarcoma; osrc
melanotic neuroectodermal tumor
  • infantile melanotic neuroectodermal neoplasm
chromosome 3q29 deletion syndrome
  • microdeletion 3q29 syndrome
- elite association - COSMIC cancer census association via MalaCards
Search MELTF in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MELTF

genes like me logo Genes that share disorders with MELTF: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MELTF Gene

Publications for MELTF Gene

  1. A novel iron uptake mechanism mediated by GPI-anchored human p97. (PMID: 7556058) Kennard ML … Jefferies WA (The EMBO journal 1995) 3 4 22 58
  2. Transport and expression in human melanomas of a transferrin-like glycosylphosphatidylinositol-anchored protein. (PMID: 8300636) Food MR … Jefferies WA (The Journal of biological chemistry 1994) 3 4 22 58
  3. Human melanotransferrin (p97) has only one functional iron-binding site. (PMID: 1544447) Baker EN … Hellström I (FEBS letters 1992) 3 4 22 58
  4. Biochemical and spectroscopic studies of human melanotransferrin (MTf): electron-paramagnetic resonance evidence for a difference between the iron-binding site of MTf and other transferrins. (PMID: 18691669) Farnaud S … Richardson DR (The international journal of biochemistry & cell biology 2008) 3 22 58
  5. Melanotransferrin induces human melanoma SK-Mel-28 cell invasion in vivo. (PMID: 17196552) Bertrand Y … Béliveau R (Biochemical and biophysical research communications 2007) 3 22 58

Products for MELTF Gene

Sources for MELTF Gene

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