Aliases for MELK Gene

Aliases for MELK Gene

  • Maternal Embryonic Leucine Zipper Kinase 2 3 4 5
  • Tyrosine-Protein Kinase MELK 3 4
  • Protein Kinase PK38 3 4
  • Protein Kinase Eg3 3 4
  • PEg3 Kinase 3 4
  • EC 2.7.11.1 4 52
  • HPK38 3 4
  • EC 2.7.10.2 4
  • EC 2.7.11 52
  • KIAA0175 4
  • HMELK 4

External Ids for MELK Gene

Previous GeneCards Identifiers for MELK Gene

  • GC09P036885
  • GC09P036742
  • GC09P036562

Summaries for MELK Gene

GeneCards Summary for MELK Gene

MELK (Maternal Embryonic Leucine Zipper Kinase) is a Protein Coding gene. Diseases associated with MELK include Colorectal Cancer and Glioblastoma Multiforme. Among its related pathways are Neuroscience. Gene Ontology (GO) annotations related to this gene include calcium ion binding and protein kinase activity. An important paralog of this gene is SIK3.

UniProtKB/Swiss-Prot Summary for MELK Gene

  • Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis.

Gene Wiki entry for MELK Gene

Additional gene information for MELK Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MELK Gene

Genomics for MELK Gene

GeneHancer (GH) Regulatory Elements for MELK Gene

Promoters and enhancers for MELK Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J036571 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +1.2 1155 4.1 ZBTB40 SIN3A USF1 POLR2G SP1 GTF2E2 PHF8 FOS ZFX ZNF10 MELK piR-32214-679 RF00017-7547
GH09J036419 Enhancer 1 Ensembl ENCODE 12.3 -152.8 -152766 1.8 ZNF217 TCF12 NCOR1 TCF7 SKI TEAD1 TBX3 FOXA2 OSR2 BCL11A RNF38 MELK GNE piR-32214-676 FJ601678-148 lnc-RNF38-1
GH09J036436 Enhancer 0.6 Ensembl 11.5 -129.2 -129161 13.8 EP300 CTCF REST RAD21 SMC3 ZNF384 ZNF654 RFX5 FEZF1 YY1 RNF38 HMGB3P24 MELK CLTA GNE FJ601678-148 piR-32214-676 lnc-RNF38-1
GH09J036415 Enhancer 0.6 Ensembl ENCODE 11.2 -156.5 -156538 1.8 POLR2A CTCF EBF1 RAD21 NR2F6 MELK piR-32214-676 FJ601678-148 RNF38 lnc-RNF38-1
GH09J036922 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 2.3 +351.1 351139 3.6 ZNF217 TCF12 JUND FOS ZNF639 ZIC2 ZNF423 EP300 ZEB1 POLR2A MELK RF00994-1123 piR-45035-183 lnc-RNF38-4-001 PAX5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MELK on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MELK

Top Transcription factor binding sites by QIAGEN in the MELK gene promoter:
  • E2F
  • E2F-1
  • Ik-3
  • NF-kappaB
  • NF-kappaB1
  • NF-kappaB2
  • RelA

Genomic Locations for MELK Gene

Genomic Locations for MELK Gene
chr9:36,572,862-36,677,683
(GRCh38/hg38)
Size:
104,822 bases
Orientation:
Plus strand
chr9:36,572,859-36,677,679
(GRCh37/hg19)
Size:
104,821 bases
Orientation:
Plus strand

Genomic View for MELK Gene

Genes around MELK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MELK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MELK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MELK Gene

Proteins for MELK Gene

  • Protein details for MELK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14680-MELK_HUMAN
    Recommended name:
    Maternal embryonic leucine zipper kinase
    Protein Accession:
    Q14680
    Secondary Accessions:
    • A6P3A7
    • A6P3A8
    • B1AMQ6
    • B7Z1E6
    • B7Z5M5
    • B7Z6Q7
    • B7Z6R8
    • B7Z6Y0
    • B7Z7Q1
    • D3DRP8
    • F5H0Y0
    • F5H2R4
    • F5H689
    • Q7L3C3

    Protein attributes for MELK Gene

    Size:
    651 amino acids
    Molecular mass:
    74642 Da
    Quaternary structure:
    • Monomer. Interacts with ZNF622 and PPP1R8.
    Miscellaneous:
    • Potential therapeutic target for treatment of somatic tumors, such as brain and breast cancers, down-regulation of MELK inhibiting tumorigenesis (PubMed:17960622, PubMed:20861186).
    SequenceCaution:
    • Sequence=BAA11492.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MELK Gene

    Alternative splice isoforms for MELK Gene

neXtProt entry for MELK Gene

Selected DME Specific Peptides for MELK Gene

Q14680:
  • FRQIVSA
  • FAKVKLA
  • RQIVSAV
  • LKPENLL
  • RDLKPEN

Post-translational modifications for MELK Gene

  • Autophosphorylated: autophosphorylation of the T-loop at Thr-167 and Ser-171 is required for activation. Thr-478 phosphorylation during mitosis promotes interaction with PPP1R8 (Probable).
  • Ubiquitination at Lys44, Lys395, Lys406, Lys434, Lys536, Lys597, and Lys650
  • Modification sites at PhosphoSitePlus

Domains & Families for MELK Gene

Gene Families for MELK Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Plasma proteins
  • Potential drug targets
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for MELK Gene

Blocks:
  • Kinase-associated, C-terminal
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MELK Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ55799, highly similar to Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (B7Z6Y0_HUMAN)
  • cDNA FLJ55288, highly similar to Maternal embryonic leucine zipper kinase (EC2.7.11.1) (B7Z7Q1_HUMAN)
  • Protein kinase PK38 (MELK_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q14680

UniProtKB/Swiss-Prot:

MELK_HUMAN :
  • The KA1 domain mediates binding to phospholipids and targeting to membranes.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
Domain:
  • The KA1 domain mediates binding to phospholipids and targeting to membranes.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
genes like me logo Genes that share domains with MELK: view

Function for MELK Gene

Molecular function for MELK Gene

UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence={ECO:0000255 PROSITE-ProRule:PRU10027, ECO:0000269 PubMed:16216881};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=. ;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by autophosphorylation of the T-loop at Thr-167 and Ser-171: in contrast to other members of the SNF1 subfamily, phosphorylation at Thr-167 is not mediated by STK11/LKB1 but via autophosphorylation instead. Inhibited by calcium-binding. Kinase activity is also regulated by reducing agents: dithiothreitol (DTT) or reduced glutathione are required for kinase activity in vitro; such dependence is however not due to the presence of disulfide bonds.
UniProtKB/Swiss-Prot Induction:
Up-regulated in many cancers cells. Up-regulated upon treatment with radiation or 5-fluorouracil (5-FU) in colorectal cancer cells, suggesting that it might be associated with increased resistance of colorectal cells against radiation and 5-FU. Down-regulated upon siomycin A, a thiazole antibiotic, treatment, leading to inhibit tumor growth in vivo.

Enzyme Numbers (IUBMB) for MELK Gene

Gene Ontology (GO) - Molecular Function for MELK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IBA,IDA 12400006
GO:0004715 non-membrane spanning protein tyrosine kinase activity IDA,IBA 16216881
GO:0005509 calcium ion binding IDA 16216881
genes like me logo Genes that share ontologies with MELK: view
genes like me logo Genes that share phenotypes with MELK: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MELK

CRISPR Products

miRNA for MELK Gene

miRTarBase miRNAs that target MELK

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MELK Gene

Localization for MELK Gene

Subcellular locations from UniProtKB/Swiss-Prot for MELK Gene

Cell membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MELK gene
Compartment Confidence
plasma membrane 5
nucleus 4
cytosol 3
cytoskeleton 2
mitochondrion 2
extracellular 1
endosome 1
lysosome 1
endoplasmic reticulum 0
golgi apparatus 0

Gene Ontology (GO) - Cellular Components for MELK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IBA 21873635
GO:0005886 plasma membrane IEA,IDA 21145462
GO:0005938 cell cortex IDA 16159311
GO:0016020 membrane IEA,HDA 19946888
genes like me logo Genes that share ontologies with MELK: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MELK Gene

Pathways & Interactions for MELK Gene

PathCards logo

SuperPathways for MELK Gene

SuperPathway Contained pathways
1 Neuroscience
genes like me logo Genes that share pathways with MELK: view

Pathways by source for MELK Gene

1 Cell Signaling Technology pathway for MELK Gene

SIGNOR curated interactions for MELK Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for MELK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS 12400006
GO:0006468 protein phosphorylation IBA 21873635
GO:0006915 apoptotic process IEA,IDA 17280616
GO:0007049 cell cycle IEA --
GO:0008283 cell proliferation IDA 17280616
genes like me logo Genes that share ontologies with MELK: view

Drugs & Compounds for MELK Gene

(5) Drugs for MELK Gene - From: DrugBank, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0
OTSSP167 Pharma MELK inhibitor 0
OTSSP167 hydrochloride Pharma MELK inhibitor,highly potent and selective 0

(1) Additional Compounds for MELK Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0

(2) ApexBio Compounds for MELK Gene

Compound Action Cas Number
OTSSP167 MELK inhibitor 1431697-89-0
OTSSP167 hydrochloride MELK inhibitor,highly potent and selective
genes like me logo Genes that share compounds with MELK: view

Drug Products

Transcripts for MELK Gene

mRNA/cDNA for MELK Gene

9 REFSEQ mRNAs :
20 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MELK Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
SP1: - - - -
SP2: - - -
SP3: - - - -
SP4:
SP5: -
SP6: - - -

Relevant External Links for MELK Gene

GeneLoc Exon Structure for
MELK

Expression for MELK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MELK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MELK Gene

This gene is overexpressed in Testis (x5.2) and Esophagus - Mucosa (x5.0).

Protein differential expression in normal tissues from HIPED for MELK Gene

This gene is overexpressed in Lung (68.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MELK Gene



Protein tissue co-expression partners for MELK Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MELK

SOURCE GeneReport for Unigene cluster for MELK Gene:

Hs.184339

mRNA Expression by UniProt/SwissProt for MELK Gene:

Q14680-MELK_HUMAN
Tissue specificity: Expressed in placenta, kidney, thymus, testis, ovary and intestine.

Evidence on tissue expression from TISSUES for MELK Gene

  • Intestine(4.3)
  • Bone marrow(4.2)
  • Skin(4.1)
  • Spleen(4.1)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with MELK: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MELK Gene

Orthologs for MELK Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MELK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MELK 31 30
  • 99.39 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MELK 31 30
  • 92.68 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MELK 31 30
  • 90.97 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Melk 30
  • 88.25 (n)
mouse
(Mus musculus)
Mammalia Melk 17 31 30
  • 84.19 (n)
oppossum
(Monodelphis domestica)
Mammalia MELK 31
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MELK 31
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 31
  • 80 (a)
OneToMany
MELK 31 30
  • 67.7 (n)
OneToMany
lizard
(Anolis carolinensis)
Reptilia MELK 31
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia melk 30
  • 67.08 (n)
Str.7658 30
African clawed frog
(Xenopus laevis)
Amphibia LOC397927 30
zebrafish
(Danio rerio)
Actinopterygii melk 31 30
  • 61.06 (n)
OneToOne
wufb71b01 30
fruit fly
(Drosophila melanogaster)
Insecta CG3105 32
  • 32 (a)
worm
(Caenorhabditis elegans)
Secernentea pig-1 31 30
  • 49.56 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SNF1 31
  • 23 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons CIPK7 30
  • 50.91 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 46 (a)
OneToOne
Cin.11515 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11515 30
Species where no ortholog for MELK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MELK Gene

ENSEMBL:
Gene Tree for MELK (if available)
TreeFam:
Gene Tree for MELK (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MELK: view image

Paralogs for MELK Gene

(22) SIMAP similar genes for MELK Gene using alignment to 1 proteins:

  • MELK_HUMAN
genes like me logo Genes that share paralogs with MELK: view

Variants for MELK Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MELK Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs144052967 An ovarian mucinous carcinoma sample p.Thr460Met
rs34655121 - p.Arg333Lys
rs35142210 - p.Lys219Arg
rs35233455 - p.Thr56Met
rs55845414 - p.Thr348Ile

Additional dbSNP identifiers (rs#s) for MELK Gene

Structural Variations from Database of Genomic Variants (DGV) for MELK Gene

Variant ID Type Subtype PubMed ID
esv2667249 CNV deletion 23128226
esv2738428 CNV deletion 23290073
esv3308549 CNV mobile element insertion 20981092
esv3386783 CNV insertion 20981092
esv3408641 CNV insertion 20981092
esv3620400 CNV loss 21293372
nsv1124413 CNV deletion 24896259
nsv1125318 OTHER inversion 24896259
nsv1134924 CNV tandem duplication 24896259
nsv1136014 CNV deletion 24896259
nsv614211 CNV loss 21841781
nsv6530 CNV deletion 18451855
nsv831550 CNV loss 17160897

Variation tolerance for MELK Gene

Residual Variation Intolerance Score: 29.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.61; 65.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MELK Gene

Human Gene Mutation Database (HGMD)
MELK
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MELK

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MELK Gene

Disorders for MELK Gene

MalaCards: The human disease database

(3) MalaCards diseases for MELK Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
colorectal cancer
  • crc
glioblastoma multiforme
  • adult glioblastoma multiforme
medulloblastoma
  • mdb
- elite association - COSMIC cancer census association via MalaCards
Search MELK in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

MELK_HUMAN
  • Note=Defects in MELK are associated with some cancers, such as brain or breast cancers. Expression is dramatically increased in aggressive undifferentiated tumors, correlating with poor patient outcome in breast and brain cancers, suggesting a role in tumor-initiating cells and proliferation via its function in cell proliferation regulation.

Additional Disease Information for MELK

genes like me logo Genes that share disorders with MELK: view

No data available for Genatlas for MELK Gene

Publications for MELK Gene

  1. Dysregulated expression of Fau and MELK is associated with poor prognosis in breast cancer. (PMID: 19671159) Pickard MR … Williams GT (Breast cancer research : BCR 2009) 3 4 23 54
  2. Maternal embryonic leucine zipper kinase is a key regulator of the proliferation of malignant brain tumors, including brain tumor stem cells. (PMID: 17722061) Nakano I … Kornblum HI (Journal of neuroscience research 2008) 3 4 23 54
  3. Maternal embryonic leucine zipper kinase transcript abundance correlates with malignancy grade in human astrocytomas. (PMID: 17960622) Marie SK … Caballero OL (International journal of cancer 2008) 3 4 23 54
  4. Involvement of maternal embryonic leucine zipper kinase (MELK) in mammary carcinogenesis through interaction with Bcl-G, a pro-apoptotic member of the Bcl-2 family. (PMID: 17280616) Lin ML … Katagiri T (Breast cancer research : BCR 2007) 3 4 23 54
  5. CDC25B phosphorylated by pEg3 localizes to the centrosome and the spindle poles at mitosis. (PMID: 15908796) Mirey G … Ducommun B (Cell cycle (Georgetown, Tex.) 2005) 3 4 23 54

Products for MELK Gene

  • Boster Bio Antibodies for MELK
  • Boster Bio ELISA Kits for MELK

Sources for MELK Gene