This gene encodes a homeobox protein and probable transcriptional regulator. The orthologous protein in mouse controls expression of 3-phosphoinositide dependent protein kinase 1, which promotes survival of pancreatic beta-cells. [provided by RefSeq, Sep 2016] See more...

Aliases for MEIS3 Gene

Aliases for MEIS3 Gene

  • Meis Homeobox 3 2 3 5
  • MRG2 2 3 4
  • Meis1-Related Protein 2 3 4
  • Homeobox Protein Meis3 3 4
  • Meis1, Myeloid Ecotropic Viral Integration Site 1 Homolog 3 (Mouse) 2
  • Meis1, Myeloid Ecotropic Viral Integration Site 1 Homolog 3 3
  • DKFZp547H236 2
  • MEIS3 5

External Ids for MEIS3 Gene

Previous GeneCards Identifiers for MEIS3 Gene

  • GC17P016056
  • GC17P016804
  • GC17P015633
  • GC19M052598
  • GC19M047906

Summaries for MEIS3 Gene

Entrez Gene Summary for MEIS3 Gene

  • This gene encodes a homeobox protein and probable transcriptional regulator. The orthologous protein in mouse controls expression of 3-phosphoinositide dependent protein kinase 1, which promotes survival of pancreatic beta-cells. [provided by RefSeq, Sep 2016]

GeneCards Summary for MEIS3 Gene

MEIS3 (Meis Homeobox 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific. An important paralog of this gene is MEIS2.

UniProtKB/Swiss-Prot Summary for MEIS3 Gene

  • Transcriptional regulator which directly modulates PDPK1 expression, thus promoting survival of pancreatic beta-cells. Also regulates expression of NDFIP1, BNIP3, and CCNG1.

Additional gene information for MEIS3 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MEIS3 Gene

Genomics for MEIS3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MEIS3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J047418 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +3.3 3254 1.7 PRDM10 KDM1A MTA2 ZNF24 PATZ1 REST EZH2 SCRT2 ZBTB20 ZBTB10 MEIS3 ZC3H4 NOP53-AS1 BICRA CCDC9 DHX34 lnc-MEIS3-2
GH19J047421 Promoter/Enhancer 1.3 Ensembl ENCODE CraniofacialAtlas 600.7 +0.6 589 1.8 ARHGAP35 PRDM10 ZNF629 ZNF512 IKZF1 ZNF692 PRDM1 ZIC2 ZSCAN4 PKNOX1 MEIS3 ZC3H4 BICRA ENSG00000268746 NOP53 PPP5D1 NOP53-AS1 EHD2 KDELR1 INAFM1
GH19J047420 Enhancer 0.8 ENCODE CraniofacialAtlas 600.7 +1.8 1804 0.6 IKZF1 PRDM1 PATZ1 EZH2 ZNF341 EGR1 ZBTB48 ZBTB17 WT1 ZFHX2 MEIS3 DHX34 lnc-MEIS3-2
GH19J047423 Enhancer 0.6 CraniofacialAtlas 600.7 -0.9 -911 0.4 ZNF512 NKRF ZNF248 ZKSCAN1 ZNF266 ZIK1 KDM1A POLR2A NONO ZNF366 MEIS3 ZC3H4 BICRA CCDC9 NOP53 KDELR1 NOP53-AS1 SNORD23 lnc-DHX34-1 SLC8A2
GH19J047225 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.9 +192.9 192885 8.3 ZNF221 BRCA1 RNF2 ARHGAP35 SP1 HNRNPL CREB1 GATAD2A CTCF ATF7 BBC3 lnc-ZC3H4-1 ZC3H4 BICRA ENSG00000268810 NOP53-AS1 CCDC9 NOP53 SNORD23 PPP5D1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MEIS3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MEIS3

Top Transcription factor binding sites by QIAGEN in the MEIS3 gene promoter:
  • CREB
  • CUTL1
  • E4BP4
  • NRSF form 1
  • NRSF form 2
  • USF-1
  • USF1
  • YY1

Genomic Locations for MEIS3 Gene

Genomic Locations for MEIS3 Gene
chr19:47,403,118-47,422,233
(GRCh38/hg38)
Size:
19,116 bases
Orientation:
Minus strand
chr19:47,906,381-47,922,785
(GRCh37/hg19)
Size:
16,405 bases
Orientation:
Minus strand

Genomic View for MEIS3 Gene

Genes around MEIS3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MEIS3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MEIS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEIS3 Gene

Proteins for MEIS3 Gene

  • Protein details for MEIS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99687-MEIS3_HUMAN
    Recommended name:
    Homeobox protein Meis3
    Protein Accession:
    Q99687
    Secondary Accessions:
    • A8K1N5
    • Q6NT73
    • Q8TC66
    • Q9NPW2

    Protein attributes for MEIS3 Gene

    Size:
    375 amino acids
    Molecular mass:
    41115 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MEIS3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MEIS3 Gene

Post-translational modifications for MEIS3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MEIS3 Gene

Domains & Families for MEIS3 Gene

Gene Families for MEIS3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for MEIS3 Gene

Suggested Antigen Peptide Sequences for MEIS3 Gene

GenScript: Design optimal peptide antigens:
  • Meis1-related protein 2 (MEIS3_HUMAN)
  • MEIS3 protein (Q49A38_HUMAN)
  • MEIS1-related protein 2 (Q8TCW1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q99687

UniProtKB/Swiss-Prot:

MEIS3_HUMAN :
  • Belongs to the TALE/MEIS homeobox family.
Family:
  • Belongs to the TALE/MEIS homeobox family.
genes like me logo Genes that share domains with MEIS3: view

Function for MEIS3 Gene

Molecular function for MEIS3 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional regulator which directly modulates PDPK1 expression, thus promoting survival of pancreatic beta-cells. Also regulates expression of NDFIP1, BNIP3, and CCNG1.
GENATLAS Biochemistry:
homeo domain protein,murine Meis1 (myeloid ecotropic viral integration site 1) ortholog,PBX1 related,ubiquitously expressed,binding DNA cooperatively with the heterodimer E2A/myogenic transcription factors

Phenotypes From GWAS Catalog for MEIS3 Gene

Gene Ontology (GO) - Molecular Function for MEIS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IEA,IBA 21873635
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
GO:0043565 sequence-specific DNA binding IDA 17178831
genes like me logo Genes that share ontologies with MEIS3: view

Phenotypes for MEIS3 Gene

genes like me logo Genes that share phenotypes with MEIS3: view

Animal Models for MEIS3 Gene

MGI Knock Outs for MEIS3:

Animal Model Products

CRISPR Products

miRNA for MEIS3 Gene

miRTarBase miRNAs that target MEIS3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MEIS3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MEIS3 Gene

Localization for MEIS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MEIS3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MEIS3 gene
Compartment Confidence
nucleus 5
extracellular 2
plasma membrane 1
cytoskeleton 1
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MEIS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with MEIS3: view

Pathways & Interactions for MEIS3 Gene

PathCards logo

SuperPathways for MEIS3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MEIS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001654 eye development IBA 21873635
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0007420 brain development IBA 21873635
GO:0008284 positive regulation of cell proliferation IBA 21873635
genes like me logo Genes that share ontologies with MEIS3: view

No data available for Pathways by source and SIGNOR curated interactions for MEIS3 Gene

Drugs & Compounds for MEIS3 Gene

No Compound Related Data Available

Transcripts for MEIS3 Gene

mRNA/cDNA for MEIS3 Gene

4 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MEIS3

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MEIS3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13
SP1:
SP2: - - -
SP3:
SP4:
SP5: - -

Relevant External Links for MEIS3 Gene

GeneLoc Exon Structure for
MEIS3

Expression for MEIS3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MEIS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MEIS3 Gene

This gene is overexpressed in Brain - Amygdala (x4.5), Uterus (x4.4), Brain - Anterior cingulate cortex (BA24) (x4.3), and Brain - Cortex (x4.3).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MEIS3

SOURCE GeneReport for Unigene cluster for MEIS3 Gene:

Hs.380923

Evidence on tissue expression from TISSUES for MEIS3 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with MEIS3: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MEIS3 Gene

Orthologs for MEIS3 Gene

This gene was present in the common ancestor of animals.

Orthologs for MEIS3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MEIS3 30 31
  • 98.97 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MEIS3 30 31
  • 90.64 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MEIS3 30 31
  • 90.59 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Meis3 30
  • 87.11 (n)
Mouse
(Mus musculus)
Mammalia Meis3 30 17 31
  • 86.76 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 22 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 73 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia MGC52546 30
Zebrafish
(Danio rerio)
Actinopterygii meis3 31
  • 59 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta hth 31
  • 42 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 35 (a)
OneToMany
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.3310 30
Species where no ortholog for MEIS3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MEIS3 Gene

ENSEMBL:
Gene Tree for MEIS3 (if available)
TreeFam:
Gene Tree for MEIS3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MEIS3: view image

Paralogs for MEIS3 Gene

(12) SIMAP similar genes for MEIS3 Gene using alignment to 9 proteins:

  • MEIS3_HUMAN
  • H0YLL0_HUMAN
  • H0YMV2_HUMAN
  • H0YNA8_HUMAN
  • H3BLU4_HUMAN
  • Q49A38_HUMAN
  • Q8TCW1_HUMAN
  • U3KQJ9_HUMAN
  • U3KQV2_HUMAN

Pseudogenes.org Pseudogenes for MEIS3 Gene

genes like me logo Genes that share paralogs with MEIS3: view

Variants for MEIS3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MEIS3 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
710147 Likely Benign: not provided 47,417,209(-) C/T MISSENSE_VARIANT
775418 Benign: not provided 47,415,084(-) C/T SYNONYMOUS_VARIANT
rs140643747 Benign: Abnormality of neuronal migration 47,416,947(-) G/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for MEIS3 Gene

Structural Variations from Database of Genomic Variants (DGV) for MEIS3 Gene

Variant ID Type Subtype PubMed ID
esv2479786 CNV loss 19546169
esv2758765 CNV loss 17122850
nsv1057003 CNV loss 25217958
nsv428366 CNV loss 18775914
nsv517901 CNV loss 19592680
nsv521341 CNV gain 19592680
nsv9738 CNV gain 18304495

Variation tolerance for MEIS3 Gene

Residual Variation Intolerance Score: 84.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.39; 42.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MEIS3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MEIS3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEIS3 Gene

Disorders for MEIS3 Gene

No disorders were found for MEIS3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MEIS3 Gene

Publications for MEIS3 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  2. Identification of a conserved family of Meis1-related homeobox genes. (PMID: 9049632) Steelman S … Buchberg AM (Genome research 1997) 3 4
  3. Identification of a new family of Pbx-related homeobox genes. (PMID: 8950991) Nakamura T … Copeland NG (Oncogene 1996) 2 3
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. (PMID: 28611215) Fei T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2017) 3

Products for MEIS3 Gene

  • Signalway ELISA kits for MEIS3

Sources for MEIS3 Gene