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Aliases for MEIS3 Gene

Aliases for MEIS3 Gene

  • Meis Homeobox 3 2 3 5
  • Meis1-Related Protein 2 3 4
  • Homeobox Protein Meis3 3 4
  • MRG2 3 4
  • Meis1, Myeloid Ecotropic Viral Integration Site 1 Homolog 3 (Mouse) 2
  • Meis1, Myeloid Ecotropic Viral Integration Site 1 Homolog 3 3

External Ids for MEIS3 Gene

Previous GeneCards Identifiers for MEIS3 Gene

  • GC17P016056
  • GC17P016804
  • GC17P015633
  • GC19M052598
  • GC19M047906

Summaries for MEIS3 Gene

Entrez Gene Summary for MEIS3 Gene

  • This gene encodes a homeobox protein and probable transcriptional regulator. The orthologous protein in mouse controls expression of 3-phosphoinositide dependent protein kinase 1, which promotes survival of pancreatic beta-cells. [provided by RefSeq, Sep 2016]

GeneCards Summary for MEIS3 Gene

MEIS3 (Meis Homeobox 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific. An important paralog of this gene is MEIS2.

UniProtKB/Swiss-Prot for MEIS3 Gene

  • Transcriptional regulator which directly modulates PDPK1 expression, thus promoting survival of pancreatic beta-cells. Also regulates expression of NDFIP1, BNIP3, and CCNG1.

Additional gene information for MEIS3 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEIS3 Gene

Genomics for MEIS3 Gene

GeneHancer (GH) Regulatory Elements for MEIS3 Gene

Promoters and enhancers for MEIS3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J047418 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 600.7 +3.1 3092 2.1 ZBTB7A GLIS2 GMEB1 ZNF24 PRDM10 ZEB2 REST PATZ1 MTA2 SCRT2 MEIS3 ZC3H4 NOP53-AS1 BICRA CCDC9 DHX34 GC19P047388
GH19J047422 Promoter/Enhancer 1.3 Ensembl ENCODE 600.7 +0.3 340 0.6 SP7 KLF14 PRDM1 EGR1 GLIS2 PKNOX1 ZBTB8A PRDM10 ZIC2 POLR2A MEIS3 ZC3H4 BICRA PNMA8A GC19P047388
GH19J047420 Enhancer 0.7 ENCODE 600.7 +1.7 1706 0.3 SP7 PRDM1 GMEB1 IKZF1 ZEB2 PATZ1 ZNF341 EGR1 ZBTB48 ZBTB17 MEIS3 GC19P047388
GH19J047421 Enhancer 0.7 ENCODE 600.7 +1.2 1186 0.2 PRDM1 GLIS2 GMEB1 IKZF1 PRDM10 ZIC2 ZSCAN4 ZEB2 PATZ1 ZNF692 MEIS3 SNORD23 GC19P047388
GH19J047225 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 10.9 +192.9 192917 8.3 HDGF SP1 ZNF652 ZFX CC2D1A ELF3 ZKSCAN8 MNT CBFA2T2 ZNF148 BBC3 BICRA ENSG00000268810 NOP53-AS1 CCDC9 NOP53 PPP5D1 INAFM1 LIG1 SNORD23
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MEIS3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MEIS3 gene promoter:
  • CREB
  • CUTL1
  • E4BP4
  • NRSF form 1
  • NRSF form 2
  • USF-1
  • USF1
  • YY1

Genomic Locations for MEIS3 Gene

Genomic Locations for MEIS3 Gene
chr19:47,403,118-47,422,265
(GRCh38/hg38)
Size:
19,148 bases
Orientation:
Minus strand
chr19:47,906,381-47,922,785
(GRCh37/hg19)
Size:
16,405 bases
Orientation:
Minus strand

Genomic View for MEIS3 Gene

Genes around MEIS3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MEIS3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MEIS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEIS3 Gene

Proteins for MEIS3 Gene

  • Protein details for MEIS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99687-MEIS3_HUMAN
    Recommended name:
    Homeobox protein Meis3
    Protein Accession:
    Q99687
    Secondary Accessions:
    • A8K1N5
    • Q6NT73
    • Q8TC66
    • Q9NPW2

    Protein attributes for MEIS3 Gene

    Size:
    375 amino acids
    Molecular mass:
    41115 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MEIS3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MEIS3 Gene

Post-translational modifications for MEIS3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MEIS3 Gene

Domains & Families for MEIS3 Gene

Gene Families for MEIS3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins
  • Transcription factors

Protein Domains for MEIS3 Gene

Suggested Antigen Peptide Sequences for MEIS3 Gene

GenScript: Design optimal peptide antigens:
  • Meis1-related protein 2 (MEIS3_HUMAN)
  • MEIS3 protein (Q49A38_HUMAN)
  • MEIS1-related protein 2 (Q8TCW1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q99687

UniProtKB/Swiss-Prot:

MEIS3_HUMAN :
  • Belongs to the TALE/MEIS homeobox family.
Family:
  • Belongs to the TALE/MEIS homeobox family.
genes like me logo Genes that share domains with MEIS3: view

Function for MEIS3 Gene

Molecular function for MEIS3 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional regulator which directly modulates PDPK1 expression, thus promoting survival of pancreatic beta-cells. Also regulates expression of NDFIP1, BNIP3, and CCNG1.
GENATLAS Biochemistry:
homeo domain protein,murine Meis1 (myeloid ecotropic viral integration site 1) ortholog,PBX1 related,ubiquitously expressed,binding DNA cooperatively with the heterodimer E2A/myogenic transcription factors

Phenotypes From GWAS Catalog for MEIS3 Gene

Gene Ontology (GO) - Molecular Function for MEIS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IEA --
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
GO:0043565 sequence-specific DNA binding IDA 17178831
genes like me logo Genes that share ontologies with MEIS3: view

Phenotypes for MEIS3 Gene

genes like me logo Genes that share phenotypes with MEIS3: view

Animal Models for MEIS3 Gene

MGI Knock Outs for MEIS3:

Animal Model Products

CRISPR Products

miRNA for MEIS3 Gene

miRTarBase miRNAs that target MEIS3

Clone Products

  • Applied Biological Materials (abm): Clones for MEIS3 - Now 50% OFF >
  • * MEIS3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * MEIS3 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MEIS3 Gene

Localization for MEIS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MEIS3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MEIS3 gene
Compartment Confidence
nucleus 4
extracellular 1
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MEIS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with MEIS3: view

Pathways & Interactions for MEIS3 Gene

PathCards logo

SuperPathways for MEIS3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MEIS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0045944 positive regulation of transcription by RNA polymerase II IEA --
GO:0051897 positive regulation of protein kinase B signaling IEA --
GO:2001234 negative regulation of apoptotic signaling pathway IEA --
genes like me logo Genes that share ontologies with MEIS3: view

No data available for Pathways by source and SIGNOR curated interactions for MEIS3 Gene

Drugs & Compounds for MEIS3 Gene

No Compound Related Data Available

Transcripts for MEIS3 Gene

Unigene Clusters for MEIS3 Gene

Meis homeobox 3:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for MEIS3 - Now 50% OFF >
  • * MEIS3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * MEIS3 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for MEIS3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13
SP1:
SP2: - - -
SP3:
SP4:
SP5: - -

Relevant External Links for MEIS3 Gene

GeneLoc Exon Structure for
MEIS3
ECgene alternative splicing isoforms for
MEIS3

Expression for MEIS3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MEIS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MEIS3 Gene

This gene is overexpressed in Brain - Amygdala (x4.5), Uterus (x4.4), Brain - Anterior cingulate cortex (BA24) (x4.3), and Brain - Cortex (x4.3).

NURSA nuclear receptor signaling pathways regulating expression of MEIS3 Gene:

MEIS3

SOURCE GeneReport for Unigene cluster for MEIS3 Gene:

Hs.380923

Evidence on tissue expression from TISSUES for MEIS3 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with MEIS3: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MEIS3 Gene

Orthologs for MEIS3 Gene

This gene was present in the common ancestor of animals.

Orthologs for MEIS3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MEIS3 35 34
  • 98.97 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MEIS3 35 34
  • 90.64 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MEIS3 35 34
  • 90.59 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Meis3 34
  • 87.11 (n)
mouse
(Mus musculus)
Mammalia Meis3 17 35 34
  • 86.76 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 22 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 73 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia MGC52546 34
zebrafish
(Danio rerio)
Actinopterygii meis3 35
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta hth 35
  • 42 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 35 (a)
OneToMany
Cin.3310 34
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3310 34
Species where no ortholog for MEIS3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MEIS3 Gene

ENSEMBL:
Gene Tree for MEIS3 (if available)
TreeFam:
Gene Tree for MEIS3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MEIS3: view image

Paralogs for MEIS3 Gene

(12) SIMAP similar genes for MEIS3 Gene using alignment to 9 proteins:

  • MEIS3_HUMAN
  • H0YLL0_HUMAN
  • H0YMV2_HUMAN
  • H0YNA8_HUMAN
  • H3BLU4_HUMAN
  • Q49A38_HUMAN
  • Q8TCW1_HUMAN
  • U3KQJ9_HUMAN
  • U3KQV2_HUMAN

Pseudogenes.org Pseudogenes for MEIS3 Gene

genes like me logo Genes that share paralogs with MEIS3: view

Variants for MEIS3 Gene

Sequence variations from dbSNP and Humsavar for MEIS3 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs140643747 benign, Abnormality of neuronal migration 47,416,947(-) G/A/C/T 5_prime_UTR_variant, coding_sequence_variant, missense_variant
rs1000020503 -- 47,409,726(-) G/A intron_variant
rs1000087745 -- 47,403,890(-) C/T intron_variant
rs1000559046 -- 47,405,770(-) G/A/C intron_variant
rs1000980476 -- 47,420,720(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MEIS3 Gene

Variant ID Type Subtype PubMed ID
esv2479786 CNV loss 19546169
esv2758765 CNV loss 17122850
nsv1057003 CNV loss 25217958
nsv428366 CNV loss 18775914
nsv517901 CNV loss 19592680
nsv521341 CNV gain 19592680
nsv9738 CNV gain 18304495

Variation tolerance for MEIS3 Gene

Residual Variation Intolerance Score: 84.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.39; 42.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MEIS3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MEIS3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEIS3 Gene

Disorders for MEIS3 Gene

Additional Disease Information for MEIS3

No disorders were found for MEIS3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MEIS3 Gene

Publications for MEIS3 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. Identification of a conserved family of Meis1-related homeobox genes. (PMID: 9049632) Steelman S … Buchberg AM (Genome research 1997) 3 4 58
  3. Identification of a new family of Pbx-related homeobox genes. (PMID: 8950991) Nakamura T … Copeland NG (Oncogene 1996) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. (PMID: 28611215) Fei T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2017) 3 58

Products for MEIS3 Gene

Sources for MEIS3 Gene

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