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Aliases for MEIS3 Gene

Aliases for MEIS3 Gene

  • Meis Homeobox 3 2 3 5
  • Meis1-Related Protein 2 3 4
  • MRG2 3 4
  • Meis1, Myeloid Ecotropic Viral Integration Site 1 Homolog 3 (Mouse) 2
  • Meis1, Myeloid Ecotropic Viral Integration Site 1 Homolog 3 3
  • Homeobox Protein Meis3 3

External Ids for MEIS3 Gene

Previous GeneCards Identifiers for MEIS3 Gene

  • GC17P016056
  • GC17P016804
  • GC17P015633
  • GC19M052598
  • GC19M047906

Summaries for MEIS3 Gene

Entrez Gene Summary for MEIS3 Gene

  • This gene encodes a homeobox protein and probable transcriptional regulator. The orthologous protein in mouse controls expression of 3-phosphoinositide dependent protein kinase 1, which promotes survival of pancreatic beta-cells. [provided by RefSeq, Sep 2016]

GeneCards Summary for MEIS3 Gene

MEIS3 (Meis Homeobox 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is MEIS2.

UniProtKB/Swiss-Prot for MEIS3 Gene

  • Transcriptional regulator which directly modulates PDPK1 expression, thus promoting survival of pancreatic beta-cells. Also regulates expression of NDFIP1, BNIP3, and CCNG1.

Additional gene information for MEIS3 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEIS3 Gene

Genomics for MEIS3 Gene

GeneHancer (GH) Regulatory Elements for MEIS3 Gene

Promoters and enhancers for MEIS3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I047418 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 550.8 +3.3 3286 1.7 ZNF133 SIN3A ZNF76 ZBTB7B ZNF335 GLIS2 ZNF366 SCRT2 EGR2 ZNF202 MEIS3 ZC3H4 NOP53-AS1 BICRA CCDC9 DHX34 GC19P047388
GH19I047422 Enhancer 0.8 ENCODE 550.8 +0.4 411 0.4 PKNOX1 KLF17 ZNF335 GLIS2 EGR1 EGR2 SP3 YY2 ZNF398 ZNF645 MEIS3 ZC3H4 BICRA GC19P047388
GH19I047420 Enhancer 0.7 ENCODE 550.8 +1.7 1706 0.3 KLF1 KLF17 ZFHX2 ZNF366 ZBTB48 EGR1 PATZ1 VEZF1 KLF8 EGR2 MEIS3 GC19P047388
GH19I047421 Enhancer 0.7 ENCODE 550.8 +1.2 1186 0.2 ZSCAN4 ZIC2 GLIS2 ZNF366 ZBTB48 POLR2A PATZ1 PRDM10 MAZ ZEB2 MEIS3 EHD2 SNORD23 GC19P047388
GH19I047607 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 10.9 -188.8 -188804 6.9 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 POLR2B ZNF207 ZNF143 BICRA ZNF541 ZC3H4 MEIS3 PRKD2 CCDC9 LIG1 KPTN ENSG00000277383 ENSG00000268746
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MEIS3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MEIS3 gene promoter:

Genomic Locations for MEIS3 Gene

Genomic Locations for MEIS3 Gene
chr19:47,403,118-47,422,265
(GRCh38/hg38)
Size:
19,148 bases
Orientation:
Minus strand
chr19:47,906,381-47,922,785
(GRCh37/hg19)

Genomic View for MEIS3 Gene

Genes around MEIS3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MEIS3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MEIS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEIS3 Gene

Proteins for MEIS3 Gene

  • Protein details for MEIS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99687-MEIS3_HUMAN
    Recommended name:
    Homeobox protein Meis3
    Protein Accession:
    Q99687
    Secondary Accessions:
    • A8K1N5
    • Q6NT73
    • Q8TC66
    • Q9NPW2

    Protein attributes for MEIS3 Gene

    Size:
    375 amino acids
    Molecular mass:
    41115 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MEIS3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MEIS3 Gene

Post-translational modifications for MEIS3 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MEIS3 Gene

Domains & Families for MEIS3 Gene

Gene Families for MEIS3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins
  • Transcription factors

Protein Domains for MEIS3 Gene

Suggested Antigen Peptide Sequences for MEIS3 Gene

Graphical View of Domain Structure for InterPro Entry

Q99687

UniProtKB/Swiss-Prot:

MEIS3_HUMAN :
  • Belongs to the TALE/MEIS homeobox family.
Family:
  • Belongs to the TALE/MEIS homeobox family.
genes like me logo Genes that share domains with MEIS3: view

Function for MEIS3 Gene

Molecular function for MEIS3 Gene

GENATLAS Biochemistry:
homeo domain protein,murine Meis1 (myeloid ecotropic viral integration site 1) ortholog,PBX1 related,ubiquitously expressed,binding DNA cooperatively with the heterodimer E2A/myogenic transcription factors
UniProtKB/Swiss-Prot Function:
Transcriptional regulator which directly modulates PDPK1 expression, thus promoting survival of pancreatic beta-cells. Also regulates expression of NDFIP1, BNIP3, and CCNG1.

Phenotypes From GWAS Catalog for MEIS3 Gene

Gene Ontology (GO) - Molecular Function for MEIS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
GO:0043565 sequence-specific DNA binding IDA 17178831
genes like me logo Genes that share ontologies with MEIS3: view

Phenotypes for MEIS3 Gene

MGI mutant phenotypes for MEIS3:
inferred from 1 alleles
GenomeRNAi human phenotypes for MEIS3:
genes like me logo Genes that share phenotypes with MEIS3: view

Animal Models for MEIS3 Gene

MGI Knock Outs for MEIS3:

Animal Model Products

miRNA for MEIS3 Gene

miRTarBase miRNAs that target MEIS3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MEIS3 Gene

Localization for MEIS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MEIS3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MEIS3 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MEIS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with MEIS3: view

Pathways & Interactions for MEIS3 Gene

SuperPathways for MEIS3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MEIS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription by RNA polymerase II IEA --
GO:0045944 positive regulation of transcription by RNA polymerase II IEA --
GO:0051897 positive regulation of protein kinase B signaling IEA --
GO:2001234 negative regulation of apoptotic signaling pathway IEA --
genes like me logo Genes that share ontologies with MEIS3: view

No data available for Pathways by source and SIGNOR curated interactions for MEIS3 Gene

Drugs & Compounds for MEIS3 Gene

No Compound Related Data Available

Transcripts for MEIS3 Gene

Unigene Clusters for MEIS3 Gene

Meis homeobox 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MEIS3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13
SP1:
SP2: - - -
SP3:
SP4:
SP5: - -

Relevant External Links for MEIS3 Gene

GeneLoc Exon Structure for
MEIS3
ECgene alternative splicing isoforms for
MEIS3

Expression for MEIS3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MEIS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MEIS3 Gene

This gene is overexpressed in Brain - Amygdala (x4.5), Uterus (x4.4), Brain - Anterior cingulate cortex (BA24) (x4.3), and Brain - Cortex (x4.3).

NURSA nuclear receptor signaling pathways regulating expression of MEIS3 Gene:

MEIS3

SOURCE GeneReport for Unigene cluster for MEIS3 Gene:

Hs.380923

Evidence on tissue expression from TISSUES for MEIS3 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with MEIS3: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MEIS3 Gene

Orthologs for MEIS3 Gene

This gene was present in the common ancestor of animals.

Orthologs for MEIS3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MEIS3 33 34
  • 98.97 (n)
cow
(Bos Taurus)
Mammalia MEIS3 33 34
  • 90.64 (n)
dog
(Canis familiaris)
Mammalia MEIS3 33 34
  • 90.59 (n)
rat
(Rattus norvegicus)
Mammalia Meis3 33
  • 87.11 (n)
mouse
(Mus musculus)
Mammalia Meis3 33 16 34
  • 86.76 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 22 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 73 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia MGC52546 33
zebrafish
(Danio rerio)
Actinopterygii meis3 34
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta hth 34
  • 42 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 35 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3310 33
Species where no ortholog for MEIS3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MEIS3 Gene

ENSEMBL:
Gene Tree for MEIS3 (if available)
TreeFam:
Gene Tree for MEIS3 (if available)

Paralogs for MEIS3 Gene

Paralogs for MEIS3 Gene

Pseudogenes.org Pseudogenes for MEIS3 Gene

genes like me logo Genes that share paralogs with MEIS3: view

Variants for MEIS3 Gene

Sequence variations from dbSNP and Humsavar for MEIS3 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs140643747 benign, Abnormality of neuronal migration 47,416,947(-) G/A/C/T 5_prime_UTR_variant, coding_sequence_variant, missense_variant
rs1000020503 -- 47,409,726(-) G/A intron_variant
rs1000087745 -- 47,403,890(-) C/T intron_variant
rs1000559046 -- 47,405,770(-) G/A/C intron_variant
rs1000980476 -- 47,420,720(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MEIS3 Gene

Variant ID Type Subtype PubMed ID
nsv9738 CNV gain 18304495
nsv521341 CNV gain 19592680
nsv517901 CNV loss 19592680
nsv428366 CNV loss 18775914
nsv1057003 CNV loss 25217958
esv2758765 CNV loss 17122850
esv2479786 CNV loss 19546169

Variation tolerance for MEIS3 Gene

Residual Variation Intolerance Score: 84.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.39; 42.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MEIS3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MEIS3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEIS3 Gene

Disorders for MEIS3 Gene

Additional Disease Information for MEIS3

No disorders were found for MEIS3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MEIS3 Gene

Publications for MEIS3 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. Identification of a conserved family of Meis1-related homeobox genes. (PMID: 9049632) Steelman S … Buchberg AM (Genome research 1997) 3 4 58
  3. Identification of a new family of Pbx-related homeobox genes. (PMID: 8950991) Nakamura T … Copeland NG (Oncogene 1996) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. MEIS3 is repressed in A549 lung epithelial cells by deoxynivalenol and the repression contributes to the deleterious effect. (PMID: 26763390) Toyotome T … Kamei K (The Journal of toxicological sciences 2016) 3 58

Products for MEIS3 Gene

Sources for MEIS3 Gene

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