This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcription regulators, and several members have been shown to be essential contributors to developmental programs. Multiple transcript variants encoding distinct isoforms have been described for ... See more...

Aliases for MEIS2 Gene

Aliases for MEIS2 Gene

  • Meis Homeobox 2 2 3 5
  • MRG1 2 3 4
  • Meis1-Related Protein 1 3 4
  • Homeobox Protein Meis2 3 4
  • HsT18361 2 3
  • Meis1, Myeloid Ecotropic Viral Integration Site 1 Homolog 2 (Mouse) 2
  • Meis1, Myeloid Ecotropic Viral Integration Site 1 Homolog 2 3
  • TALE Homeobox Protein Meis2 3
  • Meis (Mouse) Homolog 2 2
  • Meis1-Related Gene 1 3
  • Meis Homolog 2 3
  • CPCMR 3
  • MEIS2 5

External Ids for MEIS2 Gene

Previous GeneCards Identifiers for MEIS2 Gene

  • GC15M032527
  • GC15M030078
  • GC15M034762
  • GC15M034899
  • GC15M034970
  • GC15M037183
  • GC15M014029

Summaries for MEIS2 Gene

Entrez Gene Summary for MEIS2 Gene

  • This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcription regulators, and several members have been shown to be essential contributors to developmental programs. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MEIS2 Gene

MEIS2 (Meis Homeobox 2) is a Protein Coding gene. Diseases associated with MEIS2 include Cleft Palate, Cardiac Defects, And Mental Retardation and Chromosome 15Q14 Deletion Syndrome. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription factor binding. An important paralog of this gene is MEIS1.

UniProtKB/Swiss-Prot Summary for MEIS2 Gene

  • Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3 is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoform 3 and isoform 4 can bind to a EPHA8 promoter sequence containing the DNA motif 5'-CGGTCA-3'; in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA sequence 5'-TGACAG-3'in the activator ACT sequence of the D(1A) dopamine receptor (DRD1) promoter and activate DRD1 transcription; isoform 5 cannot activate DRD1 transcription.

Gene Wiki entry for MEIS2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MEIS2 Gene

Genomics for MEIS2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MEIS2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MEIS2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MEIS2

Top Transcription factor binding sites by QIAGEN in the MEIS2 gene promoter:
  • E2F
  • E2F-1
  • E2F-2

Genomic Locations for MEIS2 Gene

Genomic Locations for MEIS2 Gene
chr15:36,889,204-37,101,311
(GRCh38/hg38)
Size:
212,108 bases
Orientation:
Minus strand
chr15:37,181,406-37,393,504
(GRCh37/hg19)
Size:
212,099 bases
Orientation:
Minus strand

Genomic View for MEIS2 Gene

Genes around MEIS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MEIS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MEIS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEIS2 Gene

Proteins for MEIS2 Gene

  • Protein details for MEIS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14770-MEIS2_HUMAN
    Recommended name:
    Homeobox protein Meis2
    Protein Accession:
    O14770
    Secondary Accessions:
    • A6NJI5
    • A8MWD5
    • B3KP98
    • B3KPQ6
    • Q96DI2
    • Q96KI4
    • Q96KI5
    • Q9NRS1
    • Q9NRS2
    • Q9NRS3

    Protein attributes for MEIS2 Gene

    Size:
    477 amino acids
    Molecular mass:
    51790 Da
    Quaternary structure:
    • Monomer and homodimer (PubMed:26550823). Heterodimer with HOXB13 (Ref.16). Isoform 2 interacts with TLX1. Isoform 3 interacts with HOXA13 and PBX1 isoform PBX1b. Isoform 4 interacts with SP1, SP3 and KLF4. Isoform 4 and isoform 5 interact with PBX1 isoform PBX1a; the interaction partially relieves MEIS2 autoinhibition. Isoform 3 also known as MEIS2b is part of a PDX1:PBX1b:Meis2B complex; Meis2B is recruited by PBX1b and can be replaced by isoform 4 in a small fraction of complexes. Can form trimeric complexes including HOXB8 and PBX2 or PBX3.

    Three dimensional structures from OCA and Proteopedia for MEIS2 Gene

    Alternative splice isoforms for MEIS2 Gene

neXtProt entry for MEIS2 Gene

Post-translational modifications for MEIS2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MEIS2 Gene

Domains & Families for MEIS2 Gene

Gene Families for MEIS2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for MEIS2 Gene

Suggested Antigen Peptide Sequences for MEIS2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ31374 fis, clone NB9N42000430, highly similar to HOMEOBOX PROTEIN MEIS2 (B3KP81_HUMAN)
  • cDNA FLJ31476 fis, clone NT2NE2001617, highly similar to HOMEOBOX PROTEIN MEIS2 (B3KP98_HUMAN)
  • cDNA FLJ32058 fis, clone NTONG2001657, highly similar to Homo sapiens Meis1, myeloid ecotropic viral integration site 1 homolog 2 (mouse) (MEIS2), transcript variant h, mRNA (B3KPQ6_HUMAN)
  • Meis1-related protein 1 (MEIS2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O14770

UniProtKB/Swiss-Prot:

MEIS2_HUMAN :
  • Belongs to the TALE/MEIS homeobox family.
Family:
  • Belongs to the TALE/MEIS homeobox family.
genes like me logo Genes that share domains with MEIS2: view

Function for MEIS2 Gene

Molecular function for MEIS2 Gene

UniProtKB/Swiss-Prot Function:
Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3 is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoform 3 and isoform 4 can bind to a EPHA8 promoter sequence containing the DNA motif 5'-CGGTCA-3'; in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA sequence 5'-TGACAG-3'in the activator ACT sequence of the D(1A) dopamine receptor (DRD1) promoter and activate DRD1 transcription; isoform 5 cannot activate DRD1 transcription.
GENATLAS Biochemistry:
homeo domain protein,murine Meis1 (myeloid ecotropic viral integration site 1) ortholog,PBX1 related,expressed in hematopoietic tissues and brain,binding DNA cooperatively with the heterodimer E2A/myogenic transcription factors

Phenotypes From GWAS Catalog for MEIS2 Gene

Gene Ontology (GO) - Molecular Function for MEIS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 10764806
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IDA 10764806
GO:0003677 DNA binding IDA 26550823
GO:0003700 DNA-binding transcription factor activity NAS 10764806
genes like me logo Genes that share ontologies with MEIS2: view
genes like me logo Genes that share phenotypes with MEIS2: view

Human Phenotype Ontology for MEIS2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MEIS2 Gene

MGI Knock Outs for MEIS2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MEIS2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for MEIS2 Gene

Localization for MEIS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MEIS2 Gene

Nucleus. Cytoplasm, perinuclear region.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MEIS2 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 2
cytoskeleton 2
plasma membrane 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MEIS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with MEIS2: view

Pathways & Interactions for MEIS2 Gene

PathCards logo

SuperPathways for MEIS2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MEIS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II TAS 10764806
GO:0001654 eye development IEA,IBA 21873635
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription by RNA polymerase II TAS 10764806
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with MEIS2: view

No data available for Pathways by source and SIGNOR curated interactions for MEIS2 Gene

Drugs & Compounds for MEIS2 Gene

(1) Additional Compounds for MEIS2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MEIS2: view

Transcripts for MEIS2 Gene

mRNA/cDNA for MEIS2 Gene

9 REFSEQ mRNAs :
24 NCBI additional mRNA sequence :
27 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MEIS2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MEIS2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b · 16c ^
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - - - - - -
SP8: - - - - - - - - - -
SP9: - - - - -
SP10: - - - - - -
SP11: - - - -
SP12: - -
SP13: - -
SP14: - - -
SP15: - -
SP16: -
SP17: - -
SP18: -
SP19:
SP20:
SP21:
SP22:

ExUns: 17a · 17b · 17c ^ 18a · 18b · 18c · 18d · 18e · 18f · 18g
SP1: -
SP2: -
SP3: -
SP4: -
SP5: - - -
SP6: - - -
SP7: -
SP8: -
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17: - - -
SP18: - - -
SP19:
SP20:
SP21:
SP22: - - -

Relevant External Links for MEIS2 Gene

GeneLoc Exon Structure for
MEIS2

Expression for MEIS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MEIS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MEIS2 Gene

This gene is overexpressed in Fetal Brain (25.3), Ovary (13.1), Salivary gland (11.4), and Prostate (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MEIS2 Gene



Protein tissue co-expression partners for MEIS2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MEIS2

SOURCE GeneReport for Unigene cluster for MEIS2 Gene:

Hs.510989

mRNA Expression by UniProt/SwissProt for MEIS2 Gene:

O14770-MEIS2_HUMAN
Tissue specificity: Expressed in various tissues. Expressed at high level in the lymphoid organs of hematopoietic tissues. Also expressed in some regions of the brain, such as the putamen.

Evidence on tissue expression from TISSUES for MEIS2 Gene

  • Nervous system(4.9)
  • Muscle(4.5)
  • Heart(2.5)
  • Kidney(2.2)
  • Eye(2.2)
  • Skin(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for MEIS2 Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • digestive
  • integumentary
  • nervous
  • skeleton
Regions:
Head and neck:
  • brain
  • chin
  • eye
  • face
  • forehead
  • head
  • jaw
  • lip
  • mandible
  • mouth
  • nose
  • skull
General:
  • skin
genes like me logo Genes that share expression patterns with MEIS2: view

No data available for mRNA differential expression in normal tissues for MEIS2 Gene

Orthologs for MEIS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MEIS2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MEIS2 30 31
  • 100 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia MEIS2 31
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia MEIS2 30 31
  • 97.49 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MEIS2 30 31
  • 97.06 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia MEIS2 31
  • 96 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Meis2 30 17 31
  • 95.46 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Meis2 30
  • 95.11 (n)
Chicken
(Gallus gallus)
Aves MEIS2 30 31
  • 91.3 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia MEIS2 31
  • 90 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia meis2 30
  • 81.05 (n)
Zebrafish
(Danio rerio)
Actinopterygii MEIS2 (3 of 3) 31
  • 89 (a)
OneToMany
meis2b 31
  • 88 (a)
OneToMany
meis2a 30 31
  • 83.38 (n)
OneToMany
-- 30
Fruit Fly
(Drosophila melanogaster)
Insecta hth 31
  • 49 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea unc-62 32
  • 59 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 43 (a)
OneToMany
Species where no ortholog for MEIS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for MEIS2 Gene

ENSEMBL:
Gene Tree for MEIS2 (if available)
TreeFam:
Gene Tree for MEIS2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MEIS2: view image

Paralogs for MEIS2 Gene

(12) SIMAP similar genes for MEIS2 Gene using alignment to 8 proteins:

  • MEIS2_HUMAN
  • B3KP81_HUMAN
  • H0YKE5_HUMAN
  • H0YKN2_HUMAN
  • H0YM65_HUMAN
  • H0YMX5_HUMAN
  • U3KQ95_HUMAN
  • U3KQI2_HUMAN
genes like me logo Genes that share paralogs with MEIS2: view

Variants for MEIS2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MEIS2 Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
567456 Uncertain Significance: Cleft palate, cardiac defects, and mental retardation 37,093,642(-) TCT/AGA MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
657998 Uncertain Significance: Cleft palate, cardiac defects, and mental retardation 37,098,070(-) T/C MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR_VARIANT
705193 Likely Benign: not provided 37,036,904(-) C/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
706870 Likely Benign: Cleft palate, cardiac defects, and mental retardation 37,083,868(-) T/C NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
707087 Likely Benign: not provided 36,950,362(-) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for MEIS2 Gene

Structural Variations from Database of Genomic Variants (DGV) for MEIS2 Gene

Variant ID Type Subtype PubMed ID
esv2571731 CNV deletion 19546169
esv2676776 CNV deletion 23128226
esv2678174 CNV deletion 23128226
esv2749573 CNV deletion 23290073
esv3636163 CNV gain 21293372
esv3636164 CNV gain 21293372
esv3636165 CNV gain 21293372
esv3636167 CNV loss 21293372
esv3636168 CNV loss 21293372
nsv1069852 CNV deletion 25765185
nsv1143779 CNV deletion 24896259
nsv1496 CNV deletion 18451855
nsv518513 CNV loss 19592680
nsv569198 CNV loss 21841781
nsv569199 CNV loss 21841781
nsv569200 CNV gain 21841781
nsv952610 CNV deletion 24416366
nsv977862 CNV deletion 23825009

Variation tolerance for MEIS2 Gene

Residual Variation Intolerance Score: 21.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.87; 18.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MEIS2 Gene

Human Gene Mutation Database (HGMD)
MEIS2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MEIS2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEIS2 Gene

Disorders for MEIS2 Gene

MalaCards: The human disease database

(10) MalaCards diseases for MEIS2 Gene - From: OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
cleft palate, cardiac defects, and mental retardation
  • cpcmr
chromosome 15q14 deletion syndrome
  • 15q14 microdeletion syndrome
learning disability
  • academic skill disorder
peters-plus syndrome
  • ptrpls
cleft lip/palate
  • alveolar cleft lip and palate
- elite association - COSMIC cancer census association via MalaCards
Search MEIS2 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

MEIS2_HUMAN
  • Cleft palate, cardiac defects, and mental retardation (CPCMR) [MIM:600987]: An autosomal dominant disease characterized by multiple congenital malformations, mild-to-severe intellectual disability with poor speech, and delayed psychomotor development. Congenital malformations include heart defects, cleft lip/palate, distally-placed thumbs and toes, and cutaneous syndactyly between the second and third toes. {ECO:0000269 PubMed:24678003, ECO:0000269 PubMed:25712757, ECO:0000269 PubMed:27225850}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for MEIS2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Tumor Gene Database
(TGDB)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with MEIS2: view

No data available for Genatlas for MEIS2 Gene

Publications for MEIS2 Gene

  1. Three-amino acid extension loop homeodomain proteins Meis2 and TGIF differentially regulate transcription. (PMID: 10764806) Yang Y … Mouradian MM (The Journal of biological chemistry 2000) 3 4 23
  2. Chromosomal mapping to 15q14 and expression analysis of the human MEIS2 homeobox gene. (PMID: 9383298) Smith JE … Takeshita K (Mammalian genome : official journal of the International Mammalian Genome Society 1997) 2 3 4
  3. De novo MEIS2 mutation causes syndromic developmental delay with persistent gastro-esophageal reflux. (PMID: 27225850) Fujita A … Matsumoto N (Journal of human genetics 2016) 3 4
  4. DNA-dependent formation of transcription factor pairs alters their binding specificity. (PMID: 26550823) Jolma A … Taipale J (Nature 2015) 3 4
  5. MEIS2 involvement in cardiac development, cleft palate, and intellectual disability. (PMID: 25712757) Louw JJ … Devriendt K (American journal of medical genetics. Part A 2015) 3 4

Products for MEIS2 Gene

  • Signalway ELISA kits for MEIS2

Sources for MEIS2 Gene