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Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. [provided by RefSeq, Jul 2008] See more...
Aliases for MEIS1 Gene
Aliases for MEIS1 Gene
External Ids for MEIS1 Gene
- HGNC: 7000
- Entrez Gene: 4211
- Ensembl: ENSG00000143995
- OMIM: 601739
- UniProtKB: O00470
Previous GeneCards Identifiers for MEIS1 Gene
- GC02P066796
- GC02P066620
- GC02P066637
- GC02P066574
- GC02P066516
- GC02P066660
- GC02P066397
Summaries for MEIS1 Gene
-
Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. [provided by RefSeq, Jul 2008]
GeneCards Summary for MEIS1 Gene
MEIS1 (Meis Homeobox 1) is a Protein Coding gene. Diseases associated with MEIS1 include Restless Legs Syndrome and Restless Legs Syndrome 7. Among its related pathways are Transcriptional misregulation in cancer and Mesodermal Commitment Pathway. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and chromatin binding. An important paralog of this gene is MEIS2.
UniProtKB/Swiss-Prot Summary for MEIS1 Gene
-
Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias.
Additional gene information for MEIS1 Gene
- HGNC(7000)
- Entrez Gene(4211)
- Ensembl(ENSG00000143995)
- OMIM(601739)
- UniProtKB(O00470)
- Open Targets Platform(ENSG00000143995)
- Monarch Initiative
- Search for MEIS1 at DataMed
- Search for MEIS1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MEIS1 Gene
Genomics for MEIS1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MEIS1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MEIS1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MEIS1
- Top Transcription factor binding sites by QIAGEN in the MEIS1 gene promoter:
-
- AREB6
- c-Ets-1
- CREB
- CUTL1
- deltaCREB
- E2F
- Gfi-1
- S8
- SRY
- STAT5B
Genomic Locations for MEIS1 Gene
Genomic Locations for MEIS1 Gene
- chr2:66,433,452-66,573,869
- (GRCh38/hg38)
- Size:
- 140,418 bases
- Orientation:
- Plus strand
- chr2:66,660,584-66,801,001
- (GRCh37/hg19)
- Size:
- 140,418 bases
- Orientation:
- Plus strand
Genomic View for MEIS1 Gene
Genes around MEIS1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2p14 by HGNC
- 2p14 by Entrez Gene
- 2p14 by Ensembl
MEIS1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MEIS1 Gene
Proteins for MEIS1 Gene
-
Protein details for MEIS1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O00470-MEIS1_HUMAN
- Recommended name:
- Homeobox protein Meis1
- Protein Accession:
- O00470
- A8MV50
Protein attributes for MEIS1 Gene
- Size:
- 390 amino acids
- Molecular mass:
- 43016 Da
- Quaternary structure:
-
- Interacts with the N-terminal region of PBX1 to form a heterodimer which binds DNA including a cAMP-responsive sequence in CYP17. Also forms heterodimers with PBX2. Forms heterotrimers with PBX1 or PBX2 and a number of HOX proteins including HOXA9, HOXD4 and HOXD9 where it acts as a non-DNA-binding partner. Also forms heterotrimers with PBX1 and HOX proteins including HOXD9 and HOXD10 where PBX1 is the non-DNA-binding partner. Heterodimer with DLX3 (PubMed:26550823). Heterodimer with HOXB13 (PubMed:28473536).
Protein Expression for MEIS1 Gene
Post-translational modifications for MEIS1 Gene
Other Protein References for MEIS1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ MEIS1 Antibody
- Novus Biologicals Antibodies for MEIS1
-
Abcam antibodies for MEIS1
- Invitrogen Antibodies for MEIS1 (AFLGC-MEIS1)
- antibodies-online: Show 39 available MEIS1 Antibodies ranked by validation data
- Compare Top MEIS1 Antibodies
-
Recommended
- 48 WB Antibodies (anti-human)
- 6 IHC (p) Antibodies (anti-human)
- 5 IHC Antibodies (anti-human)
- 1 EIA Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 14 WB Antibodies (anti-rat)
- 4 IHC (p) Antibodies (anti-rat)
- 24 WB Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
-
Santa Cruz Biotechnology (SCBT) Antibodies for MEIS1
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MEIS1
- Origene Custom Protein Services for MEIS1
-
Abcam proteins for MEIS1
Assay Products
-
Signalway ELISA kits for MEIS1
No data available for DME Specific Peptides for MEIS1 Gene
Domains & Families for MEIS1 Gene
Gene Families for MEIS1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Predicted intracellular proteins
- Transcription factors
Protein Domains for MEIS1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for MEIS1 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ40855 fis, clone TRACH2016317, highly similar to HOMEOBOX PROTEIN MEIS1 (B3KUX4_HUMAN)
- cDNA FLJ52704, highly similar to Homeobox protein Meis1 (B7Z4T5_HUMAN)
- Homeobox protein Meis1 (MEIS1_HUMAN)
- Leukemogenic homolog protein (Q8IZZ2_HUMAN)
- Meis1 protein (Q9HCQ4_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O00470- Family:
-
- Belongs to the TALE/MEIS homeobox family.
Function for MEIS1 Gene
Molecular function for MEIS1 Gene
- UniProtKB/Swiss-Prot Function:
- Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias.
- GENATLAS Biochemistry:
- homeo domain protein,unusual,murine Meis1 (myeloid ecotropic viral integration site 1) ortholog,expressed in fetal liver,normal immunohematopoietic tissues and cerebellum,binding DNA cooperatively with the heterodimer E2A/myogenic transcription factors
Phenotypes From GWAS Catalog for MEIS1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IEA | -- |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IEA,IBA | 21873635 |
| GO:0003677 | DNA binding | IEA,IDA | 26550823 |
| GO:0003682 | chromatin binding | IEA | -- |
Phenotypes for MEIS1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MEIS1 - Select products 50% OFF >
- * MEIS1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MEIS1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MEIS1
-
Santa Cruz Biotechnology (SCBT) CRISPR for MEIS1
miRNA for MEIS1 Gene
- miRTarBase miRNAs that target MEIS1
-
- hsa-miR-204-5p (MIRT000189)
- hsa-miR-155-5p (MIRT000287)
- hsa-miR-98-5p (MIRT004946)
- hsa-let-7a-5p (MIRT004962)
- hsa-miR-495-3p (MIRT007195)
- hsa-miR-101-3p (MIRT027307)
- hsa-miR-21-5p (MIRT030714)
- hsa-miR-484 (MIRT041845)
- hsa-miR-196b-5p (MIRT053331)
- dre-miR-144-3p (MIRT054401)
- hsa-miR-4311 (MIRT498822)
- mmu-miR-1943-5p (MIRT600642)
- hsa-miR-1286 (MIRT762239)
- hsa-miR-3667-3p (MIRT766558)
- hsa-miR-4421 (MIRT768836)
- hsa-miR-4668-3p (MIRT770846)
- hsa-miR-4722-5p (MIRT771565)
- hsa-miR-4780 (MIRT772255)
- hsa-miR-548c-3p (MIRT774320)
- hsa-miR-5699-3p (MIRT775183)
- hsa-miR-623 (MIRT776086)
- hsa-miR-6511b-5p (MIRT776873)
- hsa-miR-6748-3p (MIRT778322)
- hsa-miR-6780b-3p (MIRT779041)
- hsa-miR-6811-5p (MIRT779765)
- hsa-miR-6841-3p (MIRT780202)
- hsa-miR-7152-5p (MIRT781533)
- hsa-miR-873-5p (MIRT782491)
Targeted motifs for MEIS1 Gene
HOMER Transcription Factor Regulatory Elements motif MEIS1
- Consensus sequence: VGCTGWCAVB Submotif: canonical Cell Type: MastCells GEO ID: GSE48085
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MEIS1
- Browse OriGene Inhibitory RNA Products For MEIS1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MEIS1
Clone Products
- Applied Biological Materials (abm): Clones for MEIS1 - Select products 50% OFF >
- * MEIS1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG225804
- MG225806
- MR225804
- MR225804L1
- MR225804L2
- MR225804L3
- MR225804L4
- MR225806
- MR225806L1
- MR225806L2
- MR225806L3
- MR225806L4
- RC208135
- RC208135L1
- RC208135L2
- RC208135L3
- RC208135L4
- RG208135
- RR210388
- RR210388L3
- RR210388L4
- MR225804L1V
- MR225804L2V
- MR225804L3V
- MR225804L4V
- MR225806L1V
- MR225806L2V
- MR225806L3V
- MR225806L4V
- RC208135L1V
- RC208135L2V
- RC208135L3V
- RC208135L4V
- RR210388L3V
- RR210388L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MEIS1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MEIS1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for MEIS1 Gene
Localization for MEIS1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MEIS1 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 3 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | ISA | -- |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005667 | transcription factor complex | IEA | -- |
Pathways & Interactions for MEIS1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||
| 2 | Signaling pathways regulating pluripotency of stem cells | ||
| 3 | Transcriptional misregulation in cancer | ||
| 4 | Transcriptional Regulatory Network in Embryonic Stem Cell |
Transcriptional Regulatory Network in Embryonic Stem Cell
-
|
|
| 5 | Developmental Biology | ||
Pathways by source for MEIS1 Gene
1 BioSystems pathway for MEIS1 Gene
2 KEGG pathways for MEIS1 Gene
1 Qiagen pathway for MEIS1 Gene
- Transcriptional Regulatory Network in Embryonic Stem Cell
Interacting Proteins for MEIS1 Gene
Selected Interacting proteins:
O00470-MEIS1_HUMAN
ENSP00000272369
for MEIS1 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for MEIS1
SIGNOR curated interactions for MEIS1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001525 | angiogenesis | IEA,IBA | 21873635 |
| GO:0001654 | eye development | IBA | 21873635 |
| GO:0002089 | lens morphogenesis in camera-type eye | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0007275 | multicellular organism development | IEA | -- |
Drugs & Compounds for MEIS1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| cyclic amp | Experimental | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for MEIS1 Gene
mRNA/cDNA for MEIS1 Gene
- 1 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 17 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000272369 4566 nts (view in UCSC)
- ENST00000398506 3530 nts (view in UCSC)
- ENST00000409517 1733 nts (view in UCSC)
- ENST00000409622 551 nts (view in UCSC)
- ENST00000437869 363 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MEIS1 - Select products 50% OFF >
- * MEIS1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MEIS1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MEIS1
-
Santa Cruz Biotechnology (SCBT) CRISPR for MEIS1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MEIS1
- Browse OriGene Inhibitory RNA Products For MEIS1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MEIS1
Clone Products
- Applied Biological Materials (abm): Clones for MEIS1 - Select products 50% OFF >
- * MEIS1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG225804
- MG225806
- MR225804
- MR225804L1
- MR225804L2
- MR225804L3
- MR225804L4
- MR225806
- MR225806L1
- MR225806L2
- MR225806L3
- MR225806L4
- RC208135
- RC208135L1
- RC208135L2
- RC208135L3
- RC208135L4
- RG208135
- RR210388
- RR210388L3
- RR210388L4
- MR225804L1V
- MR225804L2V
- MR225804L3V
- MR225804L4V
- MR225806L1V
- MR225806L2V
- MR225806L3V
- MR225806L4V
- RC208135L1V
- RC208135L2V
- RC208135L3V
- RC208135L4V
- RR210388L3V
- RR210388L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MEIS1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MEIS1
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16a | · | 16b | · | 16c | ^ | 17a | · | 17b | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - |
| ExUns: | 18a | · | 18b |
|---|---|---|---|
| SP1: | |||
| SP2: | |||
| SP3: | |||
| SP4: | |||
| SP5: | |||
| SP6: | |||
| SP7: | |||
| SP8: | |||
| SP9: | |||
| SP10: |
Relevant External Links for MEIS1 Gene
- GeneLoc Exon Structure for
- MEIS1
Expression for MEIS1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Mesenchymal Stem Cells (Uncategorized)
- Umbilical Cord (Extraembryonic Tissues)
- Inner Cell Mass (Early Embryonic Tissues)
- Blood (Hematopoietic System)
- NULL (Uncategorized)
- Trophoblast (Extraembryonic Tissues)
- Heart (Cardiovascular System)
-
Uterus (Reproductive System)
This gene is overexpressed in Fetal ovary (27.4) and Ovary (22.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MEIS1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MEIS1
SOURCE GeneReport for Unigene cluster for MEIS1 Gene:
Hs.526754mRNA Expression by UniProt/SwissProt for MEIS1 Gene:
O00470-MEIS1_HUMAN
Tissue specificity:
Expressed at low level in normal immunohepatopoietic tissues, including the fetal liver. Expressed in a subset of myeloid leukemia cell lines, with the highest expression seen in those with a megakaryocytic-erythroid phenotype. Also expressed at high levels in the cerebellum.
Evidence on tissue expression from TISSUES for MEIS1 Gene
- Nervous system(3.8)
- Bone marrow(2.8)
- Heart(2.7)
- Muscle(2.6)
- Spleen(2.5)
- Kidney(2.5)
- Skin(2.4)
- Blood(2.4)
- Intestine(2.3)
- Lung(2.3)
- Pancreas(2.1)
- Liver(2)
Primer Products
-
OriGene qPCR primer pairs for MEIS1
-
OriGene qPCR primer pairs and template standards for MEIS1
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MEIS1 Gene
Orthologs for MEIS1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | MEIS1 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | MEIS1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | MEIS1 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Meis1 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | MEIS1 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | MEIS1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | MEIS1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | MEIS1 31 |
|
OneToOne | |
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.607 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | meis1 30 31 |
|
OneToMany | |
| meis4.1a 31 |
|
OneToMany | |||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.12496 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | hth 31 32 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | unc-62 32 |
|
|
|
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for MEIS1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
Evolution for MEIS1 Gene
- ENSEMBL:
- Gene Tree for MEIS1 (if available)
- TreeFam:
- Gene Tree for MEIS1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MEIS1: view image
Paralogs for MEIS1 Gene
Paralogs for MEIS1 Gene
(12) SIMAP similar genes for MEIS1 Gene using alignment to 15 proteins:
- MEIS1_HUMAN
- B7Z4T5_HUMAN
- E9PBY5_HUMAN
- E9PDC4_HUMAN
- F5GYS8_HUMAN
- F8W8U3_HUMAN
- H0YNY8_HUMAN
- Q53R57_HUMAN
- Q53RD5_HUMAN
- U3KPR8_HUMAN
- U3KPU2_HUMAN
- U3KQA7_HUMAN
- U3KQH3_HUMAN
- U3KQK9_HUMAN
- U3KQR9_HUMAN
Variants for MEIS1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MEIS1 Gene
| SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 720729 | Benign: not provided | 66,568,725(+) | C/T | SYNONYMOUS_VARIANT | |
| rs61752693 | - | p.Arg272His |
Residual Variation Intolerance Score:
32.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.48;
43.54% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MEIS1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEIS1 Gene
Disorders for MEIS1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| restless legs syndrome |
|
|
| restless legs syndrome 7 |
|
|
| myeloid leukemia |
|
|
| acute leukemia |
|
|
| acute promyelocytic leukemia |
|
Search MEIS1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
MEIS1_HUMAN- Restless legs syndrome 7 (RLS7) [MIM:612853]: A neurologic sleep/wake disorder characterized by uncomfortable and unpleasant sensations in the legs that appear at rest, usually at night, inducing an irresistible desire to move the legs. The disorder results in nocturnal insomnia and chronic sleep deprivation. The majority of patients also have periodic limb movements in sleep, which are characterized by involuntary, highly stereotypical, regularly occurring limb movements that occur during sleep. {ECO:0000305 PubMed:19620614}. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry.
Additional Disease Information for MEIS1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for MEIS1 Gene
Publications for MEIS1 Gene
- MEIS1 intronic risk haplotype associated with restless legs syndrome affects its mRNA and protein expression levels. (PMID: 19126776) Xiong L … Rouleau GA (Human molecular genetics 2009) 3 23 41
- Homeodomain proteins MEIS1 and PBXs regulate the lineage-specific transcription of the platelet factor 4 gene. (PMID: 12609849) Okada Y … Doi T (Blood 2003) 3 4 23
- Cloning and mapping of the MEIS1 gene, the human homolog of a murine leukemogenic gene. (PMID: 9226379) Smith JE … Takeshita K (Genomics 1997) 3 4 23
- Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice. (PMID: 7565694) Moskow JJ … Buchberg AM (Molecular and cellular biology 1995) 2 3 23
- DNA-dependent formation of transcription factor pairs alters their binding specificity. (PMID: 26550823) Jolma A … Taipale J (Nature 2015) 3 4
ExternalLinks
Products for MEIS1 Gene
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