Aliases for MEIS1 Gene
External Ids for MEIS1 Gene
Previous GeneCards Identifiers for MEIS1 Gene
Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. [provided by RefSeq, Jul 2008]
GeneCards Summary for MEIS1 Gene
MEIS1 (Meis Homeobox 1) is a Protein Coding gene. Diseases associated with MEIS1 include Restless Legs Syndrome and Restless Legs Syndrome 7. Among its related pathways are Signaling pathways regulating pluripotency of stem cells and Mesodermal Commitment Pathway. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and chromatin binding. An important paralog of this gene is MEIS2.
UniProtKB/Swiss-Prot Summary for MEIS1 Gene
Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias.