Aliases for MEIOB Gene

Aliases for MEIOB Gene

  • Meiosis Specific With OB-Fold 2 3 5
  • Meiosis-Specific With OB Domain-Containing Protein 3 4
  • Meiosis Specific With OB Domains 2 3
  • C16orf73 3 4
  • Chromosome 16 Open Reading Frame 73 2
  • EC 3.1.-.- 4
  • MGC35212 2
  • SPGF22 3
  • Gs129 3
  • MEIOB 5

External Ids for MEIOB Gene

Previous HGNC Symbols for MEIOB Gene

  • C16orf73

Previous GeneCards Identifiers for MEIOB Gene

  • GC16M001884
  • GC16M001886

Summaries for MEIOB Gene

GeneCards Summary for MEIOB Gene

MEIOB (Meiosis Specific With OB-Fold) is a Protein Coding gene. Diseases associated with MEIOB include Spermatogenic Failure 22 and Male Infertility With Azoospermia Or Oligozoospermia Due To Single Gene Mutation. Gene Ontology (GO) annotations related to this gene include chromatin binding and single-stranded DNA 3'-5' exodeoxyribonuclease activity.

UniProtKB/Swiss-Prot Summary for MEIOB Gene

  • Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3'-5' exonuclease activity in vitro (By similarity).

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MEIOB Gene

Genomics for MEIOB Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MEIOB Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J001882 Enhancer 0.7 Ensembl 609.2 0.0 -22 0.4 CEBPG CREB1 CTCF ZNF629 ZHX2 PKNOX1 CEBPA CEBPB FOXA2 ZGPAT MEIOB LINC00254 FAHD1 LINC02124 HS3ST6
GH16J001825 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.5 +55.7 55679 6.9 SP1 HNRNPL CREB1 GATAD2A TEAD4 PRDM10 REST ZNF629 TFE3 ZNF512 FAHD1 HAGH CRAMP1 TELO2 ENSG00000261505 UBE2I SRRM2 ENSG00000260051 E4F1 UNKL
GH16J001832 Enhancer 1.3 Ensembl ENCODE dbSUPER 11.8 +50.9 50894 2 RNF2 ARHGAP35 GATAD2A TFE3 LEF1 IKZF1 JUND DDX20 MTA2 ZIC2 FAHD1 HAGH ENSG00000261505 HS3ST6 IGFALS MEIOB MAPK8IP3 GNPTG TSR3 TELO2
GH16J001913 Enhancer 1 FANTOM5 Ensembl ENCODE 12.6 -29.4 -29407 1.4 ZBTB33 TARDBP FOXA1 CTBP1 FOXA2 KLF4 PKNOX1 GATAD2B PCBP1 ZFHX2 FAHD1 HAGH MEIOB HS3ST6 CEROX1 lnc-NDUFB10-2
GH16J001928 Promoter/Enhancer 1.8 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 5.5 -45.5 -45497 1.2 HNRNPL CTCF KDM1A ZNF692 BACH1 JUND LARP7 ZNF143 RBFOX2 ZNF24 CRAMP1 UNKL UBE2I TSC2 TELO2 E4F1 FAHD1 ENSG00000261207 ENSG00000260051 HAGH
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MEIOB on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MEIOB

Genomic Locations for MEIOB Gene

Genomic Locations for MEIOB Gene
chr16:1,833,986-1,884,294
(GRCh38/hg38)
Size:
50,309 bases
Orientation:
Minus strand
chr16:1,883,984-1,934,295
(GRCh37/hg19)
Size:
50,312 bases
Orientation:
Minus strand

Genomic View for MEIOB Gene

Genes around MEIOB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MEIOB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MEIOB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEIOB Gene

Proteins for MEIOB Gene

  • Protein details for MEIOB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N635-MEIOB_HUMAN
    Recommended name:
    Meiosis-specific with OB domain-containing protein
    Protein Accession:
    Q8N635
    Secondary Accessions:
    • B1AK39
    • C9J0S1
    • Q96RY0

    Protein attributes for MEIOB Gene

    Size:
    442 amino acids
    Molecular mass:
    49313 Da
    Quaternary structure:
    • Component of a multiprotein complex with RPA2 and SPATA22.
    SequenceCaution:
    • Sequence=AAH29829.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAK61296.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for MEIOB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MEIOB Gene

Post-translational modifications for MEIOB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MEIOB Gene

No data available for DME Specific Peptides for MEIOB Gene

Domains & Families for MEIOB Gene

Gene Families for MEIOB Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for MEIOB Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8N635

UniProtKB/Swiss-Prot:

MEIOB_HUMAN :
  • Belongs to the MEIOB family.
Family:
  • Belongs to the MEIOB family.
genes like me logo Genes that share domains with MEIOB: view

No data available for Suggested Antigen Peptide Sequences for MEIOB Gene

Function for MEIOB Gene

Molecular function for MEIOB Gene

UniProtKB/Swiss-Prot Function:
Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3'-5' exonuclease activity in vitro (By similarity).

Enzyme Numbers (IUBMB) for MEIOB Gene

Phenotypes From GWAS Catalog for MEIOB Gene

Gene Ontology (GO) - Molecular Function for MEIOB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding ISS --
GO:0003697 single-stranded DNA binding IBA,ISS --
GO:0004518 nuclease activity IEA --
GO:0004527 exonuclease activity IEA --
genes like me logo Genes that share ontologies with MEIOB: view
genes like me logo Genes that share phenotypes with MEIOB: view

Human Phenotype Ontology for MEIOB Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MEIOB Gene

MGI Knock Outs for MEIOB:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MEIOB

No data available for miRNA , Transcription Factor Targets and HOMER Transcription for MEIOB Gene

Localization for MEIOB Gene

Subcellular locations from UniProtKB/Swiss-Prot for MEIOB Gene

Cytoplasm. Nucleus. Chromosome. Note=Co-localizes with the RPA complex on meiotic chromosome axes. Accumulates on resected DNA. Localization is dependent on SPATA22 (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MEIOB gene
Compartment Confidence
nucleus 4
cytoskeleton 1
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MEIOB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005694 chromosome IEA --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with MEIOB: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MEIOB Gene

Pathways & Interactions for MEIOB Gene

PathCards logo

SuperPathways for MEIOB Gene

No Data Available

Interacting Proteins for MEIOB Gene

Gene Ontology (GO) - Biological Process for MEIOB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000712 resolution of meiotic recombination intermediates ISS --
GO:0000724 double-strand break repair via homologous recombination ISS --
GO:0007129 synapsis ISS --
GO:0007140 male meiotic nuclear division ISS --
GO:0007141 male meiosis I IEA --
genes like me logo Genes that share ontologies with MEIOB: view

No data available for Pathways by source and SIGNOR curated interactions for MEIOB Gene

Drugs & Compounds for MEIOB Gene

No Compound Related Data Available

Transcripts for MEIOB Gene

mRNA/cDNA for MEIOB Gene

2 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MEIOB

Alternative Splicing Database (ASD) splice patterns (SP) for MEIOB Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: -
SP2:
SP3:
SP4: - -
SP5:

Relevant External Links for MEIOB Gene

GeneLoc Exon Structure for
MEIOB

Expression for MEIOB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MEIOB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MEIOB Gene

This gene is overexpressed in Testis (x41.9).

Protein differential expression in normal tissues from HIPED for MEIOB Gene

This gene is overexpressed in Urinary Bladder (46.9), Testis (6.5), and Adrenal (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MEIOB Gene



Protein tissue co-expression partners for MEIOB Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MEIOB

SOURCE GeneReport for Unigene cluster for MEIOB Gene:

Hs.729604

mRNA Expression by UniProt/SwissProt for MEIOB Gene:

Q8N635-MEIOB_HUMAN
Tissue specificity: In fetal gonads, specifically expressed in the ovary starting at the 14th weeks post fertilization (PubMed:24068956). In the adult, restricted to testis (PubMed:28206990).

Evidence on tissue expression from TISSUES for MEIOB Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with MEIOB: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MEIOB Gene

Orthologs for MEIOB Gene

This gene was present in the common ancestor of animals.

Orthologs for MEIOB Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC750018 30
  • 99.54 (n)
MEIOB 31
  • 99 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia MEIOB 30 31
  • 88.54 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MEIOB 30 31
  • 87.47 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Meiob 30 17 31
  • 86.78 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Meiob 30
  • 85.57 (n)
Oppossum
(Monodelphis domestica)
Mammalia MEIOB 31
  • 78 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia MEIOB 31
  • 72 (a)
OneToOne
Chicken
(Gallus gallus)
Aves C14H16ORF73 30
  • 73.06 (n)
MEIOB 31
  • 67 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia MEIOB 31
  • 68 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia meiob 30
  • 68.16 (n)
Zebrafish
(Danio rerio)
Actinopterygii meiob 30 31
  • 58.91 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta hdm 30 31
  • 40.3 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011538 30
  • 40.02 (n)
Species where no ortholog for MEIOB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MEIOB Gene

ENSEMBL:
Gene Tree for MEIOB (if available)
TreeFam:
Gene Tree for MEIOB (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MEIOB: view image

Paralogs for MEIOB Gene

(1) SIMAP similar genes for MEIOB Gene using alignment to 4 proteins:

  • MEIOB_HUMAN
  • H3BSU6_HUMAN
  • H3BU10_HUMAN
  • H3BU18_HUMAN
genes like me logo Genes that share paralogs with MEIOB: view

No data available for Paralogs for MEIOB Gene

Variants for MEIOB Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MEIOB Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
711956 Benign: not provided 1,841,902(-) C/A MISSENSE_VARIANT
715773 Benign: not provided 1,834,371(-) G/A INTRON_VARIANT
786285 Benign: not provided 1,857,736(-) G/A MISSENSE_VARIANT
791645 Benign: not provided 1,853,267(-) C/T MISSENSE_VARIANT
rs1555472691 Pathogenic: SPERMATOGENIC FAILURE 22. Spermatogenic failure 22 (SPGF22) [MIM:617706] 1,862,053(-) T/Ap.Asn64Ile MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for MEIOB Gene

Structural Variations from Database of Genomic Variants (DGV) for MEIOB Gene

Variant ID Type Subtype PubMed ID
dgv335n27 CNV gain 19166990
dgv4857n54 CNV loss 21841781
dgv778e212 CNV loss 25503493
esv1009942 CNV insertion 20482838
esv1701785 CNV insertion 17803354
esv2422427 CNV duplication 17116639
esv2671641 CNV deletion 23128226
esv3553003 CNV deletion 23714750
nsv1040440 CNV gain 25217958
nsv1042986 CNV loss 25217958
nsv1046474 CNV loss 25217958
nsv1051692 CNV loss 25217958
nsv457337 CNV loss 19166990
nsv517196 CNV gain+loss 19592680
nsv518641 CNV loss 19592680
nsv519366 CNV loss 19592680
nsv525861 CNV loss 19592680
nsv571175 CNV loss 21841781
nsv571177 CNV gain 21841781
nsv833119 CNV loss 17160897

Variation tolerance for MEIOB Gene

Gene Damage Index Score: 9.71; 89.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MEIOB Gene

Human Gene Mutation Database (HGMD)
MEIOB
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MEIOB

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEIOB Gene

Disorders for MEIOB Gene

MalaCards: The human disease database

(4) MalaCards diseases for MEIOB Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search MEIOB in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

MEIOB_HUMAN
  • Spermatogenic failure 22 (SPGF22) [MIM:617706]: An infertility disorder caused by spermatogenesis defects that result in non-obstructive azoospermia. {ECO:0000269 PubMed:28206990}. Note=The disease is caused by mutations affecting the gene represented in this entry.
genes like me logo Genes that share disorders with MEIOB: view

No data available for Genatlas for MEIOB Gene

Publications for MEIOB Gene

  1. Meiosis-specific proteins MEIOB and SPATA22 cooperatively associate with the single-stranded DNA-binding replication protein A complex and DNA double-strand breaks. (PMID: 28453612) Xu Y … Wang PJ (Biology of reproduction 2017) 2 3
  2. MEIOB targets single-strand DNA and is necessary for meiotic recombination. (PMID: 24068956) Souquet B … Livera G (PLoS genetics 2013) 3 4
  3. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels RJ … Higgs DR (Human molecular genetics 2001) 3 4
  4. A truncating MEIOB mutation responsible for familial primary ovarian insufficiency abolishes its interaction with its partner SPATA22 and their recruitment to DNA double-strand breaks. (PMID: 31000419) Caburet S … Veitia RA (EBioMedicine 2019) 3
  5. A novel nuclear complex of DRR1, F-actin and COMMD1 involved in NF-κB degradation and cell growth suppression in neuroblastoma. (PMID: 28604741) Mu P … Kadomatsu K (Oncogene 2017) 3

Products for MEIOB Gene

  • Signalway Proteins for MEIOB

Sources for MEIOB Gene