Aliases for MEIOB Gene
External Ids for MEIOB Gene
Previous HGNC Symbols for MEIOB Gene
Previous GeneCards Identifiers for MEIOB Gene
GeneCards Summary for MEIOB Gene
MEIOB (Meiosis Specific With OB-Fold) is a Protein Coding gene. Diseases associated with MEIOB include Spermatogenic Failure 22 and Male Infertility With Azoospermia Or Oligozoospermia Due To Single Gene Mutation. Gene Ontology (GO) annotations related to this gene include chromatin binding and single-stranded DNA 3'-5' exodeoxyribonuclease activity.
UniProtKB/Swiss-Prot Summary for MEIOB Gene
Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3'-5' exonuclease activity in vitro (By similarity).