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Aliases for MEIOB Gene

Aliases for MEIOB Gene

  • Meiosis Specific With OB Domains 2 3 5
  • C16orf73 3 4
  • Meiosis-Specific With OB Domain-Containing Protein 3
  • Chromosome 16 Open Reading Frame 73 2
  • EC 3.1.-.- 4
  • SPGF22 3
  • Gs129 3

External Ids for MEIOB Gene

Previous HGNC Symbols for MEIOB Gene

  • C16orf73

Previous GeneCards Identifiers for MEIOB Gene

  • GC16M001884
  • GC16M001886

Summaries for MEIOB Gene

GeneCards Summary for MEIOB Gene

MEIOB (Meiosis Specific With OB Domains) is a Protein Coding gene. Diseases associated with MEIOB include Spermatogenic Failure 22. Gene Ontology (GO) annotations related to this gene include chromatin binding and single-stranded DNA 3-5 exodeoxyribonuclease activity.

UniProtKB/Swiss-Prot for MEIOB Gene

  • Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3-5 exonuclease activity in vitro (By similarity).

Additional gene information for MEIOB Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEIOB Gene

Genomics for MEIOB Gene

GeneHancer (GH) Regulatory Elements for MEIOB Gene

Promoters and enhancers for MEIOB Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I001871 Promoter/Enhancer 1.3 EPDnew Ensembl 550.4 +12.0 12003 1 HDAC1 PKNOX1 ATF1 RB1 ZBTB40 POLR2B EGR1 ATF7 CREM SMAD5 LOC102723890 MEIOB FAHD1 HAGH HS3ST6 RAB26 SNORD60 TRAF7 JPT2 LINC00254
GH16I001825 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.4 +55.7 55679 6.9 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 ZNF213 ZNF143 ZNF548 SP3 FAHD1 HAGH GC16M001827 GC16M001829 ENSG00000261505 SRRM2 TELO2 ENSG00000260051 CRAMP1 ENSG00000260954
GH16I001832 Enhancer 1.2 ENCODE dbSUPER 11.3 +50.9 50851 1.7 PKNOX1 FOXA2 MLX ARNT ARID4B ZNF766 E2F8 SP5 ZNF592 KAT8 FAHD1 HAGH IGFALS MEIOB MAPK8IP3 JPT2 GC16M001827 GC16M001829 PIR46763
GH16I001913 Enhancer 0.9 FANTOM5 ENCODE 12.5 -29.3 -29306 1 TFAP4 PKNOX1 KLF1 FOXA2 KLF17 SIN3A ZBTB7B HIC1 ZFHX2 CTBP1 FAHD1 HAGH MEIOB HS3ST6 ENSG00000260807 PIR49138
GH16I001839 Enhancer 0.8 ENCODE 11.8 +44.5 44471 0.7 HDGF KLF17 MZF1 ZNF76 ZNF335 SCRT2 SP3 ZNF398 ZEB2 ZFP69B PIR46763 FAHD1 HS3ST6 MEIOB CRAMP1 TELO2 IFT140 ENSG00000261505 GNPTG TSR3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MEIOB on UCSC Golden Path with GeneCards custom track

Genomic Locations for MEIOB Gene

Genomic Locations for MEIOB Gene
chr16:1,833,983-1,884,294
(GRCh38/hg38)
Size:
50,312 bases
Orientation:
Minus strand
chr16:1,883,984-1,934,295
(GRCh37/hg19)

Genomic View for MEIOB Gene

Genes around MEIOB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MEIOB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MEIOB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEIOB Gene

Proteins for MEIOB Gene

  • Protein details for MEIOB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N635-MEIOB_HUMAN
    Recommended name:
    Meiosis-specific with OB domain-containing protein
    Protein Accession:
    Q8N635
    Secondary Accessions:
    • B1AK39
    • C9J0S1
    • Q96RY0

    Protein attributes for MEIOB Gene

    Size:
    442 amino acids
    Molecular mass:
    49313 Da
    Quaternary structure:
    • Component of a multiprotein complex with RPA2 and SPATA22.
    SequenceCaution:
    • Sequence=AAH29829.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAK61296.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for MEIOB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MEIOB Gene

Post-translational modifications for MEIOB Gene

No Post-translational modifications

Other Protein References for MEIOB Gene

No data available for DME Specific Peptides for MEIOB Gene

Domains & Families for MEIOB Gene

Gene Families for MEIOB Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MEIOB Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8N635

UniProtKB/Swiss-Prot:

MEIOB_HUMAN :
  • Belongs to the MEIOB family.
Family:
  • Belongs to the MEIOB family.
genes like me logo Genes that share domains with MEIOB: view

No data available for Suggested Antigen Peptide Sequences for MEIOB Gene

Function for MEIOB Gene

Molecular function for MEIOB Gene

UniProtKB/Swiss-Prot Function:
Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3-5 exonuclease activity in vitro (By similarity).

Enzyme Numbers (IUBMB) for MEIOB Gene

Gene Ontology (GO) - Molecular Function for MEIOB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding ISS,IEA --
GO:0003697 single-stranded DNA binding IEA,ISS --
GO:0004518 nuclease activity IEA --
GO:0004527 exonuclease activity IEA --
genes like me logo Genes that share ontologies with MEIOB: view
genes like me logo Genes that share phenotypes with MEIOB: view

Human Phenotype Ontology for MEIOB Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MEIOB Gene

MGI Knock Outs for MEIOB:

Clone Products

No data available for Phenotypes From GWAS Catalog , miRNA , Transcription Factor Targets and HOMER Transcription for MEIOB Gene

Localization for MEIOB Gene

Subcellular locations from UniProtKB/Swiss-Prot for MEIOB Gene

Cytoplasm. Nucleus. Chromosome. Note=Co-localizes with the RPA complex on meiotic chromosome axes. Accumulates on resected DNA. Localization is dependent on SPATA22 (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MEIOB gene
Compartment Confidence
nucleus 4
cytosol 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MEIOB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005694 chromosome IEA --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with MEIOB: view

Pathways & Interactions for MEIOB Gene

SuperPathways for MEIOB Gene

No Data Available

Interacting Proteins for MEIOB Gene

Gene Ontology (GO) - Biological Process for MEIOB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000712 resolution of meiotic recombination intermediates ISS --
GO:0000724 double-strand break repair via homologous recombination IEA,ISS --
GO:0007129 synapsis ISS,IEA --
GO:0007140 male meiotic nuclear division IEA,ISS --
GO:0007141 male meiosis I IEA --
genes like me logo Genes that share ontologies with MEIOB: view

No data available for Pathways by source and SIGNOR curated interactions for MEIOB Gene

Drugs & Compounds for MEIOB Gene

No Compound Related Data Available

Transcripts for MEIOB Gene

mRNA/cDNA for MEIOB Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MEIOB Gene

Meiosis specific with OB domains:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MEIOB Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: -
SP2:
SP3:
SP4: - -
SP5:

Relevant External Links for MEIOB Gene

GeneLoc Exon Structure for
MEIOB
ECgene alternative splicing isoforms for
MEIOB

Expression for MEIOB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MEIOB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MEIOB Gene

This gene is overexpressed in Testis (x41.9).

Protein differential expression in normal tissues from HIPED for MEIOB Gene

This gene is overexpressed in Urinary Bladder (46.9), Testis (6.5), and Adrenal (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MEIOB Gene



Protein tissue co-expression partners for MEIOB Gene

NURSA nuclear receptor signaling pathways regulating expression of MEIOB Gene:

MEIOB

SOURCE GeneReport for Unigene cluster for MEIOB Gene:

Hs.729604

mRNA Expression by UniProt/SwissProt for MEIOB Gene:

Q8N635-MEIOB_HUMAN
Tissue specificity: In fetal gonads, specifically expressed in the ovary starting at the 14th weeks post fertilization (PubMed:24068956). In the adult, restricted to testis (PubMed:28206990).

Evidence on tissue expression from TISSUES for MEIOB Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with MEIOB: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MEIOB Gene

Orthologs for MEIOB Gene

This gene was present in the common ancestor of animals.

Orthologs for MEIOB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC750018 33
  • 99.54 (n)
MEIOB 34
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MEIOB 33 34
  • 88.54 (n)
dog
(Canis familiaris)
Mammalia MEIOB 33 34
  • 87.47 (n)
mouse
(Mus musculus)
Mammalia Meiob 33 16 34
  • 86.78 (n)
rat
(Rattus norvegicus)
Mammalia Meiob 33
  • 85.57 (n)
oppossum
(Monodelphis domestica)
Mammalia MEIOB 34
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MEIOB 34
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves C14H16ORF73 33
  • 73.06 (n)
MEIOB 34
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MEIOB 34
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia meiob 33
  • 68.16 (n)
zebrafish
(Danio rerio)
Actinopterygii meiob 33 34
  • 58.91 (n)
fruit fly
(Drosophila melanogaster)
Insecta hdm 33 34
  • 40.3 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011538 33
  • 40.02 (n)
Species where no ortholog for MEIOB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MEIOB Gene

ENSEMBL:
Gene Tree for MEIOB (if available)
TreeFam:
Gene Tree for MEIOB (if available)

Paralogs for MEIOB Gene

(1) SIMAP similar genes for MEIOB Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MEIOB: view

No data available for Paralogs for MEIOB Gene

Variants for MEIOB Gene

Sequence variations from dbSNP and Humsavar for MEIOB Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
VAR_080034 Spermatogenic failure 22 (SPGF22) [MIM:617706] p.Asn64Ile
rs1000010350 -- 1,854,295(-) C/A intron_variant
rs1000022022 -- 1,836,988(-) C/G intron_variant
rs1000037678 -- 1,854,564(-) G/A intron_variant
rs1000472736 -- 1,838,682(-) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MEIOB Gene

Variant ID Type Subtype PubMed ID
nsv833119 CNV loss 17160897
nsv571177 CNV gain 21841781
nsv571175 CNV loss 21841781
nsv525861 CNV loss 19592680
nsv519366 CNV loss 19592680
nsv518641 CNV loss 19592680
nsv517196 CNV gain+loss 19592680
nsv457337 CNV loss 19166990
nsv1051692 CNV loss 25217958
nsv1046474 CNV loss 25217958
nsv1042986 CNV loss 25217958
nsv1040440 CNV gain 25217958
esv3553003 CNV deletion 23714750
esv2671641 CNV deletion 23128226
esv2422427 CNV duplication 17116639
esv1701785 CNV insertion 17803354
esv1009942 CNV insertion 20482838
dgv778e212 CNV loss 25503493
dgv4857n54 CNV loss 21841781
dgv335n27 CNV gain 19166990

Variation tolerance for MEIOB Gene

Gene Damage Index Score: 9.71; 89.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MEIOB Gene

Human Gene Mutation Database (HGMD)
MEIOB
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MEIOB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEIOB Gene

Disorders for MEIOB Gene

MalaCards: The human disease database

(1) MalaCards diseases for MEIOB Gene - From: HGMD, OMIM, ClinVar, Swiss-Prot, and GeneCards

Disorder Aliases PubMed IDs
spermatogenic failure 22
  • spgf22
- elite association - COSMIC cancer census association via MalaCards
Search MEIOB in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

MEIOB_HUMAN
  • Spermatogenic failure 22 (SPGF22) [MIM:617706]: An infertility disorder caused by spermatogenesis defects that result in non-obstructive azoospermia. {ECO:0000269 PubMed:28206990}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for MEIOB

genes like me logo Genes that share disorders with MEIOB: view

No data available for Genatlas for MEIOB Gene

Publications for MEIOB Gene

  1. MEIOB targets single-strand DNA and is necessary for meiotic recombination. (PMID: 24068956) Souquet B … Livera G (PLoS genetics 2013) 3 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  3. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels RJ … Higgs DR (Human molecular genetics 2001) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. A familial study of azoospermic men identifies three novel causative mutations in three new human azoospermia genes. (PMID: 28206990) Gershoni M … Kleiman SE (Genetics in medicine : official journal of the American College of Medical Genetics 2017) 4 58

Products for MEIOB Gene

Sources for MEIOB Gene

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