Aliases for MEIG1 Gene

Aliases for MEIG1 Gene

  • Meiosis/Spermiogenesis Associated 1 2 3 5
  • Meiosis Expressed Gene 1 Protein Homolog 3 4
  • Spermatogenesis Associated 39 2 3
  • BA2K17.3 2 3
  • SPATA39 2 3
  • Long Meiosis Expressed Gene 1 Protein Isoform 3
  • Meiosis Expressed Gene 1 Homolog (Mouse) 2
  • Meiosis Expressed Gene 1 Homolog 3
  • MEIG1 5

External Ids for MEIG1 Gene

Previous GeneCards Identifiers for MEIG1 Gene

  • GC10U900466
  • GC10P015042
  • GC10P014911
  • GC10P015001

Summaries for MEIG1 Gene

GeneCards Summary for MEIG1 Gene

MEIG1 (Meiosis/Spermiogenesis Associated 1) is a Protein Coding gene. Diseases associated with MEIG1 include Cardiomyopathy, Familial Hypertrophic, 7.

UniProtKB/Swiss-Prot Summary for MEIG1 Gene

Additional gene information for MEIG1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MEIG1 Gene

Genomics for MEIG1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MEIG1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J014950 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 -1.3 -1289 4.9 RNF2 SP1 HNRNPL CREB1 CTCF PRDM10 ZNF629 TFE3 LEF1 IKZF1 DCLRE1C MEIG1 lnc-CDNF-3 SUV39H2
GH10J015207 Enhancer 0.8 FANTOM5 ENCODE 12.5 +254.3 254271 1.9 CREB1 ZNF37A ZNF10 RUNX3 ZBTB40 CBFB IRF2 IRF4 ETV6 MLLT1 LOC105376434 MEIG1 NMT2 CDNF OLAH RPP38-DT LOC107984211 FAM171A1
GH10J014874 Enhancer 0.2 Ensembl 10.7 -79.6 -79627 0.4 HSPA14 CDNF MEIG1 ENSG00000272853 SUV39H2 lnc-CDNF-1
GH10J015149 Enhancer 0.8 FANTOM5 Ensembl 1.3 +195.1 195073 0.6 CREB1 ZNF248 YBX1 ZNF580 ZIK1 EHMT2 ZNF513 HIC1 YY2 YY1 NMT2 RPP38-DT MEIG1 PPIAP30 LOC107984210 RPP38
GH10J014958 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas 0.4 +5.8 5773 2.8 PRDM10 ZNF629 REST RFX1 LEF1 IKZF1 ZNF692 POLR2A ZHX2 ETV6 SUV39H2 HSPA14 CDNF DCLRE1C MEIG1 HSALNG0076340 OLAH
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MEIG1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MEIG1

Top Transcription factor binding sites by QIAGEN in the MEIG1 gene promoter:
  • Egr-1
  • Evi-1
  • FOXL1
  • ITF-2
  • p53
  • Tal-1beta
  • YY1

Genomic Locations for MEIG1 Gene

Genomic Locations for MEIG1 Gene
33,823 bases
Plus strand
28,612 bases
Plus strand

Genomic View for MEIG1 Gene

Genes around MEIG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MEIG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MEIG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEIG1 Gene

Proteins for MEIG1 Gene

  • Protein details for MEIG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Meiosis expressed gene 1 protein homolog
    Protein Accession:

    Protein attributes for MEIG1 Gene

    88 amino acids
    Molecular mass:
    10795 Da
    Quaternary structure:
    • Interacts with PACRG.

    Three dimensional structures from OCA and Proteopedia for MEIG1 Gene

neXtProt entry for MEIG1 Gene

Post-translational modifications for MEIG1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MEIG1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MEIG1 Gene

Domains & Families for MEIG1 Gene

Gene Families for MEIG1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MEIG1 Gene


Suggested Antigen Peptide Sequences for MEIG1 Gene

GenScript: Design optimal peptide antigens:
  • Meiosis expressed gene 1 protein homolog (MEIG1_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MEIG1 family.
  • Belongs to the MEIG1 family.
genes like me logo Genes that share domains with MEIG1: view

Function for MEIG1 Gene

Molecular function for MEIG1 Gene

UniProtKB/Swiss-Prot Function:
Essential for spermiogenesis.

Phenotypes From GWAS Catalog for MEIG1 Gene

genes like me logo Genes that share phenotypes with MEIG1: view

Animal Models for MEIG1 Gene

MGI Knock Outs for MEIG1:

Animal Model Products

CRISPR Products

miRNA for MEIG1 Gene

miRTarBase miRNAs that target MEIG1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MEIG1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MEIG1 Gene

Localization for MEIG1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MEIG1 gene
Compartment Confidence
nucleus 4
cytoskeleton 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MEIG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with MEIG1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MEIG1 Gene

Pathways & Interactions for MEIG1 Gene

PathCards logo

SuperPathways for MEIG1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MEIG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007283 spermatogenesis IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with MEIG1: view

No data available for Pathways by source and SIGNOR curated interactions for MEIG1 Gene

Drugs & Compounds for MEIG1 Gene

No Compound Related Data Available

Transcripts for MEIG1 Gene

mRNA/cDNA for MEIG1 Gene

8 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MEIG1

Alternative Splicing Database (ASD) splice patterns (SP) for MEIG1 Gene

No ASD Table

Relevant External Links for MEIG1 Gene

GeneLoc Exon Structure for

Expression for MEIG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MEIG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MEIG1 Gene

This gene is overexpressed in Testis (x16.9).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MEIG1

SOURCE GeneReport for Unigene cluster for MEIG1 Gene:

genes like me logo Genes that share expression patterns with MEIG1: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MEIG1 Gene

Orthologs for MEIG1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MEIG1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 31
  • 98 (a)
MEIG1 30
  • 97.73 (n)
-- 31
  • 95 (a)
(Bos Taurus)
Mammalia MEIG1 30 31
  • 94.32 (n)
(Canis familiaris)
Mammalia MEIG1 30 31
  • 93.94 (n)
(Monodelphis domestica)
Mammalia MEIG1 31
  • 92 (a)
(Rattus norvegicus)
Mammalia Meig1 30
  • 88.64 (n)
(Mus musculus)
Mammalia Meig1 30 17 31
  • 87.12 (n)
(Ornithorhynchus anatinus)
Mammalia MEIG1 31
  • 86 (a)
(Gallus gallus)
Aves MEIG1 30 31
  • 79.31 (n)
(Anolis carolinensis)
Reptilia MEIG1 31
  • 48 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia meig1 30
  • 77.27 (n)
(Danio rerio)
Actinopterygii meig1 30 31
  • 68.58 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 58 (a)
Species where no ortholog for MEIG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MEIG1 Gene

Gene Tree for MEIG1 (if available)
Gene Tree for MEIG1 (if available)
Evolutionary constrained regions (ECRs) for MEIG1: view image

Paralogs for MEIG1 Gene

No data available for Paralogs for MEIG1 Gene

Variants for MEIG1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MEIG1 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
rs4750568 - p.Lys9Thr

Additional dbSNP identifiers (rs#s) for MEIG1 Gene

Structural Variations from Database of Genomic Variants (DGV) for MEIG1 Gene

Variant ID Type Subtype PubMed ID
dgv178e212 CNV gain 25503493
dgv678n100 CNV gain 25217958
dgv68n27 CNV gain 19166990
dgv69n27 CNV gain 19166990
dgv961n54 CNV gain 21841781
dgv962n54 CNV gain 21841781
dgv963n54 CNV loss 21841781
dgv964n54 CNV gain 21841781
esv2733506 CNV deletion 23290073
esv2760142 CNV gain 21179565
esv3622433 CNV loss 21293372
esv3622434 CNV gain 21293372
esv3891763 CNV gain 25118596
nsv1037136 CNV gain+loss 25217958
nsv1038491 CNV gain 25217958
nsv1045188 CNV loss 25217958
nsv24586 CNV deletion 16902084
nsv435909 CNV deletion 17901297
nsv466753 CNV loss 19166990
nsv469720 CNV gain 16826518
nsv470922 CNV gain 18288195
nsv520429 CNV gain+loss 19592680
nsv550007 CNV gain+loss 21841781
nsv825256 CNV gain 20364138
nsv831793 CNV loss 17160897

Variation tolerance for MEIG1 Gene

Residual Variation Intolerance Score: 75.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.96; 19.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MEIG1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEIG1 Gene

Disorders for MEIG1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MEIG1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cardiomyopathy, familial hypertrophic, 7
  • cmh7
- elite association - COSMIC cancer census association via MalaCards
Search MEIG1 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with MEIG1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MEIG1 Gene

Publications for MEIG1 Gene

  1. Germ cell-specific disruption of the Meig1 gene causes impaired spermiogenesis in mice. (PMID: 23258628) Teves ME … Zhang Z (Andrology 2013) 2 3
  2. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. MEIG1 is essential for spermiogenesis in mice. (PMID: 19805151) Zhang Z … Strauss JF (Proceedings of the National Academy of Sciences of the United States of America 2009) 3
  5. Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. (PMID: 17643375) Jeronimo C … Coulombe B (Molecular cell 2007) 3

Products for MEIG1 Gene

Sources for MEIG1 Gene