Aliases for MEGF6 Gene

Aliases for MEGF6 Gene

  • Multiple EGF Like Domains 6 2 3 5
  • Multiple Epidermal Growth Factor-Like Domains Protein 6 3 4
  • Epidermal Growth Factor-Like Protein 3 3 4
  • Multiple EGF-Like Domains Protein 6 3 4
  • EGF-Like-Domain, Multiple 3 2 3
  • EGF-Like Protein 3 3 4
  • EGFL3 3 4
  • Multiple EGF-Like-Domains 6 2
  • KIAA0815 4
  • MEGF6 5

External Ids for MEGF6 Gene

Previous HGNC Symbols for MEGF6 Gene

  • EGFL3

Previous GeneCards Identifiers for MEGF6 Gene

  • GC01M003396
  • GC01M002699

Summaries for MEGF6 Gene

GeneCards Summary for MEGF6 Gene

MEGF6 (Multiple EGF Like Domains 6) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is MEGF11.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MEGF6 Gene

Genomics for MEGF6 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MEGF6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MEGF6 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MEGF6

Top Transcription factor binding sites by QIAGEN in the MEGF6 gene promoter:
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1b
  • NRSF form 1
  • NRSF form 2

Genomic Locations for MEGF6 Gene

Genomic Locations for MEGF6 Gene
136,820 bases
Minus strand
123,554 bases
Minus strand

Genomic View for MEGF6 Gene

Genes around MEGF6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MEGF6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MEGF6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEGF6 Gene

Proteins for MEGF6 Gene

  • Protein details for MEGF6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Multiple epidermal growth factor-like domains protein 6
    Protein Accession:
    Secondary Accessions:
    • Q4AC86
    • Q5VV39

    Protein attributes for MEGF6 Gene

    1541 amino acids
    Molecular mass:
    161185 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA32467.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAE19678.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=BAE19678.1; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for MEGF6 Gene


neXtProt entry for MEGF6 Gene

Post-translational modifications for MEGF6 Gene

  • Glycosylation at Asn252 and Asn739
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MEGF6 Gene

Domains & Families for MEGF6 Gene

Gene Families for MEGF6 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for MEGF6 Gene

Suggested Antigen Peptide Sequences for MEGF6 Gene

GenScript: Design optimal peptide antigens:
  • Epidermal growth factor-like protein 3 (MEGF6_HUMAN)
genes like me logo Genes that share domains with MEGF6: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MEGF6 Gene

Function for MEGF6 Gene

Phenotypes From GWAS Catalog for MEGF6 Gene

Gene Ontology (GO) - Molecular Function for MEGF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 21078624
genes like me logo Genes that share ontologies with MEGF6: view
genes like me logo Genes that share phenotypes with MEGF6: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MEGF6

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MEGF6

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MEGF6 Gene

Localization for MEGF6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MEGF6 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MEGF6 gene
Compartment Confidence
extracellular 4
plasma membrane 3
cytoskeleton 2
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytokinetic bridge (2)
  • Microtubules (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MEGF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with MEGF6: view

Pathways & Interactions for MEGF6 Gene

PathCards logo

SuperPathways for MEGF6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MEGF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with MEGF6: view

No data available for Pathways by source and SIGNOR curated interactions for MEGF6 Gene

Drugs & Compounds for MEGF6 Gene

No Compound Related Data Available

Transcripts for MEGF6 Gene

mRNA/cDNA for MEGF6 Gene

6 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MEGF6

Alternative Splicing Database (ASD) splice patterns (SP) for MEGF6 Gene

No ASD Table

Relevant External Links for MEGF6 Gene

GeneLoc Exon Structure for

Expression for MEGF6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MEGF6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MEGF6 Gene

This gene is overexpressed in Artery - Aorta (x6.0) and Artery - Coronary (x4.5).

Protein differential expression in normal tissues from HIPED for MEGF6 Gene

This gene is overexpressed in Gallbladder (32.4), Pancreas (22.4), and Fetal heart (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MEGF6 Gene

Protein tissue co-expression partners for MEGF6 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MEGF6

SOURCE GeneReport for Unigene cluster for MEGF6 Gene:


Evidence on tissue expression from TISSUES for MEGF6 Gene

  • Nervous system(4.2)
  • Spleen(4.2)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with MEGF6: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MEGF6 Gene

Orthologs for MEGF6 Gene

This gene was present in the common ancestor of animals.

Orthologs for MEGF6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MEGF6 30
  • 97.71 (n)
(Bos Taurus)
Mammalia MEGF6 30 31
  • 83.7 (n)
(Canis familiaris)
Mammalia MEGF6 30 31
  • 83.39 (n)
(Mus musculus)
Mammalia Megf6 30 17 31
  • 75.17 (n)
(Rattus norvegicus)
Mammalia Megf6 30
  • 74.88 (n)
(Monodelphis domestica)
Mammalia MEGF6 31
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 37 (a)
(Gallus gallus)
Aves MEGF6 30 31
  • 65.96 (n)
(Anolis carolinensis)
Reptilia MEGF6 31
  • 61 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia megf6 30
  • 59.54 (n)
(Danio rerio)
Actinopterygii LOC557764 30
  • 58.73 (n)
megf6a 31
  • 55 (a)
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13668 30
(Caenorhabditis elegans)
Secernentea CELE_Y64G10A.7 30
  • 47.5 (n)
Y64G10A.7 31
  • 38 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 44 (a)
Species where no ortholog for MEGF6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for MEGF6 Gene

Gene Tree for MEGF6 (if available)
Gene Tree for MEGF6 (if available)
Evolutionary constrained regions (ECRs) for MEGF6: view image

Paralogs for MEGF6 Gene

Paralogs for MEGF6 Gene

(11) SIMAP similar genes for MEGF6 Gene using alignment to 3 proteins:

  • H7C557_HUMAN
  • H7C5N9_HUMAN Pseudogenes for MEGF6 Gene

genes like me logo Genes that share paralogs with MEGF6: view

Variants for MEGF6 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MEGF6 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
710836 Benign: not provided 3,498,793(-) C/T MISSENSE_VARIANT
711682 Benign: not provided 3,514,574(-) C/A MISSENSE_VARIANT
712404 Benign: not provided 3,501,198(-) C/T MISSENSE_VARIANT
713842 Benign: not provided 3,595,444(-) G/T SYNONYMOUS_VARIANT
716608 Likely Benign: not provided 3,501,864(-) G/A MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for MEGF6 Gene

Structural Variations from Database of Genomic Variants (DGV) for MEGF6 Gene

Variant ID Type Subtype PubMed ID
dgv26e59 CNV duplication 20981092
dgv7n67 CNV gain 20364138
esv1003247 CNV insertion 20482838
esv1062679 CNV deletion 17803354
esv1072885 CNV insertion 17803354
esv1491138 CNV insertion 17803354
esv1595391 CNV insertion 17803354
esv1645766 CNV deletion 17803354
esv2470115 CNV loss 19546169
esv2672292 CNV deletion 23128226
esv2758915 CNV gain 17122850
esv2862902 CNV duplication 24192839
esv28730 CNV loss 19812545
esv3352832 CNV duplication 20981092
esv3413189 CNV duplication 20981092
esv3417230 CNV duplication 20981092
esv3563537 CNV deletion 23714750
esv3563648 CNV deletion 23714750
esv3585042 CNV gain 21293372
esv3585043 CNV loss 21293372
esv3585044 CNV gain 21293372
esv3585045 CNV gain 21293372
esv3893545 CNV loss 25118596
nsv1004180 CNV gain 25217958
nsv1009360 CNV gain 25217958
nsv1012423 CNV gain 25217958
nsv10494 CNV loss 18304495
nsv1075038 CNV deletion 25765185
nsv1120184 CNV tandem duplication 24896259
nsv1128585 CNV duplication 24896259
nsv1132823 CNV insertion 24896259
nsv1132824 CNV insertion 24896259
nsv1135753 CNV deletion 24896259
nsv1140107 CNV insertion 24896259
nsv1140403 CNV tandem duplication 24896259
nsv1140736 CNV deletion 24896259
nsv1142741 CNV deletion 24896259
nsv1142742 CNV deletion 24896259
nsv1146093 CNV insertion 26484159
nsv1153001 CNV insertion 26484159
nsv160325 CNV insertion 16902084
nsv160621 CNV deletion 16902084
nsv160986 CNV deletion 16902084
nsv299 CNV insertion 18451855
nsv470687 CNV loss 18288195
nsv474159 CNV novel sequence insertion 20440878
nsv519082 CNV gain 19592680
nsv545124 CNV loss 21841781
nsv545125 CNV loss 21841781
nsv545126 CNV loss 21841781
nsv545127 CNV loss 21841781
nsv818333 CNV loss 17921354
nsv818444 CNV loss 17921354
nsv825253 CNV loss 20364138
nsv830203 CNV loss 17160897
nsv951959 CNV deletion 24416366

Variation tolerance for MEGF6 Gene

Residual Variation Intolerance Score: 99.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 17.40; 98.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MEGF6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEGF6 Gene

Disorders for MEGF6 Gene

No disorders were found for MEGF6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MEGF6 Gene

Publications for MEGF6 Gene

  1. Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening. (PMID: 9693030) Nakayama M … Ohara O (Genomics 1998) 2 3 4
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  3. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D … Nagase T (DNA research : an international journal for rapid publication of reports on genes and genomes 2002) 3 4
  4. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. (PMID: 29676528) Khanna R … Parnaik VK (The FEBS journal 2018) 3
  5. MEGF6 Promotes the Epithelial-to-Mesenchymal Transition via the TGFβ/SMAD Signaling Pathway in Colorectal Cancer Metastasis. (PMID: 29719292) Hu H … Wang X (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018) 3

Products for MEGF6 Gene

Sources for MEGF6 Gene