This gene is a maternally expressed imprinted gene. Multiple alternatively spliced transcript variants have been transcribed from this gene and all of them are long non-coding RNAs (lncRNAs). This gene is expressed in many normal tissues, but its expression is lost in multiple cancer cell lines of various tissue origins. It inhibits tumor cell proliferation in vitro. It also in... See more...

Aliases for MEG3 Gene

Subcategory (RNA class) for MEG3 Gene

lncRNA

Quality Score for this RNA gene is

16

Aliases for MEG3 Gene

  • Maternally Expressed 3 2 3 5
  • Maternally Expressed 3 (Non-Protein Coding) 2 3
  • Long Intergenic Non-Protein Coding RNA 23 2 3
  • MEG3 2 171
  • Very Putative Protein From MEG3 Locus 3
  • Non-Protein Coding RNA 23 2
  • Onco-LncRNA-83 3
  • NONHSAG015923 94
  • HSALNG0103778 169
  • Lnc-DLK1-35 170
  • NCRNA00023 3
  • LINC00023 3
  • PRO0518 3
  • PRO2160 3
  • Prebp1 3
  • FP504 3
  • GTL2 3

External Ids for MEG3 Gene

Previous GeneCards Identifiers for MEG3 Gene

  • GC14P098688
  • GC14P095112
  • GC14P099282
  • GC14P099287
  • GC14P099285
  • GC14P100363
  • GC14P100364
  • GC14P100368
  • GC14P100371
  • GC14P100373
  • GC14P101292
  • GC14P081473
  • GC14P101245
  • GC14P101214
  • GC14P101795
  • GC14P103594
  • GC14P103811
  • GC14P102088
  • GC14P102322
  • GC14P102493
  • GC14P102668
  • GC14P102840
  • GC14P103014
  • GC14P103212
  • GC14P103411

Summaries for MEG3 Gene

Entrez Gene Summary for MEG3 Gene

  • This gene is a maternally expressed imprinted gene. Multiple alternatively spliced transcript variants have been transcribed from this gene and all of them are long non-coding RNAs (lncRNAs). This gene is expressed in many normal tissues, but its expression is lost in multiple cancer cell lines of various tissue origins. It inhibits tumor cell proliferation in vitro. It also interacts with the tumor suppressor p53, and regulates p53 target gene expression. Its deletion enhances angiogenesis in vivo. Many experimental evidences demonstrate that this gene is a lncRNA tumor suppressor. [provided by RefSeq, Mar 2012]

GeneCards Summary for MEG3 Gene

MEG3 (Maternally Expressed 3) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with MEG3 include Kagami-Ogata Syndrome and Heroin Dependence. Among its related pathways are LncRNA-mediated mechanisms of therapeutic resistance.

Gene Wiki entry for MEG3 Gene

Rfam classification for MEG3 Gene

  • Maternally expressed 3 conserved region 2
  • microRNA mir-770

Additional gene information for MEG3 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary and piRNA Summary for MEG3 Gene

Genomics for MEG3 Gene

GeneHancer (GH) Regulatory Elements for MEG3 Gene

Promoters and enhancers for MEG3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J100819 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.3 +47.1 47126 13.4 RBPJ NR2F6 MIXL1 NFYC RAD21 MNT POLR2A ELF3 CEBPG CTCF ENSG00000274884 GQ183494 MEG8 ENSG00000258399 DLK1 MEG3 MIR493 MIR337 MIR431 MIR127
GH14J100707 Enhancer 1.3 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 16.5 -69.1 -69101 4.8 CTCF MIXL1 MAX SP1 SP5 CREB1 GATAD2A RXRB SCRT2 TCF7 LOC105370669 MEG3 MIR770 piR-44336
GH14J100833 Enhancer 1.2 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.5 +59.5 59542 10.9 MIXL1 ZNF652 ZIC2 CEBPA ZNF629 RCOR2 SCRT2 ESRRA FOS ZFP69B MEG3 MIR493 MIR337 MIR127 MIR431 MIR433 MIR136 RTL1 SNORD112 MIR370
GH14J100475 Enhancer 1.3 Ensembl ENCODE dbSUPER 9.3 -302.7 -302663 3.4 ZBTB6 MLX RBPJ POLR2A CTBP1 NR2F1 NR2F6 CREB1 MIXL1 HLF BEGAIN MEG3 DLK1 HMGN1P25 LOC105370664 WDR25
GH14J100706 Enhancer 0.7 Ensembl 15.2 -72.9 -72909 1 TRIM22 SOX6 IKZF1 HDGF CREB1 YBX1 CTBP1 ZSCAN4 HES1 ZNF311 MEG3 YY1 MIR770 WDR25 BEGAIN MEG9 DIO3OS MIR337 MIR493 MIR431
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MEG3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MEG3 gene promoter:
  • c-Myc
  • CREB
  • deltaCREB
  • Max1
  • Olf-1

Genomic Locations for MEG3 Gene

Genomic Locations for MEG3 Gene
chr14:100,779,410-100,861,031
(GRCh38/hg38)
Size:
81,622 bases
Orientation:
Plus strand
chr14:101,245,747-101,327,368
(GRCh37/hg19)
Size:
81,622 bases
Orientation:
Plus strand

Genomic View for MEG3 Gene

Genes around MEG3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MEG3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MEG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEG3 Gene

Proteins for MEG3 Gene

Post-translational modifications for MEG3 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MEG3 Gene

Domains & Families for MEG3 Gene

Gene Families for MEG3 Gene

Suggested Antigen Peptide Sequences for MEG3 Gene

GenScript: Design optimal peptide antigens:
  • PREBP1 protein (Q8NDX4_HUMAN)
  • cDNA FLJ31163 fis, clone KIDNE1000050 (Q96NA9_HUMAN)
  • Very putative protein from MEG3 locus (YYY4_HUMAN)
genes like me logo Genes that share domains with MEG3: view

No data available for Protein Domains , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MEG3 Gene

Function for MEG3 Gene

Phenotypes From GWAS Catalog for MEG3 Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MEG3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MEG3 Gene

Localization for MEG3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MEG3 gene
Compartment Confidence
nucleus 1

Gene Ontology (GO) - Cellular Components for MEG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016442 RISC complex IEA --
genes like me logo Genes that share ontologies with MEG3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MEG3 Gene

Pathways & Interactions for MEG3 Gene

genes like me logo Genes that share pathways with MEG3: view

Pathways by source for MEG3 Gene

1 BioSystems pathway for MEG3 Gene

Gene Ontology (GO) - Biological Process for MEG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030308 negative regulation of cell growth IEA --
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MEG3: view

No data available for SIGNOR curated interactions for MEG3 Gene

Drugs & Compounds for MEG3 Gene

(2) Drugs for MEG3 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Platinum compounds Pharma 0
radiotherapy Pharma 0
genes like me logo Genes that share compounds with MEG3: view

Transcripts for MEG3 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MEG3

Alternative Splicing Database (ASD) splice patterns (SP) for MEG3 Gene

No ASD Table

Relevant External Links for MEG3 Gene

GeneLoc Exon Structure for
MEG3
ECgene alternative splicing isoforms for
MEG3

Expression for MEG3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MEG3 Gene

mRNA differential expression in normal tissues according to GTEx for MEG3 Gene

This gene is overexpressed in Pituitary (x7.7), Brain - Cerebellum (x4.6), and Brain - Cerebellar Hemisphere (x4.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from MOPED for MEG3 Gene



NURSA nuclear receptor signaling pathways regulating expression of MEG3 Gene:

MEG3

SOURCE GeneReport for Unigene cluster for MEG3 Gene:

Hs.654863
genes like me logo Genes that share expression patterns with MEG3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MEG3 Gene

Orthologs for MEG3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MEG3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNORD112 33
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNORD112 33
  • 81 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SNORD112 33
  • 60 (a)
ManyToMany
Species where no ortholog for MEG3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MEG3 Gene

ENSEMBL:
Gene Tree for MEG3 (if available)
TreeFam:
Gene Tree for MEG3 (if available)

Paralogs for MEG3 Gene

No data available for Paralogs for MEG3 Gene

Variants for MEG3 Gene

Sequence variations from dbSNP and Humsavar for MEG3 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000004293 -- 100,855,781(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000069088 -- 100,825,398(+) C/T upstream_transcript_variant
rs1000080532 -- 100,849,316(+) T/G intron_variant, non_coding_transcript_variant
rs1000098373 -- 100,860,945(+) G/A genic_downstream_transcript_variant, non_coding_transcript_variant
rs1000133179 -- 100,849,577(+) A/G intron_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MEG3 Gene

Variant ID Type Subtype PubMed ID
esv2751158 CNV gain 17911159
esv3635516 CNV gain 21293372
esv3635518 CNV gain 21293372
nsv470669 CNV loss 18288195
nsv483116 CNV gain 15286789
nsv509549 CNV insertion 20534489
nsv827055 CNV gain 20364138
nsv832876 CNV loss 17160897

Additional Variant Information for MEG3 Gene

Human Gene Mutation Database (HGMD)
MEG3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MEG3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MEG3 Gene

Disorders for MEG3 Gene

MalaCards: The human disease database

(64) MalaCards diseases for MEG3 Gene - From: LncRNADisease, HGMD, ClinVar, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
kagami-ogata syndrome
  • kos
heroin dependence
pancreatic endocrine carcinoma
  • carcinoma of endocrine pancreas
liver disease
  • disorder of liver
pituitary carcinoma
  • carcinoma of the pituitary gland
- elite association - COSMIC cancer census association via MalaCards
Search MEG3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MEG3

genes like me logo Genes that share disorders with MEG3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MEG3 Gene

Publications for MEG3 Gene

  1. Identification of an imprinted gene, Meg3/Gtl2 and its human homologue MEG3, first mapped on mouse distal chromosome 12 and human chromosome 14q. (PMID: 10759892) Miyoshi N … Ishino F (Genes to cells : devoted to molecular & cellular mechanisms 2000) 2 3 23 56
  2. Long non-coding RNA MEG3 inhibits the proliferation of cervical carcinoma cells through the induction of cell cycle arrest and apoptosis. (PMID: 23790166) Qin R … Guo F (Neoplasma 2013) 2 3 56
  3. The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes. (PMID: 19966805) Wallace C … Clayton DG (Nature genetics 2010) 3 43 56
  4. Deletions and epimutations affecting the human 14q32.2 imprinted region in individuals with paternal and maternal upd(14)-like phenotypes. (PMID: 18176563) Kagami M … Ogata T (Nature genetics 2008) 3 23 56
  5. Hypermethylation of the promoter region is associated with the loss of MEG3 gene expression in human pituitary tumors. (PMID: 15644399) Zhao J … Klibanski A (The Journal of clinical endocrinology and metabolism 2005) 3 23 56

Products for MEG3 Gene

Sources for MEG3 Gene