This gene is a maternally expressed imprinted gene. Multiple alternatively spliced transcript variants have been transcribed from this gene and all of them are long non-coding RNAs (lncRNAs). This gene is expressed in many normal tissues, but its expression is lost in multiple cancer cell lines of various tissue origins. It inhibits tumor cell proliferation in vitro. It also in... See more...

Aliases for MEG3 Gene

Data sources for MEG3 Gene:

RNA type for MEG3 Gene


Aliases for MEG3 Gene

External Ids for MEG3 Gene

Previous GeneCards Identifiers for MEG3 Gene

  • GC14P098688
  • GC14P095112
  • GC14P099282
  • GC14P099287
  • GC14P099285
  • GC14P100363
  • GC14P100364
  • GC14P100368
  • GC14P100371
  • GC14P100373
  • GC14P101292
  • GC14P081473
  • GC14P101245
  • GC14P101214
  • GC14P101795
  • GC14P103594
  • GC14P103811
  • GC14P104069
  • GC14P104431
  • GC14P102088
  • GC14P102322
  • GC14P102493
  • GC14P102668
  • GC14P102840
  • GC14P103014
  • GC14P103212
  • GC14P103411
  • GC14P104771
  • GC14P105271

Summaries for MEG3 Gene

Entrez Gene Summary for MEG3 Gene

  • This gene is a maternally expressed imprinted gene. Multiple alternatively spliced transcript variants have been transcribed from this gene and all of them are long non-coding RNAs (lncRNAs). This gene is expressed in many normal tissues, but its expression is lost in multiple cancer cell lines of various tissue origins. It inhibits tumor cell proliferation in vitro. It also interacts with the tumor suppressor p53, and regulates p53 target gene expression. Its deletion enhances angiogenesis in vivo. Many experimental evidences demonstrate that this gene is a lncRNA tumor suppressor. [provided by RefSeq, Mar 2012]

GeneCards Summary for MEG3 Gene

MEG3 (Maternally Expressed 3) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with MEG3 include Kagami-Ogata Syndrome and Liver Disease. Among its related pathways are LncRNA-mediated mechanisms of therapeutic resistance.

Gene Wiki entry for MEG3 Gene

Rfam classification for MEG3 Gene

  • Maternally expressed 3 conserved region 2
  • microRNA mir-770
  • Maternally expressed 8 exon 2
  • Maternally expressed 8 exon 3

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary and piRNA Summary for MEG3 Gene

Genomics for MEG3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MEG3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MEG3 on the GeneHancer Hub at the UCSC Golden Path

Top Transcription factor binding sites by QIAGEN in the MEG3 gene promoter:
  • c-Myc
  • CREB
  • deltaCREB
  • Max1
  • Olf-1

Genomic Locations for MEG3 Gene

Latest Assembly
81,623 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
34,919 bases
Plus strand

(GRCh37/hg19 by Ensembl)
81,622 bases
Plus strand

Genomic View for MEG3 Gene

Genes around MEG3 on UCSC Golden Path with GeneCards custom track
MEG3 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MEG3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MEG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEG3 Gene

Proteins for MEG3 Gene

Post-translational modifications for MEG3 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MEG3 Gene

Domains & Families for MEG3 Gene

Gene Families for MEG3 Gene

Suggested Antigen Peptide Sequences for MEG3 Gene

GenScript: Design optimal peptide antigens:
  • PREBP1 protein (Q8NDX4_HUMAN)
  • cDNA FLJ31163 fis, clone KIDNE1000050 (Q96NA9_HUMAN)
  • Very putative protein from MEG3 locus (YYY4_HUMAN)
genes like me logo Genes that share domains with MEG3: view

No data available for Protein Domains , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MEG3 Gene

Function for MEG3 Gene

Phenotypes From GWAS Catalog for MEG3 Gene

Human Phenotype Ontology for MEG3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for MEG3 Gene

Localization for MEG3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MEG3 gene
Compartment Confidence
nucleus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endosome 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MEG3 Gene

Pathways & Interactions for MEG3 Gene

genes like me logo Genes that share pathways with MEG3: view

Pathways by source for MEG3 Gene

1 BioSystems pathway for MEG3 Gene

Gene Ontology (GO) - Biological Process for MEG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030308 negative regulation of cell growth IEA --
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MEG3: view

No data available for Interacting Proteins and SIGNOR curated interactions for MEG3 Gene

Drugs & Compounds for MEG3 Gene

(2) Drugs for MEG3 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Platinum compounds Pharma 0
radiotherapy Pharma 0
genes like me logo Genes that share compounds with MEG3: view

Transcripts for MEG3 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MEG3 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS0000602674_9606 lncRNA 1351 4

Ensembl: ENST00000520714 (view in UCSC) ,

LncBook: HSALNT0215922, HSALNT0215923,

LNCipedia: lnc-DLK1-35:32, lnc-DLK1-35:34,


URS00002882A0_9606 lncRNA 635 4

Ensembl: ENST00000521812 (view in UCSC) ,

LncBook: HSALNT0215947, HSALNT0215948,

LNCipedia: lnc-DLK1-35:89,


URS00002E623F_9606 lncRNA 505 4

Ensembl: ENST00000521256 (view in UCSC) ,

LncBook: HSALNT0215959,

LNCipedia: lnc-DLK1-35:103,


URS00002C6CC0_9606 lncRNA 502 4

Ensembl: ENST00000455286 (view in UCSC) ,

LncBook: HSALNT0215934,

LNCipedia: lnc-DLK1-35:72,


URS00004331A4_9606 lncRNA 461 4

Ensembl: ENST00000452514 (view in UCSC) ,

LncBook: HSALNT0215938,

LNCipedia: lnc-DLK1-35:76,


MEG3 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MEG3 Gene

34 NCBI additional mRNA sequence :

CRISPR products for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MEG3

Alternative Splicing Database (ASD) splice patterns (SP) for MEG3 Gene

No ASD Table

Relevant External Links for MEG3 Gene

GeneLoc Exon Structure for

Expression for MEG3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MEG3 Gene

mRNA differential expression in normal tissues according to GTEx for MEG3 Gene

This gene is overexpressed in Pituitary (x7.7), Brain - Cerebellum (x4.6), and Brain - Cerebellar Hemisphere (x4.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from MOPED for MEG3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MEG3

SOURCE GeneReport for Unigene cluster for MEG3 Gene:

genes like me logo Genes that share expression patterns with MEG3: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MEG3 Gene

Orthologs for MEG3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MEG3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SNORD112 30
  • 99 (a)
(Canis familiaris)
Mammalia SNORD112 30
  • 81 (a)
(Bos Taurus)
Mammalia SNORD112 30
  • 60 (a)
Species where no ortholog for MEG3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MEG3 Gene

Gene Tree for MEG3 (if available)
Gene Tree for MEG3 (if available)
Alliance of Genome Resources:
Additional Orthologs for MEG3

Paralogs for MEG3 Gene

No data available for Paralogs for MEG3 Gene

Variants for MEG3 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MEG3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MEG3 Gene

Variant ID Type Subtype PubMed ID
esv2751158 CNV gain 17911159
esv3635516 CNV gain 21293372
esv3635518 CNV gain 21293372
nsv470669 CNV loss 18288195
nsv483116 CNV gain 15286789
nsv509549 CNV insertion 20534489
nsv827055 CNV gain 20364138
nsv832876 CNV loss 17160897

Additional Variant Information for MEG3 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MEG3 Gene

Disorders for MEG3 Gene

MalaCards: The human disease database

(67) MalaCards diseases for MEG3 Gene - From: LNC, CVR, ORP, COP, and GCD

Disorder Aliases PubMed IDs
kagami-ogata syndrome
  • uniparental disomy, paternal, chromosome 14
liver disease
  • disorder of liver
pancreatic endocrine carcinoma
  • carcinoma of endocrine pancreas
heroin dependence
pituitary carcinoma
  • carcinoma of the pituitary gland
- elite association - COSMIC cancer census association via MalaCards
Search MEG3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MEG3

genes like me logo Genes that share disorders with MEG3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MEG3 Gene

Publications for MEG3 Gene

  1. Long non-coding RNA MEG3 inhibits the proliferation of cervical carcinoma cells through the induction of cell cycle arrest and apoptosis. (PMID: 23790166) Qin R … Guo F (Neoplasma 2013) 2 3 72
  2. The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes. (PMID: 19966805) Wallace C … Clayton DG (Nature genetics 2010) 3 40 72
  3. Deletions and epimutations affecting the human 14q32.2 imprinted region in individuals with paternal and maternal upd(14)-like phenotypes. (PMID: 18176563) Kagami M … Ogata T (Nature genetics 2008) 3 22 72
  4. Hypermethylation of the promoter region is associated with the loss of MEG3 gene expression in human pituitary tumors. (PMID: 15644399) Zhao J … Klibanski A (The Journal of clinical endocrinology and metabolism 2005) 3 22 72
  5. Identification of an imprinted gene, Meg3/Gtl2 and its human homologue MEG3, first mapped on mouse distal chromosome 12 and human chromosome 14q. (PMID: 10759892) Miyoshi N … Ishino F (Genes to cells : devoted to molecular & cellular mechanisms 2000) 2 3 22

Products for MEG3 Gene

Sources for MEG3 Gene