The protein encoded by this gene is a DNA-binding transcription factor that activates many muscle-specific, growth factor-induced, and stress-induced genes. The encoded protein can act as a homodimer or as a heterodimer and is involved in several cellular processes, including muscle development, neuronal differentiation, cell growth control, and apoptosis. Defects in this gene ... See more...

Aliases for MEF2A Gene

Aliases for MEF2A Gene

  • Myocyte Enhancer Factor 2A 2 3 5
  • Serum Response Factor-Like Protein 1 3 4
  • Myocyte-Specific Enhancer Factor 2A 3 4
  • RSRFC4 2 3
  • RSRFC9 2 3
  • MADS Box Transcription Enhancer Factor 2, Polypeptide A (Myocyte Enhancer Factor 2A) 3
  • ADCAD1 3
  • MEF2A 5
  • Mef2 3
  • MEF2 4

External Ids for MEF2A Gene

Previous GeneCards Identifiers for MEF2A Gene

  • GC15P096823
  • GC15P093977
  • GC15P097698
  • GC15P097841
  • GC15P097874
  • GC15P097923
  • GC15P100107
  • GC15P076235

Summaries for MEF2A Gene

Entrez Gene Summary for MEF2A Gene

  • The protein encoded by this gene is a DNA-binding transcription factor that activates many muscle-specific, growth factor-induced, and stress-induced genes. The encoded protein can act as a homodimer or as a heterodimer and is involved in several cellular processes, including muscle development, neuronal differentiation, cell growth control, and apoptosis. Defects in this gene could be a cause of autosomal dominant coronary artery disease 1 with myocardial infarction (ADCAD1). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]

GeneCards Summary for MEF2A Gene

MEF2A (Myocyte Enhancer Factor 2A) is a Protein Coding gene. Diseases associated with MEF2A include Coronary Artery Disease, Autosomal Dominant, 1 and Myocardial Infarction. Among its related pathways are Neuroscience and Nuclear Events (kinase and transcription factor activation). Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein heterodimerization activity. An important paralog of this gene is MEF2C.

UniProtKB/Swiss-Prot Summary for MEF2A Gene

  • Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter.

Gene Wiki entry for MEF2A Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MEF2A Gene

Genomics for MEF2A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MEF2A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MEF2A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MEF2A

Top Transcription factor binding sites by QIAGEN in the MEF2A gene promoter:
  • AP-4
  • ATF-2
  • CRE-BP1
  • E47
  • HTF
  • Pax-4a
  • USF-1
  • USF-1:USF-2
  • USF1
  • USF2

Genomic Locations for MEF2A Gene

Genomic Locations for MEF2A Gene
chr15:99,565,417-99,716,488
(GRCh38/hg38)
Size:
151,072 bases
Orientation:
Plus strand
chr15:100,017,370-100,256,671
(GRCh37/hg19)
Size:
239,302 bases
Orientation:
Plus strand

Genomic View for MEF2A Gene

Genes around MEF2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MEF2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MEF2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEF2A Gene

Proteins for MEF2A Gene

  • Protein details for MEF2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02078-MEF2A_HUMAN
    Recommended name:
    Myocyte-specific enhancer factor 2A
    Protein Accession:
    Q02078
    Secondary Accessions:
    • B4DFQ7
    • F6XG23
    • O43814
    • Q14223
    • Q14224
    • Q59GX4
    • Q7Z6C9
    • Q96D14

    Protein attributes for MEF2A Gene

    Size:
    507 amino acids
    Molecular mass:
    54811 Da
    Quaternary structure:
    • Binds DNA as a homo- or heterodimer. Dimerizes with MEF2D. Interacts with HDAC7 (By similarity). Interacts with PIAS1; the interaction enhances sumoylation. Interacts with HDAC4, HDAC9 and SLC2A4RG. Interacts (via the N-terminal) with MAPK7; the interaction results in the phosphorylation and transcriptional activity of MEF2A.
    SequenceCaution:
    • Sequence=AAH53871.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAD92222.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MEF2A Gene

    Alternative splice isoforms for MEF2A Gene

neXtProt entry for MEF2A Gene

Post-translational modifications for MEF2A Gene

  • Constitutive phosphorylation on Ser-408 promotes Lys-403 sumoylation thus preventing acetylation at this site. Dephosphorylation on Ser-408 by PPP3CA upon neuron depolarization promotes a switch from sumoylation to acetylation on residue Lys-403 leading to inhibition of dendrite claw differentiation. Phosphorylation on Thr-312 and Thr-319 are the main sites involved in p38 MAPK signaling and activate transcription. Phosphorylated on these sites by MAPK14/p38alpha and MAPK11/p38beta, but not by MAPK13/p38delta nor by MAPK12/p38gamma. Phosphorylation on Ser-408 by CDK5 induced by neurotoxicity inhibits MEF2A transcriptional activation leading to apoptosis of cortical neurons. Phosphorylation on Thr-312, Thr-319 and Ser-355 can be induced by EGF.
  • Sumoylation on Lys-403 is enhanced by PIAS1 and represses transcriptional activity. Phosphorylation on Ser-408 is required for sumoylation. Has no effect on nuclear location nor on DNA binding. Sumoylated with SUMO1 and, to a lesser extent with SUMO2 and SUMO3. PIASx facilitates sumoylation in postsynaptic dendrites in the cerebellar cortex and promotes their morphogenesis (By similarity).
  • Acetylation on Lys-403 activates transcriptional activity. Acetylated by p300 on several sites in diffentiating myocytes. Acetylation on Lys-4 increases DNA binding and transactivation (By similarity). Hyperacetylation by p300 leads to enhanced cardiac myocyte growth and heart failure.
  • Proteolytically cleaved in cerebellar granule neurons on several sites by caspase 3 and caspase 7 following neurotoxicity. Preferentially cleaves the CDK5-mediated hyperphosphorylated form which leads to neuron apoptosis and transcriptional inactivation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for MEF2A

No data available for DME Specific Peptides for MEF2A Gene

Domains & Families for MEF2A Gene

Gene Families for MEF2A Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for MEF2A Gene

InterPro:
Blocks:
  • Transcription factor, MADS-box
ProtoNet:

Suggested Antigen Peptide Sequences for MEF2A Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ50129, highly similar to Myocyte-specific enhancer factor 2A (B4DFQ7_HUMAN)
  • Serum response factor-like protein 1 (MEF2A_HUMAN)
  • MEF2A protein (Q7Z6C9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q02078

UniProtKB/Swiss-Prot:

MEF2A_HUMAN :
  • Belongs to the MEF2 family.
Family:
  • Belongs to the MEF2 family.
genes like me logo Genes that share domains with MEF2A: view

Function for MEF2A Gene

Molecular function for MEF2A Gene

UniProtKB/Swiss-Prot Function:
Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter.
GENATLAS Biochemistry:
myocyte-specific enhancer binding factor 2A,interacting with members of the MyoD family of transcriptional activator,also interacting with TWIST to inhibit myogenesis,negatively regulated by MITR in association with HDAC1,also expressed in muscle cells

Phenotypes From GWAS Catalog for MEF2A Gene

Gene Ontology (GO) - Molecular Function for MEF2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IBA 21873635
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 20590529
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 7760790
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IDA,ISM 19274049
GO:0001085 RNA polymerase II transcription factor binding IPI 15466416
genes like me logo Genes that share ontologies with MEF2A: view
genes like me logo Genes that share phenotypes with MEF2A: view

Human Phenotype Ontology for MEF2A Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MEF2A Gene

MGI Knock Outs for MEF2A:

Animal Model Products

CRISPR Products

Transcription Factor Targets for MEF2A Gene

Selected GeneGlobe predicted Target genes for MEF2A
Targeted motifs for MEF2A Gene
HOMER Transcription Factor Regulatory Elements motif MEF2A
  • Consensus sequence: CCAAAAATAG Submotif: canonical Cell Type: HL1 GEO ID: GSE21529

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MEF2A

Clone Products

  • Addgene plasmids for MEF2A

No data available for Enzyme Numbers (IUBMB) for MEF2A Gene

Localization for MEF2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for MEF2A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MEF2A gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MEF2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISS --
GO:0005634 nucleus IBA,IDA 16484498
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IDA 16043483
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with MEF2A: view

Pathways & Interactions for MEF2A Gene

genes like me logo Genes that share pathways with MEF2A: view

Pathways by source for MEF2A Gene

5 GeneGo (Thomson Reuters) pathways for MEF2A Gene
  • Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
  • Immune response Function of MEF2 in T lymphocytes
  • Signal transduction Activation of PKC via G-Protein coupled receptor
  • Signal transduction Calcium signaling
  • Signal transduction IP3 signaling
15 Qiagen pathways for MEF2A Gene
  • CCKBR-Gastrin Stimulated Signaling
  • CRHR Pathway
  • Crosstalk Between CARM1 and ESRs
  • ERK5 Signaling
  • G12-G13 in Cellular Signaling
2 Cell Signaling Technology pathways for MEF2A Gene

SIGNOR curated interactions for MEF2A Gene

Activates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for MEF2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000002 mitochondrial genome maintenance ISS --
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 16484498
GO:0000165 MAPK cascade IDA 9858528
GO:0006351 transcription, DNA-templated IDA 16043483
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with MEF2A: view

Drugs & Compounds for MEF2A Gene

(17) Drugs for MEF2A Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(9) Additional Compounds for MEF2A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MEF2A: view

Transcripts for MEF2A Gene

mRNA/cDNA for MEF2A Gene

22 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MEF2A

Clone Products

  • Addgene plasmids for MEF2A

Alternative Splicing Database (ASD) splice patterns (SP) for MEF2A Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - -
SP6: -
SP7: - - - - - - - - - - -
SP8: - - - - - - - - -
SP9: - - - - -
SP10: - - - - - - - -
SP11: - - - - -
SP12: - - - -

ExUns: 14 ^ 15 ^ 16 ^ 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for MEF2A Gene

GeneLoc Exon Structure for
MEF2A

Expression for MEF2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MEF2A Gene

Protein differential expression in normal tissues from HIPED for MEF2A Gene

This gene is overexpressed in Pancreas (23.8), Peripheral blood mononuclear cells (20.3), Blymphocyte (16.1), and Fetal heart (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MEF2A Gene



Protein tissue co-expression partners for MEF2A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MEF2A

SOURCE GeneReport for Unigene cluster for MEF2A Gene:

Hs.268675

mRNA Expression by UniProt/SwissProt for MEF2A Gene:

Q02078-MEF2A_HUMAN
Tissue specificity: Isoform MEF2 and isoform MEFA are expressed only in skeletal and cardiac muscle and in the brain. Isoform RSRFC4 and isoform RSRFC9 are expressed in all tissues examined.

Evidence on tissue expression from TISSUES for MEF2A Gene

  • Nervous system(4.9)
  • Muscle(4.7)
  • Heart(4.7)
  • Pancreas(4.4)
  • Skin(3)
  • Kidney(2.5)
  • Liver(2.4)
  • Blood(2.3)
  • Spleen(2.3)
  • Lung(2.2)
  • Intestine(2.2)
  • Bone marrow(2.1)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with MEF2A: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MEF2A Gene

Orthologs for MEF2A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MEF2A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MEF2A 30 31
  • 99.73 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Mef2a 30 17 31
  • 91.09 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MEF2A 30 31
  • 89.34 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MEF2A 30 31
  • 88.91 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Mef2a 30
  • 86.07 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia MEF2A 31
  • 86 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia MEF2A 31
  • 85 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-mir-1737 31
  • 86 (a)
OneToOne
MEF2A 30
  • 82.45 (n)
Lizard
(Anolis carolinensis)
Reptilia MEF2A 31
  • 83 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia mef2a-prov 30
Zebrafish
(Danio rerio)
Actinopterygii mef2aa 30 31
  • 71.58 (n)
OneToMany
MEF2A (2 of 2) 31
  • 69 (a)
OneToMany
mef2a 30
Fruit Fly
(Drosophila melanogaster)
Insecta Mef2 31 32
  • 34 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea mef-2 32
  • 81 (a)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SMP1 31 33
  • 19 (a)
ManyToMany
RLM1 31
  • 17 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 97 (a)
OneToMany
Species where no ortholog for MEF2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for MEF2A Gene

ENSEMBL:
Gene Tree for MEF2A (if available)
TreeFam:
Gene Tree for MEF2A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MEF2A: view image

Paralogs for MEF2A Gene

Paralogs for MEF2A Gene

(6) SIMAP similar genes for MEF2A Gene using alignment to 6 proteins:

  • MEF2A_HUMAN
  • F8W966_HUMAN
  • H0YKY6_HUMAN
  • H0YM62_HUMAN
  • H0YNI2_HUMAN
  • L0R504_HUMAN

Pseudogenes.org Pseudogenes for MEF2A Gene

genes like me logo Genes that share paralogs with MEF2A: view

Variants for MEF2A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MEF2A Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
735182 Benign: not provided 99,706,776(+) C/T SYNONYMOUS_VARIANT
753730 Benign: not provided 99,671,621(+) G/A SYNONYMOUS_VARIANT,INTRON_VARIANT
762680 Likely Benign: not provided 99,710,698(+) G/A SYNONYMOUS_VARIANT
778574 Benign: not provided 99,712,504(+) C/CCAGCAG INFRAME_INSERTION
779275 Benign: not provided 99,712,688(+) A/G MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for MEF2A Gene

Structural Variations from Database of Genomic Variants (DGV) for MEF2A Gene

Variant ID Type Subtype PubMed ID
dgv4769n54 CNV gain 21841781
esv2500079 CNV deletion 19546169
esv3349241 CNV insertion 20981092
esv3637430 CNV gain 21293372
esv3892741 CNV gain 25118596
nsv1045838 CNV gain 25217958
nsv1051560 CNV gain 25217958
nsv1143792 CNV deletion 24896259
nsv428313 CNV gain 18775914
nsv472018 CNV novel sequence insertion 20440878
nsv513438 CNV insertion 21212237

Variation tolerance for MEF2A Gene

Residual Variation Intolerance Score: 31.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.68; 32.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MEF2A Gene

Human Gene Mutation Database (HGMD)
MEF2A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MEF2A

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEF2A Gene

Disorders for MEF2A Gene

MalaCards: The human disease database

(10) MalaCards diseases for MEF2A Gene - From: OMIM, ClinVar, GTR, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
coronary artery disease, autosomal dominant, 1
  • adcad1
myocardial infarction
  • myocardial infarction, susceptibility to
muscle hypertrophy
  • mslhp
heart disease
  • congenital heart disease
ichthyosis, congenital, autosomal recessive 9
  • arci9
- elite association - COSMIC cancer census association via MalaCards
Search MEF2A in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

MEF2A_HUMAN
  • Coronary artery disease, autosomal dominant, 1 (ADCAD1) [MIM:608320]: A common heart disease characterized by reduced or absent blood flow in one or more of the arteries that encircle and supply the heart. Its most important complication is acute myocardial infarction. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for MEF2A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with MEF2A: view

No data available for Genatlas for MEF2A Gene

Publications for MEF2A Gene

  1. Transcription factor MEF2A mutations in patients with coronary artery disease. (PMID: 15496429) Bhagavatula MR … Wang Q (Human molecular genetics 2004) 3 4 23 41
  2. Human myocyte-specific enhancer factor 2 comprises a group of tissue-restricted MADS box transcription factors. (PMID: 1516833) Yu YT … Nadal-Ginard B (Genes & development 1992) 2 3 4 23
  3. Regulatory polymorphism in transcription factor KLF5 at the MEF2 element alters the response to angiotensin II and is associated with human hypertension. (PMID: 20086047) Oishi Y … Nagai R (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010) 3 23 41
  4. Association and functional analyses of MEF2A as a susceptibility gene for premature myocardial infarction and coronary artery disease. (PMID: 20031581) Guella I … Duga S (Circulation. Cardiovascular genetics 2009) 3 23 41
  5. Lack of association between the MEF2A gene and myocardial infarction. (PMID: 18086930) Lieb W … Erdmann J (Circulation 2008) 3 4 41

Products for MEF2A Gene

  • Addgene plasmids for MEF2A

Sources for MEF2A Gene