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The multiprotein Mediator complex is a coactivator required for activation of RNA polymerase II transcription by DNA bound transcription factors. The protein encoded by this gene is thought to be a subunit of the Mediator complex. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
MED9 (Mediator Complex Subunit 9) is a Protein Coding gene. Diseases associated with MED9 include Smith-Magenis Syndrome and Jacobsen Syndrome. Among its related pathways are Developmental Biology and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003712 | transcription coregulator activity | IEA | -- |
GO:0005515 | protein binding | IPI | 14638676 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO:0016592 | mediator complex | IEA,IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||
2 | Metabolism |
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3 | Developmental Biology |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006357 | regulation of transcription by RNA polymerase II | IEA | -- |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 |
---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||
SP2: | - | - | |||||||||
SP3: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | MED9 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | MED9 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Med9 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Med9 30 |
|
||
Cow (Bos Taurus) |
Mammalia | MED9 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | MED9 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | MED9 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | MED9 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | med9 30 |
|
||
Str.15073 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.33549 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | si:ch73-105m5.1 30 |
|
||
MED9 31 |
|
OneToOne | |||
Dr.28799 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.10572 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | MED9 31 |
|
OneToOne |
Disorder | Aliases | PubMed IDs |
---|---|---|
smith-magenis syndrome |
|
|
jacobsen syndrome |
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|
potocki-lupski syndrome |
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|