MED9 Gene (Protein Coding)

Mediator Complex Subunit 9

GC17P017476
GIFtS:
35
The multiprotein Mediator complex is a coactivator required for activation of RNA polymerase II transcription by DNA bound transcription factors. The protein encoded by this gene is thought to be a subunit of the Mediator complex. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008] See more...

Aliases for MED9 Gene

Aliases for MED9 Gene

  • Mediator Complex Subunit 9 2 3 4 5
  • MED25 2 3 4
  • Mediator Of RNA Polymerase II Transcription Subunit 9 3 4
  • Mediator Of RNA Polymerase II Transcription, Subunit 9 Homolog (S. Cerevisiae) 2
  • Mediator Of RNA Polymerase II Transcription, Subunit 9 Homolog 3
  • Mediator Subunit 25 3
  • FLJ10193 2
  • MED9 5

External Ids for MED9 Gene

Previous GeneCards Identifiers for MED9 Gene

  • GC17P017322
  • GC17P017324
  • GC17P017380
  • GC17P017132

Summaries for MED9 Gene

Entrez Gene Summary for MED9 Gene

  • The multiprotein Mediator complex is a coactivator required for activation of RNA polymerase II transcription by DNA bound transcription factors. The protein encoded by this gene is thought to be a subunit of the Mediator complex. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

GeneCards Summary for MED9 Gene

MED9 (Mediator Complex Subunit 9) is a Protein Coding gene. Diseases associated with MED9 include Smith-Magenis Syndrome and Jacobsen Syndrome. Among its related pathways are Developmental Biology and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).

UniProtKB/Swiss-Prot Summary for MED9 Gene

  • Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Additional gene information for MED9 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MED9 Gene

Genomics for MED9 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for MED9 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MED9 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MED9

Top Transcription factor binding sites by QIAGEN in the MED9 gene promoter:
  • Oct-B1
  • oct-B2
  • oct-B3
  • POU2F1
  • POU2F1a
  • POU2F2
  • POU2F2 (Oct-2.1)
  • POU2F2C
  • USF-1
  • USF1

Genomic Locations for MED9 Gene

Latest Assembly
chr17:17,476,994-17,493,221
(GRCh38/hg38)
Size:
16,228 bases
Orientation:
Plus strand

Previous Assembly
chr17:17,380,314-17,396,535
(GRCh37/hg19 by Entrez Gene)
Size:
16,222 bases
Orientation:
Plus strand

chr17:17,380,300-17,396,540
(GRCh37/hg19 by Ensembl)
Size:
16,241 bases
Orientation:
Plus strand

Genomic View for MED9 Gene

Genes around MED9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MED9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MED9 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MED9 Gene

Proteins for MED9 Gene

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  • Protein details for MED9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NWA0-MED9_HUMAN
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 9
    Protein Accession:
    Q9NWA0

    Protein attributes for MED9 Gene

    Size:
    146 amino acids
    Molecular mass:
    16403 Da
    Quaternary structure:
    • Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.

neXtProt entry for MED9 Gene

Protein Expression for MED9 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for MED9 Gene

  • Ubiquitination at Lys99
  • Modification sites at PhosphoSitePlus

Other Protein References for MED9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MED9 Gene

Domains & Families for MED9 Gene

Gene Families for MED9 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MED9 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MED9 Gene

GenScript: Design optimal peptide antigens:
  • Mediator complex subunit 9 (MED9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NWA0

UniProtKB/Swiss-Prot:

MED9_HUMAN :
  • Belongs to the Mediator complex subunit 9 family.
Family:
  • Belongs to the Mediator complex subunit 9 family.
genes like me logo Genes that share domains with MED9: view

Function for MED9 Gene

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  6. Cell Lines for research

Molecular function for MED9 Gene

UniProtKB/Swiss-Prot Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Phenotypes From GWAS Catalog for MED9 Gene

Gene Ontology (GO) - Molecular Function for MED9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003712 transcription coregulator activity IEA --
GO:0005515 protein binding IPI 14638676
genes like me logo Genes that share ontologies with MED9: view
genes like me logo Genes that share phenotypes with MED9: view

Animal Models for research

miRNA for MED9 Gene

miRTarBase miRNAs that target MED9

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MED9

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MED9 Gene

Localization for MED9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MED9 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MED9 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Midbody (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MED9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0016592 mediator complex IEA,IBA 21873635
genes like me logo Genes that share ontologies with MED9: view

Pathways & Interactions for MED9 Gene

genes like me logo Genes that share pathways with MED9: view

Gene Ontology (GO) - Biological Process for MED9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with MED9: view

No data available for SIGNOR curated interactions for MED9 Gene

Drugs & Compounds for MED9 Gene

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  1. Drug products for research
No Compound Related Data Available

Transcripts for MED9 Gene

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mRNA/cDNA for MED9 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MED9

Alternative Splicing Database (ASD) splice patterns (SP) for MED9 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3
SP1: -
SP2: - -
SP3:

Relevant External Links for MED9 Gene

GeneLoc Exon Structure for
MED9

Expression for MED9 Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MED9 Gene

mRNA expression in normal human tissues for MED9 Gene
mRNA expression by BioGPS for MED9 GenemRNA expression by GTEx for MED9 Gene

Protein differential expression in normal tissues from HIPED for MED9 Gene

This gene is overexpressed in Monocytes (30.7), Fetal Brain (11.8), CD4 Tcells (8.6), and Placenta (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MED9 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MED9

SOURCE GeneReport for Unigene cluster for MED9 Gene:

Hs.244595

Evidence on tissue expression from TISSUES for MED9 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with MED9: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MED9 Gene

Orthologs for MED9 Gene

This gene was present in the common ancestor of animals.

Orthologs for MED9 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia MED9 30 31
  • 99.32 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia MED9 30 31
  • 85.39 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Med9 30 17 31
  • 83.21 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Med9 30
  • 82.19 (n)
Cow
(Bos Taurus)
 Mammalia MED9 30 31
  • 79.08 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia MED9 31
  • 74 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves MED9 30 31
  • 83.15 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia MED9 31
  • 55 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia med9 30
  • 78.62 (n)
Str.15073 30
African clawed frog
(Xenopus laevis)
 Amphibia Xl.33549 30
Zebrafish
(Danio rerio)
 Actinopterygii si:ch73-105m5.1 30
  • 71.91 (n)
MED9 31
  • 65 (a)
 OneToOne
Dr.28799 30
Rainbow Trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.10572 30
Fruit Fly
(Drosophila melanogaster)
 Insecta MED9 31
  • 27 (a)
 OneToOne
Species where no ortholog for MED9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MED9 Gene

ENSEMBL:
Gene Tree for MED9 (if available)
TreeFam:
Gene Tree for MED9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MED9: view image

Paralogs for MED9 Gene

Pseudogenes.org Pseudogenes for MED9 Gene

genes like me logo Genes that share paralogs with MED9: view

No data available for Paralogs for MED9 Gene

Variants for MED9 Gene

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dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MED9 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MED9 Gene

Variant ID Type Subtype PubMed ID
nsv1065710 CNV gain 25217958
nsv155 OTHER inversion 15895083
nsv499114 OTHER inversion 21111241
nsv827909 CNV gain 20364138

Variation tolerance for MED9 Gene

Residual Variation Intolerance Score: 45.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.68; 45.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MED9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MED9

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MED9 Gene

Disorders for MED9 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MED9 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
smith-magenis syndrome
  • sms
jacobsen syndrome
  • jbs
potocki-lupski syndrome
  • ptls
- elite association - COSMIC cancer census association via MalaCards
Search MED9 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MED9

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with MED9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MED9 Gene

Publications for MED9 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PMID: 15175163) Sato S … Conaway RC (Molecular cell 2004) 3 4
  3. Genes in a refined Smith-Magenis syndrome critical deletion interval on chromosome 17p11.2 and the syntenic region of the mouse. (PMID: 11997338) Bi W … Lupski JR (Genome research 2002) 2 3
  4. H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids. (PMID: 30804502) Nakamura K … Groth A (Nature cell biology 2019) 3
  5. DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity. (PMID: 29656893) Gupta R … Choudhary C (Cell 2018) 3

ExternalLinks

View latest publications for MED9 gene in Mastermind

Products for MED9 Gene

  • Addgene plasmids for MED9

Sources for MED9 Gene