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Aliases for MED9 Gene

Aliases for MED9 Gene

  • Mediator Complex Subunit 9 2 3 4 5
  • MED25 3 4
  • Mediator Of RNA Polymerase II Transcription, Subunit 9 Homolog (S. Cerevisiae) 2
  • Mediator Of RNA Polymerase II Transcription, Subunit 9 Homolog 3
  • Mediator Of RNA Polymerase II Transcription Subunit 9 3
  • Mediator Subunit 25 3

External Ids for MED9 Gene

Previous GeneCards Identifiers for MED9 Gene

  • GC17P017322
  • GC17P017324
  • GC17P017380
  • GC17P017132

Summaries for MED9 Gene

Entrez Gene Summary for MED9 Gene

  • The multiprotein Mediator complex is a coactivator required for activation of RNA polymerase II transcription by DNA bound transcription factors. The protein encoded by this gene is thought to be a subunit of the Mediator complex. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

GeneCards Summary for MED9 Gene

MED9 (Mediator Complex Subunit 9) is a Protein Coding gene. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Metabolism. Gene Ontology (GO) annotations related to this gene include RNA polymerase II transcription cofactor activity.

UniProtKB/Swiss-Prot for MED9 Gene

  • Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Additional gene information for MED9 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MED9 Gene

Genomics for MED9 Gene

GeneHancer (GH) Regulatory Elements for MED9 Gene

Promoters and enhancers for MED9 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I017476 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.7 748 2.7 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF207 KLF13 SP3 ZHX2 GC17P017477 MED9 SMCR8 DRG2 FLII LOC644422 TOP3A MYO15A GC17P017485
GH17I017444 Enhancer 1.2 Ensembl ENCODE 19 -31.0 -30994 3.2 PKNOX1 CLOCK FOXA2 MLX ARID4B NEUROD1 SIN3A FEZF1 DMAP1 ZBTB7B MED9 SMCR8 LOC644422 DRG2 RPL13P12 ACTG1P24 TOM1L2 GC17P017438 TSEN15P1
GH17I017040 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 8 -433.1 -433122 6.1 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 MPRIP GC17P017043 GC17P017048 PIR46780 PIR43427 MPRIP-AS1 FLCN PIGL PLD6 NCOR1
GH17I017580 Enhancer 1.3 Ensembl ENCODE dbSUPER 10.6 +104.4 104362 1.9 ELF3 FOXA2 MLX ARID4B KLF17 THRB RAD21 RARA YY1 THAP11 MED9 PEMT LOC100419436 RNU6-468P ENSG00000264666 EEF1A1P43
GH17I017582 Promoter/Enhancer 1.2 EPDnew dbSUPER 10.6 +105.4 105443 0.1 TFAP4 MXI1 FOXA2 SAP130 ARID4B MAX RAD21 YY1 HNF4G NR2F6 PEMT MED9 RNU6-468P ENSG00000264666 EEF1A1P43
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MED9 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MED9 gene promoter:

Genomic Locations for MED9 Gene

Genomic Locations for MED9 Gene
chr17:17,476,986-17,493,226
(GRCh38/hg38)
Size:
16,241 bases
Orientation:
Plus strand
chr17:17,380,300-17,396,540
(GRCh37/hg19)

Genomic View for MED9 Gene

Genes around MED9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MED9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MED9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MED9 Gene

Proteins for MED9 Gene

  • Protein details for MED9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NWA0-MED9_HUMAN
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 9
    Protein Accession:
    Q9NWA0

    Protein attributes for MED9 Gene

    Size:
    146 amino acids
    Molecular mass:
    16403 Da
    Quaternary structure:
    • Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.

neXtProt entry for MED9 Gene

Post-translational modifications for MED9 Gene

  • Ubiquitination at posLast=9999
  • Modification sites at PhosphoSitePlus

Other Protein References for MED9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MED9 Gene

Domains & Families for MED9 Gene

Gene Families for MED9 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MED9 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MED9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NWA0

UniProtKB/Swiss-Prot:

MED9_HUMAN :
  • Belongs to the Mediator complex subunit 9 family.
Family:
  • Belongs to the Mediator complex subunit 9 family.
genes like me logo Genes that share domains with MED9: view

Function for MED9 Gene

Molecular function for MED9 Gene

UniProtKB/Swiss-Prot Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Phenotypes From GWAS Catalog for MED9 Gene

Gene Ontology (GO) - Molecular Function for MED9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001104 RNA polymerase II transcription cofactor activity IEA --
GO:0005515 protein binding IPI 14638676
genes like me logo Genes that share ontologies with MED9: view
genes like me logo Genes that share phenotypes with MED9: view

miRNA for MED9 Gene

miRTarBase miRNAs that target MED9

Clone Products

  • Addgene plasmids for MED9

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MED9 Gene

Localization for MED9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MED9 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MED9 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Midbody (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MED9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0016592 mediator complex IEA,IBA --
genes like me logo Genes that share ontologies with MED9: view

Pathways & Interactions for MED9 Gene

genes like me logo Genes that share pathways with MED9: view

Gene Ontology (GO) - Biological Process for MED9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with MED9: view

No data available for SIGNOR curated interactions for MED9 Gene

Drugs & Compounds for MED9 Gene

No Compound Related Data Available

Transcripts for MED9 Gene

mRNA/cDNA for MED9 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MED9 Gene

Mediator complex subunit 9:
Representative Sequences:

Clone Products

  • Addgene plasmids for MED9

Alternative Splicing Database (ASD) splice patterns (SP) for MED9 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3
SP1: -
SP2: - -
SP3:

Relevant External Links for MED9 Gene

GeneLoc Exon Structure for
MED9
ECgene alternative splicing isoforms for
MED9

Expression for MED9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MED9 Gene

Protein differential expression in normal tissues from HIPED for MED9 Gene

This gene is overexpressed in Monocytes (30.7), Fetal Brain (11.8), CD4 Tcells (8.6), and Placenta (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MED9 Gene



NURSA nuclear receptor signaling pathways regulating expression of MED9 Gene:

MED9

SOURCE GeneReport for Unigene cluster for MED9 Gene:

Hs.244595

Evidence on tissue expression from TISSUES for MED9 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with MED9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MED9 Gene

Orthologs for MED9 Gene

This gene was present in the common ancestor of animals.

Orthologs for MED9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MED9 33 34
  • 99.32 (n)
dog
(Canis familiaris)
Mammalia MED9 33 34
  • 85.39 (n)
mouse
(Mus musculus)
Mammalia Med9 33 16 34
  • 83.21 (n)
rat
(Rattus norvegicus)
Mammalia Med9 33
  • 82.19 (n)
cow
(Bos Taurus)
Mammalia MED9 33 34
  • 79.08 (n)
oppossum
(Monodelphis domestica)
Mammalia MED9 34
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves MED9 33 34
  • 83.15 (n)
lizard
(Anolis carolinensis)
Reptilia MED9 34
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia med9 33
  • 78.62 (n)
Str.15073 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.33549 33
zebrafish
(Danio rerio)
Actinopterygii si:ch73-105m5.1 33
  • 71.91 (n)
MED9 34
  • 65 (a)
OneToOne
Dr.28799 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10572 33
fruit fly
(Drosophila melanogaster)
Insecta MED9 34
  • 27 (a)
OneToOne
Species where no ortholog for MED9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MED9 Gene

ENSEMBL:
Gene Tree for MED9 (if available)
TreeFam:
Gene Tree for MED9 (if available)

Paralogs for MED9 Gene

Pseudogenes.org Pseudogenes for MED9 Gene

genes like me logo Genes that share paralogs with MED9: view

No data available for Paralogs for MED9 Gene

Variants for MED9 Gene

Sequence variations from dbSNP and Humsavar for MED9 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000166224 -- 17,487,229(+) C/G/T intron_variant
rs1000411298 -- 17,478,634(+) C/T intron_variant
rs1000479786 -- 17,492,360(+) G/T 3_prime_UTR_variant
rs1000527883 -- 17,489,767(+) T/C intron_variant
rs1000633677 -- 17,486,543(+) C/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MED9 Gene

Variant ID Type Subtype PubMed ID
nsv1065710 CNV gain 25217958
nsv155 OTHER inversion 15895083
nsv499114 OTHER inversion 21111241
nsv827909 CNV gain 20364138

Variation tolerance for MED9 Gene

Residual Variation Intolerance Score: 45.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.68; 45.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MED9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MED9

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MED9 Gene

Disorders for MED9 Gene

Additional Disease Information for MED9

No disorders were found for MED9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MED9 Gene

Publications for MED9 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PMID: 15175163) Sato S … Conaway RC (Molecular cell 2004) 3 4 58
  3. Genes in a refined Smith-Magenis syndrome critical deletion interval on chromosome 17p11.2 and the syntenic region of the mouse. (PMID: 11997338) Bi W … Lupski JR (Genome research 2002) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The Dual Estrogen Receptor α Inhibitory Effects of the Tissue-Selective Estrogen Complex for Endometrial and Breast Safety. (PMID: 26487511) Han SJ … O'Malley BW (Molecular pharmacology 2016) 3 58

Products for MED9 Gene

  • Addgene plasmids for MED9

Sources for MED9 Gene

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