Aliases for MED7 Gene
- Mediator Complex Subunit 7 2 3 4 5
- Cofactor Required For Sp1 Transcriptional Activation, Subunit 9, 33kDa 2 3
- RNA Polymerase Transcriptional Regulation Mediator Subunit 7 Homolog 3 4
- Cofactor Required For Sp1 Transcriptional Activation Subunit 9 3 4
- Mediator Of RNA Polymerase II Transcription Subunit 7 3 4
- Activator-Recruited Cofactor 34 KDa Component 3 4
- Transcriptional Coactivator CRSP33 3 4
External Ids for MED7 Gene
Previous HGNC Symbols for MED7 Gene
Previous GeneCards Identifiers for MED7 Gene
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for MED7 Gene
MED7 (Mediator Complex Subunit 7) is a Protein Coding gene. Diseases associated with MED7 include Amyotrophic Lateral Sclerosis 1. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and RNA Polymerase II Transcription Initiation And Promoter Clearance. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity. An important paralog of this gene is HAVCR2.
UniProtKB/Swiss-Prot Summary for MED7 Gene
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.