Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a component of the Mediator complex. The Mediator complex interacts with DNA-binding gene-specific transcription factors to modulate transcription by RNA polymerase II. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
MED4 (Mediator Complex Subunit 4) is a Protein Coding gene. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Developmental Biology. Gene Ontology (GO) annotations related to this gene include nuclear receptor transcription coactivator activity.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003712 | transcription coregulator activity | IDA | 10882111 |
GO:0005515 | protein binding | IPI | 14638676 |
GO:0030374 | nuclear receptor transcription coactivator activity | NAS | 10235266 |
GO:0042809 | vitamin D receptor binding | NAS | 10235266 |
GO:0046966 | thyroid hormone receptor binding | IDA | 10198638 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IDA,IEA | 10235267 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0016020 | membrane | HDA | 19946888 |
GO:0016592 | mediator complex | IEA,IDA | 10882111 |
GO:0070847 | core mediator complex | IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||
2 | Gene Expression |
.48
|
|
3 | Metabolism |
.40
|
|
4 | Thyroid hormone signaling pathway | ||
5 | Developmental Biology |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006357 | regulation of transcription by RNA polymerase II | IBA,IEA | 21873635 |
GO:0006366 | transcription by RNA polymerase II | IDA | 10882111 |
GO:0006367 | transcription initiation from RNA polymerase II promoter | TAS | -- |
GO:0045893 | positive regulation of transcription, DNA-templated | IDA | 10198638 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | MED4 33 32 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | MED4 33 32 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | MED4 33 32 |
|
OneToOne | |
rat (Rattus norvegicus) |
Mammalia | Med4 32 |
|
||
mouse (Mus musculus) |
Mammalia | Med4 17 33 32 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | MED4 33 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | MED4 33 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | MED4 33 32 |
|
OneToOne | |
lizard (Anolis carolinensis) |
Reptilia | MED4 33 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | med4 32 |
|
||
Str.17110 32 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.8738 32 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | med4 33 32 |
|
OneToOne | |
Dr.18060 32 |
|
||||
fruit fly (Drosophila melanogaster) |
Insecta | MED4 33 32 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | MED4_ANOGA 32 |
|
||
worm (Caenorhabditis elegans) |
Secernentea | mdt-4 33 |
|
OneToOne | |
sea squirt (Ciona savignyi) |
Ascidiacea | CSA.4706 33 |
|
OneToOne |
SNP ID | Clin | Chr 13 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000198369 | -- | 48,082,217(-) | G/A | intron_variant | |
rs1000532691 | -- | 48,080,592(-) | A/G | intron_variant | |
rs1000557701 | -- | 48,093,142(-) | G/A | intron_variant | |
rs1000586458 | -- | 48,080,320(-) | C/T | intron_variant | |
rs1000586691 | -- | 48,077,402(-) | T/G | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2676750 | CNV | deletion | 23128226 |
esv3632017 | CNV | loss | 21293372 |
nsv832601 | CNV | gain | 17160897 |
No disorders were found for MED4 Gene.