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This gene encodes a component of the Mediator complex. The Mediator complex interacts with DNA-binding gene-specific transcription factors to modulate transcription by RNA polymerase II. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012] See more...
Aliases for MED4 Gene
Aliases for MED4 Gene
External Ids for MED4 Gene
- HGNC: 17903
- Entrez Gene: 29079
- Ensembl: ENSG00000136146
- OMIM: 605718
- UniProtKB: Q9NPJ6
Previous HGNC Symbols for MED4 Gene
- VDRIP
Previous GeneCards Identifiers for MED4 Gene
- GC13M047550
- GC13M048627
- GC13M029442
Summaries for MED4 Gene
-
This gene encodes a component of the Mediator complex. The Mediator complex interacts with DNA-binding gene-specific transcription factors to modulate transcription by RNA polymerase II. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
GeneCards Summary for MED4 Gene
MED4 (Mediator Complex Subunit 4) is a Protein Coding gene. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Thyroid hormone signaling pathway. Gene Ontology (GO) annotations related to this gene include nuclear receptor transcription coactivator activity.
UniProtKB/Swiss-Prot Summary for MED4 Gene
-
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Additional gene information for MED4 Gene
- HGNC(17903)
- Entrez Gene(29079)
- Ensembl(ENSG00000136146)
- OMIM(605718)
- UniProtKB(Q9NPJ6)
- Open Targets Platform(ENSG00000136146)
- Monarch Initiative
- Search for MED4 at DataMed
- Search for MED4 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MED4 Gene
Genomics for MED4 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MED4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MED4 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MED4
- Top Transcription factor binding sites by QIAGEN in the MED4 gene promoter:
-
- AP-1
- c-Fos
- c-Jun
- Nkx2-5
- p300
- POU3F1
- PPAR-gamma1
- PPAR-gamma2
- SRY
- STAT5B
Genomic Locations for MED4 Gene
Genomic Locations for MED4 Gene
- chr13:48,053,323-48,095,141
- (GRCh38/hg38)
- Size:
- 41,819 bases
- Orientation:
- Minus strand
- chr13:48,627,459-48,669,267
- (GRCh37/hg19)
- Size:
- 41,809 bases
- Orientation:
- Minus strand
Genomic View for MED4 Gene
Genes around MED4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 13q14.2 by HGNC
- 13q14.2 by Entrez Gene
- 13q14.2 by Ensembl
MED4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MED4 Gene
Proteins for MED4 Gene
-
Protein details for MED4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NPJ6-MED4_HUMAN
- Recommended name:
- Mediator of RNA polymerase II transcription subunit 4
- Protein Accession:
- Q9NPJ6
- B4DX67
- Q53GB4
- Q53H68
- Q5T912
- Q6FHC4
- Q6IA79
- Q9BS95
- Q9NYR5
Protein attributes for MED4 Gene
- Size:
- 270 amino acids
- Molecular mass:
- 29745 Da
- Quaternary structure:
-
- Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
Protein Expression for MED4 Gene
Post-translational modifications for MED4 Gene
Other Protein References for MED4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences MED4 Antibody (LS-B3562) and MED4 Antibody (LS-B4986)
- G Biosciences Immunotag™ MED4 Antibody
- NSJ Bioreagents MED4 Antibody
- Creative Diagnostics Anti-MED4 monoclonal antibody
-
Custom Antibody ServicesOriGene Antibodies for MED4
- Novus Biologicals Antibodies for MED4
-
Abcam antibodies for MED4
- Invitrogen Antibodies for MED4 (AFLGC-MED4)
-
Custom Antibody ServicesProSci Antibodies for MED4
-
Santa Cruz Biotechnology (SCBT) Antibodies for MED4
- Sino Biological Antibodies for MED4
Protein Products
-
OriGene Purified Proteins for MED4
- Search Origene for MassSpec and Protein Over-expression Lysates for MED4
- Origene Custom Protein Services for MED4
- ProSpec Recombinant Proteins for MED4
-
Signalway Proteins for MED4
-
Abcam proteins for MED4
Assay Products
- antibodies-online: Show 12 available MED4 Elisa Kits ranked by validation data
- Compare Top MED4 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for MED4 Gene
Domains & Families for MED4 Gene
Gene Families for MED4 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for MED4 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for MED4 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ50738, highly similar to Mediator complex subunit 4 (B4DX67_HUMAN)
- Vitamin D3 receptor-interacting protein complex 36 kDa component (MED4_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9NPJ6- Family:
-
- Belongs to the Mediator complex subunit 4 family.
Function for MED4 Gene
Molecular function for MED4 Gene
- UniProtKB/Swiss-Prot Function:
- Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Phenotypes From GWAS Catalog for MED4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003712 | transcription coregulator activity | IEA,IDA | 10882111 |
| GO:0005515 | protein binding | IPI | 14638676 |
| GO:0030374 | nuclear receptor transcription coactivator activity | NAS | 10235266 |
| GO:0042809 | vitamin D receptor binding | NAS | 10235266 |
| GO:0046966 | thyroid hormone receptor binding | IDA | -- |
Phenotypes for MED4 Gene
- GenomeRNAi human phenotypes for MED4:
-
- Mildly decreased CFP-tsO45G cell surface transport
- no effect
- Decreased viability
- Increased shRNA abundance (Z-score > 2)
- Decreased Salmonella enterica Typhimurium invasion
- Decreased Salmonella-containing vacuole maturation
- Decreased Salmonella enterica Typhimurium binding
- Decreased Salmonella enterica Typhimurium effector injection
- Decreased Salmonella enterica Typhimurium ruffling
- Decreased Salmonella enterica Typhimurium membrane closure
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Inconclusive
- Decreased viability in pancreas lineage
- Decreased HIV-LTR-beta-galactosidase protein expression
- Decreased homologous recombination repair frequency
- Decreased p24 protein expression
- Decreased Tat-dependent HIV-LTR-beta-galactosidase protein expression
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MED4 - Select products 50% OFF >
- * MED4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MED4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MED4
-
Santa Cruz Biotechnology (SCBT) CRISPR for MED4
miRNA for MED4 Gene
- miRTarBase miRNAs that target MED4
-
- hsa-miR-425-5p (MIRT016676)
- hsa-miR-186-5p (MIRT021128)
- hsa-miR-23b-3p (MIRT023475)
- hsa-miR-4446-5p (MIRT547418)
- hsa-miR-4755-5p (MIRT547419)
- hsa-miR-5006-3p (MIRT547420)
- hsa-miR-1261 (MIRT547421)
- hsa-miR-3924 (MIRT547422)
- hsa-miR-642a-5p (MIRT547423)
- hsa-miR-921 (MIRT547424)
- hsa-miR-3606-5p (MIRT547425)
- hsa-miR-3689f (MIRT547426)
- hsa-miR-3689e (MIRT547427)
- hsa-miR-3689b-5p (MIRT547428)
- hsa-miR-3689a-5p (MIRT547429)
- hsa-miR-1246 (MIRT547430)
- hsa-miR-8076 (MIRT547431)
- hsa-miR-8062 (MIRT547432)
- hsa-miR-8079 (MIRT547433)
- hsa-miR-1245a (MIRT547434)
- hsa-miR-190a-5p (MIRT547435)
- hsa-miR-190b (MIRT547436)
- hsa-miR-1324 (MIRT571399)
- hsa-miR-670-5p (MIRT571400)
- hsa-miR-5089-3p (MIRT571401)
- hsa-miR-6752-3p (MIRT571402)
- hsa-miR-4676-3p (MIRT571403)
- hsa-miR-892c-3p (MIRT571404)
- hsa-miR-452-5p (MIRT571405)
- hsa-miR-3133 (MIRT571407)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MED4
- Browse OriGene Inhibitory RNA Products For MED4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MED4
Clone Products
- Applied Biological Materials (abm): Clones for MED4 - Select products 50% OFF >
- * MED4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for MED4
- Addgene plasmids for MED4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MED4
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MED4 Gene
Localization for MED4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MED4 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| golgi apparatus | 1 |
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IDA | 10235267 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0016020 | membrane | HDA | 19946888 |
| GO:0016592 | mediator complex | IEA,IDA | 10882111 |
| GO:0070847 | core mediator complex | IBA | 21873635 |
Pathways & Interactions for MED4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||
| 2 | Gene Expression |
.48
|
|
| 3 | Metabolism |
.40
|
|
| 4 | Thyroid hormone signaling pathway | ||
| 5 | Developmental Biology | ||
Pathways by source for MED4 Gene
9 Reactome pathways for MED4 Gene
1 KEGG pathway for MED4 Gene
1 GeneGo (Thomson Reuters) pathway for MED4 Gene
- Transcription Ligand-Dependent Transcription of Retinoid-Target genes
Interacting Proteins for MED4 Gene
Selected Interacting proteins:
Q9NPJ6-MED4_HUMAN
ENSP00000258648
for MED4 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for MED4
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006357 | regulation of transcription by RNA polymerase II | IEA,IBA | 21873635 |
| GO:0006366 | transcription by RNA polymerase II | IDA | 10882111 |
| GO:0006367 | transcription initiation from RNA polymerase II promoter | TAS | -- |
| GO:0045893 | positive regulation of transcription, DNA-templated | IDA | -- |
No data available for SIGNOR curated interactions for MED4 Gene
Transcripts for MED4 Gene
mRNA/cDNA for MED4 Gene
- 2 REFSEQ mRNAs :
- 13 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000258648 2254 nts (view in UCSC)
- ENST00000378586 931 nts (view in UCSC)
- ENST00000417167 911 nts (view in UCSC)
- ENST00000495013 460 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MED4 - Select products 50% OFF >
- * MED4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MED4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MED4
-
Santa Cruz Biotechnology (SCBT) CRISPR for MED4
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MED4
- Browse OriGene Inhibitory RNA Products For MED4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MED4
Clone Products
- Applied Biological Materials (abm): Clones for MED4 - Select products 50% OFF >
- * MED4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for MED4
- Addgene plasmids for MED4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MED4
Relevant External Links for MED4 Gene
- GeneLoc Exon Structure for
- MED4
Expression for MED4 Gene
This gene is overexpressed in Breast (16.9), Liver (13.5), Monocytes (11.2), and Peripheral blood mononuclear cells (6.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MED4 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MED4
SOURCE GeneReport for Unigene cluster for MED4 Gene:
Hs.181112Evidence on tissue expression from TISSUES for MED4 Gene
- Kidney(2.4)
- Muscle(2.3)
- Liver(2.2)
- Heart(2.2)
- Lung(2.1)
- Nervous system(4.7)
- Intestine(4.4)
- Blood(4.3)
- Skin(2.6)
- Thyroid gland(2.4)
Primer Products
-
OriGene qPCR primer pairs for MED4
-
OriGene qPCR primer pairs and template standards for MED4
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MED4 Gene
Orthologs for MED4 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | MED4 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | MED4 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | MED4 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Med4 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Med4 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | MED4 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | MED4 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | MED4 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | MED4 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | med4 30 |
|
||
| Str.17110 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.8738 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | med4 30 31 |
|
OneToOne | |
| Dr.18060 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | MED4 30 31 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | MED4_ANOGA 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | mdt-4 31 |
|
OneToOne | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.4706 31 |
|
OneToOne |
- Species where no ortholog for MED4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for MED4 Gene
- ENSEMBL:
- Gene Tree for MED4 (if available)
- TreeFam:
- Gene Tree for MED4 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MED4: view image
Paralogs for MED4 Gene
(6) SIMAP similar genes for MED4 Gene using alignment to 3 proteins:
- MED4_HUMAN
- Q5T911_HUMAN
- U4PSC4_HUMAN
No data available for Paralogs for MED4 Gene
Variants for MED4 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MED4 Gene
| SNP ID | Clinical significance and condition | Chr 13 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 773271 | Benign: not provided | 48,077,193(-) | A/T | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2676750 | CNV | deletion | 23128226 |
| esv3632017 | CNV | loss | 21293372 |
| nsv832601 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
52.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.58;
30.49% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MED4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MED4
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MED4 Gene
Disorders for MED4 Gene
Additional Disease Information for MED4
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No disorders were found for MED4 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MED4 Gene
Publications for MED4 Gene
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 4
- Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex. (PMID: 10235266) Rachez C … Freedman LP (Nature 1999) 2 3 4
- MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PMID: 15989967) Zhang X … Roeder RG (Molecular cell 2005) 3 4
- The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A … Ross MT (Nature 2004) 3 4
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
ExternalLinks
Products for MED4 Gene
- Custom Antibody ServicesOriGene Antibodies for MED4
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for MED4
- Search Origene for MassSpec and Protein Over-expression Lysates for MED4
- Origene Custom Protein Services for MED4
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MED4
- Browse OriGene Inhibitory RNA Products For MED4
- OriGene qPCR primer pairs for MED4
- OriGene qPCR primer pairs and template standards for MED4
- OriGene CRISPR knockouts for MED4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MED4
- Sino Biological Human cDNA Clone for MED4
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for MED4
- Browse Sino Biological Assays
- Browse Antibodies
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for MED4
- Novus Biologicals proteins and lysates for MED4
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for MED4
- Abcam proteins for MED4
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- VectorBuilder Custom and pre-made DNA vectors for MED4 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for MED4 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for MED4 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for MED4 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for MED4
- Addgene plasmids for MED4
- antibodies-online: Show 11 available MED4 Antibodies ranked by validation data
- Compare Top MED4 Antibodies
- antibodies-online: Show 12 available MED4 Elisa Kits ranked by validation data
- Compare Top MED4 Elisa Kits
- Quality Products:
- antibodies-online: Show 14 available MED4 Proteins ranked by validation data
- Compare Top MED4 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for MED4
- Search Santa Cruz Biotechnology (SCBT) for MED4 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for MED4
- Custom Antibody ServicesProSci Antibodies for MED4
- Search for MED4 Proteins at ProSci
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MED4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MED4
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MED4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MED4
- Signalway Proteins for MED4
Sources for MED4 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
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